Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
  • B29D11/00—Producing optical elements, e.g. lenses or prisms
  • B29D11/00009—Production of simple or compound lenses
  • B29D11/00038—Production of contact lenses
  • B29D11/00125—Auxiliary operations, e.g. removing oxygen from the mould, conveying moulds from a storage to the production line in an inert atmosphere
  • B29D11/00192—Demoulding, e.g. separating lenses from mould halves
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
  • B29C33/00—Moulds or cores; Details thereof or accessories therefor
  • B29C33/56—Coatings, e.g. enameled or galvanised; Releasing, lubricating or separating agents
  • B29C33/60—Releasing, lubricating or separating agents
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
  • B29D11/00—Producing optical elements, e.g. lenses or prisms
  • B29D11/00009—Production of simple or compound lenses
  • B29D11/00038—Production of contact lenses
  • B29D11/00125—Auxiliary operations, e.g. removing oxygen from the mould, conveying moulds from a storage to the production line in an inert atmosphere
  • B29D11/00192—Demoulding, e.g. separating lenses from mould halves
  • B29D11/00201—Demoulding, e.g. separating lenses from mould halves using cooling means

Definitions

• the present invention relates to cleaning and separating polymeric molded articles. More specifically, this invention relates to deblocking molded articles and removing extr actable materials from the article.
• a large number of polymeric articles are formed by placing a monomeric or prepolymeric material into a mold and then causing polymerization of the material.
• molded polymeric articles typically contain impurities and unpolymerized monomeric materials that can be leached out or extracted from the articles.
• extractable residual materials from a molded polymeric contact lens are extracted with an organic solvent, such as an alcohol.
• the alcohol extraction process removes undesirable extractable materials, the alcohol remains in the polymeric network of the lens and must be removed before the lens can be further processed or be worn safely.
• an alcohol extracted lens is dried to remove the alcohol.
• the drying step is time- consuming and tends to leave dry residue spots on the lens.
• An additional problem associated with producing a polymerized article on a mold is that the polymerized article formed on the mold needs to be separated or released from the mold without damaging the molded article and, preferably, without damaging the mold.
• a critical step in the production of contact lenses using molds is releasing or deblocking the lenses without damaging the lenses from the molds in which the lenses were formed.
• This separation problem is particularly severe when the molded article contains tacky polymeric material, such as silicone.
• a conventional method for releasing a contact lens from a mold uses a manual process to gently remove the lens in heated water, for example, disclosed in U.S. Pat. No 5,264,161 to Druskis et al.
• such manual process is labor intensive and prone to defects caused by handling errors.
• a mold release agent e.g., a wax or silicone formulation
• a mold release agent can be applied on the mold before a polymerizable material is injected into and polymerized in the mold to ensure proper release of the molded article.
• a mold release agent cannot be utilized since the release agent may adversely interact with the polymer of the molded article or the environment in which the molded article is used.
• a process that produces substantially dried molded article such that the time-consuming drying step and problems associated with the drying step can be minimized or eliminated.
• the process has the steps of contacting or treating the molded article with a treating solution which contains a liquid liquifiable gas, preferably liquid carbon dioxide. Particularly, the process has the steps of contacting the molded article with an extracting solvent and contacting the molded article with liquid carbon dioxide.
• the present invention also provides a treating medium for deblocking and extracting a molded article.
• the treating medium preferably contains between about 50 wt% and about 99 wt% of liquid carbon dioxide and between about 50 wt% and about 1 wt% of an extracting solvent, based on the total weight of the medium.
• the process of the invention provides efficient and reliable means for deblocking a molded article from the mold in which the article was formed and extracting undesirable and unpolymerized polymerizable materials from the molded article.
• the treated molded article produced with the present process is deblocked from the mold and fully extracted as well as substantially or fully dried such that the molded article can be further processed, e.g., coated or plasma treated, or packaged for future use.
• the present process is particularly suitable for molded articles containing tacky polymeric materials, such as silicone, silicone elastomers and silicone copolymers.
• Fig. 1 illustrates an exemplary treating apparatus suitable for the present deblocking and extracting process.
• the present invention provides a process for deblocking a molded article, especially a molded hydrogel article, from the mold in which the article was formed, and extracting extractable materials from the molded article.
