CN114484967A - Low-temperature transportation device for biological samples - Google Patents
Low-temperature transportation device for biological samples Download PDFInfo
- Publication number
- CN114484967A CN114484967A CN202210159765.4A CN202210159765A CN114484967A CN 114484967 A CN114484967 A CN 114484967A CN 202210159765 A CN202210159765 A CN 202210159765A CN 114484967 A CN114484967 A CN 114484967A
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- box
- plate
- air
- box body
- bottle
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- 239000012472 biological sample Substances 0.000 title claims abstract description 26
- 238000002156 mixing Methods 0.000 claims description 50
- 239000000523 sample Substances 0.000 claims description 17
- 238000010992 reflux Methods 0.000 claims description 3
- 210000003141 lower extremity Anatomy 0.000 claims description 2
- 238000007872 degassing Methods 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 44
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 22
- 239000007788 liquid Substances 0.000 abstract description 18
- 239000007789 gas Substances 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 5
- 239000003507 refrigerant Substances 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 238000004378 air conditioning Methods 0.000 description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- 238000005057 refrigeration Methods 0.000 description 7
- 235000011089 carbon dioxide Nutrition 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 238000010276 construction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000576 supplementary effect Effects 0.000 description 1
Images
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
- F25D3/105—Movable containers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D17/00—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces
- F25D17/04—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating air, e.g. by convection
- F25D17/06—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating air, e.g. by convection by forced circulation
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/02—Doors; Covers
- F25D23/026—Doors; Covers for open-top cabinets
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/06—Walls
- F25D23/062—Walls defining a cabinet
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
- F25D25/005—Charging, supporting, and discharging the articles to be cooled using containers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D29/00—Arrangement or mounting of control or safety devices
- F25D29/003—Arrangement or mounting of control or safety devices for movable devices
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
Abstract
The invention discloses a low-temperature transportation device for biological samples, which relates to the field of transportation and storage equipment, and adopts the technical scheme that the low-temperature transportation device comprises a box body, wherein a top cover is arranged on the upper side of the box body, and a bearing frame and a bottle rack are arranged in the box body; a refrigerating bottle is placed on the bottle rack, nontoxic liquefied gas is filled in the refrigerating bottle, and one end of the refrigerating bottle is provided with a gas discharge nozzle; at least one bearing box used for placing the biological sample is arranged on the frame body of the bearing frame. The invention has the beneficial effects that: according to the structure of the scheme, bottled liquid nitrogen is used as a refrigerant, so that the consumption of the liquid nitrogen in the low-temperature transportation process can be greatly reduced. The refrigerated transport time of biological samples is increased in an unattended situation compared to prior art solutions. And the device can be repeatedly used only by properly filling or replacing the liquid nitrogen bottle. Has good practicability for the transportation of a small amount of samples.
Description
Technical Field
The invention relates to the field of transportation and storage equipment, in particular to a low-temperature transportation device for biological samples.
Background
For the transportation of biological samples, the transportation needs to be carried out under low temperature conditions, usually below zero degree, and at present, a refrigerated vehicle, dry ice or liquid nitrogen is usually used for constructing a low-temperature transportation environment meeting the conditions. For the refrigerator car, the whole cost is higher, and the finished product needs to be purchased for use, so that the refrigerator car is not suitable for transporting small samples. For the transportation mode of combining the dry ice with the heat preservation box, under the condition of summer temperature, 10KG dry ice blocks can approximately ensure the low-temperature environment of about two days for a small box body, and are not suitable for express transportation for more than 3 days. And the dry ice is solid carbon dioxide, and if the concentration of the transportation environment is too high after the dry ice is sublimated into gas, danger can be caused, and the dry ice is not very safe.
Liquid nitrogen transportation is also a common low-temperature transportation mode at present, but the liquid nitrogen transportation at present needs to be attended by special persons, and the transportation cost is high.
Disclosure of Invention
In view of the above technical problems, the present invention provides a cryogenic transport device for biological samples.
