EP0955947B1 - Anordnung zur verabreichung von medikamenten - Google Patents

Anordnung zur verabreichung von medikamenten Download PDF

Info

Publication number
EP0955947B1
EP0955947B1 EP98900505A EP98900505A EP0955947B1 EP 0955947 B1 EP0955947 B1 EP 0955947B1 EP 98900505 A EP98900505 A EP 98900505A EP 98900505 A EP98900505 A EP 98900505A EP 0955947 B1 EP0955947 B1 EP 0955947B1
Authority
EP
European Patent Office
Prior art keywords
delivery system
delivery
housing
arm
gap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP98900505A
Other languages
English (en)
French (fr)
Other versions
EP0955947A1 (de
Inventor
Richard Harland
Stephen D. Acres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MetaMorphix International Inc
Original Assignee
MetaMorphix International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MetaMorphix International Inc filed Critical MetaMorphix International Inc
Publication of EP0955947A1 publication Critical patent/EP0955947A1/de
Application granted granted Critical
Publication of EP0955947B1 publication Critical patent/EP0955947B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D9/00—Bandages, poultices, compresses specially adapted to veterinary purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals

Definitions

  • the present invention relates to the administration of drugs or vaccines to vertebrate subjects. More particularly, the invention relates to a pharmaceutical delivery system for use with a variety of delivery devices, wherein the system prevents, or reduces the incidence of, inappropriate or accidental administration of a drug or vaccine to a person operating the delivery system.
  • Drugs and vaccines are routinely administered to vertebrate subjects by needle and syringe, and the accidental administration of drugs or vaccines to technicians, for example by needle stick, is not uncommon. Devices that deliver drugs or vaccines via air injection, jet injection or particle bombardment can also be accidently discharged, thereby delivering a drug or vaccine to an inappropriate recipient. The administration of veterinary drugs and vaccines is often carried out under less than ideal conditions, which greatly increases the potential for such inappropriate administrations.
  • WO90/13270 describes a medicated ear tag.
  • FR-A-2599976 describes a transdermal therapeutic device.
  • a vaccine intended to prevent reproductive maturation in a domestic animal could, if accidently administered to a human, prevent reproductive maturation in the human.
  • EP-A-376 143 discloses a device for prolonged medicine application corresponding the preamble of claim 1 of the invention.
  • the invention relates to a pharmaceutical delivery system.
  • the delivery system has first and second substantially planar opposing arms that are connected to each other at one end of a housing, and open at an opposite end to define a gap.
  • the gap is sized to receive a body part of a vertebrate.
  • a delivery means is disposed on one of the opposing arms of the housing, and is capable of delivering a pharmaceutical to a vertebrate body part inserted within the gap. Delivery of the pharmaceutical is carried out along a direction substantially normal to the plane of the opposing arms.
  • the invention relates to a pharmaceutical delivery system
  • a pharmaceutical delivery system comprising a housing formed from opposing arms that are held together by a dynamic fastener at a closed end of the housing. At an opposite end of the housing, the arms are open to define a gap into which a vertebrate body part can be inserted for administration of a pharmaceutical.
  • the system also includes a delivery means arranged on one arm. A pharmaceutical can be delivered from the delivery means to a vertebrate body part disposed within the housing.
  • the gaps provided at the open ends of the system housings are preferably sized to accommodate a skin flap, ear, tail, fin or wing of a vertebrate, but small enough to reduce the possibility of accidently inserting an adult human appendage into the gap.
  • the delivery systems can employ any known pharmaceutical delivery mechanism, such as, but not limited to, a needle syringe, an air injector, a jet injector or a particle injector.
  • the above pharmaceutical delivery systems can also include means for applying tracking indicia on body parts inserted within the system housings.
  • Such indicia can include dye marks, tattoos, scars, brands, tags, or fin or ear notches.
  • the delivery systems can further include means for positioning and maintaining a vertebrate body part within the delivery system, such as mechanical, hydraulic, inflatable, or other adjustable means that reduce the size of the gap provided by the opposing arms of the housing.
  • a "pharmaceutical” intends any compound or composition of matter which, when administered to a vertebrate subject, induces a desired pharmacologic, immunologic, and/or physiologic effect by local and/or systemic action.