• the term "hydrogel” as used herein indicates a polymeric material that is capable of absorbing at least about 10 wt% water.
• the process provides a deblocked and extracted molded article that is substantially dried, preferably fully dried.
• the process has the steps of contacting, preferably immersing, a molded article formed in or on a mold with an extracting solvent and contacting, preferably immersing, the molded article with a liquid liquifiable gas, preferably with liquid carbon dioxide.
• the extracting solvent deblocks the molded article from the mold and extracts extractable materials from the molded article.
• the preferred liquid carbon dioxide contacting step of the present invention which is conveniently conducted in a vessel that can be operated under moderately pressurized environment, may sequentially follow the solvent contacting step. Alternatively, the preferred liquid carbon dioxide contacting step can be simultaneously conducted with the solvent contacting step.
• Extracting solvents suitable for the present invention include, without limitation thereto, alcohols, preferably alcohols having up to 5 carbon atoms, e.g., ethanol, propanol, isopropanol, butanol, isobutanol and tert-butanol; glycols, preferably glycols having up to 5 carbon atoms, e.g., ethylene glycol and glycerol; ketones, preferably ketones having up to 5 carbon atoms, e.g., acetone; alkanes, preferably alkanes having 5 to 7 carbon atoms, e.g., hexane; aromatic solvents, preferably benzene or benzene substituted by up to three C C 2 alkyl groups, e.
• alcohols preferably alcohols having up to 5 carbon atoms, e.g., ethanol, propanol, isopropanol, butanol, isobutanol and tert-but
• More preferred extracting solvents include alcohols, glycols, ketones, ethers, alkanes and aromatic solvents, including the preferences disclosed hereinbefore. Of the preferred extracting solvents, even more preferred are alcohols and glycols, and most preferred is isopropanol.
• the extracting solvent contacting step of the invention may be conducted in ambient environment.
• the solvent contacting step may be conducted in a pressurizable environment, e.g., in a pressurizable vessel, such that the solvent contacting step and the carbon dioxide contacting step can be conducted in one apparatus.
• the solvent contacting step can be a single- or multi-step process.
• the solvent contacting step is a step that exposes the molded article to a series of solvent batches such that the polymeric network of the molded article is subjected to a series of solvent exchange substeps. The duration of each solvent exchange substep depends on the type of the polymer that forms the molded article, the type of the extracting solvent used and the size of the molded article.
• each substep when a siloxane-copoiymer hydrogel contact lens on a mold is treated and isopropanol is used as the extracting solvent, each substep lasts preferably between about 1 minute and about 60 minutes, more preferably between about 2 minutes and about 30 minutes, most preferably between about 5 minutes and about 15 minutes.
• the extracting solvent contacting step can be conducted in a vessel that continuously feeds and circulates the extracting solvent such that the extracting solvent contacting step is conducted in a continuous fashion.
• the extracting solvent extracts extractable materials, e.g., unpolymerized monomer or prepolymer and impurities, from the molded article and promotes deblocking of the article from the mold.
• Suitable liquid carbon dioxide for the liquid carbon dioxide contacting step of the invention has a pressure at least about 500 psi and a temperature between about 0°C and about 31 °C, preferably at the saturation pressure and room temperature.
• liquid carbon dioxide is used at room temperature, thereby eliminating the need for regulating the temperature of liquid carbon dioxide.
• other liquifiable gases e.g., nitrous oxide, ethane, propane, ammonia, and azeotropes, e.g., chlorofluoro- carbons
• a suitable liquifiable gas is in the gaseous phase in ambient enviroment.
• the present invention is highly advantageous in that the deblocking and extracting process can be conducted under ambient temperature and moderately elevated pressure and is not as time-consuming and labor-intensive as a conventional organic solvent extraction process. Consequently, the deblocking and extracting process is highly economical when compared to conventional solvent extraction processes and high pressure supercritical fluid extraction processes.
• the solvent contacting step is followed by the liquid carbon dioxide contacting step.
• the liquid carbon dioxide replaces the extracting solvent in the polymeric network and further extracts undesirable materials from the polymeric network.
• the molded article treated with the extracting solvent is placed in a pressurizable vessel and then liquid carbon dioxide is introduced in the vessel, contacting the molded article with the liquid carbon dioxide, preferably immersing the molded article in liquid carbon dioxide.
• the molded article can be treated in the pressurizable vessel with the extracting solvent so that the solvent treated molded article can be treated with liquid carbon dioxide without the need for additional handling of the molded article.
• the liquid carbon dioxide contacting step may also be conducted in a series of substeps.