The technical scheme is that the bottle storage box comprises a box body, wherein a top cover is arranged on the upper side of the box body, a bearing frame is arranged in the box body, and the box body is provided with a bottle rack;
a refrigerating bottle is placed on the bottle rack, nontoxic liquefied gas is filled in the refrigerating bottle, and one end of the refrigerating bottle is provided with a gas discharge nozzle;
at least one carrying box for placing a biological sample is arranged on the frame body of the carrying frame;
a main temperature sensor is arranged in the box body, a cold air electromagnetic valve is arranged outside the air discharge nozzle, and the main temperature sensor is electrically connected with the cold air electromagnetic valve through a control module to form a control loop;
and a battery is also arranged in the box body and is electrically connected with the main temperature sensor, the control module and the cold air electromagnetic valve to form a power supply passage.
The refrigerating bottle is filled with liquid nitrogen, the air release nozzle adopts a downward-pressing type air release structure of the existing similar bottle body, and the air release nozzle is in an open state when the refrigerating bottle is placed on the bottle frame. Through releasing the liquid nitrogen of the refrigerating bottle, the liquid nitrogen is released into low-temperature nitrogen, and the low-temperature transportation environment construction of the biological sample in the bearing box is realized.
When the main temperature sensor senses that the internal temperature is higher than a set value, the control module controls the main electromagnetic valve to be opened, and a certain amount of nitrogen is released, so that the biological sample is ensured to be in a required low-temperature condition.
Preferably, the air tap of the refrigerating bottle is communicated with the inside of the bearing box through a pipeline;
the sensing end of the main temperature sensor faces the interior of the bearing box.
Preferably, the bearing frame comprises a slide rail fixedly connected with the bottom plate of the box body, the bearing box is connected with the slide rail in a sliding manner, and a mixing box is fixedly arranged on one side of the slide rail;
the air inlet end of the cold air electromagnetic valve is communicated with the air discharge nozzle, and the air outlet end of the cold air electromagnetic valve is communicated with the cold air inlet end of the mixing box through a pipeline; the air outlet end of the mixing box is communicated with the air inlet end of the bearing box through an air outlet electromagnetic valve and a pipeline; the exhaust end of the bearing box is communicated with the backflow air inlet end of the mixing box through an air pump, a backflow electromagnetic valve and an exhaust pipe which are arranged in sequence;
the interior of the mixing box is a cavity, and the cold air inlet end and the backflow air inlet end are both communicated with the interior of the mixing box;
an auxiliary temperature sensor is arranged in a cavity of the mixing box, and a pressure release valve is arranged on the wall of the mixing box; the pressure relief valve is arranged at the top of the mixing box;
the auxiliary temperature sensor is electrically connected with the control module to form a feedback path, and the control module is electrically connected with the air outlet electromagnetic valve, the air pump and the backflow electromagnetic valve to form a control loop.
The cold air electromagnetic valve, the air outlet electromagnetic valve and the backflow electromagnetic valve are all normally closed electromagnetic valves.
Preferably, the slide rail comprises two vertical plates which are vertically arranged, a space is reserved between the two vertical plates, and the bearing box is positioned between the two vertical plates;
the side, facing the slide rail, of the mixing box is symmetrically provided with two transverse plate groups, each transverse plate group comprises two transverse plates which are arranged up and down, the transverse plates are horizontally arranged above the vertical plates, and the transverse plates on the same side are superposed with the vertical plates in the projection of the horizontal plane; a space is reserved between the two transverse plates on the same side, and a space is reserved between the lower transverse plate on the lower side and the upper surface of the vertical plate;
the two sides of the outer wall of the bearing box are symmetrically provided with sliding blocks, the sliding blocks are in a shape like a Chinese character '7', and the sliding blocks are positioned between the transverse plate and the vertical plate on the lower side and are in sliding connection;
the upper transverse plate is provided with a cover cap, one end of the cover cap is hinged with one side of the box body of the mixing box, and the other end of the cover cap is inserted into the side support plate arranged on the bottom plate of the box body.
Preferably, a vertical fixing groove is formed in the upper side of the bottom plate of the box body corresponding to the side support plate, and the side support plate is inserted into the bottom plate through the fixing groove;
a vertical plug board is arranged at the top end of the side support board, a slot is formed in one end, away from the mixing box, of the cover cap, and the cover cap and the side support board are in plug-in connection with the plug board through the slot;
a clamping groove is formed in a plate body of the inserting plate, a spring pin is arranged on the cover cap corresponding to the clamping groove of the inserting plate, and a push-pull block is arranged on the upper side of the cover cap corresponding to the spring pin;
the air pump is fixedly arranged on the air pump support, the air pump support is connected with the sliding rail in a sliding mode, and a spring is arranged on one side, facing the side supporting plate, of the air pump.
