EP0910804A1 - Procede d'imagerie par resonance magnetique a diffusion ponderee - Google Patents

Procede d'imagerie par resonance magnetique a diffusion ponderee

Info

Publication number
EP0910804A1
EP0910804A1 EP98907116A EP98907116A EP0910804A1 EP 0910804 A1 EP0910804 A1 EP 0910804A1 EP 98907116 A EP98907116 A EP 98907116A EP 98907116 A EP98907116 A EP 98907116A EP 0910804 A1 EP0910804 A1 EP 0910804A1
Authority
EP
European Patent Office
Prior art keywords
navigator
signal
measured
gradient
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98907116A
Other languages
German (de)
English (en)
Inventor
John Samuel Van Den Brink
Arianne Margarethe Corinne Van Muiswinkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Priority to EP98907116A priority Critical patent/EP0910804A1/fr
Publication of EP0910804A1 publication Critical patent/EP0910804A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56341—Diffusion imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
    • G01R33/56554—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by acquiring plural, differently encoded echo signals after one RF excitation, e.g. correction for readout gradients of alternating polarity in EPI

Definitions

  • the invention relates to a magnetic resonance (MR) method for the imaging of an object arranged in a steady magnetic field, the following steps being repeatedly executed according to said method: excitation of spins in a part of the object; measurement of MR signals along a predetermined trajectory containing a plurality of lines in k-space by application of a read gradient and other gradients, application of a navigator gradient for the measurement of navigator MR signals and application of an additional gradient in order to achieve diffusion sensitivity of the MR signal, said method also including the determination of a phase correction from phases and moduli of the measured navigator MR signals so as to correct the measured MR signals and the determination of an image of the part of the object from the corrected MR signals.
  • MR magnetic resonance
  • the invention also relates to an MR device for carrying out such a method.
  • a method of the kind set forth is known from the article "Diffusion-
  • gradients are to be understood as temporary magnetic fields which are superposed on a steady magnetic field and cause a gradient in the steady magnetic field in three respective orthogonal directions.
  • a gradient in the first direction is generally referred to as a read out gradient
  • a gradient in the second direction as a phase encoding gradient
  • a gradient in the third direction as a selection gradient.
  • the known method is applied in medical diagnostics so as to acquire MR images of diffusion phenomena in the tissue of the part of the body, for example a part of the brain of a human or animal.
  • an additional gradient which includes a bipolar gradient having a high b-value is applied. This results in an increased sensitivity of the MR signal to spins which move due to diffusion in the tissue to be imaged.
  • the measured MR signals are corrected for macroscopic motion by means of a phase correction. Such phase correction is determined from the phases of the measured navigator MR signals. After this correction, an image of the part of the brain is reconstructed. It is a drawback of the known method that strip-shaped artefacts are liable to occur at areas in the reconstructed image which correspond to regions in the brain which contain a large quantity of cerebrospinal fluid (CSF).
  • CSF cerebrospinal fluid
  • the method according to the invention is characterized in that a corrected phase is determined for a measured navigator MR signal from a measuring point, for which the modulus of the measured navigator MR signal is smaller than a threshold value, from the phases of the measured navigator MR signal from different reference measuring points for which the moduli of the navigator MR signal exceed the threshold value.
  • the invention is based on the recognition of the fact that the presence of a strong diffusion motion due to a high value of the additional gradient reduces the value of the moduli of the measuring points in the navigator MR signal which correspond to regions of the brain which contain a large quantity of CSF. Because of the low value of the moduli, the error in the determination of the phase increases.
  • the artefacts in the MR image can be reduced when for the measuring points having a modulus smaller than the threshold value the corrected phase is determined from the phases of the various reference measuring points of the navigator MR signal for which the phase can be determined with a sufficiently small error.
  • a special version of the method according to the invention is characterized in that the corrected phase of the measured navigator MR signal from the measuring point is determined by interpolation of the phases of the measured navigator MR signal from neighboring reference measuring points.
  • the phase of the measuring points for which the modulus of the measured navigator MR signal is smaller than the threshold value can thus be simply determined.
  • the phase of the measured navigator MR signal varies, for example as a linear function of the distance in the direction of the navigator gradient.
  • a further version of the method according to the invention is characterized in that the corrected phase of the measured navigator MR signal from the measuring point is estimated by interpolation of the mean phase of the phases of the measured navigator MR signal from different reference measuring points for which the value of a co-ordinate in a direction of the navigator gradient is smaller than the corresponding co- ordinate of the measuring point and the mean phase of the phases of the measured navigator MR signal from different reiarence measuring points for which the value of a co-ordinate in a direction of the navigator gradient is larger than the corresponding co-ordinate of the measuring point.
