CA2294134A1 - Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases - Google Patents

Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases Download PDF

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Publication number
CA2294134A1
CA2294134A1 CA002294134A CA2294134A CA2294134A1 CA 2294134 A1 CA2294134 A1 CA 2294134A1 CA 002294134 A CA002294134 A CA 002294134A CA 2294134 A CA2294134 A CA 2294134A CA 2294134 A1 CA2294134 A1 CA 2294134A1
Authority
CA
Canada
Prior art keywords
compound
administration
glucosidase inhibitor
pharmaceutically acceptable
alpha glucosidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002294134A
Other languages
English (en)
Inventor
Stephen Alistair Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9712865.6A external-priority patent/GB9712865D0/en
Priority claimed from GBGB9806708.5A external-priority patent/GB9806708D0/en
Application filed by Individual filed Critical Individual
Publication of CA2294134A1 publication Critical patent/CA2294134A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

L'invention concerne une méthode de traitement, chez un mammifère, du diabète sucré et des états associés à ce diabète, cette méthode consistant à administrer à un mammifère nécessitant un tel traitement, une dose efficace, non toxique et acceptable sur le plan pharmacologique, d'un agent de sensibilisation à l'insuline et d'un agent anti-hyperglycémiant inhibant les alpha-glucosidases.
CA002294134A 1997-06-18 1998-06-15 Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases Abandoned CA2294134A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9712865.6 1997-06-18
GBGB9712865.6A GB9712865D0 (en) 1997-06-18 1997-06-18 Novel method of treatment
GBGB9806708.5A GB9806708D0 (en) 1998-03-27 1998-03-27 Novel method
GB9806708.5 1998-03-27
PCT/EP1998/003691 WO1998057635A1 (fr) 1997-06-18 1998-06-15 Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases

Publications (1)

Publication Number Publication Date
CA2294134A1 true CA2294134A1 (fr) 1998-12-23

Family

ID=26311746

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002294134A Abandoned CA2294134A1 (fr) 1997-06-18 1998-06-15 Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases

Country Status (24)

Country Link
EP (1) EP0975343A1 (fr)
JP (1) JP2001523271A (fr)
KR (1) KR20010013845A (fr)
CN (1) CN1274282A (fr)
AP (1) AP9901720A0 (fr)
AR (2) AR013352A1 (fr)
AU (1) AU8799998A (fr)
BG (1) BG103966A (fr)
BR (1) BR9810186A (fr)
CA (1) CA2294134A1 (fr)
CO (1) CO4940453A1 (fr)
DZ (1) DZ2519A1 (fr)
EA (1) EA200000040A1 (fr)
IL (1) IL133138A0 (fr)
MA (1) MA26510A1 (fr)
NO (1) NO996270L (fr)
NZ (1) NZ501345A (fr)
OA (1) OA11631A (fr)
PE (1) PE89199A1 (fr)
PL (1) PL337577A1 (fr)
SK (1) SK179499A3 (fr)
TR (1) TR199903072T2 (fr)
UY (1) UY25051A1 (fr)
WO (1) WO1998057635A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200103061T2 (tr) 1999-04-23 2002-05-21 Smithkline Beecham P.L.C. Yeni farmasötik madde.
WO2002080936A1 (fr) 2001-04-04 2002-10-17 Ortho Mcneil Pharmaceutical, Inc. Polytherapie comprenant des inhibiteurs de reabsorption du glucose et des modulateurs ppar
JP4590158B2 (ja) 2001-04-04 2010-12-01 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド グルコース再吸収阻害剤およびレチノイド−ｘ受容体モジュレーターを含んで成る併用療法
FR2832930A1 (fr) * 2001-12-03 2003-06-06 Lipha Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
JP2004067575A (ja) * 2002-08-06 2004-03-04 Yaizu Suisankagaku Industry Co Ltd 糖尿病治療薬効果促進剤
CN101121004B (zh) * 2006-08-08 2010-07-21 鲁南制药集团股份有限公司 含有胰岛素增敏剂和米格列醇的药物组合物
CN101584705B (zh) * 2008-05-24 2010-10-27 鲁南制药集团股份有限公司 一种治疗糖尿病及其并发症的药物组合物
CN101584688B (zh) * 2008-05-24 2010-11-10 鲁南制药集团股份有限公司 一种治疗糖尿病及其并发症的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900435A (en) * 1991-08-26 1999-05-04 Pharmacia & Upjohn Company Composition, food product and uses of 3-guanidinopropionic acid
US5917052A (en) * 1994-09-28 1999-06-29 Shaman Pharmaceuticals, Inc. Hypoglycemic agent from cryptolepis
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes

Also Published As

Publication number Publication date
AU8799998A (en) 1999-01-04
WO1998057635A1 (fr) 1998-12-23
AR014881A1 (es) 2001-04-11
JP2001523271A (ja) 2001-11-20
IL133138A0 (en) 2001-03-19
BR9810186A (pt) 2000-08-08
UY25051A1 (es) 2000-09-29
EP0975343A1 (fr) 2000-02-02
CN1274282A (zh) 2000-11-22
MA26510A1 (fr) 2004-12-20
PE89199A1 (es) 1999-10-23
NO996270D0 (no) 1999-12-17
NO996270L (no) 1999-12-17
AR013352A1 (es) 2000-12-27
OA11631A (en) 2004-11-22
BG103966A (bg) 2000-07-31
KR20010013845A (ko) 2001-02-26
TR199903072T2 (xx) 2000-07-21
NZ501345A (en) 2001-10-26
PL337577A1 (en) 2000-08-28
CO4940453A1 (es) 2000-07-24
AP9901720A0 (en) 1999-12-31
SK179499A3 (en) 2000-11-07
DZ2519A1 (fr) 2003-02-01
EA200000040A1 (ru) 2000-08-28

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Legal Events

Date Code Title Description
FZDE Discontinued