EP0845987A4 - C-PROTEINASE INHIBITORS FOR THE TREATMENT OF CONDITIONS RELATED TO COLLAGEN OVERPRODUCTION - Google Patents
C-PROTEINASE INHIBITORS FOR THE TREATMENT OF CONDITIONS RELATED TO COLLAGEN OVERPRODUCTIONInfo
- Publication number
- EP0845987A4 EP0845987A4 EP96930499A EP96930499A EP0845987A4 EP 0845987 A4 EP0845987 A4 EP 0845987A4 EP 96930499 A EP96930499 A EP 96930499A EP 96930499 A EP96930499 A EP 96930499A EP 0845987 A4 EP0845987 A4 EP 0845987A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- overproduction
- collagen
- treatment
- disorders related
- proteinase inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000008186 Collagen Human genes 0.000 title 1
- 108010035532 Collagen Proteins 0.000 title 1
- 229940019748 antifibrinolytic proteinase inhibitors Drugs 0.000 title 1
- 229920001436 collagen Polymers 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 238000012261 overproduction Methods 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US203895P | 1995-08-08 | 1995-08-08 | |
US602038 | 1995-08-08 | ||
US60120396A | 1996-02-14 | 1996-02-14 | |
US601203 | 1996-02-14 | ||
US60918796A | 1996-03-01 | 1996-03-01 | |
US609187 | 1996-03-01 | ||
PCT/US1996/012876 WO1997005865A1 (en) | 1995-08-08 | 1996-08-08 | C-proteinase inhibitors for the treatment of disorders related to the overproduction of collagen |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0845987A1 EP0845987A1 (en) | 1998-06-10 |
EP0845987A4 true EP0845987A4 (en) | 2000-05-24 |
Family
ID=27357060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96930499A Withdrawn EP0845987A4 (en) | 1995-08-08 | 1996-08-08 | C-PROTEINASE INHIBITORS FOR THE TREATMENT OF CONDITIONS RELATED TO COLLAGEN OVERPRODUCTION |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0845987A4 (ko) |
JP (1) | JPH11511137A (ko) |
KR (1) | KR19990036271A (ko) |
CN (1) | CN1198096A (ko) |
AU (1) | AU6951296A (ko) |
BR (1) | BR9609883A (ko) |
CA (1) | CA2229098A1 (ko) |
MX (1) | MX9801093A (ko) |
WO (1) | WO1997005865A1 (ko) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
JPH11510697A (ja) * | 1995-08-08 | 1999-09-21 | トーマス ジェファソン ユニバーシティー | 組換え体c−プロテイナーゼ、ならびにそのプロセス、方法および使用 |
US5994351A (en) * | 1998-07-27 | 1999-11-30 | Pfizer Inc. | Arylsulfonylamino hydroxamic acid derivatives |
US6747027B1 (en) | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
ATE233552T1 (de) * | 1996-07-22 | 2003-03-15 | Monsanto Co | Thiol-sulfonen als metalloproteinaseinhibitoren |
SK21499A3 (en) * | 1996-08-23 | 2000-05-16 | Pfizer | Arylsulfonylamino hydroxamic acid derivatives |
US6376506B1 (en) | 1997-01-23 | 2002-04-23 | Syntex (U.S.A.) Llc | Sulfamide-metalloprotease inhibitors |
ZA98376B (en) * | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
GB9706255D0 (en) | 1997-03-26 | 1997-05-14 | Smithkline Beecham Plc | Novel compounds |
US6037139A (en) * | 1997-06-03 | 2000-03-14 | Wisconsin Alumni Research Foundation | System for assaying modulators of procollagen maturation |
ID29293A (id) | 1997-07-22 | 1999-01-28 | Shionogi & Co | KOMPOSISI UNTUK MENGOBATI ATAU MENCEGAH GLOMERULOPATI (Pecahan dari No. W20000054) |
KR100352316B1 (ko) * | 1997-07-31 | 2002-09-12 | 더 프록터 앤드 갬블 캄파니 | 메탈로프로테아제억제제로서사용되는술포닐아미노치환히드록삼산유도체 |
US6130220A (en) * | 1997-10-16 | 2000-10-10 | Syntex (Usa) Inc. | Sulfamide-metalloprotease inhibitors |
US6107291A (en) * | 1997-12-19 | 2000-08-22 | Amgen Inc. | Azepine or larger medium ring derivatives and methods of use |