  • This step ensures that the phases of a reference measuring point having a small co-ordinate and the phase of a reference measuring point having a co-ordinate larger than the corresponding co-ordinate of the measuring point, the modulus of said reference measuring points satisfying the condition imposed, are taken into account to a limited extent only in determining the corrected phase of the measuring point, thus reducing possible errors which are due to a phase which deviates from the expected phase variation because of a strongly varying modulus of said reference measuring points.
  • a further version of the method according to the invention is characterized in that a linear interpolation or a higher-order interpolation is used for determining the corrected phase.
  • a linear or higher-order interpolation can be used in dependence on the expected phase variation of the navigator MR signal as a function of the distance in the direction of the navigator gradient, the interpolation function being in correspondence with the phases determined for the reference points.
  • a further version of the method according to the invention is characterized in that the threshold value is determined by a function of a maximum value of the moduli of the measured navigator MR signal.
  • the maximum value of the moduli of the measured navigator MR signal divided by two is an example of such a function. This step determines a part of the navigator MR signal for which the phase of the measured navigator MR signal is inaccurate.
  • a further version of the method according to the invention is characterized in that the additional gradient contains a bipolar gradient.
  • the bipolar gradient is a gradient enabling measurement of a displacement due to diffusion of the spins in the tissue in the direction of the gradient.
  • a further version of the method according to the invention is characterized in that a refocusing RF pulse is generated at the temporal center of the bipolar gradient. Due to the generating of this refocusing RF pulse, a measurement of the transverse relaxation time T 2 is obtained instead of the time constant T * 2 of the free induction decay signal.
  • a further version of the method according to the invention is characterized in that two 90° RF pulses with an interval TM are generated at the temporal center of the bipolar gradient.
  • high b-values of the additional gradient can be achieved; a high signal-to-noise ratio can then also be achieved for measurements on biological tissue with a longitudinal relaxation time T, of the magnetization which exceeds the transverse relaxation time T 2 of the magnetization.
  • a further version of the method according to the invention is characterized in that an inversion recovery RF pulse is generated a period of time TI before the excitation.
  • a 180° RF pulse is an example of such an inversion recovery pulse.
  • the period of time TI between the inversion recovery RF pulse and the excitation by means of an RF pulse can be chosen to be such that the contrast between different types of tissue is enhanced.
  • the invention also relates to an MR device which is characterized in that the processing unit also includes means for determining a threshold value of moduli of the measured navigator MR signal, and correction means for determining a corrected phase of a measured navigator MR signal from a measuring point for which a modulus of the measured navigator MR signal is smaller than the threshold value from the phases of the measured navigator MR signal from different reference measuring points for which the moduli of the navigator MR signal are larger than the threshold value.
  • Fig. 1 shows an MR device
  • Fig. 2 shows a first diffusion-weighted EPI pulse sequence
  • Fig. 3 shows a graph illustrating a first version of the method for determining the phase of a measured navigator MR signal from a measuring point with a small value of the modulus
  • Fig. 4 shows a graph illustrating a second version of the method for determining the phase of a measured navigator MR signal from a measuring point with a small value of the modulus
  • Fig. 5 shows a pulse sequence containing two 90° RF pulses and the additional gradient
  • Fig. 6 shows a pulse sequence containing an inversion recovery RF pulse prior to an excitation RF pulse.
  • Fig. 1 shows a magnetic resonance device which includes a first magnet system 2 for generating a steady magnetic field, and also several gradient coils 3 for generating additional magnetic fields having a gradient in the X, Y, Z directions.
  • the Z direction of the co-ordinate system shown corresponds to the direction of the steady magnetic field in the magnet system 2 by convention.
  • the measuring co-ordinate system x, y, z to be used can be chosen independently of the X, Y, Z system shown in Fig. 1.
  • the gradient coils are fed by a power supply unit 4.
  • An RF transmitter coil 5 serves to generate RF magnetic fields and is connected to an RF transmitter and modulator 6.
  • a receiver coil is used to receive the magnetic resonance signal generated by the RF field in the object 7 to be examined, for example a human or animal body.
  • This coil may be the same coil as the RF transmitter coil 5. Furthermore, the magnet system 2 encloses an examination space which is large enough to accommodate a part of the body 7 to be examined.
  • the RF coil 5 is arranged around or on the part of the body 7 to be examined in this examination space.
  • the RF transmitter coil 5 is connected to a signal amplifier and demodulation unit 10 via a transmission/reception circuit 9.
  • the control unit 11 controls the RF transmitter and modulator 6 and the power supply unit 4 so as to generate special pulse sequences which contain RF pulses and gradients.
  • the phase and amplitude obtained from the demodulation unit 10 are applied to a processing unit 12.
  • the processing unit 12 processes the presented signal values so as to form an image by transformation. This image can be visualized, for example by means of a monitor 13.
  • EPI echo planar imaging
  • Fig. 2 shows a first pulse sequence 20 and a second pulse sequence 30 which are used in a first version.