• each carbon dioxide treating substep depends on the type of the polymer that forms the molded article, the type of the extracting solvent used and the size of the molded article. For example, when a siloxane-copolymer hydrogel contact lens is treated, each substep may last preferably between about 1 minute and about 60 minutes, more preferably between about 2 minutes and about 30 minutes, most preferably between about 5 minutes and about 15 minutes.
• the liquid carbon dioxide is removed from the vessel and the pressure of the vessel is lowered to ambient pressure. The resulting molded article is deblocked from the mold, extracted and completely or substantially dried.
• the molded article is simultaneously contacted or treated with a treating mixture that contains the extracting solvent and liquid carbon dioxide.
• the extracting solvent and liquid carbon dioxide are simultaneously supplied or a mixture of the extracting solvent and liquid carbon dioxide is introduced into the treating vessel which contains the molded articles on molds.
• the treating mixture contains between about 1 wt% and about 50 wt%, more preferably between about 5 wt% and about 40 wt%, most preferably between about 10 wt% and about 30 wt%, of an extracting solvent and between about 99 wt% and about 50 wt%, more preferably between about 95 wt% and about 60 wt%, most preferably between about 90 wt% and about 70 wt%, of liquid carbon dioxide, based on the total weight of the treating mixture.
• the simultaneous treating step may also be conducted in a series of substeps, and the duration of the treating step or substeps depends on the type of the polymer that forms the molded article, the type of the extracting solvent and the size of the molded article.
• each substep may last preferably between about 1 minute and about 60 minutes, more preferably between about 2 minutes and about 30 minutes, most preferably between about 5 minutes and about 15 minutes.
• the present simultaneous treating process simultaneously deblocks the molded articles from the molds and extracts extractable materials from the molded articles.
• the molded articles treated with the simultaneous treating process are substantially dried.
• the deblocked and extracted molded article can be further dried in a conventional manner, e.g., vacuum dried, before the article is further processed.
• the molded articles that are subjected to the simultaneous treatment process are again treated with liquid carbon dioxide so that the extracted and deblocked molded articles are fully dried and the extracting solvent is fully removed from the molded articles.
• Hydrogel molded articles which may be treated in accordance with the present invention include a wide variety of polymeric articles which are formed by initiating polymerization of a monomeric or pre-polymeric mixture in a mold.
• polymeric articles include, without limitation thereto, medical devices and components, such as drug delivery devices (transdermal, ophthalmic, parenteral, etc.) and components thereof; and, in particular, ophthalmic devices including vision correction devices, such as contact lenses, ocular implants, ocular onlays, and components thereof.
• Ophthalmic lenses e.g., contact lenses and intraocular lenses
• Ophthalmic lenses that can be treated with the present process contain various hydrogel-forming monomers, including hydroxyesters of acrylic or methacrylic acid, e.g., hydroxyethyl methacrylate (HEMA), hydroxyoctyl methacrylate, hydroxyethyl acrylate, glyceryl methacrylate, hydroxypropyl methacrylate, hydroxypropyl acrylate, methacrylic acid (MAA), hydroxyethyl methacrylamide (HMA), dimethylacrylamide (DMA), N-vinylpyrrolidone (NVP); polyorganosiloxanes, e.g.
• HEMA hydroxyethyl methacrylate
• HMA hydroxyethyl methacrylamide
• DMA dimethylacrylamide
• polyorganosiloxanes e.g.
• ophthalmic lenses are siloxane-copolymer hydrogel ophthalmic lenses, for example, as disclosed in WO 96/31792, which application in its entirety is herein incorporated by reference.
• Fig. 1 illustrates an exemplary apparatus suitable for the present invention. More particularly, Fig. 1 illustrates a lens-treating apparatus 10, which can be sealed and operated under pressurized environment.
• the apparatus 10 is surrounded with insulation 12 sufficient to maintain the applied fluid at the desired temperature and pressure ranges.
• Trays 14 support a plurality of lenses 16 affixed to molds 18.
• the support trays either have perforations or are sufficiently porous to allow the treating fluids to flow through the trays.
• the trays 14 with the lenses 16 on the molds 18 are loaded into lens-treating apparatus 10, either manually or via an automated lens distribution system.
• the treating fluids either sequentially or simultaneously as discussed above, enter through inlet 20 to fill the apparatus 10.
• the treating fluids pass through a flow distribution member 24, which distributes the fluids uniformly across a cross-section of the apparatus perpendicular to the flow.
• the treating fluids flow through the trays 14, contacting the lenses 16 and the molds 18.
• the apparatus 10 may optionally be equipped with agitation means 22 to provide uniform distribution of the treatment fluids in the apparatus.
• the treating fluids can be supplied into the apparatus in a continuous fashion.
• the contact lenses 16 on the molds 18 can be passed through the lens-treating apparatus 10 in a continuous manner known in the production engineering art.
