EP0918698B1 - Distribution simultanee de constituants de dentifrice physiquement separes, selon des rapports constants - Google Patents

Distribution simultanee de constituants de dentifrice physiquement separes, selon des rapports constants Download PDF

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Publication number
EP0918698B1
EP0918698B1 EP97932135A EP97932135A EP0918698B1 EP 0918698 B1 EP0918698 B1 EP 0918698B1 EP 97932135 A EP97932135 A EP 97932135A EP 97932135 A EP97932135 A EP 97932135A EP 0918698 B1 EP0918698 B1 EP 0918698B1
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EP
European Patent Office
Prior art keywords
dispenser
dentifrice
components
component
sidewalls
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EP97932135A
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German (de)
English (en)
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EP0918698A1 (fr
Inventor
James G. Masters
Richard J. Sullivan
Michael Prencipe
A. Patrick Connan
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Colgate Palmolive Co
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Colgate Palmolive Co
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/325—Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
    • B65D35/22—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with two or more compartments

Definitions

  • the present invention is directed to a packaging system for storing and simultaneously dispensing physically separated components of a multicomponent dentifrice at constant predetermined ingredient ratios in a multilayer unmixed relationship.
  • Multicomponent dentifrice compositions are known to the art wherein the individual components containing reactive ingredients are physically segregated during storage and are simultaneously dispensed as viscous paste or liquid materials which interact when mixed with each other, as during brushing, the components being dispensed at specific predetermined ingredient ratios for optimum efficacy and performance.
  • One effective way of depositing fluoride on teeth is to use a two-component dentifrice composition comprised of a calcium containing component and the other a fluoride containing component to precipitate calcium fluoride on teeth.
  • US 5,045,305 teaches a two component dentifrice for fluoridating teeth in which one component contains CaCl 2 and the other contains fluoride ions in the form of NaF, the separate components being admixed immediately prior to introduction in the mouth to effect precipitation of CaF 2.
  • US. Patent No. 5,145,668 discloses a method of fluoridating teeth wherein there is mixed during toothbrushing a first component comprising a soluble calcium salt such as CaCl 2 and a second component containing a hydrolyzable complex fluoride compound such as sodium fluorosilicate (Na 2 SiF 6 ) the mixing of the components resulting in hydrolysis of the complex fluoride compound and precipitation of calcium fluoride and its deposition on tooth surfaces.
  • a first component comprising a soluble calcium salt such as CaCl 2 and a second component containing a hydrolyzable complex fluoride compound such as sodium fluorosilicate (Na 2 SiF 6 ) the mixing of the components resulting in hydrolysis of the complex fluoride compound and precipitation of calcium fluoride and its deposition on tooth surfaces.
  • a hydrolyzable complex fluoride compound such as sodium fluorosilicate (Na 2 SiF 6 )
  • US 5,476,647 discloses a two-component fluoride deposition system wherein the first component of the system contains a soluble calcium source and a soluble Ca-complexing anion such as ethylene diaminetetraacetic acid, the calcium being partially bound to the Ca-complex agent.
  • the second component contains a fluoride salt such as sodium fluoride or stannous fluoride.
  • a dentifrice for fluoridating teeth utilizing two separate physically segregated semi-solid dentifrice components which contain fluoride salt and calcium ion containing abrasive ingredients which are reactive when mixed together upon application to teeth, the first component being an aqueous, semi-solid dentifrice composition containing a fluoride ion releasing salt such as an alkali metal salt such as sodium fluoride in a vehicle in which the ingredients thereof are non-reactive with the fluoride salt, and the second component is comprised of a vehicle containing a calcium ion containing abrasive such as hydrated dicalcium phosphate wherein the individual dentifrice components are substantially rheologically equivalent and are simultaneously extruded from a dual compartmented container.
  • a fluoride ion releasing salt such as an alkali metal salt such as sodium fluoride in a vehicle in which the ingredients thereof are non-reactive with the fluoride salt
  • the second component is comprised of a vehicle containing
  • the most convenient and least cost way to dispense physically separated components of multi-component dentifrices is from a collapsible, compartmented plastic tube.
  • Dual compartmented collapsible tubes for the simultaneous coextrusion of two physically separated dentifrice components are known to the art whereby compression of the tube, as by squeezing, dispenses a single banded multilayer ribbon product.
  • the bodies of these dual compartmented tubes are typically sealed at one end and are manufactured from plastic sheet.
  • the structure of the dual compartmented tube further includes a partition within the tube body for defining separate compartments therein and a relatively rigid neck portion is provided at the unsealed end having a discharge opening extending therethrough, the outer peripheral surface of the neck portion being threaded or otherwise constructed to enable a cap to be threaded or otherwise attached thereon to seal the tube.
  • a partition within the tube body for defining separate compartments therein and a relatively rigid neck portion is provided at the unsealed end having a discharge opening extending therethrough, the outer peripheral surface of the neck portion being threaded or otherwise constructed to enable a cap to be threaded or otherwise attached thereon to seal the tube.
