EP0904082A4 - Combination therapy for reducing the risks associated with cardiovascular disease - Google Patents

Combination therapy for reducing the risks associated with cardiovascular disease

Info

Publication number
EP0904082A4
EP0904082A4 EP97918595A EP97918595A EP0904082A4 EP 0904082 A4 EP0904082 A4 EP 0904082A4 EP 97918595 A EP97918595 A EP 97918595A EP 97918595 A EP97918595 A EP 97918595A EP 0904082 A4 EP0904082 A4 EP 0904082A4
Authority
EP
European Patent Office
Prior art keywords
reducing
combination therapy
cardiovascular disease
risks associated
risks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP97918595A
Other languages
German (de)
French (fr)
Other versions
EP0904082A1 (en
Inventor
Jonathan A Tobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612082.9A external-priority patent/GB9612082D0/en
Priority claimed from GBGB9616804.2A external-priority patent/GB9616804D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0904082A1 publication Critical patent/EP0904082A1/en
Publication of EP0904082A4 publication Critical patent/EP0904082A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
EP97918595A 1996-04-17 1997-04-14 Combination therapy for reducing the risks associated with cardiovascular disease Ceased EP0904082A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US1568996P 1996-04-17 1996-04-17
US15689P 1996-04-17
GB9612082 1996-06-10
GBGB9612082.9A GB9612082D0 (en) 1996-06-10 1996-06-10 Combination therapy for reducing the risks associated with cardiovascular disease
US2097796P 1996-06-24 1996-06-24
US20977P 1996-06-24
GBGB9616804.2A GB9616804D0 (en) 1996-08-09 1996-08-09 Combination therapy for reducing the risks associated with cardiovascular disease
GB9616804 1996-08-09
PCT/US1997/006127 WO1997038694A1 (en) 1996-04-17 1997-04-14 Combination therapy for reducing the risks associated with cardiovascular disease

Publications (2)

Publication Number Publication Date
EP0904082A1 EP0904082A1 (en) 1999-03-31
EP0904082A4 true EP0904082A4 (en) 2001-09-26

Family

ID=27451457

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97918595A Ceased EP0904082A4 (en) 1996-04-17 1997-04-14 Combination therapy for reducing the risks associated with cardiovascular disease

Country Status (5)