US6107337A (en) * | 1998-08-06 | 2000-08-22 | Pfizer Inc. | Arylsulfonylamino hydroxamic acid derivatives |
WO2000034313A1 (en) | 1998-12-10 | 2000-06-15 | F. Hoffmann-La Roche Ag | Procollagen c-proteinase inhibitors |
US6492394B1 (en) | 1998-12-22 | 2002-12-10 | Syntex (U.S.A.) Llc | Sulfonamide hydroxamates |
EP1149072B1 (en) * | 1998-12-22 | 2004-06-30 | F. Hoffmann-La Roche Ag | Sulfonamide hydroxamates |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
US6506936B1 (en) * | 1999-02-25 | 2003-01-14 | Fibrogen, Inc. | N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production |
NZ513831A (en) | 1999-03-03 | 2001-09-28 | Procter & Gamble | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
BR0009244A (pt) | 1999-03-03 | 2002-04-16 | Procter & Gamble | Inibidores de metaloprotease di-hétero substituìdos |
US6448278B2 (en) | 1999-12-23 | 2002-09-10 | Pfizer Inc. | Procollagen C-proteinase inhibitors |
US6462063B1 (en) | 2000-02-04 | 2002-10-08 | Fibrogen, Inc. | C-proteinase inhibitors |
US6645993B2 (en) | 2001-03-30 | 2003-11-11 | Warner-Lambert Company | 3-heterocyclylpropanohydroxamic acid PCP inhibitors |
AU2003221786A1 (en) | 2002-04-25 | 2003-11-10 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
IL165259A0 (en) * | 2002-05-29 | 2005-12-18 | Merck & Co Inc | Compounds useful in the treatment of anthraxa and inhibiting lethal factor |
US7105539B2 (en) | 2002-12-03 | 2006-09-12 | Enobia Pharma | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex |
AU2004303492A1 (en) | 2003-12-19 | 2005-07-07 | Basf Aktiengesellschaft | Benzoyl-substituted phenylalanine amides |
AU2005250351A1 (en) | 2004-05-11 | 2005-12-15 | Merck & Co., Inc. | Process for making n-sulfonated-amino acid derivatives |
US8093236B2 (en) * | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
DK2494993T3 (en) | 2007-05-04 | 2018-11-12 | Marina Biotech Inc | Amino acid lipids and uses thereof |
WO2009097893A1 (en) * | 2008-02-04 | 2009-08-13 | Proyecto De Biomedicina Cima, S.L. | Methods for the treatment of cardiac disease associated to myocardial fibrosis using an inhibitor of pcp |
KR102641718B1 (ko) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체 |
CA3115830C (en) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
CN114222730A (zh) | 2019-08-14 | 2022-03-22 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4687841A (en) * | 1985-10-18 | 1987-08-18 | Monsanto Company | Peptide hydroxamic acid derivatives |
EP0262399A2 (en) * | 1986-08-29 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Cyclic enol derivatives, production and use thereof |
WO1991015507A1 (en) * | 1990-04-10 | 1991-10-17 | Beecham Group Plc | Phosphonopeptides with collagenase inhibiting activity |
EP0606046A1 (en) * | 1993-01-06 | 1994-07-13 | Ciba-Geigy Ag | Arylsulfonamido-substituted hydroxamic acids |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
US5292926A (en) * | 1988-01-25 | 1994-03-08 | Santen Pharmaceutical Co., Ltd. | Cysteine derivatives |
FR2626882B1 (fr) * | 1988-02-08 | 1991-11-08 | Ire Celltarg Sa | Conjugues de derives de vinca comportant une chaine detergente en position c-3 |
NZ229004A (en) * | 1988-05-19 | 1993-09-27 | Immunobiology Res Inst Inc | Tetrapeptides having t cell helper acitivity |
FR2655339B2 (fr) * | 1989-04-19 | 1992-04-10 | Medgenix Group Sa | Composes et complexes utiles notamment en imagerie medicale. |
US5149794A (en) * | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