  • U.S. 4,487,757 discloses a dual compartmented collapsible tube separated into two compartments by a partition which extends to the dispensing nozzle which physically segregates and dispenses a dual component toothpaste containing reactive ingredients, wherein one component contains an alkali metal bicarbonate salt (e.g., NaHCO 3 ) and the other contains an acid or acid salt (e.g., citric acid) which is reactive with the bicarbonate salt to produce effervescence (carbon dioxide) upon simultaneous dispensing of unmixed layers of both components and intimate mixing thereof during toothbrushing.
  • an alkali metal bicarbonate salt e.g., NaHCO 3
  • an acid or acid salt e.g., citric acid
  • U.S. 4,687,663 discloses a dual compartmented tube in which the dual component dentifrice dispensed is composed of a first hydrogen peroxide containing gel and a sodium bicarbonate containing second component.
  • the tube is separated into two compartments by a partition extending into the dispensing nozzle.
  • U.S. Patents 5,020,694 and U.S. 5,038,963 describe rigid piston type multicompartmented dispensing containers for simultaneous coextrusion of two or more dentifrice components in a predetermined proportion. These rigid containers have the advantage of control over the coextrusion process.
  • plastic material is involved in their construction. For environmental and cost reasons, packaging with less plastic material is commercially desirable. Therefore, there is a need in the art for a non-rigid plastic compartmented container or tube for storing and simultaneously dispensing physically separated dentifrice components containing reactive ingredients at constant predetermined ingredient ratios whereby optimum interaction between reactive ingredients is obtained, such container requiring considerably less plastic material for its manufacture.
  • FR-A-2 260 506 discloses a multicompartment container made of flexible material and a dividing wall thinner than the outer walls and movable.
  • a means for the constant codispensing in predetermined proportions of physically separated dentifrice components containing different reactive ingredients from a multicompartmented, nonrigid, container having collapsible sidewalls the container including (1) a collapsible body portion formed from a plastic web material which deforms under a deflective force of about 0.45 kg (about 1.0 pound) or greater applied thereto and (2) a moveable partition within the container body defining separate compartments, the partition being a membrane which has a thickness less than that of the body sidewalls which deforms under a deflective force of less than 0.23 kg (0.5 pounds) and is displaced in response to a pressure differential developed thereacross upon compression of the container sidewalls, the displacement of the membrane substantially vitiating the pressure differential and equalizing the compressive forces exerted on the dentifrice components housed in the container compartments, whereby substantially constant codispensing of the components in predetermined proportions is attained when the components are formulated
  • substantially equivalent Compressive Force means that the individual components of the multicomponent dentifrice of the present invention are formulated so that the force required to actuate the flow and extrusion of an individually housed dentifrice component from the container outlet does not differ by more than 20% from any other separately housed component so that correctly proportioned interaction between the different reactive ingredients of the components is achieved when the components are ultimately mixed together.
  • Compressive Force measured in kg (pounds (lbs)), as used herein, and in the appended claims, means the force required to extrude 1-2 grams of a dentifrice component housed in a stainless steel container, a distance of 5 millimeters (mm) through an aperture opening of 3.8mm diameter at a temperature of 23°C at a fixed rate of 150 millimeters/minute (mm/min).
  • the dentifrice component is placed in a stainless steel container having a 2.0 centimeter (cm) inside diameter.
  • the bottom of the stainless steel container is equipped with an orifice which is 20mm in length and has an inside orifice diameter of 0.38cm.
  • a frictionless teflon piston with an outside diameter which is equal to the inside diameter of the stainless steel container is placed on top of the dentifrice.
  • An Instron® compression tester is operated to measure the force required to move the teflon piston down a 5mm distance at 150 mm/min.
  • the Compressive Force required for extrusion is obtained at the inflection point (change in slope) in a force vs. distance curve; the force applied by the piston causing the dentifrice component to flow increasing linearly until there is a change in the slope indicating the initiation of dentifrice component extrusion.
  • the compression force measured at the inflection point for each component be within ⁇ 20% of the other.
  • the compressive force required to effect extrusion of the dentifrice components of the present invention may be adjusted by the selection and concentration of the ingredients of the dentifrice vehicle in which the reactive ingredients are incorporated.
  • the dentifrice vehicle used in the practice of the invention is adjusted to impart to the dentifrice component the pasty consistency, body and non-tacky nature which is characteristic of conventional toothpastes or gels.
  • the vehicle is non-reactive with the reactive ingredients of the dentifrice and includes water, a suitable humectant such as glycerin, sorbitol, propylene glycol, polyethylene glycol, or any suitable mixture thereof and a thickening agent.
  • the humectant typically comprises about 10 to about 70% by weight of the dentifrice component and preferably about 20 to about 50% by weight of the dentifrice component Water may be included in the vehicle at a concentration of about 6 to about 70% by weight of the component and preferably about 15 to about 40% by weight.
  • Thickening agents incorporated in the dentifrice components of the present invention include natural and synthetic gums and colloids examples of which include iota carrageenan, kappa carrageenan, lamda carrageenan and mixtures thereof, xanthan gum, carboxymethyl cellulose, sodium carboxymethyl cellulose, starch, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, laponites and magnesium aluminum silicates.
  • Preferred thickening agents are thickeners which impart elastic structure to the dentifrice components so that progressive, variable thickening of the dentifrice component on storage is avoided.