Country Link
EP (1) EP0904082A4 (en)
JP (1) JP2000508659A (en)
AU (1) AU732465B2 (en)
CA (1) CA2251972A1 (en)
WO (1) WO1997038694A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0946178A4 (en) * 1996-09-18 2003-05-07 Merck & Co Inc Combination therapy for reducing the risks associated with cardiovascular disease
AU9454098A (en) * 1997-09-24 1999-04-12 Nova Molecular, Inc. Methods for increasing apoe levels for the treatment of neurodegenerative disease
PL343851A1 (en) * 1997-12-12 2001-09-10 Warner Lambert Co Antihyperlipidemic statin-lp(a) inhibitor combinations
US6235311B1 (en) * 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
GB2336534A (en) 1998-04-24 1999-10-27 Alec James Coppen Anti-depressant - Folic Acid Combination
AR030414A1 (en) * 2000-04-03 2003-08-20 Astrazeneca Ab PHARMACEUTICAL COMBINATION THAT INCLUDES A BLOCKING BETA AND A REDUCED HMG-COA INHIBITOR, PHARMACEUTICAL FORMULATION, TRANSPORTABLE PARTS EQUIPMENT, USE OF THIS COMBINATION AND THIS FORMULATION TO PREPARE MEDICATIONS
DK1272220T4 (en) * 2000-04-10 2016-11-28 Nicholas John Wald Cardiovascular disease prevention formulation
GB2361185A (en) 2000-04-10 2001-10-17 Nicholas J Wald Pharmaceutical formulation for the prevention of cardiovascular disease
SE0002354D0 (en) * 2000-06-22 2000-06-22 Astrazeneca Ab New formulation
US6916849B2 (en) 2000-10-23 2005-07-12 Sankyo Company, Limited Compositions for improving lipid content in the blood
AU2001295991A1 (en) * 2000-10-23 2002-05-06 Sankyo Company Limited Compositions for improving lipids in blood
AU2002211005A1 (en) 2000-11-07 2002-05-21 Sankyo Company Limited Lipid peroxide-lowering compositions
CA2427618A1 (en) * 2000-11-29 2002-06-06 Smithkline Beecham Corporation Composition containing statins and calcium for improved cardiovascular health
AU2002221131A1 (en) * 2000-12-14 2002-06-24 Sankyo Company Limited Blood lipid ameliorant composition
US7037934B2 (en) 2000-12-14 2006-05-02 Sankyo Company, Limited Blood lipid ameliorant composition
CA2430764A1 (en) * 2000-12-14 2002-06-20 Sankyo Company, Limited Blood lipid ameliorant composition
TWI284529B (en) * 2000-12-18 2007-08-01 Sankyo Co A composition for lowering triglyceride
ES2274013T3 (en) * 2001-01-26 2007-05-16 Schering Corporation RECEIVER ACTIVATOR (S) COMBINATIONS ACTIVATED BY THE PROOFISER OF PEROXISOMES (PPAR) AND INHIBITOR (S) M OF THE ABSORPTION OF STELORS AND TREATMENTS FOR VASCULAR DISORDERS.
AU2003281176A1 (en) * 2002-07-11 2004-02-02 Sankyo Company, Limited Medicinal composition for mitigating blood lipid or lowering blood homocystein
JP4611622B2 (en) * 2002-07-11 2011-01-12 第一三共株式会社 Pharmaceutical composition for improving blood lipid or reducing blood homocysteine
AR040588A1 (en) 2002-07-26 2005-04-13 Schering Corp PHARMACEUTICAL FORMULATION INCLUDING AN INHIBITOR OF CHOLESTEROL ABSORPTION AND AN INHIBITOR OF A HMGCO TO REDUCTASE
JP4607436B2 (en) * 2002-08-02 2011-01-05 第一三共株式会社 Pharmaceutical composition containing an HMG-CoA reductase inhibitor
WO2004012740A1 (en) * 2002-08-02 2004-02-12 Sankyo Company, Limited MEDICINAL COMPOSITION CONTAINING HMG-CoA REDUCTASE INHIBITOR
AU2004305154A1 (en) * 2003-12-23 2005-07-07 Medicure International Inc. Combination therapies employing a composition comprising a HMG CoA reductase inhibitor and a vitamin B6 related compound
DK1732605T3 (en) * 2004-03-29 2019-06-11 Wyeth Llc Multi-vitamin and mineral supplements
US7375112B2 (en) * 2005-01-05 2008-05-20 Medicure International Inc. Compounds and methods for regulating triglyceride levels
CA2664421A1 (en) * 2006-09-22 2008-03-27 Braincells, Inc. Hmg coa reductase mediated modulation of neurogenesis
EP2810644A1 (en) * 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases
JP6443935B2 (en) * 2013-07-26 2018-12-26 学校法人 久留米大学 Combination of aspirin and folic acid for the treatment or prevention of arteriosclerosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084482A (en) * 1990-04-10 1992-01-28 The Lithox Corporation Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds
DE4326698A1 (en) * 1993-08-09 1995-03-09 Puetter Medice Chem Pharm Use of a combination of folic acid, vitamin B6 and vitamin B12 for the prophylaxis and therapy of arteriosclerosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895107A (en) * 1970-04-15 1975-07-15 Morrison L M CSA and CSC in man and mammals to inhibit atherosclerosis and the recurrence of cardiovascular incidents in atherosclerotic mammals
US5631401A (en) * 1994-02-09 1997-05-20 Abbott Laboratories Inhibitors of protein farnesyltransferase and squalene synthase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084482A (en) * 1990-04-10 1992-01-28 The Lithox Corporation Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds
DE4326698A1 (en) * 1993-08-09 1995-03-09 Puetter Medice Chem Pharm Use of a combination of folic acid, vitamin B6 and vitamin B12 for the prophylaxis and therapy of arteriosclerosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
"The Merck Manual of Diagnosis and Therapy", 1992, XP002170578 *
BERG VAN DEN M ET AL: "COMBINED VITAMIN B6 PLUS FOLIC ACID THERAPY IN YOUNG PATIENTS WITH ARTERIOSCLEROSIS AND HYPERHOMOCYSTEINEMIA", JOURNAL OF VASCULAR SURGERY,US,ST. LOUIS, MO, vol. 20, no. 6, December 1994 (1994-12-01), pages 933 - 940, XP000853837, ISSN: 0741-5214 *
BOUSHEY C. ET AL.: "A quantitative assessment of plasma homocysteine as a risk factor for vascular disease", JAMA, vol. 274, no. 13, 4 October 1995 (1995-10-04), pages 1049 - 1057, XP001005592 *
DOBS A. ET AL.: "Lipid-lowering diets in patients, a new HMG-CoA reductase inhibitor: compliance and adequacy", AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 54, no. 4, October 1991 (1991-10-01), pages 696-700, XP001006920 *
FEHER M D ET AL: "LONG-TERM SAFETY OF STATIN-FIBRATE COMBINATION TREATMENT IN THE MANAGEMENT OF HYPERCHOLESTEROLAEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE", BRITISH HEART JOURNAL,BRITISH MEDICAL ASSOCIATION, LONDON,GB, vol. 74, no. 1, 1995, pages 14 - 17, XP000925445, ISSN: 0007-0769 *
FROHLICH J J: "LIPOPROTEINS AND HOMOCYST(E)INE AS RISK FACTORS FOR ATHEROSCLEROSIS:ASSESSMENT AND TREATMENT", CANADIAN JOURNAL OF CARDIOLOGY,XX,PULSUS GROUP, INC, vol. 11, no. SUPPL. C, 1995, pages 18C - 23C, XP000910760, ISSN: 0828-282X *
MAYER E L ET AL: "HOMOCYSTEINE AND CORONARY ATHEROSCLEROSIS", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,XX,XX, vol. 27, no. 3, 1 March 1996 (1996-03-01), pages 517 - 527, XP000990693, ISSN: 0735-1097 *
See also references of WO9738694A1 *
TONSTAD S: "Low dose colestipol in adolescents with familial hypercholesterolaemia", ARCHIVES OF DISEASE IN CHILDHOOD, vol. 74, no. 2, February 1996 (1996-02-01), pages 157 - 160, XP001000237 *

Also Published As

Publication number Publication date
EP0904082A1 (en) 1999-03-31
CA2251972A1 (en) 1997-10-23
JP2000508659A (en) 2000-07-11
AU2666597A (en) 1997-11-07
WO1997038694A1 (en) 1997-10-23
AU732465B2 (en) 2001-04-26

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