  • the first pulse sequence 20 contains an excitation RF pulse and temporary magnetic gradient fields.
  • the first pulse sequence 20 starts by application of a first excitation RF pulse 100, having a flip angle , and a first selection gradient 110 for excitation of the spins within an object, for example a part of the brain of a human or animal.
  • the flip angle a amounts to, for example 90°.
  • the first selection gradient 110 is a temporary magnetic field which is oriented in the z- direction and has a gradient extending in the z-direction. After slice selection, an additional gradient is applied so as to obtain diffusion weighting.
  • the additional gradient G aux contains a bipolar gradient which comprises two equal but temporally shifted parts 170, 171, a first refocusing RF pulse 101 being generated halfway in time between the two parts.
  • the first refocusing RF pulse 101 is rendered selective by application of a second selection gradient 111 which has the same properties as the first selection gradient 110.
  • a first initial phase encoding gradient 120 and a read out gradient 151 are applied in the pulse sequence 20.
  • the initial phase encoding gradient and the read out gradient are both temporary magnetic gradient fields oriented in the z-direction, their gradients extending mutually pe ⁇ endicularly and both in a plane pe ⁇ endicular to the z- axis.
  • Further phase encoding gradients 121, 122, 123, 124, referred to as blips are applied after the second and further zero crossings of the read gradients 151, 152, 153, 154 in such a manner that the k-space is scanned along lines which are uniformly distributed in the k- space.
  • the MR signals 181, 182, 183, 184, 185 are measured in the presence of the read gradients 151, 152, 153, 154. Subsequent to the read gradient 155, a first rephasing gradient 125 is applied. After that, the pulse sequence 20 is repeated for different values of the first initial phase encoding gradients and the first rephasing gradients in order to measure a complete set of MR signals which correspond to, for example, 64, 128 or 256 lines in the k- space. In order to compensate the phase variations due to a macroscopic motion of the body, the pulse sequence 20 also includes a first navigator gradient 150 for measuring a first navigator MR signal 180.
  • a second refocusing RF pulse 102 is generated so as to determine the transverse relaxation time T 2 of the tissue instead of the time constant T * 2 of the free induction decay signal.
  • the second refocusing RF pulse 102 is rendered selective by application of a third selection gradient 112.
  • Navigator MR signals are known per se from United States patent specification 4,937,526.
  • the first navigator gradient 150 is applied in such a manner that when the first lobe 151 of the read out gradient is described by a function f(t), the first navigator gradient 150 is described by the same function f(t).
  • the first navigator gradient 150 is applied and the second refocusing RF pulse 102 is generated before the first initial phase encoding gradient 120 and after the first additional gradient 171.
  • a first navigator MR signal 180 is measured in the presence of the first navigator gradient 150.
  • the measured first navigator MR signal 180 of the first pulse sequence 20 of a series of pulse sequences for obtaining a set for the reconstruction of an image is used as a reference signal.
  • a phase correction for the measured MR signals 187-191 is derived from a measured second navigator MR signal 186 of a next second pulse sequence 30 and the first navigator MR signal 180.
  • Fig. 2 also shows the second pulse sequence 30 which is identical to the first pulse sequence 20, except for the second initial phase encoding gradient 126 and the second rephasing gradient 127.
  • the measured first and second navigator MR signals 187- 191 are subjected to a ID Fourier transformation and sequences are obtained which contain the phase of the navigator MR signal 186 as a function of the position in the direction of the navigator gradient.
  • the measured MR signals 187-191 are also subjected to a ID Fourier transformation and a sequence ( .( ⁇ mry (x)) is obtained which contains the phases of the measured MR signals 187-191 as a function of the distance in the direction of the read out gradient 157-161 which is chosen to be the same as the direction of the first navigator gradient 150 in the present example.
  • a phase correction is derived from the sequences ⁇ ⁇ n , ⁇ ⁇ v2 for correction of the sequence
  • the moduli of the measured navigator MR signals are liable to vary strongly due to the presence of CSF.
  • An major error then occurs in the determination of the phase of the measured navigator MR signal 180, 186 for measuring points with a small value of the modulus relative to the maximum value of the modulus of a measuring point occurring in the measured navigator MR signal 180, 186.
  • the phases of the measured navigator MR signal 180, 186 are corrected before said non-linear phase correction is determined so as to correct the measured MR signals 187-191.
  • a corrected phase of the navigator MR signal 180 from a measuring point with a modulus of the measured navigator MR signal 180 which is smaller than a threshold value is determined from the phases of the measured navigator MR signal 180 from different reference measuring points with moduli of the navigator MR signal 180 which are larger than the threshold value. Consequently, in regions where the MR signal has a modulus which is too small, the non-linear inte ⁇ olation is replaced by a linear or higher-order inte ⁇ olation of the known phase of the reference measuring points.
  • the corrected phase of the measuring point is determined by linear inte ⁇ olation of the phases of the measured navigator MR signal 180 from two neighboring reference measuring points, a first neighboring reference measuring point having a co-ordinate in the navigator gradient direction which is smaller than a corresponding co-ordinate of the measuring point whereas another neighboring reference measuring point has a co-ordinate in the direction of the navigator gradient which is larger than the corresponding co-ordinate of the measuring point.