  • thickeners When such thickeners are used in the preparation of the dentifrice components used in the practice of the present invention the compressive force required for extrusion of the dentifrice component does not substantially change during storage.
  • thickeners which impart elastic structure include the different types of carrageenan, laponites, magnesium aluminum silicates available commercially under the tradename Veegum and polyoxyethylene-polyoxypropylene block copolymers available under the trademark "Pluronic".
  • a thickener which imparts the desired elastic structure to dentifrice components which is most is preferred in the practice of the present invention is a cellulose gel formed from a dried, spray dried or bulk dried, co-processed, mixture of a microcrystalline cellulose and a cellulose gum such as carboxymethylcellulose, xanthan gum or sodium alginate.
  • a cellulose gel formed from a dried, spray dried or bulk dried, co-processed, mixture of a microcrystalline cellulose and a cellulose gum such as carboxymethylcellulose, xanthan gum or sodium alginate.
  • An example of such cellulose gels are those sold by the FMC Corporation under the tradename Avicel which generally contain about 80 to about 90% by weight microcrystalline cellulose and about 10 to about 20% by weight cellulose gum.
  • the particle size range of the gel is from submicron, that is, less than 0.2 ⁇ m to about 100 ⁇ m, and preferably about 0.2 to about 20 ⁇ m.
  • a cellulose gel particularly preferred for use in the practice of the present invention is Avicel RC-591-F which is a spray dried cellullose gel having the following composition and properties: % Microcrystalline Cellulose 88 % Colloidal (0.2 ⁇ m) 70 % Carboxymethyl cellulose 12 Initial Viscosity 39-175 at 1.2% Set Up Viscosity 1250 mPa.s at 1.2% Thickening agents such as Avicel RC-591-F may be incorporated in the dentifrice components of the present invention at a concentration of about 0.05 to about 2% by weight and preferably about 0.1 to about 1.5% by weight.
  • Surfactants are used in the preparation of dentifrice components of the present invention to aid in the thorough dispersion of the dentifrice components throughout the oral cavity when applied thereto as well as to improve the cosmetic acceptability and detersive and foaming properties of the combined components.
  • the surfactant is included in the dentifrice vehicle of the individual components of the present invention at a concentration of about 0.5 to about 3.0% by weight and preferably about 1.0 to about 2.0% by weight.
  • surfactants useful in the practice of the present invention are salts of the higher alkyl sulfates, such as sodium lauryl sulfate or other suitable alkyl sulfate having 8 to 18 carbon atoms in the alkyl group; sodium lauryl sulfoacetate, salts of sulfonated monoglycerides of higher fatty acids, such as sodium coconut monoglyceride sulfonate or other suitable sulfonated monoglycerides of a fatty acids of 10 to 18 carbon atoms; salts of amides of higher fatty acid, e.g., 12 to 16 carbon atom acids, with lower aliphatic amino acids, such as sodium-N-methyl-N-palmitoyl tauride, sodium N-lauroyl-, N-myristoyl- and N-palmitoyl sarcosinates; salts of the esters of such fatty acids with isotonic acid or with glycerol monosul
  • alkene sulfonates or alkene sulfonates or mixtures thereof having 12 to 16 carbon atoms in the carbon chain of the molecule and soaps of higher fatty acids, such as those of 12 to 18 carbon atoms, e.g., coconut fatty acids.
  • the cation of the salt may be sodium, potassium or mono-, di or triethanol amine.
  • dentifrice components which must be physically segregated from the other when each individually contains an ingredient reactive with the other.
  • peroxide compounds are very reactive ingredients and need to be separated from many dentifrice ingredients such as flavor compounds, vitamins (A, C, E), antibacterial agents such as triclosan, and polyphosphates such as sodium tripolyphosphate.
  • Cationic compounds such like stannous ion, chlorhexidine digluconate, and cetyl pyridinium chloride also must be separated from anionic components of dentifrices such as tartar control agents (sodium tripolyphosphate), calcium and silica abrasives, and the like.
  • the first component of the dual component dentifrice composition contains a water soluble, fluoride releasable salt such as an alkali metal fluoride such as NaF, KF, sodium monofluorophosphate or SnF 2 .
  • the preferred fluoride salt for the purposes of the present invention is NaF.
  • the fluoride salt is incorporated in the first component of the dentifrice composition at a concentration of about 0.1 to about 1% by weight, and preferably at about 0.25 to about 0.5% by weight. At these preferred concentrations, about 750 ppm to about 1500 ppm, fluoride ion will be available to teeth when the combined first and second components of the dentifrice composition are admixed when applied to the teeth.
  • reactive ingredients which may be incorporated in the first dentifrice component include peroxide compounds such as hydrogen peroxide and calcium peroxide or organic acidic ingredients such as citric acid or salts thereof which may be included in the first dentifrice component at a concentration of about 0.5 to about 5% by weight of the component.
  • the second component of the dentifrice composition of the present invention includes a reactive polishing or abrasive ingredient such as dicalcium phosphate or an alkali metal bicarbonate salt.
  • a reactive polishing or abrasive ingredient such as dicalcium phosphate or an alkali metal bicarbonate salt.
  • the abrasive is incorporated in the second component of the dentifrice composition of the present invention at a concentration of about 1 to about 60% by weight and preferably at about 20 to about 50% by weight of the second component.
