EP0886115A2 - Cryogenic storing device for pharmaceutical samples - Google Patents

Cryogenic storing device for pharmaceutical samples Download PDF

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Publication number
EP0886115A2
EP0886115A2 EP98109629A EP98109629A EP0886115A2 EP 0886115 A2 EP0886115 A2 EP 0886115A2 EP 98109629 A EP98109629 A EP 98109629A EP 98109629 A EP98109629 A EP 98109629A EP 0886115 A2 EP0886115 A2 EP 0886115A2
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EP
European Patent Office
Prior art keywords
bracket
edge
brackets
floors
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98109629A
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German (de)
French (fr)
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EP0886115B1 (en
EP0886115A3 (en
Inventor
Wolfgang Flohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Liquide Deutschland GmbH
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Messer Griesheim GmbH
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Publication date
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Publication of EP0886115A2 publication Critical patent/EP0886115A2/en
Publication of EP0886115A3 publication Critical patent/EP0886115A3/en
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D25/00—Charging, supporting, and discharging the articles to be cooled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped

Definitions

  • the invention relates to a frame for holding containers for cryogenic Storage of pharmaceutical or biological samples.
  • the invention has for its object ampoule towers with a provide reliable and easy-to-use security system.
  • the device contains a box-shaped housing or a frame.
  • the Device contains carrying devices, e.g. B. shelves, support bracket, Rails or other supports.
  • the carrying devices are used to carry Containers (e.g. inserts, boxes, boxes, boxes or drawers).
  • the Containers are used to hold sample containers or packaging that contain biological or pharmaceutical material.
  • the sample containers are for example ampoules, cups, straws, multi-purpose cassettes, closable Tubes.
  • the device includes a security system that slips out prevented from containers from the device.
  • the security system of the device according to the invention contains at least a swivel bracket, the swivel axis to the side to the vertical Center line of the front lies.
  • the bracket can be horizontal and / or vertical Have crossbars, e.g. B. lattice door-like bracket.
  • Two brackets are advantageous if the inserts used are smaller than the front edge to have. This is the case, for example, with narrow ampoule boxes that stand side by side on an intermediate floor.
  • the swivel axis is preferably between the start of the leading edge (at one Side) and a quarter of the leading edge.
  • The is particularly preferably Swivel axis (with a bracket) measured near a quarter of the front edge from the side or front edge beginning, so that a bracket of a folding radius from about a quarter of the length of the leading edge to the midline of the front (Locking position or closed position) and to the side (unlocking or open position) can be folded.
  • the cutouts are, for example, in the middle of the Front edges of the floors.
  • two swiveling brackets they are For example, swivel axes on both sides of the front in the range of Beginning of leading edge to about a third of the leading edge (measured by both Sides), preferably in the area around a sixth of the leading edge.
  • the bracket radius is to be dimensioned so that the bracket of the Front (closed position) can be swung to the side (open position).
  • the stirrup radius does not have to be the same for all stirrups of a device. This is particularly advantageous with two or more stirrups.
  • the swivel axes of the bracket can then lie on one edge of the front.
  • the temples, the one Front half can also cover a common pivot axis have, e.g. B. nested hollow axes (temple ends) or with an axis (Temple end) connected temple.
  • the interconnected bracket with common pivot axis can also be connected by crossbars.
  • the shape of the recesses of the floors is advantageously designed so that the full Cross section of the ironing rod can be taken from the recess.
  • brackets are made from a rectangular bent rod (e.g. Round rod or rod with rectangular or square cross-section) made of metal like aluminum or stainless steel. Stainless steel is preferred as the material for the manufacture of the bracket.
  • the device is usually made of metal.
  • For Manufacturing can use metal in a wide variety of forms (Sheet, perforated sheet, grille, bars). Can also be used as a material for manufacturing Plastic (e.g. polycarbonate) can be used.
  • the device generally has one to 40 shelves.
  • the Intermediate shelves are usually made of metal (e.g. aluminum) and are in usually built in.
  • the security system advantageously consists of a swivel bracket and a step-like edge on the front edge of the floors.
  • the step-shaped Edge can be interrupted one or more times.
  • the height of the step-shaped Edge is dimensioned so that the slots are inserted into the device can. In general, the height of the step edge is in the range of 2 up to 5 mm.
  • Fig. 1 shows an example of a diagram of the device (ampoule tower, (1)) with swivel bracket (3).
  • the recesses (4) on the front edge of the upper (5), Bottom (6) and intermediate floors (7) serve to hold the ironing rod in closed, secured position.
  • the example of a device shown schematically in Fig. 1 is as follows further described. The following figures and explanations of the example are for better understanding, but are not intended as limitations to consider the subject of the invention.
  • the device has the outer dimensions: 640 mm high, 140 mm wide (front) and 166 mm deep.
  • the box-shaped housing on the back made of aluminum sheet with 2 mm sheet thickness carries 10 intermediate shelves (7), which extend over the entire width and Extend the depth of the housing.
  • the intermediate floors (7) are also made Made of aluminum sheet.
  • the stepped edge (2) of the front consists from a fold of the sheet and has a height of 3 mm.
  • Bracket (3) consists of a round rod made of stainless steel with a diameter of 5 mm.
  • the device advantageously contains a means for locking the pivotable Bracket.
  • the bracket can be in the closed position (secured) be fixed by a tab (9). This is illustrated by Fig. 2.
  • Fig. 2 shows a partial view of the upper part of a device with tab (9) for Locking the bracket (3).
  • the recess in the floors becomes Inclusion of the ironing bar and the step-like design (2) of the floors shown on the front edge.
  • Fig. 3 shows an example of a tab (9) as a resilient element made of metal is carried out with a semi-cylindrical deformation (10) for holding the swivel bracket and a bevel or rounding (11) on the front End of the tab.
  • the bevel (11) is used to guide the bracket, the under the tab is pivoted.
  • the bracket engages with the deformation (10).
  • the Fastening hole (12) at the rear end serves as a fastening point on Housing, e.g. B. by a riveted joint.
  • a double safety device with one or more swiveling brackets and through stepped front edges of the floors is particularly advantageous.
  • the coat hanger prevents the inserts from floating out in a secured state Ampoules or other sample containers when immersed in the liquid nitrogen cooling bath. Unlocking can be carried out very conveniently. After removal the device from the cold bath and the subsequent unlocking of the Bügels will slide out of inserts through the step-shaped Execution of the front edge of the floors additionally prevented.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Warehouses Or Storage Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Refrigerator Housings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)

