EP0946881A1 - Pipette and handling automatic machine for microtitration plates with permeable bases - Google Patents
Pipette and handling automatic machine for microtitration plates with permeable basesInfo
- Publication number
- EP0946881A1 EP0946881A1 EP98952641A EP98952641A EP0946881A1 EP 0946881 A1 EP0946881 A1 EP 0946881A1 EP 98952641 A EP98952641 A EP 98952641A EP 98952641 A EP98952641 A EP 98952641A EP 0946881 A1 EP0946881 A1 EP 0946881A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pipetting
- station
- suction
- handling machine
- machine according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/0422—Plate elements with several rows of samples carried on a linear conveyor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/0425—Stacks, magazines or elevators for plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
Definitions
- the invention relates to an automatic pipetting and handling machine for microtitration plates with a permeable bottom, e.g. Filter or membrane base plates.
- Microtitration plates with permeable bottoms have been used in screening laboratories for several years. There are a variety of products that differ in the type of soils and thus in their interaction with the liquid media in the so-called wells.
- the liquid handling with these filter plates can essentially be described by the steps - filling the wells from above with liquid - and after a reaction time - suctioning down the liquid through the filter layer.
- the filling step is carried out with classic hand-held pipettes or pipetting robots and does not differ from the way of working with microtitration plates in the conventional sense.
- the suction step or the emptying of the wells does not take place via their openings, but is carried out on so-called suction stations through the bottom of the wells. These suction stations essentially have the following structure.
- the filter plate is placed on a suction pan, which has a circumferential rubber seal in the contact area of the edge of the filter plate.
- a vacuum device usually consists of a Woulff bottle for separating the liquid, a ventilation valve and a vacuum pump.
- Manual processing is carried out as follows.
- the filled filter plate is placed on the suction trough and pressed, at the same time the suction trough is subjected to negative pressure through its opening.
- the automatic processing follows the manual process by either filling the filter plate directly from a pipetting robot on the suction station or, if the pipetting robot has a plate gripping mechanism, pipetting the plates and then placing them on the suction device for the time of suction.
- the gripper arm it is possible to use the gripper arm to press the filter plate onto the suction station in order to allow it to be sucked tight and thus to build up the vacuum.
- the forces that can be used for this are naturally low.
- the possibility remains to apply the filter plate with a vacuum shock.
- the throughput of such devices is limited by the number of needles available for liquid handling, known systems being equipped with one to eight needles.
- the invention has for its object to show a compact arrangement with which filter plates can be removed, pipetted, aspirated and stored automatically, time-effectively and with high throughput from a storage system.
- Fig. 1 shows a basic structure of a pipetting and handling machine according to the invention
- Fig. 2 shows a basic structure of a donor and storage stacker
- Fig. 3 shows a basic structure of an automatic pipette
- Fig. 4 shows a basic structure of a pressure station
- the automatic pipetting and handling machine consists of a dispenser stacker 1, an automatic pipetting machine 2, a pressure station 3, a carriage 4 and a storage stacker 5.
- the carriage 4 is guided and positioned horizontally via a rail system thus in its work steps, which can be subdivided as follows: a) initial position, ie with its right serving area in the dispenser stacker 1 for receiving the filter plate b) first intermediate position, ie with its right serving area in the pipetting machine 2 c) second intermediate position, ie with its left serving area in the pipetting machine 2 d) third intermediate position, ie with its left parting surface in the pressure station 3 e) fourth intermediate position, ie with its left storage surface in the automatic pipetting machine 2 f) fifth intermediate position, ie with its right storage surface in the automatic pipetting machine 2 g) end position, ie with its right storage surface in the storage stacker 5 for dispensing the filter plate, the connection between the units dispenser stacker 1, Automatic pipetting device
- the trolley 4 has four storage areas lying next to one another, the storage area on the far right being reserved for receiving the filter plates, the storage area on the far left with a suction station 6, and the storage areas in between being occupied on the one hand with a vessel and on the other with a washing tub are.
- the middle shelves could be dispensed with if, for example, a pipetting device were used, which can fill its pipettes from behind via a separate container and, on the other hand, changes their tips after each pipetting process so that rinsing can be omitted.
