EP0972011A4 - Proteine kinase cyclino-dependante - Google Patents

Proteine kinase cyclino-dependante

Info

Publication number
EP0972011A4
EP0972011A4 EP98906202A EP98906202A EP0972011A4 EP 0972011 A4 EP0972011 A4 EP 0972011A4 EP 98906202 A EP98906202 A EP 98906202A EP 98906202 A EP98906202 A EP 98906202A EP 0972011 A4 EP0972011 A4 EP 0972011A4
Authority
EP
European Patent Office
Prior art keywords
cyclin
cdk
disclosed
protein kinase
dependent protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98906202A
Other languages
German (de)
English (en)
Other versions
EP0972011A1 (fr
Inventor
David L Gerhold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9707491.8A external-priority patent/GB9707491D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0972011A1 publication Critical patent/EP0972011A1/fr
Publication of EP0972011A4 publication Critical patent/EP0972011A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne une molécule d'acide nucléique isolée qui code une nouvelle kinase cyclino-dépendante (CDK = cyclin-dependent kinase) humaine qui comprend une nouvelle séquence de signature du domaine de liaison de la cycline et ne présente pas plusieurs résidus d'acide aminé, qui étaient conservés jusqu'à maintenant, impliqués dans la régulation du complexe cdk/cycline. L'invention concerne des protéines et des formes mutantes biologiquement actives associées.
EP98906202A 1997-02-07 1998-02-06 Proteine kinase cyclino-dependante Withdrawn EP0972011A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3785597P 1997-02-07 1997-02-07
US37855P 1997-02-07
GBGB9707491.8A GB9707491D0 (en) 1997-04-14 1997-04-14 Cyclin-dependent protein kinase
GB9707491 1997-04-14
PCT/US1998/002337 WO1998035015A1 (fr) 1997-02-07 1998-02-06 Proteine kinase cyclino-dependante

Publications (2)

Publication Number Publication Date
EP0972011A1 EP0972011A1 (fr) 2000-01-19
EP0972011A4 true EP0972011A4 (fr) 2003-04-16

Family

ID=26311373

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98906202A Withdrawn EP0972011A4 (fr) 1997-02-07 1998-02-06 Proteine kinase cyclino-dependante

Country Status (4)

Country Link
EP (1) EP0972011A4 (fr)
JP (1) JP2001511015A (fr)
CA (1) CA2280206A1 (fr)
WO (1) WO1998035015A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961813B1 (fr) 1998-12-16 2011-08-10 Novartis Vaccines and Diagnostics, Inc. Kinase de type humain dépendant de la cycline (hPNQALRE)
JP2003501038A (ja) * 1999-05-28 2003-01-14 スージェン・インコーポレーテッド 蛋白質キナーゼ
WO2009063175A1 (fr) * 2007-11-13 2009-05-22 The Institute Of Cancer Research; Royal Cancer Hospital Procédés pour déterminer la résistance à une thérapie contre le cancer

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 1 July 1995 (1995-07-01), XP002229224, Database accession no. H17727 *
DATABASE EMBL [online] EBI; 15 June 1992 (1992-06-15), XP002229248, Database accession no. x66357 *
DATABASE EMBL [online] EBI; 3 May 1993 (1993-05-03), XP002229247, Database accession no. x66362 *
DATABASE SWISS-PROT [online] EBI; 1 April 1993 (1993-04-01), XP002229225, Database accession no. P29620 *
GRANA X ET AL: "PITALRE, A NUCLEAR CDC2-RELATED PROTEIN KINASE THAT PHOSPHORYLATES THE RETINOBLASTOMA PROTEIN IN VITRO", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 91, April 1994 (1994-04-01), pages 3834 - 3838, XP000919000, ISSN: 0027-8424 *
HATA S.: "complementary DNA cloning of a novel CDC2-positive -CDC28-related protein kinase from rice", FEBS (FEDERATION OF EUROPEAN BIOECHEMICAL SOCIETIES) LETTERS, vol. 279, no. 1, 1991, pages 149 - 152, XP002229244 *
MEYERSON M ET AL: "A family of human cdc2-related protein kinases", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 8, x66362, 1992, pages 2909 - 2917, XP002128265, ISSN: 0261-4189 *
See also references of WO9835015A1 *

Also Published As

Publication number Publication date
JP2001511015A (ja) 2001-08-07
EP0972011A1 (fr) 2000-01-19
CA2280206A1 (fr) 1998-08-13
WO1998035015A1 (fr) 1998-08-13

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