EP1024696A4 - Combination therapy for reducing the risks associated with cardio- and cerebrovascular disease - Google Patents

Combination therapy for reducing the risks associated with cardio- and cerebrovascular disease

Info

Publication number
EP1024696A4
EP1024696A4 EP98957328A EP98957328A EP1024696A4 EP 1024696 A4 EP1024696 A4 EP 1024696A4 EP 98957328 A EP98957328 A EP 98957328A EP 98957328 A EP98957328 A EP 98957328A EP 1024696 A4 EP1024696 A4 EP 1024696A4
Authority
EP
European Patent Office
Prior art keywords
cardio
reducing
combination therapy
cerebrovascular disease
risks associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98957328A
Other languages
German (de)
French (fr)
Other versions
EP1024696A1 (en
Inventor
Melvin Winokur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806688.9A external-priority patent/GB9806688D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1024696A1 publication Critical patent/EP1024696A1/en
Publication of EP1024696A4 publication Critical patent/EP1024696A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
EP98957328A 1997-10-22 1998-10-16 Combination therapy for reducing the risks associated with cardio- and cerebrovascular disease Withdrawn EP1024696A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6269197P 1997-10-22 1997-10-22
US62691P 1997-10-22
GBGB9806688.9A GB9806688D0 (en) 1998-03-27 1998-03-27 Combination therapy for reducing the risks associated with cardio-and cerebrovascular diease
GB9806688 1998-03-27
PCT/US1998/021901 WO1999020110A1 (en) 1997-10-22 1998-10-16 Combination therapy for reducing the risks associated with cardio- and cerebrovascular disease

Publications (2)

Publication Number Publication Date
EP1024696A1 EP1024696A1 (en) 2000-08-09
EP1024696A4 true EP1024696A4 (en) 2004-07-14

Family

ID=26313383

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98957328A Withdrawn EP1024696A4 (en) 1997-10-22 1998-10-16 Combination therapy for reducing the risks associated with cardio- and cerebrovascular disease

Country Status (5)

Country Link
EP (1) EP1024696A4 (en)
JP (1) JP2001520174A (en)
AU (1) AU753657B2 (en)
CA (1) CA2306646A1 (en)
WO (1) WO1999020110A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184248B1 (en) * 1996-09-05 2001-02-06 Robert K. K. Lee Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
US6620834B1 (en) * 1999-07-02 2003-09-16 Hisamitsu Pharmaceutical Co., Inc. Medicinal compositions for treating colorectal cancer
ES2328446T5 (en) 2000-02-04 2014-02-27 Children's Hospital Research Foundation Use of lysosomal acid lipase to treat atherosclerosis and associated diseases
GB2361185A (en) * 2000-04-10 2001-10-17 Nicholas J Wald Pharmaceutical formulation for the prevention of cardiovascular disease
CZ302448B6 (en) 2000-07-20 2011-05-25 Lauras As Pharmaceutical composition
WO2002028270A2 (en) * 2000-10-06 2002-04-11 Probiochem, Llc The treatment of cancer utilizing a cox-2 inhibitor and a hmg-coa reductase inhibitor
US6534540B2 (en) 2000-10-06 2003-03-18 George Kindness Combination and method of treatment of cancer utilizing a COX-2 inhibitor and a 3-hydroxy-3-methylglutaryl-coenzyme-a (HMG-CoA) reductase inhibitor
WO2002094021A1 (en) * 2000-10-06 2002-11-28 Probiochem, Llc A combination and method of treatment of cancer utilizing a cox-2 inhibitor and an hmg-coa inhibitor and cystine to enhance glutathione
AU2002249812B2 (en) 2000-12-21 2005-11-10 Nicox S.A. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP4611622B2 (en) * 2002-07-11 2011-01-12 第一三共株式会社 Pharmaceutical composition for improving blood lipid or reducing blood homocysteine
CA2492781A1 (en) * 2002-07-11 2004-01-22 Sankyo Company Limited Medicinal composition for mitigating blood lipid or lowering blood homocystein
EP2808015A1 (en) 2005-05-31 2014-12-03 Mylan Laboratories, Inc Compositions comprising nebivolol
US20070037797A1 (en) * 2005-08-15 2007-02-15 Hellstrom Harold R Method of reducing the risk of adverse cardiovascular (CV) events associated with the administration of pharmaceutical agents which favor CV events
JP2009514851A (en) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド (3R, 5R) -7- [2- (4-Fluorophenyl) -5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino) carbonyl] -pyrrol-1-yl] -3,5 -Preparation of dihydroxy-heptanoic acid hemi-calcium salt
US8404275B2 (en) * 2007-07-01 2013-03-26 Vitalis Llc Combination tablet with chewable outer layer
CN104105478A (en) 2011-10-28 2014-10-15 维塔利斯公司 Anti-flush compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0671170A1 (en) * 1994-03-11 1995-09-13 Bristol-Myers Squibb Company Use of pravastatin for slowing progression coronary artery atherosclerosis
WO1997032575A1 (en) * 1996-03-05 1997-09-12 Children's Hospital Medical Center Mercapto derivatives as inhibitors of cyclooxygenases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6274896A (en) * 1995-06-06 1996-12-24 Procyte Corporation Stable copper(i) complexes as active therapeutic substances

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0671170A1 (en) * 1994-03-11 1995-09-13 Bristol-Myers Squibb Company Use of pravastatin for slowing progression coronary artery atherosclerosis
WO1997032575A1 (en) * 1996-03-05 1997-09-12 Children's Hospital Medical Center Mercapto derivatives as inhibitors of cyclooxygenases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9920110A1 *

Also Published As

Publication number Publication date
CA2306646A1 (en) 1999-04-29
WO1999020110A1 (en) 1999-04-29
JP2001520174A (en) 2001-10-30
AU1361299A (en) 1999-05-10
AU753657B2 (en) 2002-10-24
EP1024696A1 (en) 2000-08-09

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