- Dispenser stacker 1 in which the filter plates are stacked, is provided for the storage of filter plates.
- These stackers are able to either place a filter plate on a trolley or pick it up from the trolley with the aid of a respective assigned lifter and a ratchet mechanism.
- the pawls are controlled electromagnetically depending on the lifting height. According to the starting position of the car 4, it is covered with a filter plate on its rightmost storage surface by means of the lifter.
- the carriage 4 moves into the first intermediate position and the lifter of the automatic pipetting device 2 lifts the filter plate horizontally up to the pipettes, so that the corresponding wells can be filled.
- the lifter lowers the filled filter plate and transfers it to a plate holder 7, as can be seen in FIG. 3.
- the lifter lowers further in its lower end position.
- the carriage 4 moves into its second intermediate position and the lifter of the automatic pipetting device 2 lifts the suction station 6 up to the filter plate.
- the plate holder 7 releases the filter plate again and the lifter moves down to its starting position and thus places the suction station 6 with the filter plate above it on the carriage 4.
- the carriage now moves to the third intermediate position in the pressure station 3.
- the pressure station 3 consists, according to FIG.
- the lifter of the pressure station 3 lifts and presses the suction station with the filter plate attached to the contact surface, so that a sealing effect between the filter plate and suction station 6 is achieved before the vacuum is applied.
- the contact surface exerts a counterforce to the lifter on the filter plate from above and, as can be seen from FIG. 4, can consist of a stored weight. An embodiment not shown is conceivable in that the lifter presses on the filter plate from above and thus achieves the necessary sealing effect.
- the carriage 4 assumes the fifth intermediate position, the lifter is brought up to the filter plate, the plate holder 7 releases the filter plate again and the lifter assumes its starting position, thereby placing the filter plate on the carriage 4. Now the carriage 4 moves into its end position and thus comes to a stop in the storage stacker 5. The lifter of the storage stacker 5 detects the filter plate and places it in the storage stacker 5.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19746455A DE19746455C1 (en) | 1997-10-21 | 1997-10-21 | Automatic pipetting and handling device for microtitration plates with permeable bottoms |
DE19746455 | 1997-10-21 | ||
PCT/EP1998/006089 WO1999021016A1 (en) | 1997-10-21 | 1998-09-24 | Pipette and handling automatic machine for microtitration plates with permeable bases |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0946881A1 true EP0946881A1 (en) | 1999-10-06 |
Family
ID=7846152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98952641A Withdrawn EP0946881A1 (en) | 1997-10-21 | 1998-09-24 | Pipette and handling automatic machine for microtitration plates with permeable bases |
Country Status (4)
Country | Link |
---|---|
US (1) | US6395231B1 (en) |
EP (1) | EP0946881A1 (en) |
DE (1) | DE19746455C1 (en) |
WO (1) | WO1999021016A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1250955A1 (en) * | 1998-09-08 | 2002-10-23 | Tibotec N.V. | Method for the rapid screening of analytes |
DE19907329C2 (en) * | 1999-02-20 | 2001-10-18 | Eppendorf Ag | Suction device |
US6630006B2 (en) * | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
US6979425B1 (en) * | 1999-10-04 | 2005-12-27 | Robodesign International, Inc. | High capacity microarray dispensing |
EP1252522B9 (en) | 2000-01-31 | 2006-10-11 | Emory University | Immunological assay system and method |
US6387330B1 (en) * | 2000-04-12 | 2002-05-14 | George Steven Bova | Method and apparatus for storing and dispensing reagents |