Abstract

The system has a housing (1) with a swivelable bracket (3), a top (5) and a bottom (6) and with intermediate partitions (7) in between. One carrier unit at least is provided for containers and with at least one vertical swivelable bracket. At least two vertical swivelable brackets have a common swivel axis and are connected with each other and can have at least one cross bar. The system as a carrier unit contains at least one intermediate partition (7), which at the front edge has a step shaped edge (4). The system has facilities for arresting the swivelable bracket, which can be in the form of a spring shackle. A foldable handle (8) is provided at the top of the housing (1).

Description

Die Erfindung betrifft ein Gestell zur Aufnahme von Behältern zur tiefkalten Lagerung von pharmazeutischen oder biologischen Proben.The invention relates to a frame for holding containers for cryogenic Storage of pharmaceutical or biological samples.

Auf dem Markt sind sogenannte Ampullentürme erhältlich. Die Ampullentürme dienen zur tiefkalten Lagerung von biologischem Material in Flüssigstickstoff oder in tiefkalter Gasphase. Die Ampullentürme sind Gestelle mit übereinanderliegenden Zwischenböden zur Aufnahme von Einschüben (Schachteln, Boxen, Kartons oder Schubladen) mit Ampullen. Die Einschübe sind nur von einer Seite entnehmbar. In der Regel haben die Zwischenböden an der Rückseite eine hochstehende Abkantung. Bei dem Hantieren mit den Ampullentürmen kommt es oft zu einem unbeabsichtigten Herausrutschen der Einschübe an der Vorderseite. Zur Sicherung der Einschübe sind folgende Maßnahmen bekannt:

  • a) Das Gestell, bestehend aus Kasten und Zwischenböden, enthält in der Mitte der Vorderseite, nahe der Vorderkante, jeweils ein Loch, so daß ein Stab vertikal durch die Löcher geführt werden kann (Mittenstabsicherung). Die Einschübe werden durch den Sicherungsstab verriegelt und arretiert.
  • b) Die Zwischenböden sind an der Vorderkante mit einer (niedrigen) Stufe versehen, über die die Einschübe eingeführt werden können, aber ohne ein leichtes Anheben nicht entnommen werden können (Stufensicherung).
  • c) Die Schubladen enthalten an der Unterseite Vorsprünge (Federlaschen), die in Vertiefungen in den Zwischenböden einrasten. Ampullentürme mit einer solchen Einrastsicherung sind beschrieben in DE-C2-3342489.
    • So-called ampoule towers are available on the market. The ampoule towers are used for cryogenic storage of biological material in liquid nitrogen or in the cryogenic gas phase. The ampoule towers are frames with superimposed intermediate floors for receiving inserts (boxes, boxes, boxes or drawers) with ampoules. The slots can only be removed from one side. As a rule, the intermediate shelves have a raised edge on the back. When handling the ampoule towers, the slots on the front often slip out unintentionally. The following measures are known for securing the plug-in units:
  • a) The frame, consisting of box and intermediate shelves, contains a hole in the middle of the front, near the front edge, so that a rod can be guided vertically through the holes (center bar safety device). The slots are locked and locked by the security rod.
  • b) The intermediate shelves are provided with a (low) step on the front edge, through which the inserts can be inserted, but cannot be removed without lifting them slightly (step securing).
  • c) The drawers contain projections (spring clips) on the underside, which snap into recesses in the intermediate shelves. Ampoule towers with such a snap lock are described in DE-C2-3342489.

    • Die bekannten Sicherungssysteme haben erhebliche Nachteile. Bei der Mittenstabsicherung (a) muß zur Entnahme eines Einschubs mit Ampullen der Sicherungsstab über die ganze Länge herausgezogen werden. Die Handhabung ist sehr umständlich. Bei der Stufensicherung (b) kann es Vorkommen, daß die Einschübe mit den Ampullen im Flüssigstickstoffbad herausschwimmen. Die Einrastsicherung (c) verliert mit fortschreitender Benutzung ihre Zuverlässigkeit, da die Federwirkung der Federlaschen mit der Zeit nachläßt.The known security systems have considerable disadvantages. In the Center safety device (a) must be used to remove an insert with ampoules The safety rod must be pulled out over the entire length. The handling is very cumbersome. In the case of step protection (b) it can happen that the Float inserts with the ampoules in the liquid nitrogen bath. The Snap lock (c) loses its reliability with increasing use, as the spring action of the spring tabs wears off over time.

    Der Erfindung liegt die Aufgabe zugrunde, Ampullentürme mit einem zuverlässigen und leicht handhabbaren Sicherungssystem bereitzustellen.The invention has for its object ampoule towers with a provide reliable and easy-to-use security system.

    Die Aufgabe wird gelöst durch eine Vorrichtung mit den Merkmalen gemäß Anspruch 1.The object is achieved by a device with the features according to Claim 1.

    Die Vorrichtung enthält ein kastenförmiges Gehäuse oder ein Gestell. Die Vorrichtung enthält Trageeinrichtungen, z. B. Zwischenböden, Tragewinkel, Schienen oder andere Träger. Die Trageeinrichtungen dienen zum Tragen von Behältern (z. B. Einschübe, Schachteln, Boxen, Kartons oder Schubladen). Die Behälter dienen zur Aufnahme von Probebehältern oder Verpackungen, die das biolologische oder pharmazeutische Material enthalten. Die Probenbehälter sind beispielsweise Ampullen, Becher, Straws, Mehrzweckkassetten, verschließbare Röhren. Die Vorrichtung enthält ein Sicherungssystem, das ein Herausrutschen von Behältern aus der Vorrichtung verhindert.The device contains a box-shaped housing or a frame. The Device contains carrying devices, e.g. B. shelves, support bracket, Rails or other supports. The carrying devices are used to carry Containers (e.g. inserts, boxes, boxes, boxes or drawers). The Containers are used to hold sample containers or packaging that contain biological or pharmaceutical material. The sample containers are for example ampoules, cups, straws, multi-purpose cassettes, closable Tubes. The device includes a security system that slips out prevented from containers from the device.

