EP0881892A4 - Expendierbarer stent - Google Patents

Expendierbarer stent

Info

Publication number
EP0881892A4
EP0881892A4 EP97944449A EP97944449A EP0881892A4 EP 0881892 A4 EP0881892 A4 EP 0881892A4 EP 97944449 A EP97944449 A EP 97944449A EP 97944449 A EP97944449 A EP 97944449A EP 0881892 A4 EP0881892 A4 EP 0881892A4
Authority
EP
European Patent Office
Prior art keywords
stent
sections
wire
alloy
helix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP97944449A
Other languages
English (en)
French (fr)
Other versions
EP0881892B1 (de
EP0881892A1 (de
Inventor
Allen J Tower
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Numed Inc
Original Assignee
Numed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Numed Inc filed Critical Numed Inc
Publication of EP0881892A1 publication Critical patent/EP0881892A1/de
Publication of EP0881892A4 publication Critical patent/EP0881892A4/de
Application granted granted Critical
Publication of EP0881892B1 publication Critical patent/EP0881892B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C5/00—Alloys based on noble metals
    • C22C5/02—Alloys based on gold
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C5/00—Alloys based on noble metals
    • C22C5/04—Alloys based on a platinum group metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30451—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00149—Platinum or Pt-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00155—Gold or Au-based alloys