US5114953A (en) * | 1990-11-21 | 1992-05-19 | University Of Florida | Treatment for tissue ulceration |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5256657A (en) * | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
US5237057A (en) * | 1992-04-06 | 1993-08-17 | Biosite Diagnostics, Inc. | Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels |
US5393902A (en) * | 1994-04-26 | 1995-02-28 | Lever Brothers Company, Division Of Conopco, Inc. | Process for the preparation of bis(amidocarboxylic acids) |
-
1996
- 1996-08-08 AU AU69512/96A patent/AU6951296A/en not_active Abandoned
- 1996-08-08 CA CA002229098A patent/CA2229098A1/en not_active Abandoned
- 1996-08-08 BR BR9609883A patent/BR9609883A/pt not_active Application Discontinuation
- 1996-08-08 WO PCT/US1996/012876 patent/WO1997005865A1/en not_active Application Discontinuation
- 1996-08-08 MX MX9801093A patent/MX9801093A/es unknown
- 1996-08-08 KR KR1019980700939A patent/KR19990036271A/ko not_active Application Discontinuation
- 1996-08-08 JP JP9508648A patent/JPH11511137A/ja active Pending
- 1996-08-08 CN CN96197271A patent/CN1198096A/zh active Pending
- 1996-08-08 EP EP96930499A patent/EP0845987A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4687841A (en) * | 1985-10-18 | 1987-08-18 | Monsanto Company | Peptide hydroxamic acid derivatives |
EP0262399A2 (en) * | 1986-08-29 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Cyclic enol derivatives, production and use thereof |
WO1991015507A1 (en) * | 1990-04-10 | 1991-10-17 | Beecham Group Plc | Phosphonopeptides with collagenase inhibiting activity |
EP0606046A1 (en) * | 1993-01-06 | 1994-07-13 | Ciba-Geigy Ag | Arylsulfonamido-substituted hydroxamic acids |
Non-Patent Citations (10)
Title |
---|
AUST. J. CHEM. ( 1992 ), 45(2), 385-94, 1992 * |
BRINGMANN, GERHARD ET AL: "Acetogenic isoquinoline alkaloids. 66. First total synthesis of korupensamines A and B", HETEROCYCLES ( 1994 ), 39(2), 503-8, 1994, XP000561812 * |
CHEM. PHARM. BULL. ( 1990 ), 38(4), 1007-11, 1990 * |
CHEMICAL ABSTRACTS, vol. 110, no. 23, 5 June 1989, Columbus, Ohio, US; abstract no. 205068, LELIEVRE, Y. ET AL: "Synovial collagenase inhibition by actinonin. Structure-activity relations" XP002134086 * |
CHEMICAL ABSTRACTS, vol. 113, no. 17, 22 October 1990, Columbus, Ohio, US; abstract no. 147795, ODAKE, SHINJIRO ET AL: "Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids" XP002134085 * |
CHEMICAL ABSTRACTS, vol. 116, no. 17, 27 April 1992, Columbus, Ohio, US; abstract no. 174753, PERICH, JOHN W. ET AL: "Synthesis of casein-related peptides and phosphopeptides. XVI. The efficient synthesis of the casein-related O-phosphoseryl-containing peptide Ac-Glu-Ser(P)-Leu-Ser(P)-Ser(P)-Ser(P)-Glu-Glu-NHMe" XP002134088 * |
CHEMICAL ABSTRACTS, vol. 123, no. 23, 4 December 1995, Columbus, Ohio, US; abstract no. 314466, OUCHI, T. ET AL: "Synthesis of polydepsipeptide with pendant carboxylic acid groups and its hydrolysis behavior" XP002134087 * |
PATHOL. BIOL. ( 1989 ), 37(1), 43-6, 1989 * |
See also references of WO9705865A1 * |
STUD. POLYM. SCI. ( 1994 ), 12(BIODEGRADABLE PLASTICS AND POLYMERS), 528-33, 1994 * |
Also Published As
Publication number | Publication date |
---|---|
BR9609883A (pt) | 1999-03-23 |
CA2229098A1 (en) | 1997-02-20 |
AU6951296A (en) | 1997-03-05 |
CN1198096A (zh) | 1998-11-04 |
WO1997005865A1 (en) | 1997-02-20 |
EP0845987A1 (en) | 1998-06-10 |
MX9801093A (es) | 1998-04-30 |
KR19990036271A (ko) | 1999-05-25 |
JPH11511137A (ja) | 1999-09-28 |
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