DE10022693C1 (en) * | 2000-05-05 | 2001-10-11 | Cybio Instr Gmbh | Automatic pipetting system for filling microtiter plates has single row, multichannel head with mechanism for stripping nozzles from pipettes |
DE10027524A1 (en) * | 2000-06-02 | 2001-12-13 | Max Planck Gesellschaft | Device and method for processing substrate-bound samples |
GB0021987D0 (en) * | 2000-09-07 | 2000-10-25 | Astrazeneca Ab | Plate handling mechanism |
US6899848B1 (en) * | 2001-02-27 | 2005-05-31 | Hamilton Company | Automated sample treatment system: apparatus and method |
US6982063B2 (en) * | 2001-05-25 | 2006-01-03 | Matrix Technologies Corp | Automated pipetting system |
US6669432B2 (en) | 2001-08-13 | 2003-12-30 | Matrix Technologies Corp. | Apparatus and method for handling pipetting tip magazines |
WO2003022440A2 (en) * | 2001-08-16 | 2003-03-20 | Millipore Corporation | Holder for multiple well sequencing / pcr plate |
US7584240B2 (en) | 2001-11-07 | 2009-09-01 | Genvault Corporation | Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients |
US20030087455A1 (en) * | 2001-11-07 | 2003-05-08 | Eggers Mitchell D | Sample carrier system |
US20030129755A1 (en) * | 2001-11-07 | 2003-07-10 | Genvault Corporation | System and method of storing and retrieving storage elements |
US20030087425A1 (en) * | 2001-11-07 | 2003-05-08 | Eggers Mitchell D | Sample carrier |
KR20030089167A (en) * | 2002-05-17 | 2003-11-21 | (주)바이오넥스 | Liquid dispensing and handling system |
US20040096368A1 (en) * | 2002-06-28 | 2004-05-20 | Igen International, Inc. | Assay systems and components |
DE10238630A1 (en) * | 2002-08-19 | 2004-03-04 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Process for isolating biological macromolecules and device for carrying out this process |
US7718442B2 (en) * | 2002-11-22 | 2010-05-18 | Genvault Corporation | Sealed sample storage element system and method |
US20100075858A1 (en) * | 2003-04-29 | 2010-03-25 | Genvault Corporation | Biological bar code |
US7416710B1 (en) | 2003-12-31 | 2008-08-26 | Takeda San Diego, Inc. | Method and system for performing crystallization trials |
US20050226969A1 (en) * | 2004-04-12 | 2005-10-13 | Colin Dugdale | Bagel topping |
CA2567720A1 (en) * | 2004-05-24 | 2005-12-08 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
ATE461745T1 (en) * | 2004-07-27 | 2010-04-15 | Protedyne Corp | METHOD AND DEVICE FOR APPLYING A PRESSURE DIFFERENTIAL TO A PLATE HAVING A MULTIPLE TULLY |
WO2009059110A1 (en) * | 2007-11-01 | 2009-05-07 | Ge Healthcare Bio-Sciences Corp. | Isothermal titration microcalorimeter apparatus and method of use |
WO2009155612A2 (en) * | 2008-06-20 | 2009-12-23 | Genvault Corporation | Sample collection and storage devices and methods of use thereof |
CN102177237B (en) | 2008-09-12 | 2013-10-30 | 金沃特公司 | Matrices and media for storage and stabilization of biomolecules |
DE202010012318U1 (en) | 2010-09-06 | 2010-11-18 | Cybio Ag | Device for storage and provision of objects with standardized dimensions |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3650306A (en) * | 1970-09-18 | 1972-03-21 | Cooke Eng Co | Laboratory dispensing apparatus |
US4151931A (en) * | 1978-06-05 | 1979-05-01 | Eastman Kodak Company | Article dispenser apparatus for use in an automated chemical analyzer |
US4427415A (en) * | 1979-01-05 | 1984-01-24 | Cleveland Patrick H | Manifold vacuum biochemical test method and device |
US4461328A (en) * | 1982-06-04 | 1984-07-24 | Drummond Scientific Company | Pipette device |
DE3346532A1 (en) * | 1982-12-22 | 1984-07-12 | Olympus Optical Co., Ltd., Tokio/Tokyo | Method of controlling an analyser for chemical analyses |
US5047215A (en) * | 1985-06-18 | 1991-09-10 | Polyfiltronics, Inc. | Multiwell test plate |