    Das Sicherungssystem der Vorrichtung gemäß der Erfindung enthält mindestens einen schwenkbaren Bügel, wobei die Schwenkachse seitlich zur vertikalen Mittellinie der Vorderseite liegt. Der Bügel kann horizontale und/oder vertikale Querstege aufweisen, z. B. gittertürartiger Bügel. Zwei Bügel sind vorteilhaft, wenn die verwendeten Einschübe eine geringere Breite als die Vorderkante haben. Dies ist beispielsweise der Fall bei schmalen Ampullenboxen, die nebeneinander auf einem Zwischenboden stehen. Bei nur einem schwenkbaren Bügel liegt die Schwenkachse bevorzugt zwischen Vorderkantenanfang (an einer Seite) und einem Viertel der Vorderkante. Besonders bevorzugt liegt die Schwenkachse (bei einem Bügel) nahe einem Viertel der Vorderkante, gemessen von der Seite bzw. Vorderkantenanfang, so daß ein Bügel von einem Klappradius von etwa einem Viertel der Lange der Vorderkante zur Mittellinie der Vorderseite (Arretierungsstellung oder geschlossene Stellung) und zur Seite (Entarretierung oder geöffnete Stellung) geklappt werden kann. Vorteilhaft enthalten die Vorderkanten von Oberseite, Unterseite und Zwischenböden der Vorrichtung (im folgenden als Böden bezeichnet) jeweils eine Aussparung zur Aufnahme des Bügelstabes (stabförmiger Teil des Bügels, der über die gesamte Vorderseite der Vorrichtung verläuft). Die Aussparungen liegen beispielsweise in der Mitte der Vorderkanten der Böden. Bei zwei schwenkbaren Bügeln liegen die Schwenkachsen beispielsweise auf beiden Seiten der Vorderseite im Bereich von Vorderkantenanfang bis etwa ein Drittel der Vorderkante (gemessen von beiden Seiten), vorzugsweise im Bereich um ein Sechstel der Vorderkante. Die Aussparungen zur Aufnahme des Bügelstabes liegen in dem Fall von zwei Bügeln beispielsweise im Bereich von einem drittel der Vorderkante (von beiden Seiten gemessen, das heißt bei einem Drittel und zwei Drittel der Vorderkante, bezogen auf eine Seite). Der Bügelradius ist so zu bemessen, daß der Bügel von der Vorderseite (geschlossene Stellung) zur Seite weggeschwenkt werden kann (geöffnete Stellung). Die obengenannten Beispiele mit einem und zwei schwenkbaren Bügeln können auch kombiniert werden (Beispiel für drei Bügel). Der Bügelradius muß nicht bei allen Bügeln einer Vorrichtung gleich sein. Dies ist besonders vorteilhaft bei zwei und mehr Bügeln. Die Schwenkachsen der Bügel können dann jeweils an einem Rand der Vorderseite liegen. Die Bügel, die eine Vorderseitenhälfte abdecken, können auch eine gemeinsame Schwenkachse haben, z. B. ineinandergesteckte Hohlachsen (Bügelenden) oder mit einer Achse (Bügelende) verbundene Bügel. Die miteinander verbundenen Bügel mit gemeinsamer Schwenkachse können auch durch Querstege verbunden sein.The security system of the device according to the invention contains at least a swivel bracket, the swivel axis to the side to the vertical Center line of the front lies. The bracket can be horizontal and / or vertical Have crossbars, e.g. B. lattice door-like bracket. Two brackets are advantageous if the inserts used are smaller than the front edge to have. This is the case, for example, with narrow ampoule boxes that stand side by side on an intermediate floor. With only one swiveling The swivel axis is preferably between the start of the leading edge (at one Side) and a quarter of the leading edge. The is particularly preferably Swivel axis (with a bracket) measured near a quarter of the front edge from the side or front edge beginning, so that a bracket of a folding radius from about a quarter of the length of the leading edge to the midline of the front (Locking position or closed position) and to the side (unlocking or open position) can be folded. The contain advantageously Front edges of the top, bottom and shelves of the device (in hereinafter referred to as floors) each have a recess for receiving the Ironing bar (rod-shaped part of the bracket that extends over the entire front of the Device runs). The cutouts are, for example, in the middle of the Front edges of the floors. With two swiveling brackets they are For example, swivel axes on both sides of the front in the range of Beginning of leading edge to about a third of the leading edge (measured by both Sides), preferably in the area around a sixth of the leading edge. The In the case of two brackets, there are recesses for receiving the ironing bar for example in the area of a third of the front edge (from both sides measured, i.e. one third and two thirds of the leading edge on one side). The bracket radius is to be dimensioned so that the bracket of the Front (closed position) can be swung to the side (open position). The above examples with one and two swiveling brackets can also be combined (example for three brackets). The stirrup radius does not have to be the same for all stirrups of a device. This is particularly advantageous with two or more stirrups. The swivel axes of the bracket can then lie on one edge of the front. The temples, the one Front half can also cover a common pivot axis have, e.g. B. nested hollow axes (temple ends) or with an axis (Temple end) connected temple. The interconnected bracket with common pivot axis can also be connected by crossbars.