• the treatment fluids flow through the trays 14 and the contact lenses 16 and the molds 18 before exiting through a fluid outlet, which is not shown.
• the speed of the treatment fluids contacting the lenses 16 is such that the fluids contact the lenses 16 in a turbulent fashion.
• Example 1 Siloxane-copolymer hydrogel contact lenses are produced in a double-sided molding process.
• a polysiloxane macromer is prepared.
• 51.5 g (50 mmol) of the perfluoropolyether Fomblin® ZDOL (from Ausimont S.p.A, Milan) having a mean molecular weight of 1030 g/mol and containing 1.96 meq/g of hydroxyl groups according to end-group titration is introduced into a three-neck flask together with 50 mg of dibutyltin dilaurate.
• the flask contents are evacuated to about 20 mbar with stirring and subsequently decompressed with argon. This operation is repeated twice.
• 202 g of the ⁇ , ⁇ -hydroxypropyl-terminated polydimethylsiloxane KF-6001 from Shin-Etsu having a mean molecular weight of 2000 g/mol (1.00 meq/g of hydroxyl groups according to titration) are introduced into a flask.
• the flask contents are evacuated to approx. 0.1 mbar and decompressed with argon. This operation is repeated twice.
• the degassed sitoxane is dissolved in 202 ml of freshly distilled toluene kept under argon, and 100 mg of dibutyltin dilaurate (DBTDL) are added.
• DBTDL dibutyltin dilaurate
• the filtered solution is frozen in a flask in liquid nitrogen, the flask is evacuated under a high vacuum, and the solution is returned to room temperature with the flask sealed. This degassing operation is repeated twice.
• the flask containing the macromer/comonomer solution is then transferred into a glove box with an inert-gas atmosphere, where the solution is pipetted into dust-free contact-lens (polypropylene) molds having concave and convex mold halves. The molds are closed, and the polymerization reaction is effected by UV irradiation (15 mW/cm 2 , 5 min.), with simultaneous crosslinking.
• the concave mold halves are manually removed, leaving the lenses predominately affixed to the convex mold halves.
• 60 lenses affixed convex mold halves are placed inside the treatment cavity of an Autoclave Engineering model EP-2000 Supercritical CO 2 Treatment System, which is equipped with a magnetic stirrer. 7 liter of 100% isopropanol is fed to the cavity and the magnetic stirrer was set at 800 rpm. After 1 hour of the isopropanol treatment, isopropanol is drained from the cavity, and the cavity is sealed. While maintaining the treatment system at 25°C, carbon dioxide is fed into the cavity until the pressure reached 1400 psi, providing liquid carbon dioxide environment. After several minutes, carbon dioxide was evacuated from the cavity. The liquid carbon dioxide treatment is repeated two more times, and the lenses are taken out.
• the resulting lenses are deblocked from the molds and are fully dried without dry spots.
• the lenses are clear and undamaged, demonstrating the efficacy of the present invention.
• Example 2 The procedure outlined in Example 1 is repeated, except the untreated lenses on the molds are manually deblocked. The deblocked lenses are dried under vacuum over night, and the weight of the lenses are measured. The dried lenses are carefully placed over the molds, thereby reattaching the lenses on the molds. The lenses on the molds are again subjected to the above-described isopropanol and liquid carbon dioxide treatments. The resulting lenses are again measured for their weight.
• the difference between the initial weight and the final weight of the lenses indicates the amount of extractable materials removed from the lenses, and the amount of extracted material is about 6 wt% of the initial lens weight, which is slightly higher than the amount of extractable materials that is extracted with a conventional isopropanol extraction process that immerses the lens in 100% isopropanol for about 24 hours and then vacuum dries the extracted lens.
• Example 3 The procedure outlined in Example 1 is repeated, except isopropanol and carbon dioxide are fed simultaneously into the treatment system to obtain 30 wt% isopropanol and 70 wt% liquid carbon dioxide treating mixture at 25°C and 1400 psi. After one hour of the mixture treatment, the treating mixture is evacuated from the cavity and the mixture treatment is repeated. After the second treatment, the lenses are taken out of the treatment cavity.

Landscapes

• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Health & Medical Sciences (AREA)
• Manufacturing & Machinery (AREA)
• Ophthalmology & Optometry (AREA)
• Treatments Of Macromolecular Shaped Articles (AREA)
• Eyeglasses (AREA)

Applications Claiming Priority (3)

Publications (1)

Family

ID=24815597

Family Applications (1)

Country Status (6)

Families Citing this family (11)

Family Cites Families (3)

• 1997
  • 1997-08-19 ID IDP972897A patent/ID18055A/id unknown
  • 1997-08-20 ZA ZA9707463A patent/ZA977463B/xx unknown
  • 1997-08-20 EP EP97942865A patent/EP0923441A1/de not_active Ceased
  • 1997-08-20 AU AU44548/97A patent/AU4454897A/en not_active Abandoned
  • 1997-08-20 JP JP10510413A patent/JP2001502364A/ja active Pending
  • 1997-08-20 WO PCT/EP1997/004526 patent/WO1998007554A1/en not_active Application Discontinuation

Non-Patent Citations (1)

Also Published As

Similar Documents

Legal Events