Preferably, the bearing box comprises a rectangular box body, the top of the box body is open, the bottom of the box body is movably connected with the bottom of the box, and an air inlet and an air outlet are respectively arranged on two sides of the bearing box;
a sample rack is arranged in the bearing box, and two cold air boxes are respectively and fixedly arranged on two sides of the sample rack; the cold air box bodies on the two sides are respectively provided with an air inlet pipe and an air outlet pipe, and the air inlet pipe and the air outlet pipe respectively extend to the air inlet and the air outlet of the box wall of the bearing box;
the two cold air boxes are communicated through a plurality of air pipes;
the cold air box is in the shape of 'Contraband', and the sample rack is positioned between the two cold air boxes.
The air outlet of the bearing box is a female port, the air inlet is a male port, the air pumping port of the air pump 10 is a male port, and the air outlet of the mixing box 32 is a female port.
Preferably, the sample rack comprises a plurality of horizontally arranged fixing rings, the outer sides of the fixing rings are fixedly connected through vertical rods, bowl-shaped bottom supports are arranged at the bottom ends of the vertical rods, limiting plates are hinged to the tops of the vertical rods, the two limiting plates are symmetrically arranged, and the limiting plates are 7-shaped;
when the limiting plate is in a folded state, the lower surface of the upper plate of the limiting plate is attached to the upper surface of the sample test tube;
the horizontal position of limiting plate bottom is higher than the top of air conditioning box, air conditioning box upside sets up the gasbag, gasbag and air conditioning box inside intercommunication, when the gasbag was full of gas, the gasbag medial surface pasted mutually with the limiting plate lateral surface of closing up the state.
When the cover is snapped on, the cover closes the top of the carrying case.
Preferably, one side edge of the top cover is hinged with the upper edge of the side wall of the box body;
the improved box comprises a box body, and is characterized in that a side cover is arranged on one side of the box body, the lower edge of the side cover is hinged to the bottom edge of the box body, the side cover is arranged on one side far away from the hinged edge of the top cover, a connecting plate is fixedly arranged on one side of the side cover facing the inside of the box body, the connecting plate is arranged on the upper portion of the side cover, a threaded hole is formed in the connecting plate, and the top cover is connected with the side cover through a bolt and the connecting plate.
Preferably, a vertical baffle is arranged between the bearing frame and the battery, and the bottle rack and the bearing frame are arranged on the same side of the baffle;
the baffle is provided with a horizontal supporting plate, and the supporting plate is arranged on one side of the baffle, which faces the battery.
The technical scheme provided by the embodiment of the invention has the following beneficial effects: according to the structure of the scheme, bottled liquid nitrogen is used as a refrigerant, so that the consumption of the liquid nitrogen in the low-temperature transportation process can be greatly reduced. The refrigerated transport time of biological samples is increased compared to prior art solutions in an unattended situation. And the device can be repeatedly used only by properly filling or replacing the liquid nitrogen bottle. Has good practicability for the transportation of a small amount of samples.
Drawings
Fig. 1 is a schematic overall structure diagram of an embodiment of the present invention.
Fig. 2 is a schematic diagram of an uncapped state according to an embodiment of the present invention.
Fig. 3 is a first schematic internal structure diagram according to an embodiment of the present invention.
Fig. 4 is a schematic diagram illustrating the state of the hidden battery and the baffle in fig. 3.
Fig. 5 is a second schematic view of the internal structure of the embodiment of the invention.
Fig. 6 is a schematic view of the cover of fig. 4 in an open state.
Fig. 7 is a schematic view of the overall structure of the carrying box according to the embodiment of the invention.
Fig. 8 is a schematic view of the hidden wall of the carrying case of fig. 7.
Fig. 9 is a schematic view of the hidden airbag of fig. 8.