    Die Form der Aussparungen der Böden wird vorteilhaft so gestaltet, daß der volle Querschnitt des Bügelstabes von der Aussparung aufgenommen werden kann.The shape of the recesses of the floors is advantageously designed so that the full Cross section of the ironing rod can be taken from the recess.

    Im allgemeinen werden Bügel aus einem rechteckig gebogenen Stab (z. B. Rundstab oder Stab mit rechteckigem oder quadratischem Querschnitt) aus Metall wie Aluminium oder Edelstahl hergestellt. Bevorzugt wird Edelstahl als Material für die Herstellung des Bügels.In general, brackets are made from a rectangular bent rod (e.g. Round rod or rod with rectangular or square cross-section) made of metal like aluminum or stainless steel. Stainless steel is preferred as the material for the manufacture of the bracket.

    Die Vorrichtung wird in der Regel aus Metall hergestellt. Beispielweise können Bleche aus Aluminium oder Edelstahl als Material verwendet werden. Zur Herstellung kann Metall in den verschiedensten Formen eingesetzt werden (Blech, Lochblech, Gitter, Stäbe). Als Material zur Herstellung kann auch Kunststoff (z. B. Polycarbonat) eingesetzt werden.The device is usually made of metal. For example, you can Aluminum or stainless steel sheets can be used as the material. For Manufacturing can use metal in a wide variety of forms (Sheet, perforated sheet, grille, bars). Can also be used as a material for manufacturing Plastic (e.g. polycarbonate) can be used.

    Die Vorrichtung hat im allgemeinen einen bis 40 Zwischenböden. Die Zwischenböden bestehen in der Regel aus Metall (z. B. Aluminium) und sind in der Regel fest eingebaut.The device generally has one to 40 shelves. The Intermediate shelves are usually made of metal (e.g. aluminum) and are in usually built in.

    Der prinzipielle Aufbau eines Ampullenturms ist in DE 33 42 489 beschrieben, worauf hiermit Bezug genommen wird.The basic structure of an ampoule tower is described in DE 33 42 489, what is hereby referred to.

    Das Sicherungssystem besteht vorteilhaft aus einem schwenkbaren Bügel und einer stufenförmigen Kante an der Vorderkante der Böden. Die stufenförmige Kante kann ein- oder mehrfach unterbrochen sein. Die Höhe der stufenförmigen Kante wird so bemessen, daß die Einschübe in die Vorrichtung eingeführt werden können. Im allgemeinen liegt die Höhe der stufenförmigen Kante im Bereich von 2 bis 5 mm. The security system advantageously consists of a swivel bracket and a step-like edge on the front edge of the floors. The step-shaped Edge can be interrupted one or more times. The height of the step-shaped Edge is dimensioned so that the slots are inserted into the device can. In general, the height of the step edge is in the range of 2 up to 5 mm.

    Fig. 1 zeigt beispielhaft ein Schema der Vorrichtung (Ampullenturm, (1)) mit schwenkarem Bügel (3). Die Aussparungen (4) an der Vorderkante der Ober- (5), Unterseite (6) und Zwischenböden (7) dienen zur Aufnahme des Bügelstabes in geschlossener, gesicherter Stellung.Fig. 1 shows an example of a diagram of the device (ampoule tower, (1)) with swivel bracket (3). The recesses (4) on the front edge of the upper (5), Bottom (6) and intermediate floors (7) serve to hold the ironing rod in closed, secured position.