  • the term therefore encompasses those compounds or chemicals traditionally regarded as drugs, vaccines, growth promotants, and biopharmaceuticals, including, without limitation: proteins, peptides and fragments thereof (whether naturally occurring, chemically synthesized or recombinantly produced); nucleic acid molecules (polymeric forms of two or more nucleotides, either ribonucleotides (RNA) or deoxyribonucleotides (DNA) including both double- and single-stranded molecules, gene constructs, and expression vectors); carbohydrates; polysaccharides; growth promoting or enhancing steroids and chemicals; steroid and non-steroid hormones; cytokines and other biological response modifiers and/or intercellular messengers; and the like.
  • the term "pharmaceutical” includes compounds or compositions for use in all of the major therapeutic areas, and is particularly defined herein to include vaccine compositions containing an antigen capable of initiating lymphocyte activation resulting in an antigen-specific immune response, adjuvants, immunomodulators, cytokines, and the like.
  • vertebrate subject a member of the subphylum chordata, including, without limitation, mammals such as rodents, cattle, pigs, sheep, goats, horses and non-human primates; domestic animals such as dogs and cats; birds, including domestic, wild and game birds such as cocks and hens including chickens, turkeys and other gallinaceous birds; and fish.
  • mammals such as rodents, cattle, pigs, sheep, goats, horses and non-human primates
  • domestic animals such as dogs and cats
  • birds, including domestic, wild and game birds such as cocks and hens including chickens, turkeys and other gallinaceous birds
  • fish does not denote a particular age. Thus, adults, newborns, and fetuses are intended to be covered.
  • the delivery system includes a housing 4 , having first and second substantially planar opposing arms, 6 and 8, respectively, connected to each other at a closed end 10 of the housing 4.
  • the opposing arms are open at an end 12 opposite from the closed end 10 , thereby defining a gap 14 into which a vertebrate body part can be inserted.
  • the gap is sized to receive a skin flap, ear, tail, fin, or wing of a vertebrate.
  • the housing 4 can be comprised of any suitable material, for example a resilient metal or polymeric material, and can be formed by conventional methods such as casting, injection molding, milling, or the like.
  • the housing has an overall shape and outer dimension designed to fit comfortably within an operator's grasp to facilitate single-hand operation of the delivery system.
  • the delivery system 2 comprises a protrusion or extension attached to the housing 4 that enables the delivery system to be operated from a more remote location.
  • Suitable protrusions include handles or grips, and suitable extensions for use in the invention include, but are not limited to, wands, booms or poles.
  • the extension can have an adjustable length, such as wherein the extension is a telescoping pole, or the like.
  • opposing arms 6 and 8 are fixed relative to each other such that the size of the gap 14 does not change appreciably during operation of the device.
  • the housing 4 can be partially inflatable.
  • the housing When in a deflated state, the housing can be readily positioned about an vertebrate's body part. Once in place, the housing can be inflated to hold the body part in position for subsequent delivery of a drug or vaccine from the delivery system 2 .
  • the partially inflatable housing includes structural elements that maintain the overall shape of the housing, and deformable or elastic elements that allow the structure to be inflated and deflated within a selected range.
  • the partially inflatable housing further comprises means for communicating with a source of compressed gas, for example a valve body or the like.
  • the ability to hold the body part in position using the inflatable housing provides a higher degree of control over the delivery of the pharmaceutical.
  • tissue into which the pharmaceutical is to be delivered can be substantially stabilized at a selected pressure, and a targeted delivery area will not be brought out of its position within the device due to movements by the vertebrate subject or the operator.
  • the delivery system 2 includes a delivery means 16 arranged on the housing arm 6 at a selected position proximal to the closed end 10 of the housing.
  • the present delivery system is designed for use with any type of pharmaceutical delivery means known in the art, for example, conventional needle syringes, spring or compressed gas (air) injectors (U.S. Patent Nos. 1,605,763 to Smoot; 3,788,315 to Laurens; 3,853,125 to Clark et al.; 4,596,556 to Morrow et al.; and 5,062,830 to Dunlap), liquid jet injectors (U.S. Patent Nos.
