EP0865502A4 - Procede de criblage par fluorescence destine a l'identification de ligands - Google Patents

Procede de criblage par fluorescence destine a l'identification de ligands

Info

Publication number
EP0865502A4
EP0865502A4 EP96944304A EP96944304A EP0865502A4 EP 0865502 A4 EP0865502 A4 EP 0865502A4 EP 96944304 A EP96944304 A EP 96944304A EP 96944304 A EP96944304 A EP 96944304A EP 0865502 A4 EP0865502 A4 EP 0865502A4
Authority
EP
European Patent Office
Prior art keywords
fluorescence
screening method
based screening
identifying ligands
ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96944304A
Other languages
German (de)
English (en)
Other versions
EP0865502A1 (fr
Inventor
Andrew Pakula
Robert T Sauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anadys Pharmaceuticals Inc
Original Assignee
Scriptgen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scriptgen Pharmaceuticals Inc filed Critical Scriptgen Pharmaceuticals Inc
Publication of EP0865502A1 publication Critical patent/EP0865502A1/fr
Publication of EP0865502A4 publication Critical patent/EP0865502A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
EP96944304A 1995-12-07 1996-12-06 Procede de criblage par fluorescence destine a l'identification de ligands Withdrawn EP0865502A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US834695P 1995-12-07 1995-12-07
US8346P 1995-12-07
PCT/US1996/019698 WO1997020952A1 (fr) 1995-12-07 1996-12-06 Procede de criblage par fluorescence destine a l'identification de ligands

Publications (2)

Publication Number Publication Date
EP0865502A1 EP0865502A1 (fr) 1998-09-23
EP0865502A4 true EP0865502A4 (fr) 2000-08-16

Family

ID=21731102

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96944304A Withdrawn EP0865502A4 (fr) 1995-12-07 1996-12-06 Procede de criblage par fluorescence destine a l'identification de ligands

Country Status (5)

Country Link
EP (1) EP0865502A4 (fr)
JP (1) JP2000502440A (fr)
CA (1) CA2236339A1 (fr)
DE (1) DE865502T1 (fr)
WO (1) WO1997020952A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2184195C (fr) 1995-10-25 2002-04-16 Andrew Pakula Methode d'analyse pour la caracterisation de ligands de proteines cibles
AU741049B2 (en) 1996-05-09 2001-11-22 Life Technologies Corporation Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
IL129728A0 (en) 1996-11-04 2000-02-29 Dimensional Pharm Inc System method and computer program product for the visualization and interactive processing and analysis of chemical data
US6571227B1 (en) 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
IL136046A0 (en) * 1997-11-12 2001-05-20 Dimensional Pharm Inc Methods for classifying proteins
US20020010550A1 (en) 1998-09-14 2002-01-24 George M. Grass Pharmacokinetic-based drug design tool and method
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US6358708B1 (en) 1999-02-04 2002-03-19 Anadys Pharmaceuticals, Inc. Candida albicans SRB-7
US6972198B2 (en) 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
US6582907B1 (en) * 1999-12-09 2003-06-24 Pharmacia & Upjohn Company Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
US6376180B1 (en) * 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
US6671627B2 (en) 2000-02-29 2003-12-30 3-D Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
US7039621B2 (en) 2000-03-22 2006-05-02 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method, and computer program product for representing object relationships in a multidimensional space
AU2001249805A1 (en) 2000-04-03 2001-10-15 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
WO2002061419A1 (fr) 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Procede, systeme et progiciel permettant d'analyser les banques combinatoires
EP1409982A4 (fr) * 2001-06-14 2006-05-24 Anadys Pharmaceuticals Inc Procedes de criblage de ligands de molecules cibles
EP1637885A1 (fr) 2004-09-16 2006-03-22 Vivalis Méthode de criblage en employant des peptides sensibles à la conformation de protéines
GB0421285D0 (en) 2004-09-24 2004-10-27 Univ Nottingham Improvements in high content screening
US8158340B2 (en) 2005-12-28 2012-04-17 Corning Incorporated Methods for detecting conformational changes in bioentities
US10571471B2 (en) 2015-02-05 2020-02-25 Promega Corporation Luciferase-based thermal shift assays
GB202118173D0 (en) * 2021-12-15 2022-01-26 Medicines Discovery Catpult Ltd Protein stability assay

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4993093A (fr) * 1973-01-08 1974-09-04
EP0613007A2 (fr) * 1993-02-22 1994-08-31 Eli Lilly And Company Analyse pharmaceutique et anticorps

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200504A (en) * 1990-10-02 1993-04-06 The Scripps Research Institute Metallopeptides having stabilized secondary structures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4993093A (fr) * 1973-01-08 1974-09-04
EP0613007A2 (fr) * 1993-02-22 1994-08-31 Eli Lilly And Company Analyse pharmaceutique et anticorps

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 7526, Derwent World Patents Index; Class B04, AN 75-43214w, XP002024012 *
See also references of WO9720952A1 *

Also Published As

Publication number Publication date
EP0865502A1 (fr) 1998-09-23
WO1997020952A1 (fr) 1997-06-12
DE865502T1 (de) 1999-08-19
JP2000502440A (ja) 2000-02-29
CA2236339A1 (fr) 1997-06-12

Similar Documents

Publication Publication Date Title
EP0865502A4 (fr) Procede de criblage par fluorescence destine a l'identification de ligands
IL119347A0 (en) Method for identifying lymph nodes
ZA965181B (en) Filter and method for making a filter
SG44995A1 (en) Manufacturing method for polycarbonate
GB9613647D0 (en) Method for discriminating a type of multidisk
ZA965341B (en) A method for selecting mutants
EP0873142A4 (fr) Epreuves de selection de composes
GB2299877B (en) A process for detecting time information
HUP9600724A1 (en) Reagent and process for geting a substituated diflouromethyl group into a compound cointaining one or more electrophyl group
AU3628595A (en) Screening method for periodontal disease
EP0694572A3 (fr) Procédé pour la préparation de polycarbonate
ZA94407B (en) Method for identifying individuals suffering from a cellular abnormality
EP0719814A3 (fr) Procédé pour la préparation de polycarbonate
GB2318817B (en) Method for completing a wellbore
GB2312808B (en) Hydrophone and a method for manufacturing it
GB2292941B (en) Method for making a 4-hydroxy-tetraorganopiperidinyloxy
AU695875B2 (en) A method for washing immunoassay elements
GB2295624B (en) Method for metallizing a surface
EP0728141A4 (fr) Procede d'identification de composes antiparasitaires
EP0719815A3 (fr) Procédé pour la préparation de polycarbonate
AU1723599A (en) A method for identifying new anti-picornaviral compounds
AU5104696A (en) A method for identifying a novel multidrug-resistance type
GB9501962D0 (en) A process for tenderising meats
AP9701121A0 (en) Method for prearing streptogramines
GB2308079B (en) A process for analysing a fluid

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980530

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

ITCL It: translation for ep claims filed

Representative=s name: RICCARDI SERGIO & CO.

EL Fr: translation of claims filed
TCNL Nl: translation of patent claims filed
DET De: translation of patent claims
A4 Supplementary search report drawn up and despatched

Effective date: 20000705

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7G 01N 33/68 A, 7C 12Q 1/68 B, 7G 01N 33/53 B, 7G 01N 33/543 B, 7G 01N 33/58 B

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ANADYS PHARMACEUTICALS, INC.

17Q First examination report despatched

Effective date: 20010517

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20011128