    Das in Fig. 1 schematisch gezeigte Beispiel einer Vorrichtung wird im folgenden weiter beschrieben. Die folgenden Zahlengaben und Erläuterungen des Beispiels sollen einem besseren Verständnis dienen, sind aber nicht als Beschränkungen des Erfindungsgegenstandes zu betrachten. Die Vorrichtung hat die Außenmaße: 640 mm Höhe, 140 mm Breite (Vorderseite) und 166 mm Tiefe. Das kastenförmige und auf der Rückseite offene Gehäuse aus Aluminium-Blech mit 2 mm Blechdicke trägt 10 Zwischenböden (7), die sich über die gesamte Breite und Tiefe des Gehäuses erstrecken. Die Zwischenböden (7) sind ebenfalls aus Aluminium-Blech hergestellt. Die stufenförmige Kante (2) der Vorderseite besteht aus einer Abkantung des Bleches und hat eine Höhe von 3 mm. In der Mitte der Vorderseite von Zwischenböden und Ober- (5) und Unterseite (6) des Gehäuses sind halbrunde Aussparungen (4) mit einem Durchmesser von 10 mm angebracht. Die Zwischenböden (7) sind an der Rückseite nach oben abgewinkelt. Die Höhe dieser Kante beträgt 10 mm. Die Zwischenböden sind an ihren beiden seitlichen Seiten ebenfalls abgewinkelt. Die Seitenkanten dienen zur Befestigung an dem Gehäuse. Die Befestigung ist hier anhand von Nieten ausgeführt. Auf der Oberseite des Gehäuses ist ein klappbarer Griff (8) angebracht. Ober- und Unterseite tragen jeweils eine Bohrung, durch die die Bügel geführt werden (Drehpunkte). Auf den innen liegenden Seiten (an innerer Seite von Ober- und Unterseite) des Gehäuses sind die Bügelenden vor einem Herausziehen gesichert, z. B. mittels Sicherungsringen, die in eine Nut am Bügelende greifen, oder einer Abflachung des Bügelendes (z. B. platt geschlagenes Ende). Der Bügel (3) besteht aus einem Rundstab aus Edelstahl mit einem Durchmesser von 5 mm. The example of a device shown schematically in Fig. 1 is as follows further described. The following figures and explanations of the example are for better understanding, but are not intended as limitations to consider the subject of the invention. The device has the outer dimensions: 640 mm high, 140 mm wide (front) and 166 mm deep. The box-shaped housing on the back made of aluminum sheet with 2 mm sheet thickness carries 10 intermediate shelves (7), which extend over the entire width and Extend the depth of the housing. The intermediate floors (7) are also made Made of aluminum sheet. The stepped edge (2) of the front consists from a fold of the sheet and has a height of 3 mm. In the middle of Front of intermediate floors and top (5) and bottom (6) of the housing are semicircular recesses (4) with a diameter of 10 mm. The intermediate floors (7) are angled upwards at the rear. The height this edge is 10 mm. The intermediate floors are on their two side Pages also angled. The side edges are used for attachment to the Casing. The attachment is carried out using rivets. On the A hinged handle (8) is attached to the top of the housing. Top and Each side has a hole through which the brackets are guided (Pivot points). On the inside (on the inside of the top and bottom) Underside) of the housing are the temple ends before pulling them out secured, e.g. B. by means of locking rings which engage in a groove at the end of the bracket, or a flattening of the temple end (e.g. flattened end). Of the Bracket (3) consists of a round rod made of stainless steel with a diameter of 5 mm.

    Vorteilhaft enthält die Vorrichtung ein Mittel zur Arretierung des schwenkbaren Bügels. Der Bügel kann beispielsweise in geschlossener Stellung (gesichert) durch eine Lasche (9) fixiert werden. Dies wird durch Fig. 2 veranschaulicht.The device advantageously contains a means for locking the pivotable Bracket. For example, the bracket can be in the closed position (secured) be fixed by a tab (9). This is illustrated by Fig. 2.

    Fig. 2 zeigt eine Teilansicht des oberen Teils einer Vorrichtung mit Lasche (9) zur Arretierung des Bügels (3). Außerdem wird die Aussparung der Böden zur Aufnahme des Bügelstabes und die stufenförmige Ausgestaltung (2) der Böden an der Vorderkante gezeigt.Fig. 2 shows a partial view of the upper part of a device with tab (9) for Locking the bracket (3). In addition, the recess in the floors becomes Inclusion of the ironing bar and the step-like design (2) of the floors shown on the front edge.