Wherein the reference numerals are:
1. a box body; 11. a side cover; 12. a connecting plate; 13. a fixing groove 2 and a top cover; 3. a carrier; 31. a slide rail; 32. a mixing box; 33. a lower transverse plate; 34. an upper transverse plate; 35. a cover; 36. a side support plate; 37. a push-pull block; 4. a bottle holder; 5. a refrigeration bottle; 6. a carrying box; 61. a slider; 62. a sample holder; 621. a vertical rod; 622. a limiting plate; 63. a cold air box; 64. an air bag; 7. a cold air solenoid valve; 8. a battery; 9. a baffle plate; 91. a support plate; 10. an air pump; 101. a return solenoid valve; 102. an exhaust pipe; 103. a spring.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. Of course, the specific embodiments described herein are merely illustrative of the invention and are not intended to be limiting.
It should be noted that the embodiments and features of the embodiments of the present invention may be combined with each other without conflict.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings, which are merely for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be construed as limiting the invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted", "connected" and "disposed" are to be construed broadly, e.g. as being fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the creation of the present invention can be understood by those of ordinary skill in the art through specific situations.
Example 1
Referring to fig. 1 to 9, the invention provides a low-temperature transportation device for biological samples, which comprises a box body 1, wherein a top cover 2 is arranged on the upper side of the box body 1, a bearing frame 3 is arranged in the box body 1, and a bottle rack 4 is arranged in the box body 1;
a refrigerating bottle 5 is placed on the bottle rack 4, liquid nitrogen is filled in the refrigerating bottle 5, and one end of the refrigerating bottle 5 is provided with an air discharging nozzle;
at least one carrying box 6 for placing a biological sample is arranged on the frame body of the carrying frame 3;
a main temperature sensor is arranged in the box body 1, a cold air electromagnetic valve 7 is arranged outside the air discharge nozzle, and the main temperature sensor is electrically connected with the cold air electromagnetic valve 7 through a control module to form a control loop;
the box body 1 is also internally provided with a battery 8, and the battery 8 is electrically connected with the main temperature sensor, the control module and the cold air electromagnetic valve 7 to form a power supply passage.
The air release nozzle of the refrigeration bottle 5 adopts a downward-pressing air release structure of the existing similar bottle body, and is in an open state when the refrigeration bottle 5 is placed on the bottle rack 4. The liquid nitrogen in the refrigerating bottle 5 is released to be low-temperature nitrogen, so that the low-temperature transportation environment construction of the biological sample in the bearing box 6 is realized.
The air tap of the refrigeration bottle 5 is communicated with the interior of the bearing box 6 through a pipeline;
the sensing end of the main temperature sensor is arranged towards the interior of the carrying box 6.
When the main temperature sensor senses that the internal temperature is higher than the set value, the control module controls the main electromagnetic valve 7 to be opened, and a certain amount of nitrogen is released, so that the biological sample is ensured to be in a required low-temperature condition. Through the structure of this scheme, combine bottled liquid nitrogen, can realize long-time unmanned on duty low temperature transportation. According to the actual transportation time, refrigeration bottles 5 with different capacities can be added to carry different amounts of liquid nitrogen.
Through this structure, the direct input of air conditioning is to bearing 6 insides of box, and not input to whole box 1 inside, because it is less to bear 6 inner spaces of box, therefore the utilization ratio of air conditioning is higher, can reach the purpose of effectively utilizing the air conditioning cooling.
The bearing frame 3 comprises a slide rail 31 fixedly connected with the bottom plate of the box body 1, the bearing box 6 is connected with the slide rail 31 in a sliding way, and a mixing box 32 is fixedly arranged on one side of the slide rail 31;
the air inlet end of the cold air electromagnetic valve 7 is communicated with the air outlet nozzle of the refrigeration bottle 5, and the air outlet end is communicated with the cold air inlet end of the mixing box 32 through a pipeline; the air outlet end of the mixing box 32 is communicated with the air inlet end of the bearing box 6 through an air outlet electromagnetic valve and a pipeline; the exhaust end of the bearing box 6 is communicated with the reflux air inlet end of the mixing box 32 through an air pump 10, a reflux electromagnetic valve 101 and an exhaust pipe 102 which are arranged in sequence;
the interior of the mixing box 32 is a cavity, and the cold air inlet end and the backflow air inlet end are both communicated with the interior of the mixing box 32;
a secondary temperature sensor is arranged in a cavity of the mixing box 32, and a pressure release valve is arranged on the wall of the mixing box 32; the pressure relief valve is arranged at the top of the mixing box 32;
the auxiliary temperature sensor is electrically connected through the control module to form a feedback path, and the control module is electrically connected with the air outlet electromagnetic valve, the air pump 10 and the backflow electromagnetic valve 101 to form a control loop.