  • the delivery means 16 can be used for single use delivery of a pharmaceutical, such as wherein the delivery system 2 is a disposable unit.
  • the delivery means can be used for repeated delivery, in which case a controlled or metered supply of pharmaceutical and/or motive force (e.g., compressed gas) can be associated with the delivery system, either remotely or directly, by way of a suitable interface.
  • a plurality of discrete delivery means can be employed within the housing, such as wherein it is desirable to simultaneously deliver a number of different pharmaceuticals to the vertebrate subject using a single delivery system.
  • the delivery system can be configured to provide at least a partial vacuum with a body part inserted into the housing.
  • a delivery system 2' having a first delivery means 16' on one opposing arm 6' of the housing 4' , and a second delivery means 20 disposed on the other opposing arm 8' .
  • the first and second delivery means can be positioned such that they substantially oppose each other across the interior of the housing, or the delivery means can be positioned such that they are offset from each other.
  • the delivery means 16 is used to deliver a pharmaceutical to a vertebrate body part placed within the gap 14 at the open end 12 of the housing 4 .
  • Parenteral delivery of the pharmaceutical is generally preferred, for example wherein the pharmaceutical is delivered into muscle tissue, dermis, epidermis, or subcutaneous space of the vertebrate body part inserted into the housing.
  • Other modes of delivery can also be practiced, such as topical delivery from the delivery means.
  • delivery of the pharmaceutical is carried out within the housing, and proceeds in a transverse direction relative to the plane of the opposing arms 6 and 8 of the housing. More particularly, the direction of pharmaceutical delivery is generally within the range of about 5 to about 90 degrees relative to the plane of the opposing arms.
  • the delivery means can be configured to deliver the pharmaceutical into the dermis, epidermis or subcutaneous space of the body part.
  • the delivery means 16 can also be adjusted within the above range when switching between different modes of delivery with the delivery system 2 .
  • the direction of delivery can be set substantially normal to the plane of the opposing arms.
  • the direction of delivery can be reset closer to about 5 degrees relative to the plane of the opposing arms.
  • the selected angle or direction of delivery from the delivery means 16 will depend upon the mode of delivery used, and can be readily determined by those of ordinary skill in the art.
  • the gap 14 defined by the opposing arms of the housing can be dimensioned to readily receive a skin flap, ear, tail, fin or wing (e.g., a wing web) of a vertebrate, but help prevent accidental insertion of a human appendage into the gap. More particularly, the gap 14 at the open end 12 of the housing has a small enough width (w) to preclude insertion of human fingers into the body of the housing, thus preventing contact with the delivery means which could lead to inadvertent delivery of the pharmaceutical to a human operator or technician.
  • w small enough width
  • an additional level of protection can be provided by arranging the delivery means 16 at, or near to, the closed end 10 of the housing 4 .
  • the distance (l), between the open end 14 of the housing and the delivery means 16, is sufficiently long enough to prevent a human appendage inserted into the gap 14 from contacting the delivery means.
  • Yet further safety features that can be added to the delivery system 2 include, but are not limited to, pressure sensitive locking mechanisms that prevent actuation of the delivery means when a body part is incorrectly positioned within the gap in the housing.
  • a trip-arm that projects into the space within the housing, can be provided to prevent actuation of the device unless a body part is contacting the arm, indicating proper positioning of the body part within the housing.
  • the delivery system includes a housing 24 , having first and second substantially planar opposing arms, 26 and 28 , respectively, connected to each other at a closed end 30 of the housing.
  • the opposing arms are open at an end 32 opposite from the closed end 30 , thereby defining a gap 34 into which a skin flap, ear, tail, fin, wing, or wing web can be inserted.
  • a delivery means 36 is disposed on the first opposing arm, 26 , and allows for the delivery of pharmaceuticals to a body part inserted into the gap 34 .
  • the delivery means can comprise any known delivery mechanism, such as conventional needle syringes, air injectors, jet injectors or particle injectors. As described above, delivery of the pharmaceutical is carried out within the confines of the housing 24 , and proceeds along a transverse direction relative to the plane of the opposing arms.
