EP0838265B1 - Zentrifugal betätigter Rotationsmechanismus für Röhrchen - Google Patents

Zentrifugal betätigter Rotationsmechanismus für Röhrchen Download PDF

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Publication number
EP0838265B1
EP0838265B1 EP97307161A EP97307161A EP0838265B1 EP 0838265 B1 EP0838265 B1 EP 0838265B1 EP 97307161 A EP97307161 A EP 97307161A EP 97307161 A EP97307161 A EP 97307161A EP 0838265 B1 EP0838265 B1 EP 0838265B1
Authority
EP
European Patent Office
Prior art keywords
block
cup
vessel
rotor
movement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97307161A
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English (en)
French (fr)
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EP0838265A2 (de
EP0838265A3 (de
Inventor
Michael R. Walters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
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Becton Dickinson and Co
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Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of EP0838265A2 publication Critical patent/EP0838265A2/de
Publication of EP0838265A3 publication Critical patent/EP0838265A3/de
Application granted granted Critical
Publication of EP0838265B1 publication Critical patent/EP0838265B1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/02—Centrifuges consisting of a plurality of separate bowls rotating round an axis situated between the bowls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/10—Control of the drive; Speed regulating

Definitions

  • the present invention relates to an apparatus for producing rotation of a vessel about its longitudinal axis during centrifugation.
  • the apparatus of the present invention comprises: (a) a cup adapted to receive a vessel, (b) a block surrounding the cup in such a manner that the block may move in a direction parallel to the longitudinal axis when acted on by the centrifugal force, (c) a means for retarding this movement, (d) an oscillating means which encircles the cup (thereby providing for movement in a longitudinal and transverse direction), and (e) a pivoting means which connects the oscillating means to the block.
  • centrifuges typically provide for centrifugation by placing a vessel containing the sample to be subjected to centrifugation in a rotor (or other receiver adapted to contain the vessel) attached to the rotating mechanism. When the centrifuge is started, the force is applied in a direction parallel to the longitudinal axis of the vessel, toward the vessel bottom.
  • the present invention is directed to an apparatus for producing rotation of a vessel about its longitudinal axis during centrifugation.
  • the apparatus comprises: a cup adapted to receive a vessel, surrounded by a block in such a manner that the block may move in a direction parallel to the longitudinal axis when acted upon by the centrifugal force, this movement being slowed by a spring or other retarding means, and the cup also contains a cam or other oscillating means which encircles and preferably sinusoidally encircles, the cup, (thereby providing for movement in a longitudinal and transverse direction) and which is connected to the block by a pivoting means such as a cam follower.
  • the entire apparatus is of such a size that it will fit within a centrifuge rotor (or other receiver) without impeding the operation of the apparatus.
  • the block will be forced away from the vessel-containing end of the cup upon application of centrifugal force (e.g., by spinning the rotor) until the pivoting means reaches the outer edge of the oscillating means; decreasing the speed of the centrifuge will result in a decrease in centrifugal force, thereby allowing the retarding means to force the block toward the vessel end of the cup until the pivoting means reaches the other edge of the oscillating means, and thereby partially rotating the cup about its longitudinal axis.
  • centrifugal force e.g., by spinning the rotor
  • Figure 1 presents a depiction of one embodiment of an apparatus of the present invention.
  • Figure 2 presents a detail of a preferred oscillating means of this invention.
  • Figure 3 presents a depiction of another preferred embodiment of an apparatus of the present invention.
  • Figure 4 presents an overhead perspective view of the apparatus of the present invention shown in Figure 3.
  • the present invention is directed to an apparatus for producing rotation of a vessel about its longitudinal axis during centrifugation.
  • This apparatus adapted for placement in a centrifuge rotor in a centrifuge, comprises:
  • the apparatus comprises a cup (2) which has an end adapted to receive the vessel (1).
  • the cup (2) is encircled, and is preferably sinusoidally encircled, by an oscillating means (3) which is connected to the block (4) by a pivoting means (5) inside the block (4). Movement of the block (4) in the direction of the centrifugal force is retarded by the retarding means (6).
  • the oscillating means (3) is preferably a cam, and the pivoting means (5) is preferably a cam follower.
  • a preferred pattern for the oscillating means (3) is shown in Figure 2.
  • the retarding means (6) in this embodiment is, preferably, at least one spring.
  • the vessel (1) is a small diameter tube, such as those used in the QBCTM instruments marketed and sold by Becton Dickinson and Company.
  • Figure 3 shows another embodiment of the present invention.
  • the apparatus as shown in Figures 1 and 3 illustrates the mechanical processes of the centrifugally actuated tube rotator mechanism of the present invention.
  • the apparatus in each of Figures 1 and 3 uses centrifugal forces to move the associated parts required to achieve rotation of the vessel (1) about the axis of the vessel (1) while the centrifuge rotor is spinning.
  • the apparatus is comprised of a block (14) having a pivoting means (13) such as, preferably, a cam follower, an oscillating means such as, preferably, a cam or cam groove (not pictured), a retarding means comprising, preferably, at least two springs (15), and a cup (12) for placement of a vessel (1), wherein the vessel (1) is, preferably, a small diameter tube, or more preferably, a QBCTM tube as described above.
  • a pivoting means (13) such as, preferably, a cam follower, an oscillating means such as, preferably, a cam or cam groove (not pictured), a retarding means comprising, preferably, at least two springs (15), and a cup (12) for placement of a vessel (1), wherein the vessel (1) is, preferably, a small diameter tube, or more preferably, a QBCTM tube as described above.
  • centrifugal force acts upon the block (14) and the attached cam follower (13) to move the apparatus away from the centrifuge rotor center.
  • the cam follower (13) moves along a cam groove (as shown, for example, in Figure 2) on the outer circumference of the cup (12) (the cam groove is not shown in Figure 3) translating the linear movement of the block (14) and the cam follower (13) to a rotational movement of the cup (12).
  • the cup (12) is adapted to accept the vessel (1), therefore the rotational movement of the cup (12) translates directly to the vessel (1).