Definitions

  • This invention relates to intravascular implants for maintaining vascular patency in human blood vessels. More particularly, this invention relates to a radially expandable stent made from a fine wire formed into a serpentine ribbon wound into a cylindrical shape for introduction into a body vessel for balloon expansion therein in a radial fashion to support the wall of the vessel when in the expanded configuration. This invention is particularly useful in transluminar implantation of a stent for use in the coronary angioplasty to prevent restenosis.
  • Patent No. 4,886, 062 issued December 12, 1989 to Wiktor have shown stents formed of a zigzag wire wound around a mandrel in a somewhat cylindrical fashion which can then be mounted on a collapsed catheter balloon and expanded after introduction into the vessel by expanding the balloon catheter.
  • These prior art devices have been satisfactory for certain installations, but have been limited in the amount of support that can be provided to the interior of the blood vessel wall and in some cases, to the ratio of expansion possible, and in other cases in the size of the profile presented for the transluminal insertion.
  • the improvement comprises making the stent from a wire which comprises an alloy selected from the group consisting of Pt-Ir or Au-Ni, and where the alloy exhibits a tensile strength of about 155,000 to 175,000 PSI.
  • the alloy comprises about 90 wt % Pt and 10 wt % Ir.
  • alloys of this type provide the combination of strength and resilience to be readily expandable and to maintain their size and shape in the expanded state after installation.
  • welds are eliminated and the free end of the wire forming the stent is looped or wrapped around the helix at a plurality of selected locations to provide for greater dimensional stability.
  • FIG. 1 is an enlarged scale plan view of the first step of the formation of a fine wire into the ribbon of the present invention
  • FIG. 2 is a view similar to FIG. 1 of the serpentine wire ribbon formed from the wire configuration of FIG. 1
  • FIG. 3 is a view of the wire ribbon of FIG. 2 wound about a mandrel to form a helix; with the wire pigtail of the ribbon of FIG. 2 welded to the helix
  • FIG. 4 is a view similar to FIG. 3 showing the stent mounted about a collapsed balloon catheter inserted in a blood vessel
  • FIG. 5 is a view similar to FIG. 4 on a reduced scale showing the expanded stent in position in a blood vessel for holding the blood vessel in the open configuration.
  • FIG. 6 is an enlarged view of the stent of the present invention wound about the mandrel similar to FIG. 3 except for the weld construction.
  • FIG. 1 a stent in accordance with the present invention and as illustrated by the prior art in U.S. Patent No. 5,217,483 which is formed by first taking a fine wire 10 having a diameter of approximately 0.004 inch, preferably made from platinum and forming it into a generally sinusoidal form, as shown in FIG. 1 in which approximately ten cycles or segments per inch are formed in the wire.
  • These waves can be formed in any convenient manner, for instance as by bending about a rack gear by running a corresponding spur gear over a wire laid along the rack.
  • the next step is to take the wire of FIG. 1 and to further bend the sinusoids into a flat band containing alternately inverted teardrop shaped elements or loops 13.
  • Each element shares a common side with its neighbor and includes a base 17 and a pair of arcuate shaped legs 19-19 that come together in touching contact at an apex 15.
  • the apex of a loop will lie along one side edge of the band, such as edge 21 while the base of the loop lies upon the opposite side edge 23 of the band.
  • approximately forty loops 13 per inch of ribbon are present and the height or "amplitude" 34 of the loops is approximately 1/16 inch. This is accomplished by mechanically bending the partially formed loops of FIG. 1 up against each other into the shape shown in FIG. 2.
  • the fine wire 10 used to form the basic flat ribbon 12 is a soft platinum wire that has been fully annealed to remove as much spring memory as possible.
  • the straight wire before bending, being in the fully annealed condition, will retain whatever shape it is formed into.
  • the ribbon 12 is wrapped about a mandrel 14 having a diameter of 0.060 inch in a spiral or helix fashion with the edges of each helix wrap 16 of the ribbon 12 basically touching the adjacent ribbon helix edges to form a wire sleeve 18.
  • the number of circumferential sections 16 on the mandrel will determine the length of the sleeve 18, and a typical stent of this type may have a length of approximately one-and-one-half inches.
  • the free end 20 of the wire of FIG. 1 is inserted through the helix, as may be seen in FIG. 3.
  • the ribbon 12 is wound about the mandrel 14 over the top of the free end 20 of the wire 10.
  • the free end 20 extending through the helix is trimmed, and welded smoothly to the final turn or end circumferential section of the helix 16 so as not to present any increased profile and so as not to puncture or pierce the balloon catheter or the blood vessel into which it is being inserted.
  • the end turn of the helix is welded at 22 and intermediate welds such as 24 are formed to stabilize the length of the helix.
  • the first turn of the helix at the other end may also be welded to the free end at 26 so that the overall length of the stent can be constrained and maintained in the desired configuration.
  • the serpentine ribbon sleeve 18 is next placed about a collapsed balloon catheter as shown in FIG. 4.
  • the sleeve 18 generally has a diameter in the neighborhood of 1.5 mm for insertion into the blood vessels adjacent the heart.
  • the stent is mounted on a balloon catheter as shown in FIG. 4 and is inserted into the appropriate blood vessel 35.
  • the stent is guided to the desired location where there is occluding plaque 28 or a weak vessel wall or other imperfection requiring placement of a stent.
  • the balloon catheter 36 is inflated to radially expand the serpentine wire sleeve 18. As the balloon 38 expands, it expands the tight closed apex of each loop of the serpentine ribbon 12 from "touching contact" shown in FIGs. 2-4 to a spaced apart condition as shown in FIG. 5.