One side edge of the top cover 2 is hinged with the upper edge of the side wall of the box body 1;
one side of box 1 sets up side cap 11, and 11 lower limb of side cap is articulated with the base of box 1, and side cap 11 sets up in the one side of keeping away from the articulated limit of top cap 2, and side cap 11 sets up connecting plate 12 towards the fixed one side of box 1 inside, and connecting plate 12 sets up on 11 upper portions of side cap, sets up the screw hole on the connecting plate 12, and top cap 2 passes through bolt and connecting plate 12 and is connected with side cap 11.
With this structure, when the refrigerator needs to be packed, the top cover 2 and the side cover 11 can be opened at the same time, which facilitates the insertion of the refrigerant bottle 5 and the carrier box 6.
A vertical baffle 9 is arranged between the bearing frame 3 and the battery 8, and the bottle rack 4 and the bearing frame 3 are arranged on the same side of the baffle 9;
a horizontal supporting plate 91 is arranged on the baffle 9, and the supporting plate 91 is arranged on the side of the baffle 9 facing the battery 8.
The cold air solenoid valve 7, the air outlet solenoid valve and the return solenoid valve 101 are all normally closed solenoid valves.
Through this structure, the refrigeration bottle 5 and the box 6 that bears are installed and are accomplished, and the device power supply back, when main temperature sensor senses and bears the inside temperature of box 6 and be higher than the setting value, air conditioning solenoid valve 7, the solenoid valve that gives vent to anger keep the off-state, and backward flow solenoid valve 101 and air pump 10 open, and air pump 10 will bear the interior gas extraction of box 6 to the mixing box 32 in.
The secondary temperature sensor then senses the temperature in the mixing box 32 and feeds the sensing result back to the controllerA control module for judging that the temperature in the mixing box 32 is higher than a set value, controlling the air outlet solenoid valve and the return solenoid valve 101 to be closed, and then opening the cold air solenoid valve 7 for a time period
So that a certain unit volume of cold air is input into the mixing box 32 and a time period passes by the control module
And then, the temperature value fed back by the auxiliary temperature sensor is obtained again, if the temperature value is still higher than the set value, the process is repeated again, and cold air is further input until the temperature in the mixing box 32 is lower than the set value, so that the cold air which can be used for refrigerating the bearing box 6 is formed. In this process, if the pressure in the mixing tank 32 is too high, the pressure relief valve releases a certain gas to maintain the normal pressure in the mixing tank 32.
According to the temperature of the gas in the mixing box 32 fed back by the auxiliary temperature sensor, when the temperature of the gas in the mixing box 32 meets the set low temperature requirement, the cold air solenoid valve 7 and the backflow solenoid valve 101 are kept turned off, the air outlet solenoid valve is turned on and the air pump 10 is turned on, the cold air in the mixing box 32 is pumped into the bearing box 6, and the time period passes
And then the control module closes the air pump 10 and the air outlet electromagnetic valve. The above process is then repeated while waiting for the temperature inside the carrying case 6 to be higher than the set value, according to the result fed back by the main temperature sensor.
By the structure and the working method, cold air in the bearing box 6 with relatively low temperature is used as return air, and a small amount of cold air in the refrigerating bottle 5 is combined for mixing and cooling. Thereby well saving the consumption of liquid nitrogen in the refrigerating bottle 5 and further ensuring the consumption of liquid nitrogen for long-time transportation.