  • the opposing arms are held together by a moveable, dynamic fastener 38 that allows the opposing arms 26 and 28 to move towards, or away from, each other about the fastener.
  • the fastener can be pivotable, for example, hinged, thereby allowing the opposing arms to articulate about a pivot point supplied by the hinge.
  • the fastener can comprise a slidable member that allows the opposing arms to move upwards-downwards relative to each other, such as wherein the fastener is compressible.
  • Both pivotable and compressible fasteners allow the housing 24 to be positioned about a vertebrate subject's body part in an initial position, e.g., wherein the opposing arms 26 and 28 are spread apart from each other to define a maximum gap 34 .
  • the opposing arms can be brought together to define a smaller gap, holding the body part in position for delivery of a pharmaceutical from the delivery means 36 .
  • the ability to position and hold the targeted body part within the housing provides a high degree of control over the delivery of the pharmaceutical.
  • movement of the opposing arms 26 and 28 toward each other actuates the delivery means 36 .
  • the above-described safety features can be included with the delivery system 22 , such as by restricting the maximum gap size, and/or separating the delivery means from the open end of the housing, to prevent insertion of human appendages into the gap 34 , or accidental contact with the delivery means 36 .
  • the pharmaceutical delivery systems 2 and 22 can also include one or more pads disposed on an inner surface of the first or second opposing arms of the housing.
  • a delivery system 42 is shown with a pad 58 disposed on an opposing arm 48 of the housing 44 .
  • the pad faces a delivery means 56 , and reduces the size of a gap defined by the surface of the pad, and the inner surface of a second opposing arm 46 .
  • the pad 58 can be adjustably connected to the arm 48 , allowing movement of the pad relative to the arm so as to reduce or increase the size of the gap between the surface of the pad and the inner surface of the opposing arm.
  • the adjustable pad can be used to maintain the position of a body part inserted into the housing for subsequent delivery of a pharmaceutical from the delivery means.
  • the pad 58 can alternatively be inflatable, wherein the pad does not move relative to the arm 48 , but can increase in size to reduce the gap between the pad and the opposing arm.
  • FIG. 6 a different delivery system 62 is depicted.
  • the system is shown with a first pad 78 disposed on a first opposing arm 68 of the housing 64 .
  • a second pad 80 is disposed on the second opposing arm 66 , and a delivery means 76 projects through the arm 66 and second pad 80 for delivery of pharmaceutical to a body part inserted within the housing as described above.
  • the pads reduce the size of a gap defined by the inner surfaces thereof. Further, one, or both of the pads can be adjustably connected to the arm of the housing, allowing movement relative to the arm so as to reduce or increase the size of the gap.
  • the delivery systems 2, 2', 22, 42 and/or 62 can further include means for applying tracking indicia on a body part inserted into the housing for delivery of the pharmaceutical.
  • the housing can include one or more mechanisms for providing dye marks, tattoos, scars, brands, tags, ear or fin notches, or like indicia, to body parts inserted into the housing, thereby providing visual confirmation of pharmaceutical delivery in individual subjects.
  • the tracking mechanism can be actuated by actuation of the delivery means, or individually actuated by appropriate controls.
  • dyes or like materials can be included with a pharmaceutical composition delivered from the delivery system, thereby providing visual confirmation of pharmaceutical delivery.
  • associated components such as a pharmaceutical supply and/or a source of motive force (e.g., compressed gas), can be carried in a backpack, or on the operator's belt.
  • the associated components can be connected to the delivery system via an appropriate interface, thereby allowing for safe and simplified operation of the system.
  • the delivery system housings can be reconfigured for use in delivery of a pharmaceutical to human subjects.
  • the gap defined by the opposing jaws of the housing are sized to accommodate human body parts, for example arms of infants, children, adolescents or adult humans.
  • the embodiments of the invention that comprise means for adjusting, positioning and holding inserted body parts are particularly well adapted for use in this context.
  • the ability to position and hold the body part within the housing provides a high degree of control over delivery parameters, since targeted tissue can be substantially stabilized at a selected pressure, and a targeted delivery area maintained in position.