  • the abrasive is an alkali metal bicarbonate salt such as sodium bicarbonate
  • the bicarbonate salt is incorporated in the second component at a concentration of about 5 to about 25% by weight.
  • dentifrice components which may be used in the practice of the present invention include dentifrice components containing ingredients which are normally reactive and incompatible with each other such as calcium containing abrasives and polycarboxylated polymers (e.g., Gantrez) or potassium nitrate.
  • ingredients which are normally reactive and incompatible with each other such as calcium containing abrasives and polycarboxylated polymers (e.g., Gantrez) or potassium nitrate.
  • the reactive abrasive is contained in a vehicle formulated to have a composition similar to the vehicle of the first dentifrice component, so that the two components will be of similar physical characteristics, which will permit them to be more readily formulated to be coextrudable at substantially equivalent compressive forces.
  • the vehicle composition of the second component specifically the humectant content, is adjusted to accommodate the difference in component ingredients.
  • the humectant content of the second component is adjusted to accommodate the inclusion of the dicalcium phosphate abrasive.
  • the abrasive is included in the second dentifrice component at a concentration of about 10 to about 30% by weight and preferably at a concentration of about 15 to about 25% by weight. At these abrasive levels, the humectant concentration ranges from about 15 to about 70% by weight and preferably about 20 to about 40% by weight.
  • Similar adjustments in sodium bicarbonate concentrations in the second dentifrice component of the multicomponent dentifrice used in the present invention can be made so that the compressive forces required to extrude both components are substantially equivalent to provide component dispensing at a predetermined ratio to effect optimum reaction and effervesce between the bicarbonate ingredient in the second component and the organic acid or peroxide ingredient in the first component.
  • a striped dentifrice product is obtained in accordance with the practice of the present invention wherein colorants of contrasting colors are incorporated in each of the dentifrice components used in the practice of the present invention, the colorants being pharmacologically and physiologically non-toxic when used in the suggested amounts.
  • Colorants used in the practice of the present invention include both pigments and dyes.
  • Pigments used in the practice of the present invention include non-toxic, water insoluble inorganic pigments such as titanium dioxide and chromium oxide greens, ultramarine blues and pinks and ferric oxides as well as water insoluble dye lakes prepared by extending calcium or aluminum salts of FD&C dyes on alumina such as FD&C Green #1 lake, FD&C Blue #2 lake, FD&C R&D #30 lake and FD&C # Yellow 15 lake.
  • the pigments have a particle size in the range of 5-1000 ⁇ m, preferably 250-500 ⁇ m, and are present at a concentration of 0.5 to 3% by weight.
  • the dyes used in the practice of the present invention are distributed uniformly throughout the dentifrice component and are generally food color additives presently certified under the Food Drug & Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C Red No. 3 (sodium salt of tetraiodofluorescein), FD&C Yellow No. 5 (sodium salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphtol-6-monosulfonate), FD&C Green No.
  • FD&C Red No. 3 sodium salt of tetraiodofluorescein
  • FD&C Yellow No. 5 sodium salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazole-3 carboxylic acid
  • the colorant included in one of the dentifrice components be a pigment such as Ti0 2 and that colorant distributed throughout the body of the other dentifrice component be a dye and the dye be of a different color than the pigment included in the first dentifrice component.
  • flavoring or sweetening material may also be employed.
  • suitable flavoring constituents are flavoring oils, e.g., oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, and orange, and methyl salicylate.
  • suitable sweetening agents include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillartine, and sodium saccharin.
  • flavor and sweetening agents may together comprise from 0.01% to 5% or more of the preparations.
  • Non-limiting examples thereof include preservatives, silicones and chlorophyll compounds, antibacterial agents such as chlorohexidene, halogenated diphenyl ethers such as triclosan, desensitizing agents such as potassium nitrate and potassium citrate and mixtures thereof.
  • These adjuvants are incorporated in the dentifrice components in amounts which do not substantially adversely affect the properties and characteristics desired, and are selected and used in proper amounts, depending upon the particular type of dentifrice component involved.
  • the humectants e.g. glycerin, polyethylene glycol ingredients and sweetener are dispersed in a conventional mixer until the mixture becomes a homogeneous gel phase.
  • the fluoride salt or dicalcium phosphate abrasive are added into the gel phase.
  • the thickener, flavor and surfactant ingredients are added and the ingredients mixed at high speed under vacuum of about 20-100 mm Hg.
  • the resultant product is a homogeneous, semi-solid, extrudable paste product.
  • the material from which the body side walls of the multicompartmented container used in the practice of the present invention is manufactured is a flexible, resilient plastic material which is deflected when a force is applied to the web.
  • plastic web materials which deflect upon the application of a Deflective Force of about 0.45 kg to about 1.4 kg (1.0 to about 3.0 pounds) applied thereto have been found to be particularly suitable for codispensing dentifrice components from collapsible compartmented tubes in constant predetermined proportions in accordance with the practice of the present invention.
  • Deflective Force means the maximum force expressed in pounds required to deflect a plastic web bent in the form of an inverted U by a shaped adapter fitted to a compression table such as an Instron® Tensile Testing Machine, the force being applied axially downward on the arcuate section of the U-shaped web at a rate of 30.48 cm/min (12 inches per minute).