    Fig. 3 zeigt ein Beispiel für eine Lasche (9), die als federndes Element aus Metall ausgeführt ist, mit einer halbzylindrischen Verformung (10) zum Halten des schwenkbaren Bügels und einer Abschrägung oder Abrundung (11) am vorderen Ende der Lasche. Die Abschrägung (11) dient zur Führung des Bügels, der unter die Lasche geschwenkt wird. Der Bügel rastet an der Verformung (10) ein. Das Befestigungsloch (12) am hinteren Ende dient als Befestigungspunkt am Gehäuse, z. B. durch eine Nietverbindung.Fig. 3 shows an example of a tab (9) as a resilient element made of metal is carried out with a semi-cylindrical deformation (10) for holding the swivel bracket and a bevel or rounding (11) on the front End of the tab. The bevel (11) is used to guide the bracket, the under the tab is pivoted. The bracket engages with the deformation (10). The Fastening hole (12) at the rear end serves as a fastening point on Housing, e.g. B. by a riveted joint.

    Eine doppelte Sicherung durch einen oder mehrere schwenkbare Bügel und durch stufenförmige Vorderkanten der Böden ist besonders vorteilhaft. Der Bügel verhindert in gesichertem Zustand das Herausschwimmen von Einschüben mit Ampullen oder anderen Probebehältern beim Eintauchen in das Flüssigstickstoff-Kältebad. Eine Entsicherung ist sehr bequem durchführbar. Nach der Entnahme der Vorrichtung aus dem Kältebad und der darauffolgenden Entsicherung des Bügels wird ein Herausrutschen von Einschüben durch die stufenförmige Ausführung der Vorderkante der Böden zusätzlich verhindert.A double safety device with one or more swiveling brackets and through stepped front edges of the floors is particularly advantageous. The coat hanger prevents the inserts from floating out in a secured state Ampoules or other sample containers when immersed in the liquid nitrogen cooling bath. Unlocking can be carried out very conveniently. After removal the device from the cold bath and the subsequent unlocking of the Bügels will slide out of inserts through the step-shaped Execution of the front edge of the floors additionally prevented.

    Claims (8)

    Vorrichtung zur tiefkalten Lagerung von biologischem oder pharmazeutischem Material mit mindestens einer Trägereinrichtung für Behälter und mit mindestens einem vertikal schwenkbaren Bügel.Device for cryogenic storage of biological or pharmaceutical Material with at least one carrier device for containers and with at least a vertically swiveling bracket. Vorrichtung gemäß Anspruch 1, dadurch gekennzeichnet, daß mindestens zwei vertikal schwenkbare Bügel eine gemeinsame Schwenkachse besitzen.Device according to claim 1, characterized in that at least two vertically pivotable brackets have a common pivot axis. Vorrichtung gemäß Anspruch 1 oder 2, dadurch gekennzeichnet, daß mindestens zwei vertikal schwenkbare Bügel eine gemeinsame Schwenkachse besitzen und miteinander verbunden sind.Device according to claim 1 or 2, characterized in that at least two vertically pivotable brackets have a common pivot axis own and are connected. Vorrichtung gemäß einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß mindestens zwei vertikal schwenkbare Bügel eine gemeinsame Schwenkachse besitzen, miteinander verbunden sind und mindestens einen Quersteg aufweisen.Device according to one of claims 1 to 3, characterized in that at least two vertically pivotable brackets have a common pivot axis own, are connected to each other and have at least one crossbar. Vorrichtung gemäß einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß ein Bügel horizontale und/oder vertikale Querstege aufweist.Device according to one of claims 1 to 4, characterized in that a bracket has horizontal and / or vertical crossbars. Vorrichtung gemäß einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß die Vorrichtung als Trägereinrichtung mindestens einen Zwischenboden enthält, der an der Vorderkante eine stufenförmige Kante aufweist.Device according to one of claims 1 to 5, characterized in that the device contains at least one intermediate floor as a carrier device, which has a stepped edge at the front edge. Vorrichtung gemäß einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß die Vorrichtung ein Mittel zur Arretierung des schwenkbaren Bügels enthält.Device according to one of claims 1 to 6, characterized in that the device contains a means for locking the pivotable bracket. Vorrichtung gemäß einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß die Vorrichtung eine Federlasche als Mittel zur Arretierung des schwenkbaren Bügels enthält.Device according to one of claims 1 to 7, characterized in that the device a spring tab as a means for locking the pivotable Contains bracket.
    EP98109629A 1997-06-18 1998-05-27 Cryogenic storing device for pharmaceutical samples Expired - Lifetime EP0886115B1 (en)

    Applications Claiming Priority (2)