Example 2
Referring to fig. 4 to 6, on the basis of embodiment 1, the slide rail 31 includes two vertical plates vertically disposed, a space is left between the two vertical plates, and the carrying box 6 is located between the two vertical plates;
the mixing box 32 is symmetrically provided with two transverse plate groups towards one side of the slide rail 31, each transverse plate group comprises two transverse plates which are arranged up and down, the transverse plates are horizontally arranged above the vertical plates, and the transverse plates at the same side are superposed with the vertical plates in the projection of the horizontal plane; a space is reserved between the two transverse plates on the same side, and a space is reserved between the lower transverse plate 33 on the lower side and the upper surface of the vertical plate;
the two sides of the outer wall of the bearing box 6 are symmetrically provided with sliding blocks 61, the sliding blocks 61 are 7-shaped, and the sliding blocks 61 are positioned between the transverse plate 33 on the lower side and the vertical plate and are in sliding connection;
a cover cap 35 is arranged on the upper side of the upper transverse plate 34, one end of the cover cap 35 is hinged with one side of the mixing box 32, and the other end of the cover cap is inserted into a side support plate 36 arranged on the bottom plate of the box 1.
Through this structure, can realize bearing the quick connection of box 6 and slide rail 31, adopt the form of slip grafting, the staff of being convenient for inserts a plurality of boxes 6 that bear in proper order in the slide rail 31. And under the action of the sliding block 61, the limit of the bearing box 6 can be ensured.
Example 3
On the basis of the above embodiment, the vertical fixing groove 13 is arranged on the side support plate 36 corresponding to the upper side of the bottom plate of the box body 1, and the side support plate 36 is inserted into the bottom plate through the fixing groove 13;
a vertical plug board is arranged at the top end of the side support plate 36, a slot is formed in one end, away from the mixing box 32, of the cover cap 35, and the cover cap 35 and the side support plate 36 are inserted into the plug board through the slot;
a clamping groove is formed in a plate body of the inserting plate, a spring pin is arranged on the cover cap 35 corresponding to the clamping groove of the inserting plate, and a push-pull block 37 is arranged on the upper side of the cover cap 35 corresponding to the spring pin;
the air pump 10 is fixedly arranged on an air pump bracket which is connected with the slide rail 31 in a sliding manner, and one side of the air pump 10, which faces the side support plate 36, is provided with a spring 103.
With this structure, when the cassette 6 needs to be placed, the side brackets 36 and the air pump 10 can be removed first, so that the movement of placing the cassette 6 into the slide rail 31 is not interfered. The use of this structure greatly reduces the problem of possible insufficient space for the cassette 6 to be put in because of the air pump 10, because it is possible to save as much useless space as possible in view of transportation.
Example 4
Referring to fig. 7 to 9, on the basis of the above embodiment, the carrying box 6 includes a rectangular box body, the top of the box body is open, the bottom of the box body is movably connected with the bottom of the box, and both sides of the carrying box 6 are respectively provided with an air inlet and an air outlet;
a sample rack 62 is arranged in the bearing box 6, and two sides of the sample rack 62 are respectively and fixedly provided with a cold air box 63; the air inlet pipe and the air outlet pipe are respectively arranged on the box bodies of the air conditioning boxes 63 at the two sides and respectively extend to the air inlet and the air outlet of the box wall of the bearing box 6;
the two cold air boxes 63 are communicated through a plurality of air pipes;
the cold air boxes 63 are "Contraband" shaped, and the sample holder 62 is located between the two cold air boxes 63.
The air outlet of the bearing box is a female port, the air inlet is a male port, the air pumping port of the air pump 10 is a male port, and the air outlet of the mixing box 32 is a female port. Through this structure, when a plurality of bearing boxes 6 are arranged, the air inlet pipe and the air outlet pipe of the air conditioning box 63 are inserted into each other, so that the air conditioning boxes of the respective bearing boxes 6 are communicated, and the air inlet pipe and the air outlet pipe located at the end portions are respectively communicated with the air outlet of the mixing box 32 and the air inlet of the air pump 10.
Example 5
On the basis of the above-described embodiments,
the sample frame 62 comprises a plurality of horizontally arranged fixing rings, the outer sides of the fixing rings are fixedly connected through vertical rods 621, bowl-shaped bottom supports are arranged at the bottom ends of the vertical rods 621, the top ends of the vertical rods 621 are hinged with two limiting plates 622, the two limiting plates 622 are symmetrically arranged, and the limiting plates 622 are in a 7 shape;
when the limiting plate 622 is in the folded state, the lower surface of the upper plate of the limiting plate 622 is attached to the upper surface of the sample test tube;
the horizontal position of the bottom end of the limiting plate 622 is higher than the top end of the cold air box 63, the air bag 64 is arranged on the upper side of the cold air box 63, the air bag 64 is communicated with the interior of the cold air box 63, and when the air bag 64 is full of air, the inner side face of the air bag 64 is attached to the outer side face of the limiting plate 622 in a closed state. The medial and lateral sides of the same are horizontal sides of the same, respectively.