  • the phase of the navigator MR signal varies as a linear function of the distance in the direction of the navigator gradient.
  • the corrected phase can be determined from a higher-order inte ⁇ olation, for example a third-order inte ⁇ olation, of the phases of the measured navigator MR signal 180 from different neighboring reference measuring points whose co-ordinate in the navigator gradient direction is smaller than the corresponding co-ordinate of the measuring point and from different neighboring reference measuring points whose co-ordinate in the direction of the navigator gradient is larger than the corresponding co-ordinate of the measuring point.
  • the third-order inte ⁇ olation function should then be compatible with the known phases of the reference points.
  • preferably half the maximum value of the modulus occurring in the navigator MR signal is chosen as the threshold value T r .
  • Fig. 3 shows a first line 301 which represents the moduli of different reference measuring points and measuring points of a navigator MR signal.
  • the phases associated with the reference measuring points i.e. the phase of the navigator MR signal from the measuring points whose modulus is larger than the threshold value Tr, are represented by a second dashed line 302.
  • the threshold value is given by a third horizontal line 303.
  • the corrected phase ⁇ (x m ) is given by ⁇ (x )- ⁇ (x )
  • the corrected phase is determined by ⁇ (x )- ⁇ (x )
  • the corrected phase is determined from ⁇ (xj) - ⁇ (xJ) ⁇ (x 4 ) + : —- ⁇ m2 - These steps are repeated for all measuring points in the measured x 4 -x 3
  • a second version of the method enables more accurate determination of the corrected phase of the measuring point x m of the navigator MR signal 180.
  • the corrected phase of the measured navigator MR signal from the measuring point x m is determined by inte ⁇ olation of the mean phase of the phases of the measured navigator MR signal 180 from different reference measuring points x' 2 ,x" 2 whose co-ordinate in a direction of the first navigator gradient 150 is smaller than the corresponding co-ordinate of the measuring point x m , and the mean phase of the phases of the measured first navigator MR signal 180 from different reference measuring points x' 3 ,x" 3 whose coordinate in the direction of the navigator gradient is larger than the corresponding co-ordinate of the measuring point x m .
  • Fig. 4 shows a first line 301 which represents the moduli of different measuring points of a navigator MR signal.
  • the phases associated with the reference measuring points i.e. the phase of the navigator MR signal from the measuring points whose modulus is larger than the threshold value Tr, is represented by a second dashed line 302.
  • the threshold value is represented by a third horizontal line 303.
  • the corrected phase ⁇ x m is given by
  • the described steps are repeated for all measuring points of the measured navigator MR signals 186 in successive pulse sequences required so as to determine a reconstruction set for which the measuring points satisfy the condition that the moduli must be smaller than the threshold value Tr.
  • TFE Turbo Field Echo
  • TSE Turbo Spin Echo
  • GRASE Gradient And Spin Echo
  • b-values of the additional gradient are used. These high b-values can be achieved by replacing the first refocusing RF pulse 101, temporally arranged between the two parts of the additional gradient, by two 90° RF pulses 101' which are generated with an interval of duration TM.
  • Fig. 5 shows a third pulse sequence 40 which includes inter alia two 90° RF pulses 101' and the additional gradient 170, 171 and is identical to the pulse sequence 20 of Fig. 2, except for the first refocusing RF pulse 101 and the second selection gradient 111.
  • the third pulse sequence 40 utilizes two 90° RF pulses which are separated by a period TM. Furthermore, the second selection gradient 111 in the first pulse sequence 20 is replaced by two separate selection gradients 111' in the third pulse sequence 40.
  • the pulse sequence for measuring the MR signals may also include an inversion recovery RF pulse.
  • Such an inversion recovery RF pulse is generated a period of time TI before the excitation RF pulse.
  • the contrast between different types of tissue in the image can be adjusted by way of the period of time TI.
  • Fig. 6 shows a fourth pulse sequence 50 which is identical to the first pulse sequence 20, except for an inversion recovery RF pulse 104 and a selection gradient 113.
  • a 180° RF pulse is an example of an inversion recovery RF pulse.
  • a 90° saturation RF pulse can also be used to achieve a comparable effect on the contrast between the two different types of tissue in the image.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention concerne un procédé de résonance magnétique à diffusion pondérée permettant de former des images de diffusion de spins dans des tissus biologiques. Afin de corriger les mouvements macroscopiques, le procédé de résonance magnétique mesure les signaux de résonance magnétique navigateurs, et on établit à partir de ces signaux une correction de phase. Lors de l'imagerie, par exemple d'une partie d'un cerveau humain ou animal, des artefacts peuvent se produire au niveau des parties de l'image correspondant aux zones de la partie de cerveau renfermant le liquide céphalo-rachidien. Il est possible de réduire les artefacts sur l'image de résonance magnétique en déterminant une phase corrigée, dans le cas de points de mesure ayant un module inférieur à une valeur de seuil, à partir des phases de différents points de mesure de référence du signal de résonance magnétique navigateur pour lequel la phase se calcule avec une faible marge d'erreur.
EP98907116A 1997-04-17 1998-03-23 Procede d'imagerie par resonance magnetique a diffusion ponderee Withdrawn EP0910804A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98907116A EP0910804A1 (fr) 1997-04-17 1998-03-23 Procede d'imagerie par resonance magnetique a diffusion ponderee

