EP0880357A4 - Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle - Google Patents

Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle

Info

Publication number
EP0880357A4
EP0880357A4 EP96919234A EP96919234A EP0880357A4 EP 0880357 A4 EP0880357 A4 EP 0880357A4 EP 96919234 A EP96919234 A EP 96919234A EP 96919234 A EP96919234 A EP 96919234A EP 0880357 A4 EP0880357 A4 EP 0880357A4
Authority
EP
European Patent Office
Prior art keywords
peptidomimetics
peptides
synthesis
amino acids
ring closing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96919234A
Other languages
German (de)
English (en)
Other versions
EP0880357A1 (fr
Inventor
Robert H Grubbs
J Scott Miller
Helen E Blackwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of EP0880357A1 publication Critical patent/EP0880357A1/fr
Publication of EP0880357A4 publication Critical patent/EP0880357A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96919234A 1996-01-17 1996-06-07 Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle Withdrawn EP0880357A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1017096P 1996-01-17 1996-01-17
US10170P 1996-01-17
PCT/US1996/009591 WO1997026002A1 (fr) 1996-01-17 1996-06-07 Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle

Publications (2)

Publication Number Publication Date
EP0880357A1 EP0880357A1 (fr) 1998-12-02
EP0880357A4 true EP0880357A4 (fr) 1999-05-12

Family

ID=21744291

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96919234A Withdrawn EP0880357A4 (fr) 1996-01-17 1996-06-07 Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle

Country Status (3)

Country Link
EP (1) EP0880357A4 (fr)
AU (1) AU6162996A (fr)
WO (1) WO1997026002A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US6582726B1 (en) * 2000-06-21 2003-06-24 Smithkline Beecham Corporation Cross linked solid supports for solid phase synthesis
WO2002016552A2 (fr) * 2000-08-19 2002-02-28 University Of Florida Polymères fonctionnalisés
US8710178B2 (en) 2006-10-18 2014-04-29 Lincoln University Macrocyclic cysteine protease inhibitors and compositions thereof
AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
EP2342221B1 (fr) * 2008-09-22 2018-11-07 Aileron Therapeutics, Inc. Procédés pour préparer des compositions de polypeptide purifié
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
AU2014244232B2 (en) 2013-03-13 2019-05-02 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
EP3008081B1 (fr) 2013-06-14 2017-08-30 President and Fellows of Harvard College Modulateurs stabilisés du récepteur de l'insuline polypeptidique
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016049359A1 (fr) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
WO2017004548A1 (fr) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
WO2020023502A1 (fr) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et utilisations associées
US11584956B2 (en) * 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
US20200384434A1 (en) 2019-06-07 2020-12-10 Microsoft Technology Licensing, Llc Reversing bias in polymer synthesis electrode array
US11896945B2 (en) 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SCOTT J.MILLER ET AL.: "Synthesis of Conformationally Restricted Amino Acids and Peptides Employing Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 5855 - 6, XP002093028 *
SCOTT.J.MILLER ET AL: "Catalytic Ring-Closing Metathesis of Dienes: Application to the Synthesis of Eight-Membered Rings", J.AM.CHEM.SOC, vol. 117, 1995, pages 2108 - 9, XP002093029 *
See also references of WO9726002A1 *
THOMAS D.CLERK ET AL.: "Supramolecular Design by Covalent Capture. Design of a Peptide cylinder via Hydrogen-Bond-Promoted Intermolecular Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 12364 - 5, XP002093030 *

Also Published As

Publication number Publication date
EP0880357A1 (fr) 1998-12-02
WO1997026002A1 (fr) 1997-07-24
AU6162996A (en) 1997-08-11

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