Through this structure, during cold air got into gasbag 64, reduce and reveal, gasbag 64 can guarantee the fold of limiting plate 622 simultaneously under the inflation state to play the supplementary effect of fixing the sample.
When the cover 35 is snapped on, the cover 35 closes the top of the carrying case 6.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (9)
1. A low-temperature transportation device for biological samples comprises a box body (1), wherein a top cover (2) is arranged on the upper side of the box body (1), and a bearing frame (3) is arranged in the box body (1), and is characterized in that a bottle rack (4) is arranged in the box body (1);
a refrigerating bottle (5) is placed on the bottle rack (4), the refrigerating bottle (5) is filled with liquefied gas, and one end of the refrigerating bottle (5) is provided with an air release nozzle;
at least one bearing box (6) for placing a biological sample is arranged on the frame body of the bearing frame (3);
a main temperature sensor is arranged in the box body (1), a cold air electromagnetic valve (7) is arranged outside the air discharge nozzle, and the main temperature sensor is electrically connected with the cold air electromagnetic valve (7) through a control module to form a control loop;
and a battery (8) is further arranged in the box body (1), and the battery (8) is electrically connected with the main temperature sensor, the control module and the cold air electromagnetic valve (7) to form a power supply passage.
2. The cryogenic transport device for biological samples according to claim 1, characterized in that the degassing nozzle of the refrigerated bottle (5) communicates with the inside of the carrying box (6) through a pipeline;
the sensing end of the main temperature sensor faces the interior of the bearing box (6).
3. The cryogenic transport device for biological samples according to claim 2, characterized in that the carriage (3) comprises a slide rail (31) fixedly connected with the bottom plate of the box body (1), the carrying box (6) is slidably connected with the slide rail (31), and a mixing box (32) is fixedly arranged on one side of the slide rail (31);
the air inlet end of the cold air electromagnetic valve (7) is communicated with the air discharge nozzle, and the air outlet end is communicated with the cold air inlet end of the mixing box (32) through a pipeline; the air outlet end of the mixing box (32) is communicated with the air inlet end of the bearing box (6) through an air outlet electromagnetic valve and a pipeline; the exhaust end of the bearing box (6) is communicated with the backflow air inlet end of the mixing box (32) through an air pump (10), a backflow electromagnetic valve (101) and an exhaust pipe (102) which are sequentially arranged;
the interior of the mixing box (32) is a cavity, and the cold air inlet end and the backflow air inlet end are both communicated with the interior of the mixing box (32);
an auxiliary temperature sensor is arranged in a cavity of the mixing box (32), and a pressure release valve is arranged on the wall of the mixing box (32);
the auxiliary temperature sensor is electrically connected with the control module to form a feedback path, and the control module is electrically connected with the air outlet electromagnetic valve, the air pump (10) and the reflux electromagnetic valve (101) to form a control loop.
4. The cryogenic transport device for biological samples according to claim 3, characterized in that the slide (31) comprises two vertically arranged vertical plates with a space between them, the carriage (6) being located between the two vertical plates;
two transverse plate groups are symmetrically arranged on one side, facing the sliding rail (31), of the mixing box (32), each transverse plate group comprises two transverse plates which are arranged up and down, the transverse plates are horizontally arranged above the vertical plates, and the transverse plates on the same side are superposed with the vertical plates in the projection of the horizontal plane; a space is reserved between the two transverse plates on the same side, and a space is reserved between the lower transverse plate (33) on the lower side and the upper surface of the vertical plate;
the two sides of the outer wall of the bearing box (6) are symmetrically provided with sliding blocks (61), the sliding blocks (61) are 7-shaped, and the sliding blocks (61) are positioned between the transverse plate (33) and the vertical plate on the lower side and are in sliding connection;
and a cover cap (35) is arranged on the upper side of the upper transverse plate (34), one end of the cover cap (35) is hinged with one side of the mixing box (32), and the other end of the cover cap is inserted into a side support plate (36) arranged on the bottom plate of the box body (1).