Landscapes

  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Vending Machines For Individual Products (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (19)

  1. Pharmazeutisches Zuführsystem (2, 2', 22, 42, 62), umfassend:
    (a) ein Gehäuse (4, 4', 24, 44, 64) mit ersten (6, 6', 26, 46, 66) und zweiten (8, 8', 28, 48, 68) im Wesentlichen planar einander gegenüber liegenden Armen, die an einem Ende (10, 30) miteinander verbunden und am entgegengesetzten Ende (12, 32) offen sind, wobei die einander gegenüber liegenden Arme einen Spalt (14, 34) definieren, in den ein Körperteil eines Vertebraten eingeführt werden kann; und
    (b) Mittel für die Zufuhr (16, 16', 36, 56) auf einem Arm des Gehäuses, wobei das Mittel für die Zufuhr in der Lage ist, ein Arzneimittel an ein Körperteil in dem Spalt in transversaler Richtung relativ zur Ebene der einander gegenüber liegenden Arme zuzuführen, wobei das Mittel für die Zufuhr weiterhin dadurch gekennzeichnet ist, dass es ausgewählt ist aus der aus einer Nadelspritze, einem Luftinjektor, einem Strahleinspritzer und einem Teilcheninjektor bestehenden Gruppe.
  2. Das Zuführsystem nach Anspruch 1, dadurch gekennzeichnet, dass der Spalt, der durch die beiden einander gegenüber liegenden Arme definiert ist, einen Hautlappen, ein Ohr, einen Schwanz, eine Flosse oder einen Flügel eines Vertebraten aufnehmen kann, jedoch klein genug ist, um die Möglichkeit, einen menschlichen Finger in dem Spalt aufzunehmen, zu verringern oder auszuschließen.
  3. Das Zufuhrsystem nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass das Mittel für die Zufuhr auf dem Arm derart angeordnet ist, dass der Abstand zwischen dem offenen Ende des Gehäuses und dem Mittel für die Zufuhr den Kontakt zwischen dem Mittel für die Zufuhr und irgendeinem menschlichen Anhängsel, das in den Spalt eingeführt worden ist, verhindert.
  4. Das Zuführsystem nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass das Mittel für die Zufuhr derart ausgestaltet ist, dass der Dermis, der Epidermis oder in den subkutanen Bereich eines Körperteils ein Arzneimittel zugeführt werden kann, wobei das Körperteil innerhalb des Spalts, der definiert ist durch die beiden einander gegenüber liegenden Arme, lokalisiert ist.
  5. Das Zufuhrsystem nach Anspruch 1, das außerdem ein Polster (58, 78) umfasst, das auf einer inneren Oberfläche eines Arms des Gehäuses angebracht ist und dem Mittel für die Zufuhr zugewandt ist, dadurch gekennzeichnet, dass das Polster und die innere Oberfläche des gegenüber liegenden Arms einen Spalt definieren, in den ein Körperteil eines Vertebraten eingeführt werden kann.
  6. Das Zuführsystem nach Anspruch 5, dadurch gekennzeichnet, dass das Polster verstellbar mit dem Arm verbunden ist, so dass eine Bewegung des Polsters relativ zum Arm möglich ist, wodurch der Spalt, der durch das Polster und die innere Oberfläche des gegenüber liegenden Arms definiert wird, verkleinert oder vergrößert werden kann.