  • the adapter installed on the Instron® Machine is 13.97 cm (5.5 inches) high and consists of a 0.635 cm (0.25 inch) thick stainless steel block, 1 inch square, with a 0.3175 cm (0.125 inch) diameter stainless steel wire curving downwardly to an open rectangular section 5 inches wide and 6.35 cm (2.5 inches) high.
  • the adapter is fitted into the jaws of the Instron® Machine and is moved downwardly to contact and deflect the surface web being tested.
  • the plastic web being tested is held in a specimen holder consisting of a stainless steel base 0.3175 cm (0.125 inches) in thickness having a slot 2.54 cm (1 inch) wide, 10.16 cm (4 inches) long and 5.08 cm (2 inches) high.
  • a lower mount for this base mounts the base to the work platform of the Instron® Machine.
  • a specimen brace fits into the base to hold the plastic web in the base, the brace consisting of a channel 10.16 cm (4 inches) in length, 2.4765 cm (0.975 inches) wide and 5.08 cm (2 inches) high having a wall thickness of 1.5875 cm (0.625 inches).
  • the specimen brace holds the web in the base in an inverted U shape.
  • the plastic sheet material from which the body sidewalls are manufactured may be made of any suitable plastic material such as polyethylene (both low and high density) polypropylene, ethylene and propylene copolymers and polyethylene terephthalate.
  • the plastic sheet material may have a laminate structure wherein a gas barrier material such as ethylene vinyl alcohol, nylon or polyvinylidene chloride is sandwiched between layers of polyethylene or polypropylene or copolymers thereof.
  • the gas barrier materials prevent the loss of certain ingredients of the dentifrice components which enter the gas phase and permeate through the plastic materials of non-gas barrier structures.
  • the multicompartment container of the present invention has collapsible outer sidewalls and a moveable partition dividing the container into a plurality of compartments whereby the outer sidewalls of the compartments are collapsed to eject, under a compressive force applied to the outer walls, the dentifrice components from the individual compartments with the moveable partition compensating for the deformation of the outer walls of the tube.whereby the compressive forces applied to the individual dentifrice components for extrusion thereof from the container are equalized.
  • the multicompartmented tube may include a tubular body with a circular section but it could have another shape for example, oval.
  • the tube has a body which is of a type that is easily squeezable, compressible or collapsible and is comprised of a sidewall formed from a resilient plastic material that can be deflected by Deflective Force of about 0.45 kg to about 1.4 kg (1.0 to about 3.0 pounds) as hereinbefore described.
  • One end of the body is sealed while the opposing end is open and is provided with a neck through which the components of the multicomponent dentifrice are discharged through aperatures.
  • the neck is provided with engaging means to accept a closure cap.
  • the thickness of the sidewall will typically be in the range of about 0.25 to about 1.20 mm. In a preferred embodiment of the invention, the thickness of the sidewall is about 0.25 to about 0.35 mm in thickness.
  • the interior of the body is segmented longitudinally into two compartments by means of a membrane or partition.
  • the partition is flaccid and laterally moveable.
  • the partition may be integrally formed with walls of the body as a uniform part of the body.
  • the partition may be a separately formed member appropriately retained within the container body.
  • heat or adhesive sealing may be used to join the two halves of the body together with the partition joined to the peripheral margins of the sidewall. The peripheral edges of the partition are held permanently maintained to the internal surface sidewall by a suitable thermal fusion bond or adhesive bond.
  • the partition may be in a corrugated or pleated configuration so that as the outer walls of the tube are compressed or deformed, the partition will be caused to move laterally.
  • the partition may be comprised of a very flexible and flaccid thermoplastic film material such as low density polyethylene or polypropylene or may be a laminate in which a gas barrier layer is sandwiched between opposed polyethylene or polypropylene layer.
  • the partition has a thickness substantially less than that of the plastic material from which the sidewalls are formed and generally has a thickness of from 0.005 to 0.20 mm and preferably about 0.075 to about 0.15 mm.
  • the bottom of the body may have any suitable configuration.
  • the bottom of the body is sealed by crimping or squeezing together with the walls of the body being adhesively or thermally bonded together and to the internal partition.
  • the compartments of the container body are filled with the dentifrice components in the usual manner before the end of the body is sealed i.e., the container is provided with a sealing cap; then inverted and filled through the bottom end.
  • the dentifrice components containing different reactive ingredients will exhibit different flow characteristics when a compressive force is applied to the sidewall, as the dentifrice components as they flow over the interior sidewall surfaces encounter different, i.e., greater or lesser resistance to flow when compared to the other.
  • the dentifrice components are formulated to account for this difference so that the compressive force required to cause both components to flow is substantially equivalent, the Compressive Force required typically being in the range of about 0.23 kg to about 9 kg (about 0.5 to about 20 lbs) and preferably about 0.45 kg to about 4.5 kg (about 1 to about 10 lbs).
  • the Compressive Force required typically being in the range of about 0.23 kg to about 9 kg (about 0.5 to about 20 lbs) and preferably about 0.45 kg to about 4.5 kg (about 1 to about 10 lbs).
  • the difference in compressive force required to extrusion may be adjusted by modification of the geometry of the aperture through which the individual components are extruded.