    Application Number Priority Date Filing Date Title
    DE19725641A DE19725641C2 (en) 1997-06-18 1997-06-18 Device for cryogenic storage of pharmaceutical samples
    DE19725641 1997-06-18

    Publications (3)

    Publication Number Publication Date
    EP0886115A2 true EP0886115A2 (en) 1998-12-23
    EP0886115A3 EP0886115A3 (en) 2000-10-11
    EP0886115B1 EP0886115B1 (en) 2006-05-03

    Family

    ID=7832767

    Family Applications (1)

    Application Number Title Priority Date Filing Date
    EP98109629A Expired - Lifetime EP0886115B1 (en) 1997-06-18 1998-05-27 Cryogenic storing device for pharmaceutical samples

    Country Status (3)

    Country Link
    EP (1) EP0886115B1 (en)
    AT (1) ATE325319T1 (en)
    DE (2) DE19725641C2 (en)

    Cited By (4)

    * Cited by examiner, † Cited by third party
    Publication number Priority date Publication date Assignee Title
    EP1205248A2 (en) * 2000-11-08 2002-05-15 Advanced Biotechnologies Limited Storage unit
    KR101064321B1 (en) * 2009-04-03 2011-09-14 주식회사 비스 rack used in liquid nitrogen container
    CN107377030A (en) * 2017-09-04 2017-11-24 安徽省农业科学院茶叶研究所 A kind of use for laboratory cubic capacity bottle rack
    CN114484967A (en) * 2022-02-22 2022-05-13 中科康谱健康科技(山东)有限责任公司 Low-temperature transportation device for biological samples

    Citations (1)

    * Cited by examiner, † Cited by third party
    Publication number Priority date Publication date Assignee Title
    DE3342489A1 (en) 1983-11-24 1985-06-05 Messer Griesheim Gmbh, 6000 Frankfurt DEVICE FOR DEEP-COLD STORAGE OF ORGANIC OR PHARMACEUTICAL SAMPLES

    Family Cites Families (5)

    * Cited by examiner, † Cited by third party
    Publication number Priority date Publication date Assignee Title
    US1366451A (en) * 1920-06-29 1921-01-25 Eugene W Hawley Latching device for trunk-drawers
    US3902603A (en) * 1974-07-01 1975-09-02 Banner Metals Retainer bar assembly for mail carrying rack
    US4811999A (en) * 1984-02-02 1989-03-14 The Stanley Works Cabinet with pivoted locking outrigger
    US4771900A (en) * 1987-04-09 1988-09-20 Nalge Company Storage rack for box-like container
    US5168725A (en) * 1990-08-24 1992-12-08 National Health Guard, Inc. Cryogenic storage of perishable fluids

    Patent Citations (2)

    * Cited by examiner, † Cited by third party
    Publication number Priority date Publication date Assignee Title
    DE3342489A1 (en) 1983-11-24 1985-06-05 Messer Griesheim Gmbh, 6000 Frankfurt DEVICE FOR DEEP-COLD STORAGE OF ORGANIC OR PHARMACEUTICAL SAMPLES
    DE3342489C2 (en) 1983-11-24 1986-10-23 Messer Griesheim Gmbh, 6000 Frankfurt Device for cryogenic storage of biological or pharmaceutical samples

    Cited By (5)

    * Cited by examiner, † Cited by third party
    Publication number Priority date Publication date Assignee Title
    EP1205248A2 (en) * 2000-11-08 2002-05-15 Advanced Biotechnologies Limited Storage unit
    EP1205248A3 (en) * 2000-11-08 2003-04-23 Advanced Biotechnologies Limited Storage unit
    KR101064321B1 (en) * 2009-04-03 2011-09-14 주식회사 비스 rack used in liquid nitrogen container
    CN107377030A (en) * 2017-09-04 2017-11-24 安徽省农业科学院茶叶研究所 A kind of use for laboratory cubic capacity bottle rack
    CN114484967A (en) * 2022-02-22 2022-05-13 中科康谱健康科技(山东)有限责任公司 Low-temperature transportation device for biological samples

    Also Published As

    Publication number Publication date
    EP0886115B1 (en) 2006-05-03
    DE19725641C2 (en) 1999-06-10
    ATE325319T1 (en) 2006-06-15
    DE19725641A1 (en) 1998-12-24
    EP0886115A3 (en) 2000-10-11
    DE59813523D1 (en) 2006-06-08

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