US4948442A (en) * | 1985-06-18 | 1990-08-14 | Polyfiltronics, Inc. | Method of making a multiwell test plate |
AU596987B2 (en) * | 1985-08-30 | 1990-05-24 | Tosoh Corporation | Automated immunoassay analyser |
JPS63502931A (en) * | 1986-03-26 | 1988-10-27 | ベックマン インスツルメンツ インコーポレーテッド | Automated multi-purpose analytical chemistry processing facility and laboratory work equipment |
US4772487A (en) * | 1986-10-01 | 1988-09-20 | Olympus Optical Company Limited | Method and apparatus of forming solid phase reagent in micro-module |
US5000921A (en) * | 1986-10-24 | 1991-03-19 | Hanaway Richard W | Multiple pipette samples |
DE3805808A1 (en) * | 1988-02-24 | 1989-09-07 | Europ Lab Molekularbiolog | Automatic workstation for microbiological work |
GB8816982D0 (en) | 1988-07-16 | 1988-08-17 | Probus Biomedical Ltd | Bio-fluid assay apparatus |
DE3841961A1 (en) * | 1988-12-14 | 1990-06-21 | Dynatech Ag Branch Denkendorf | Device for the analysis of physiological or other liquids in the recesses of a microtest plate |
FR2657543B1 (en) * | 1990-01-26 | 1992-12-18 | Biocom Sa | MODULAR DEVICE FOR COLLECTING, INCUBATING, FILTERING MULTIPLE SAMPLES. |
SE9002579D0 (en) | 1990-08-07 | 1990-08-07 | Pharmacia Ab | METHOD AND APPARATUS FOR CARRYING OUT BIOCHEMICAL REACTIONS |
DE4107262A1 (en) * | 1991-03-07 | 1992-09-10 | Eppendorf Geraetebau Netheler | SUCTION DEVICE FOR MEMBRANE MICROTITER PLATES |
US5266272A (en) * | 1991-10-31 | 1993-11-30 | Baxter Diagnostics Inc. | Specimen processing and analyzing systems with a station for holding specimen trays during processing |
US5290521A (en) * | 1992-09-04 | 1994-03-01 | Destefano Jr Albert M | Lab-top work station |
US5324480A (en) * | 1992-12-04 | 1994-06-28 | Hamilton Company | Liquid handling system |
US5487872A (en) * | 1994-04-15 | 1996-01-30 | Molecular Device Corporation | Ultraviolet radiation transparent multi-assay plates |
US5620894A (en) * | 1995-06-16 | 1997-04-15 | Glaxo Wellcome Inc. | Apparatus for automated biological cell harvesting |
JP2832586B2 (en) * | 1995-08-04 | 1998-12-09 | 株式会社トミー精工 | DNA extraction and purification method |
JP3540905B2 (en) * | 1996-09-12 | 2004-07-07 | 塩野義製薬株式会社 | Temperature gradient type multi-stage cooler |
US5928952A (en) * | 1997-11-05 | 1999-07-27 | Zymark Corporation | Scheduled system and method for processing chemical products |
US5939024A (en) * | 1997-12-23 | 1999-08-17 | Packard Instrument Co. | Microplate assembly |
JP3584732B2 (en) * | 1998-05-08 | 2004-11-04 | 松下電器産業株式会社 | Dispensing device, dispensing method and dispensing tip mounting method |
US6106783A (en) * | 1998-06-30 | 2000-08-22 | Microliter Analytical Supplies, Inc. | Microplate assembly and closure |
US6039211A (en) * | 1998-09-22 | 2000-03-21 | Glaxo Wellcome Inc. | Position triggered dispenser and methods |
US6148878A (en) * | 1999-10-04 | 2000-11-21 | Robodesign International, Inc. | Automated microplate filling device and method |
-
1997
- 1997-10-21 DE DE19746455A patent/DE19746455C1/en not_active Expired - Fee Related
-
1998
- 1998-09-24 WO PCT/EP1998/006089 patent/WO1999021016A1/en not_active Application Discontinuation
- 1998-09-24 US US09/331,221 patent/US6395231B1/en not_active Expired - Fee Related
- 1998-09-24 EP EP98952641A patent/EP0946881A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO9921016A1 * |
Also Published As
Publication number | Publication date |
---|---|
US6395231B1 (en) | 2002-05-28 |
DE19746455C1 (en) | 1999-05-27 |
WO1999021016A1 (en) | 1999-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990617 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE GB |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: MOORE, THOMAS Inventor name: NAUMANN, UWE Inventor name: KRAEMER, WOLFGANG |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CYBIO INSTRUMENTS GMBH |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20030401 |