  • the partition may be substantially collapsed so that it can be displaced in either direction by a pressure differential across it.
  • the partition may shift laterally to the right in response to a compressive displacement of the left side of the tube which is greater than the compressive displacement of the opposite sidewall.
  • the individual components converge to form a single, banded stream of material.
  • the single stream is convenient and easy to direct with accuracy upon a limited surface area, which in the case of toothpaste components can be neatly and easily applied onto the narrow width of a toothbrush in proportions predetermined to provide optimum therapeutic delivery of the reacted ingredients when the component layers are mixed by brushing the teeth or other dental tissue in the oral cavity.
  • the container may be squeezed intermittently to dispense small portions of the components of a two component dentifrice housed in the compartments.
  • squeezing can develop greater pressure on one component than the other.
  • the pressure differential across the partition displaces the partition until the pressures equalize.
  • the partition is a pressure responsive displaceable wall for equalizing component pressures whereby a relatively constant proportion of a co-dispensed product components is achieved, as both dentifrice components are formulated to be extrudable by the same compressive force, their relative extrusion rates will be equalized by the moveable the partition.
  • the diameter of the emerging single stream may be regulated according to packaging specifications by adjusting the diameter of the apertures.
  • the stream is in the form of a cylindrical ribbon having a diameter of about 0.3 to about 2.0 cm. If different colorants are included in the individual dentifrice components, the multilayer dentifrice component stream emerges from the neck outlet passage as an attractive striped toothpaste.
  • a series of 40 mm diameter dual compartmented tubes having a body length of 158 mm was formed from a laminated sheet having the structure PE/EVOH/PE wherein PE is polyethylene and EVOH is an ethylene/vinyl alcohol copolymer, the sheet having a thickness of 0.3 mm.
  • a Deflective Force of 0.73 kg (1.6 lbs) was required to deflect the sheet as determined using the Instron® Machine in accordance with the procedure previously described.
  • the tube was segmented longitudinally into two compartments of approximately similar volume by means of a pleated partition film formed from polyethylene, having a thickness of 0.12 mm which deflected upon the application of a Deflective Force of 0.035 kg (0.077 lbs).
  • the compartments of the dual compartmented tubes were filled with dentifrice components designated 1 and 2 of a multicomponent dentifrice designated "Dentifrice A" which contained the ingredients listed in Table I.
  • the Compressive Force, as determined by the procedure previously described, to cause components 1 and 2 of Dentifrice A was substantially equivalent, that is, the Compressive Force required to extrude component 1 of Dentifrice A was 2.4% less than component 2.
  • the Compressive Forces required to extrude components 1 and 2 of Dentifrice A are recorded in Table III below.
  • the Compressive Force required for extrusion of the individual components of Dentifrice B were not within ⁇ 20% of each other, namely component 2 of Dentifrice B required a Compressive Force which was 45% lower than that of component 1.
  • the Compressive Force required for extrusion of the components of Dentifrice B are recorded in Table III below.
  • component 2 of comparative Dentifrice B was substantially equivalent to that of component 1, component 2 having a viscosity that was 12% lower than that of component 1.
  • Dentifrice B Ingredient Component 1 Wt. % Component 2 Wt. % NaF -- 0.486 Saccharin 0.20 0.20 Sorbitol -- 38.524 Glycerin 22.00 25.00 Polyethylene glycol 600 -- 3.00 Dicalcium phosphate 48.76 -- Silica Abrasive -- 18.0 Silica Thickener -- 5.50 Flavor 0.89 0.89 Sodium lauryl sulfate 1.20 1.20 TiO 2 -- -- Carboxymethyl cellulose 1.00 -- Water 25.75 -- Tetrasodium pyrophosphate 0.25 -- Viscosity, Brookfield Units 65 58 Compressive Force Required for Extrusion [kg (lbs)] Dentifrice A Dentifrice B Component 1 1.15 (2.53) 2.49 (5.5) Component 2 1.17 (2.59) 4.54 (10.0)
  • Components 1 and 2 of Dentifrice A were determined to dispense substantially equally form the multicompartment tubes in which they were housed whereas components 1 and 2 of Dentifrice B did not, although in both Dentifrices the viscosities of the individual components were substantially equivalent.