5. The cryogenic transportation device for biological samples according to claim 3, characterized in that the upper side of the bottom plate of the box body (1) is provided with vertical fixing grooves (13) corresponding to the side support plates (36), and the side support plates (36) are inserted into the bottom plate through the fixing grooves (13);
a vertical inserting plate is arranged at the top end of the side supporting plate (36), a slot is formed in one end, away from the mixing box (32), of the cover cap (35), and the cover cap (35) and the side supporting plate (36) are connected with the inserting plate in an inserting mode through the slot;
a clamping groove is formed in a plate body of the inserting plate, a spring pin is arranged on the cover cap (35) corresponding to the clamping groove of the inserting plate, and a push-pull block (37) is arranged on the upper side of the cover cap (35) corresponding to the spring pin;
the air pump (10) is fixedly arranged on an air pump support, the air pump support is connected with the sliding rail (31) in a sliding mode, and a spring (103) is arranged on one side, facing the side supporting plate (36), of the air pump (10).
6. The cryogenic transport device for biological samples according to any one of claims 1 to 5, characterized in that the carrying box (6) comprises a rectangular box body, the top of the box body is open, the bottom of the box body is movably connected with the bottom of the box body, and both sides of the carrying box (6) are respectively provided with an air inlet and an air outlet;
a sample rack (62) is arranged in the bearing box (6), and two cold air boxes (63) are respectively and fixedly arranged on two sides of the sample rack (62); the box body of the cold air box (63) at two sides is respectively provided with an air inlet pipe and an air outlet pipe, and the air inlet pipe and the air outlet pipe respectively extend to the air inlet and the air outlet of the box wall of the bearing box (6);
the two cold air boxes (63) are communicated through a plurality of air pipes;
the cold air boxes (63) are in an Contraband shape, and the sample rack (62) is positioned between the two cold air boxes (63).
7. The cryogenic transportation device for biological samples according to claim 6, wherein the sample rack (62) comprises a plurality of horizontally arranged fixing rings, the outer sides of the fixing rings are fixedly connected through a vertical rod (621), the bottom end of the vertical rod (621) is provided with a bowl-shaped bottom support, the top end of the vertical rod (621) is hinged with two limiting plates (622), the two limiting plates (622) are symmetrically arranged, and the limiting plates (622) are in a 7 shape;
when the limiting plate (622) is in a folded state, the lower surface of the upper plate of the limiting plate (622) is attached to the upper surface of the sample test tube;
the horizontal position of limiting plate (622) bottom is higher than the top of cold gas box (63), cold gas box (63) upside sets up gasbag (64), gasbag (64) and the inside intercommunication of cold gas box (63), when gasbag (64) is full of gas, gasbag (64) medial surface pastes with the limiting plate (622) lateral surface of the state of closing mutually.
8. The cryogenic transport device for biological samples according to claim 7, characterized in that one side edge of the top cover (2) is hinged to the upper edge of the side wall of the tank (1);
one side of box (1) sets up side cap (11), side cap (11) lower limb with the base of box (1) is articulated, side cap (11) set up and keep away from one side of the articulated limit of top cap (2), side cap (11) are towards the fixed connecting plate (12) that sets up in the inside one side of box (1), and connecting plate (12) set up on side cap (11) upper portion, set up the screw hole on connecting plate (12), top cap (2) pass through the bolt and connecting plate (12) with side cap (11) are connected.
9. The cryogenic transport device for biological samples according to claim 8, characterized in that a vertical baffle (9) is provided between the carrier (3) and the battery (8), the vial rack (4) being provided on the same side of the baffle (9) as the carrier (3);
the battery pack is characterized in that a horizontal supporting plate (91) is arranged on the baffle (9), and the supporting plate (91) is arranged on one side, facing the battery (8), of the baffle (9).
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| CN202210159765.4A CN114484967B (en) | 2022-02-22 | 2022-02-22 | Low-temperature conveying device for biological samples |
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| CN202210159765.4A CN114484967B (en) | 2022-02-22 | 2022-02-22 | Low-temperature conveying device for biological samples |
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