  • the stent has been expanded to 4 mm to 5 mm within the blood vessel.
  • the space 30 between adjacent loops then increases to something approximately 0.0875 inch with the loop dimension being approximately 0.025 inch
  • the loop dimension being approximately 0.025 inch
  • FIG. 2 what initially in FIG. 2 was a "wavelength" of 0.025 inch, now becomes a "wavelength” of 0.1125 inch. This is an increase of 4.5 times and is perhaps one of the more common expansion ratios found with stents of this type. With the present stent, expansion of up to 8 mm or six times has been found to be entirely satisfactory.
  • the "amplitude" or width 34 of the ribbon 12 decreases some 20 percent to 25 percent due to the lengthening of the helix wrap due to the increased circumference of the expanded sleeve.
  • the adjacent loops 13 are separated by spaces 30 at the same time the amplitude 34 of the individual helixes decrease.
  • the overall length of the sleeve 18 tends to decrease even to the point of causing the free end or pigtail 20 to bend between the welds 22, 24 and 26.
  • the pigtail 20 prevents extension of the overall length of the sleeve 18, but allows it to contract as the diameter increases. The length tends to decrease because the middle of the balloon, and hence the middle of the stent, expands the most, pulling the ends toward the center.
  • FIG. 5 The expanded condition of the stent is shown in FIG. 5 with the balloon catheter having been removed and the back portion 32 of the sleeve 18 shown in dotted lines for clarity of presentation. Even in this expanded configuration, however, it will be seen that there are ample turns of wire spaced closely enough to fully support the inner surface of the blood vessel so as to prevent collapse of the plaque occluded vessel.
  • this "finer mesh” serpentine configuration smaller diameter wire can be used without losing the necessary support for the interior surface of the blood vessel, and thus the stent presents a lower profile during introduction which increases the utility of the stent for smaller blood vessel usage.
  • This "finer mesh” also results in a more flexible sleeve which, together with the smooth uniform surface of the tightly wound serpentine wire ribbon of FIGs.
  • the wire pigtail has no sharp ends and the free end is welded to the loop of the helix, there are no sharp edges or points to tear or catch on the catheter balloon or the interior surface of the blood vessel, and thus the stent of the present invention can be more readily manipulated to the desired location.
  • the stent of the present invention is welded to the longitudinal wire at several locations, the longitudinal stability of the stent is greatly increased over the prior art devices without creating a stiff and inflexible stent that cannot be manipulated around curves and corners of the vessel into which it is to be introduced.
  • sleeves of platinum were objectionable because of its inherent high elastic limit such that it required extreme pressures to expand and to hold it in the expanded configuration without contraction sometimes causing insufficient support of the wall surfaces.
  • the elastic limit of in the annealed platinum wire can easily be overcome and the device can be fully expanded radially to support the blood vessel with very little pressure required from the balloon catheter.
  • applicant is able to provide a stent which is more radiopaque than, for instance, stainless steel, without encountering the usual modulus of elasticity problems with platinum. This allows good visibility during implantation and speeds the procedure of positioning the stent in the proper location within the vessel.
  • the stent of the prior art described above in FIGs 1-5 is made from a wire which comprises an alloy selected from the group consisting of Pt-Ir or Au-Ni, and where the alloy exhibits a tensile strength of about 155,000 to 175,000 PSI.
  • the alloy comprises about 90 wt % Pt and 10 wt % Ir. It has been found that alloys of this type are an improvement over the prior art materials, and provide the combination of strength and resilience to be readily expandable, and to maintain their size and shape in the expanded state after installation.
  • the welds 22, 24 and 26 as shown in FIG. 3, are eliminated and free end 20 is looped or wrapped (tied) around the helix at locations 40, 42 and 44.
  • Wire 20 may overlap a given coil and move back under the next coil as shown at location 42.
  • the tip of free end 20 is bent inwardly to avoid any surface profile and to avoid puncture or piercing the balloon catheter or blood vessel into which it is being inserted. It has been found that the loop and wrap configuration provides a greater dimensional stability to the expanded stent which overcomes the tendency of the prior art stents to prolapse with time.
  • a stent having good flexibility, dimensional stability, minimal impurities, very smooth surface, low profile and immunity to fatigue and corrosion.
EP97944449A 1996-10-01 1997-09-25 Expandierbarer stent Expired - Lifetime EP0881892B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2734596P 1996-10-01 1996-10-01
US2734P 1996-10-01
PCT/US1997/017211 WO1998014137A1 (en) 1996-10-01 1997-09-25 Expandable stent

Publications (3)

Publication Number Publication Date
EP0881892A1 EP0881892A1 (de) 1998-12-09
EP0881892A4 true EP0881892A4 (de) 2000-06-07
EP0881892B1 EP0881892B1 (de) 2005-01-26

Family

ID=21837180

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97944449A Expired - Lifetime EP0881892B1 (de) 1996-10-01 1997-09-25 Expandierbarer stent

Country Status (8)

Country Link
US (1) US6022370A (de)
EP (1) EP0881892B1 (de)
JP (1) JP2000501328A (de)
AU (1) AU4593997A (de)
BR (1) BR9706814A (de)
DE (1) DE69732349D1 (de)
MX (1) MX9804323A (de)
WO (1) WO1998014137A1 (de)

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JP2000501328A (ja) 2000-02-08
EP0881892B1 (de) 2005-01-26
BR9706814A (pt) 1999-12-28
AU4593997A (en) 1998-04-24
DE69732349D1 (de) 2005-03-03
WO1998014137A1 (en) 1998-04-09
US6022370A (en) 2000-02-08
MX9804323A (es) 1998-11-30
EP0881892A1 (de) 1998-12-09

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