Claims (27)

  1. Distributeur à compartiments multiples composé d'un corps ayant des parois latérales pouvant se déformer, d'un orifice de sortie et de moyens de cloison divisant de manière interne le volume intérieur du corps en une pluralité de compartiments de stockage séparés, la cloison étant formée à partir d'une matière plastique ayant une épaisseur inférieure à celle des parois latérales du corps et pouvant être déplacée pour compenser les différences de débits d'extrusion des constituants lors de la compression des parois latérales, les compartiments séparés étant remplis avec les constituants individuels du dentifrice, caractérisé en ce que l'orifice de sortie du distributeur est pourvu d'une ouverture de décharge en communication avec les compartiments séparés, la cloison pouvant être déplacée pour compenser les différences de débits d'extrusion, les constituants du dentifrice sont formulés de manière à tenir compte des différentes forces superficielles rencontrées par rapport auxdites parois latérales, pour qu'ils puissent être extrudés par l'ouverture à des forces de compression essentiellement équivalentes, la force de compression étant mesurée comme la force en kg requise pour extruder 1 à 2 g d'un constituant de dentifrice contenu dans un réservoir en acier inoxydable sur une distance de 5 mm par une ouverture de 3,8 mm de diamètre à une température de 23°C à un débit fixe de 150 mm/mn, les parois latérales du corps étant formées à partir d'une matière plastique qui se déforme sur application d'une force de déviation d'environ 0,45 kg ou plus, la force de déviation étant la force maximale, exprimée en kg, requise pour faire dévier une pièce en matière plastique recourbée en forme de U à l'envers par un adaptateur façonné fixé à une table de compression, la force étant appliquée axialement vers le bas sur la partie courbe de la pièce en forme de U à raison de 30,48 cm/mn, lesdits constituants du dentifrice étant, en outre, formulés pour que, sur compression des parois latérales du corps, un flux multicouche sous forme d'une seule bande des constituants contenant les ingrédients réactifs puisse être extrudé par l'ouverture, à des rapports prédéterminés pour fournir des niveaux optimaux des ingrédients ayant réagi lorsque les constituants extrudés sont mélangés dans la cavité buccale.
  2. Distributeur selon la revendication 1, dans lequel les forces de compression déclenchant l'extrusion des constituants du dentifrice sont à ± 20 % les unes des autres.
  3. Distributeur selon la revendication 1, dans lequel les constituants du dentifrice sont formulés pour pouvoir être extrudés à une force de compression d'environ 0,23 à environ 9 kg.
  4. Distributeur selon la revendication 1, dans lequel les constituants du dentifrice sont formulés pour pouvoir être extrudés à une force de compression d'environ 0,45 à environ 4,5 kg.
  5. Distributeur selon la revendication 1, dans lequel la matière plastique à partir de laquelle les parois latérales du corps sont formées est déformée par une force de déviation d'environ 0,45 à environ 1,4 kg.
  6. Distributeur selon la revendication 1, dans lequel les parois latérales ont une épaisseur d'environ 0,25 à environ 1,2 mm.
  7. Distributeur selon la revendication 1, dans lequel la cloison est déviée par une force de déviation inférieure à 0,23 kg.
  8. Distributeur selon la revendication 1, dans lequel la cloison a une épaisseur de paroi d'environ 0,005 à environ 0,22 mm.
  9. Distributeur selon la revendication 8, dans lequel la cloison est pliée et peut être déplacée en réponse à une force de compression appliquée sur les parois latérales du corps.
  10. Distributeur selon la revendication 1, dans lequel un constituant du dentifrice contient un épaississant qui confère une structure élastique au constituant.
  11. Distributeur selon la revendication 10, dans lequel l'épaississant est un gel cellulosique.
  12. Distributeur selon la revendication 10, dans lequel l'épaississant est une gomme carraghénane.
  13. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un abrasif contenant du calcium et un sel relargable de type fluorure.
  14. Distributeur selon la revendication 13, dans lequel le sel relargable de type fluorure est NaF.
  15. Distributeur selon la revendication 13, dans lequel l'abrasif contenant du calcium est le phosphate de calcium.
  16. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un produit à polir de type bicarbonate de métal alcalin et un acide organique.
  17. Distributeur selon la revendication 16, dans lequel le bicarbonate de métal alcalin est le bicarbonate de sodium.
  18. Distributeur selon la revendication 16, dans lequel l'acide organique est l'acide citrique.
  19. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un bicarbonate de métal alcalin et un composé peroxyde.
  20. Distributeur selon la revendication 19, dans lequel le composé peroxyde est le peroxyde d'hydrogène ou le peroxyde de calcium.
  21. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un abrasif contenant du calcium et un nitrate de potassium.
  22. Distributeur selon la revendication 21, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un abrasif contenant du calcium et un polymère polycarboxylé.
  23. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un composé peroxyde et un tripolyphosphate de sodium.
  24. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un composé peroxyde et un aromatisant.
  25. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un composé peroxyde et une vitamine.
  26. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un composé peroxyde et un agent antibactérien.
  27. Distributeur selon la revendication 1, dans lequel les ingrédients réactifs contenus dans les constituants du dentifrice sont un composé cationique et un composé anionique.