  7. Das Zuführsystem nach einem der Ansprüche 5 bis 6, dadurch gekennzeichnet, dass der durch das Polster und die innere Oberfläche des gegenüber liegenden Armes definierte Spalt einen Hautlappen, ein Ohr, einen Schwanz, eine Flosse oder einen Flügel eines Vertebraten aufnehmen kann, jedoch klein genug ist, um die Möglichkeit, ein menschliches Anhängsel in den Spalt einzuführen, verringert oder ausgeschlossen wird.
  8. Das Zufuhrsystem nach einem der Ansprüche 5-7, dadurch gekennzeichnet, dass das Mittel für die Zufuhr derart ausgestaltet ist, dass der Dermis, der Epidermis oder in den subkutanen Bereich eines Körperteils ein Arzneimittel zugeführt werden kann, wobei das Körperteil innerhalb des Spalts, der definiert ist durch das Polster und die innere Oberfläche des gegenüber liegenden Arms, lokalisiert ist.
  9. Das Zuführsystem nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass das Gehäuse aufblasbar ist und Mittel umfasst, um mit einer Quelle von komprimiertem Gas in Verbindung zu stehen.
  10. Das Zuführsystem nach einem der vorhergehenden Ansprüche, weiterhin umfassend Mittel, um Markierungen an einem Körperteil innerhalb des Spalts anzubringen.
  11. Das Zuführsystem nach Anspruch 10, dadurch gekennzeichnet, dass die Markierung ausgewählt ist aus der aus einem Farbmarker, einer Tätowierung, einer Narbe, einem Brandmal, einem Etikett und einer Kerbe eines Ohres oder einer Flosse bestehenden Gruppe.
  12. Ein pharmazeutisches Zufuhrsystem nach einem der vorhergehenden Ansprüche, wobei die im Wesentlichen planar einander gegenüber liegenden ersten und zweiten Arme zusammengehalten werden an einem dynamischen Befestigungselement (38), angebracht an dem geschlossenen Ende (30) des Gehäuses.
  13. Ein Zufuhrsystem nach Anspruch 12, wobei das Mittel für die Zufuhr auf dem ersten Arm des Gehäuses angebracht ist.
  14. Das Zuführsystem nach Anspruch 12 oder 13, dadurch gekennzeichnet, dass das Befestigungselement um die eigene Achse drehbar ist.
  15. Das Zuführsystem nach einem der Ansprüche 12 bis 14, dadurch gekennzeichnet, dass die Arme über das Befestigungselement aufeinander zu oder voneinander weg bewegt werden können, wodurch die Größe des Spaltes verkleinert oder vergrößert wird.
  16. Das Zufuhrsystem nach Anspruch 15, dadurch gekennzeichnet, dass die Bewegung der Arme aufeinander zu das Mittel für die Zufuhr in Bewegung setzt.
  17. Das Zuführsystem nach Anspruch 12 in seiner Abhängigkeit von Anspruch 5, dadurch gekennzeichnet, dass das Polster aufblasbar ist oder die Luft oder das Gas auch wieder ablassen kann, um dadurch den durch das Polster und die innere Oberfläche des gegenüber liegenden Arms definierten Spalt entweder zu verkleinern oder zu vergrößern.
  18. Das Zufuhrsystem nach einem der vorhergehenden Ansprüche, wobei ein zweites Mittel für die Zufuhr (20) auf dem anderen Arm des Gehäuses angebracht ist.
  19. Ein Zufuhrsystem nach einem der vorhergehenden Ansprüche in ihrer Abhängigkeit von Anspruch 5, wobei das Zufuhrsystem außerdem ein zweites Polster (80) auf dem anderen Arm des Gehäuses umfasst.
EP98900505A 1997-01-24 1998-01-20 Anordnung zur verabreichung von medikamenten Expired - Lifetime EP0955947B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3638797P 1997-01-24 1997-01-24
US36387 1997-01-24
PCT/CA1998/000019 WO1998032397A1 (en) 1997-01-24 1998-01-20 Pharmaceutical delivery system

