EP0842291A4 - Inhibitoren der farnesyl-protein transferase - Google Patents

Inhibitoren der farnesyl-protein transferase

Info

Publication number
EP0842291A4
EP0842291A4 EP96925425A EP96925425A EP0842291A4 EP 0842291 A4 EP0842291 A4 EP 0842291A4 EP 96925425 A EP96925425 A EP 96925425A EP 96925425 A EP96925425 A EP 96925425A EP 0842291 A4 EP0842291 A4 EP 0842291A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
protein transferase
farnesyl protein
farnesyl
transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96925425A
Other languages
English (en)
French (fr)
Other versions
EP0842291A1 (de
Inventor
Carmen Cascales
Russell B Lingham
Fernando Pelaez
Jon D Polishook
Keith C Silverman
Sheo B Singh
Deborah L Zink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9606502.4A external-priority patent/GB9606502D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0842291A1 publication Critical patent/EP0842291A1/de
Publication of EP0842291A4 publication Critical patent/EP0842291A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EP96925425A 1995-07-25 1996-07-22 Inhibitoren der farnesyl-protein transferase Withdrawn EP0842291A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US141495P 1995-07-25 1995-07-25
US1414 1995-07-25
GBGB9606502.4A GB9606502D0 (en) 1996-03-28 1996-03-28 Inhibitors of farnesyl-protein transferase
GB9606502 1996-03-28
PCT/US1996/012114 WO1997005270A1 (en) 1995-07-25 1996-07-22 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
EP0842291A1 EP0842291A1 (de) 1998-05-20
EP0842291A4 true EP0842291A4 (de) 1998-11-11

Family

ID=26309006

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96925425A Withdrawn EP0842291A4 (de) 1995-07-25 1996-07-22 Inhibitoren der farnesyl-protein transferase

Country Status (5)

Country Link
EP (1) EP0842291A4 (de)
JP (1) JPH11510388A (de)
AU (1) AU706341B2 (de)
CA (1) CA2227369A1 (de)
WO (1) WO1997005270A1 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2003956A1 (en) * 1988-11-28 1990-05-28 Sankyo Company, Limited New platelet activating factor antagonists, named "the phomactins", their preparation and use
US5082489A (en) * 1990-02-06 1992-01-21 The Royal Institution For The Advancement Of Learning (Mcgill University) Composition for biocontrol of wild buckwheat
US5364948A (en) * 1991-08-02 1994-11-15 Merck & Co., Inc. Biologically active compounds isolated from aerobic fermentation of Trichoderma viride
US5310949A (en) * 1992-09-02 1994-05-10 Merck & Co., Inc. Cholesterol lowering compounds
US5254727A (en) * 1992-10-19 1993-10-19 Merck & Co., Inc. Acyclic tricarboxylic acid compounds
EP0677513B1 (de) * 1994-04-15 1999-08-18 Takeda Chemical Industries, Ltd. Octahydro-2-Naphthalincarbonsäure-Derivate, ihre Herstellung und Verwendung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9705270A1 *

Also Published As

Publication number Publication date
CA2227369A1 (en) 1997-02-13
AU706341B2 (en) 1999-06-17
AU6594096A (en) 1997-02-26
EP0842291A1 (de) 1998-05-20
WO1997005270A1 (en) 1997-02-13
JPH11510388A (ja) 1999-09-14

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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