EP97932135A 1996-06-06 1997-05-21 Distribution simultanee de constituants de dentifrice physiquement separes, selon des rapports constants Expired - Lifetime EP0918698B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65973496A 1996-06-06 1996-06-06
US659734 1996-06-06
PCT/US1997/008622 WO1997046462A1 (fr) 1996-06-06 1997-05-21 Distribution simultanee de constituants de dentifrice physiquement separes, selon des rapports constants

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EP0918698A1 EP0918698A1 (fr) 1999-06-02
EP0918698B1 true EP0918698B1 (fr) 2001-11-07

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EP (1) EP0918698B1 (fr)
CN (1) CN1071248C (fr)
AT (1) ATE208327T1 (fr)
AU (1) AU722898B2 (fr)
BR (1) BR9709290A (fr)
CA (1) CA2254338A1 (fr)
CO (1) CO4700512A1 (fr)
DE (1) DE69708117T2 (fr)
DK (1) DK0918698T3 (fr)
ES (1) ES2167757T3 (fr)
HU (1) HU223420B1 (fr)
MY (1) MY123112A (fr)
PL (1) PL187283B1 (fr)
PT (1) PT918698E (fr)
TR (1) TR199802521T2 (fr)
WO (1) WO1997046462A1 (fr)
ZA (2) ZA974980B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350436B1 (en) 1996-11-21 2002-02-26 The Procter & Gamble Company Method of reducing staining of stannous in dentifrice compositions
US6713049B1 (en) 1999-11-12 2004-03-30 The Procter & Gamble Company Oral compositions providing optimal surface conditioning
US6187295B1 (en) 1996-11-21 2001-02-13 The Procter & Gamble Company Methods of reducing the astringency of stannous in dentifrice compositions
US5820852A (en) * 1996-11-26 1998-10-13 The Proctor & Gamble Company Oral compositions containing fluoride, pyrophosphate, and peroxide
US5950873A (en) * 1996-11-26 1999-09-14 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Dental product
US5855871A (en) * 1997-08-12 1999-01-05 Colgate-Palmolive Company Effervescent two component bicarbonate and acid containing dentifrice
US5814303A (en) * 1997-09-17 1998-09-29 Chesebrough-Pond's Usa Co., Division Of Conocpo, Inc. Dental product
US5958381A (en) * 1998-03-12 1999-09-28 Colgate Palmolive Company Bis-biguanide antiplaque dentifrice exhibiting reduced staining
US10470985B2 (en) 1999-11-12 2019-11-12 The Procter & Gamble Company Method of protecting teeth against erosion
US20040146466A1 (en) 1999-11-12 2004-07-29 The Procter & Gamble Company Method of protecting teeth against erosion
JP3860471B2 (ja) 1999-11-12 2006-12-20 ザ プロクター アンド ギャンブル カンパニー 改良された第１錫系口腔組成物
AU1479501A (en) 1999-11-12 2001-06-06 Procter & Gamble Company, The Improved dual phase stannous oral compositions
US6447758B1 (en) * 2001-05-02 2002-09-10 Colgate Palmolive Company Cationic antibacterial dentifrice exhibiting superior foaming properties
JP3875687B2 (ja) 2001-07-11 2007-01-31 ザ プロクター アンド ギャンブル カンパニー マルチチャンバ型チューブ
JP2004534701A (ja) 2001-07-11 2004-11-18 ザ プロクター アンド ギャンブル カンパニー 流体を均一に分配するための流量調整要素を備えるマルチチャンバ型チューブ
US6613310B1 (en) * 2002-07-29 2003-09-02 Colgate Palmolive Company Dual component bis-biguanide containing dentifrice of improved stability
KR101088471B1 (ko) * 2010-04-26 2011-11-30 박은정 이중형 튜브용기 및 그 제조방법
US10123953B2 (en) 2012-06-21 2018-11-13 The Procter & Gamble Company Reduction of tooth staining derived from cationic antimicrobials
CN110507064B (zh) * 2018-05-21 2022-07-15 株式会社爱茉莉太平洋 棒型内容物用的多填充式容器及其填充方法
EP3958983A1 (fr) 2019-04-26 2022-03-02 The Procter & Gamble Company Réduction de coloration de dent dérivée d'antimicrobiens cationiques
CN113086419B (zh) * 2021-03-17 2021-12-24 安牧乳业(江苏)有限公司 一种安全性高的乳饮料包装

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FR572054A (fr) * 1923-10-18 1924-05-28 Double tube flacon aplatissable, débitant des produits pâteux
FR2260506A1 (en) * 1974-02-13 1975-09-05 Allet Coche Pierre Tube with two compartments for paste products - avoids need for separate tubes for materials used at point of mixing
US4089437A (en) * 1976-06-18 1978-05-16 The Procter & Gamble Company Collapsible co-dispensing tubular container
US4487757A (en) * 1981-12-28 1984-12-11 Colgate-Palmolive Company Dispensing container of toothpaste which effervesces during toothbrushing
GB9207292D0 (en) * 1992-04-02 1992-05-13 Unilever Plc Fluid dispensers

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MY123112A (en) 2006-05-31
ZA974983B (en) 1998-12-07
CO4700512A1 (es) 1998-12-29
CA2254338A1 (fr) 1997-12-11
PT918698E (pt) 2002-04-29
CN1221384A (zh) 1999-06-30
DK0918698T3 (da) 2002-02-25
PL187283B1 (pl) 2004-06-30
EP0918698A1 (fr) 1999-06-02
PL330312A1 (en) 1999-05-10
AU722898B2 (en) 2000-08-17
WO1997046462A1 (fr) 1997-12-11
CN1071248C (zh) 2001-09-19
DE69708117T2 (de) 2002-07-04
HUP0003316A3 (en) 2002-11-28
ATE208327T1 (de) 2001-11-15
TR199802521T2 (xx) 1999-04-21
DE69708117D1 (de) 2001-12-13
ES2167757T3 (es) 2002-05-16
ZA974980B (en) 1998-12-07
HU223420B1 (hu) 2004-06-28
BR9709290A (pt) 1999-08-10
HUP0003316A2 (hu) 2001-02-28
AU3566997A (en) 1998-01-05

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