Publications (2)

Publication Number Publication Date
EP0955947A1 EP0955947A1 (de) 1999-11-17
EP0955947B1 true EP0955947B1 (de) 2003-01-02

Family

ID=21888334

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98900505A Expired - Lifetime EP0955947B1 (de) 1997-01-24 1998-01-20 Anordnung zur verabreichung von medikamenten

Country Status (8)

Country Link
EP (1) EP0955947B1 (de)
AR (1) AR011431A1 (de)
AU (1) AU734703B2 (de)
BR (1) BR9808876A (de)
CA (1) CA2276414A1 (de)
DE (1) DE69810442D1 (de)
NZ (1) NZ336847A (de)
WO (1) WO1998032397A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW573428B (en) 2001-03-15 2004-01-21 Canon Kk Image reading apparatus and illumination apparatus
FR2970863B1 (fr) * 2011-02-01 2014-01-17 Desvac Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1605763A (en) 1926-11-02 Garment retainer
US3788315A (en) 1971-04-20 1974-01-29 S Laurens Disposable cutaneous transjector
US3853125A (en) 1971-10-05 1974-12-10 W Clark Disposable needleless injector
GB2120554B (en) * 1982-05-19 1986-01-15 Robert Ernest Patterson Animal injection or drench gun with marker in the form of a gun
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
FR2599976A1 (fr) * 1986-06-16 1987-12-18 Michel Pistor Dispositif therapeutique, portable, totalement autonome, transdermique, pourvu d'au moins un organe formant aiguille ou pointe franchissant la barriere cutanee
IL88808A (en) * 1988-12-27 1996-05-14 Dermamed Ness Ziona Device for administering drugs in veterinary uses
US5059182A (en) * 1989-04-12 1991-10-22 David H. Laing Portable infusion device
EP0425617A4 (en) * 1989-05-01 1991-07-10 David John Mckeddie Medicated ear tag
US5062830A (en) 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
US5441015A (en) * 1991-08-20 1995-08-15 Farley; Michael D. Compression boot and method for treatment of injured limb

Also Published As

Publication number Publication date
EP0955947A1 (de) 1999-11-17
AR011431A1 (es) 2000-08-16
DE69810442D1 (de) 2003-02-06
CA2276414A1 (en) 1998-07-30
NZ336847A (en) 2000-05-26
AU734703B2 (en) 2001-06-21
BR9808876A (pt) 2000-10-03
AU5546398A (en) 1998-08-18
WO1998032397A1 (en) 1998-07-30

Similar Documents

Publication Publication Date Title
EP0749758B1 (de) Verbesserungen an Injektionen
CA2467569C (en) Automatic poultry injection delivery apparatus
ES2316162T3 (es) Administracion de un antibiotico inyectable en la oreja de un animal.
US11318006B2 (en) Injection apparatus
US8348881B2 (en) Device for injecting a pharmaceutical active principle
US20030088207A1 (en) Jet injector with hand piece
AU4358993A (en) Apparatus and method for injecting a pharmaceutical preparation in solid form
CA2386110C (en) Intranasal delivery system
EP0955947B1 (de) Anordnung zur verabreichung von medikamenten
US20130239979A1 (en) Animal restraint device and method
US9782243B2 (en) Animal restraint device and method
AU712482B2 (en) Injection dart system
CA2541985A1 (en) Apparatus and method for nasal delivery of compositions to birds
MXPA99006744A (en) Pharmaceutical delivery system
ES2275092T5 (es) Procedimiento de administración de un antibiótico inyectable en la oreja de un animal
US5725497A (en) Injection dart system
Deviche et al. Short‐term modulation of domestic pigeon (Columbia livia L.) behaviour induced by intraventricular administration of ACTH
Smuts Ketamine hydrochloride-A useful drug for the field immobilization of the Spotted hyaena Crocuta crocuta
US7678087B2 (en) Equine intranasal delivery system
US20200297467A1 (en) Intranasal administration device
CN116600739A (zh) 用于将流体注射到鸟类体内的装置
CA2417843C (en) Administration of an injectable antibiotic in the ear of an animal
Hollis et al. Serological responses in dairy calves to various vaccines administered via needle-free or conventional needle-based injections
DD262364A1 (de) Instrument zur verabreichung von medikamenten an tiere

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990908

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE DE DK ES FR GB IT NL SE

EL Fr: translation of claims filed
17Q First examination report despatched

Effective date: 20010619

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: METAMORPHIX INTERNATIONAL, INC.

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): BE DE DK ES FR GB IT NL SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030102

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRE;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.SCRIBED TIME-LIMIT

Effective date: 20030102

Ref country code: FR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030102

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030102

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: 20030102

REF Corresponds to:

Ref document number: 69810442

Country of ref document: DE

Date of ref document: 20030206

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030402

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030402

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030402

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030403

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030730

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20030402

EN Fr: translation not filed
26N No opposition filed

Effective date: 20031003

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1025495

Country of ref document: HK