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97201136 1997-04-17
EP97201136 1997-04-17
PCT/IB1998/000417 WO1998047015A1 (fr) 1997-04-17 1998-03-23 Procede d'imagerie par resonance magnetique a diffusion ponderee
EP98907116A EP0910804A1 (fr) 1997-04-17 1998-03-23 Procede d'imagerie par resonance magnetique a diffusion ponderee

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EP0910804A1 true EP0910804A1 (fr) 1999-04-28

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021024A1 (fr) * 1997-10-16 1999-04-29 Koninklijke Philips Electronics N.V. Procede et dispositif permettant de determiner la repartition de temperature dans un objet a l'aide de la resonance magnetique
WO2000031559A1 (fr) * 1998-11-25 2000-06-02 Koninklijke Philips Electronics N.V. Procede et dispositif a resonance magnetique
DE10105388B4 (de) 2001-02-06 2007-05-24 Siemens Ag Verfahren zur Anpassung der Ortskodierung beim Betrieb eines Magnetresonanzgeräts
DE10109511C2 (de) 2001-02-28 2003-03-27 Max Planck Gesellschaft Verfahren und Gerät zum Gewinnen von Daten für diffusionsgewichtete Magnetresonanz-Bildgebung
JP4141147B2 (ja) * 2002-02-01 2008-08-27 株式会社日立メディコ 磁気共鳴イメージング装置
WO2004046746A1 (fr) * 2002-11-18 2004-06-03 Koninklijke Philips Electronics N.V. Procede et dispositif de resonance magnetique
US8320647B2 (en) 2007-11-20 2012-11-27 Olea Medical Method and system for processing multiple series of biological images obtained from a patient
CN101509964B (zh) * 2009-03-06 2012-05-23 华东师范大学 校正磁共振成像系统中主磁场不稳定的方法

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US5254948A (en) * 1988-04-01 1993-10-19 Hitachi, Ltd. Method and apparatus for body motion corrective imaging
US4937526A (en) * 1988-11-23 1990-06-26 Mayo Foundation For Medical Education And Research Adaptive method for reducing motion and flow artifacts in NMR images
US5492123A (en) * 1993-08-13 1996-02-20 Siemens Medical Systems, Inc. Diffusion weighted magnetic resonance imaging
DE4445782C1 (de) * 1994-12-21 1996-07-25 Siemens Ag Verfahren zur Phasenkorrektur von Kernresonanzsignalen

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