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  • Centrifugal Separators (AREA)

Claims (10)

  1. Vorrichtung zur Bewirkung der Längsrotation eines Gefäßes mit einer Längsachse, die für das Einsetzen in einen Zentrifugenrotor in einer Zentrifuge ausgelegt ist, wobei die Vorrichtung folgendes umfaßt:
    (i) eine zylindrische Schale mit einem Ende, das unter der Wirkung einer Zentrifugalkraft, die durch das Umlaufen des Rotors erzeugt wird, für die Aufnahme des Gefäßes ausgelegt ist,
    (ii) einen Block, der die Schale derartig umgibt, daß sich der Block unter der Wirkung der Zentrifugalkraft frei in einer Richtung parallel zur Längsachse des Gefäßes bewegen kann,
    (iii) ein Schwenkmittel, wobei das Schwenkmittel innen an dem Block befestigt ist,
    (iv) ein Schwingmittel an der Schale und am Block durch das Schwenkmittel befestigt, derartig, daß die Bewegung des Blocks in einer Richtung parallel zur Längsachse des Gefäßes die Bewegung des Schwenkmittels im Schwingmittel verursacht, und
    (v) ein Mittel zur Verzögerung der Bewegung des Blocks,
       wobei die Längsrotation durch Variieren der Drehzahl des Umlaufs des Rotors erreicht wird, derartig, daß der Block zweiseitig gerichtet bewegt wird, um dadurch die Rotation der für die Aufnahme des Gefäßes ausgelegten Schale zu verursachen.
  2. Vorrichtung nach Anspruch 1, bei der das Mittel zur Verzögerung der Bewegung des Blocks wenigstens eine Feder ist.
  3. Vorrichtung nach Anspruch 1, bei der das Schwingmittel an der Schale eine durchgängige Nut ist, welche die Schale sinusförmig umschließt, und das Schwingmittel die Bewegung sowohl in einer Längs- als auch einer Querrichtung gewährleistet.
  4. Vorrichtung nach Anspruch 1, bei der das Schwingmittel eine Kurve oder eine Kurvennut ist.
  5. Vorrichtung nach Anspruch 1, bei der das Schwenkmittel ein Kurvenstößel ist.
  6. Verfahren zur Bewirkung der Längsrotation eines Gefäßes mit einer Längsachse, bei dem eine Vorrichtung bereitgestellt wird, die für das Einsetzen in einen Zentrifugenrotor in einer Zentrifuge ausgelegt ist, wobei die Vorrichtung folgendes umfaßt:
    (i) eine zylindrische Schale mit einem Ende, das unter der Wirkung einer Zentrifugalkraft, die durch das Umlaufen des Rotors erzeugt wird, für die Aufnahme des Gefäßes ausgelegt ist,
    (ii) einen Block, der die Schale derartig umgibt, daß sich der Block unter der Wirkung der Zentrifugalkraft frei in einer Richtung parallel zur Längsachse des Gefäßes bewegen kann,
    (iii) ein Schwenkmittel, wobei das Schwenkmittel innen an dem Block befestigt ist,
    (iv) ein Schwingmittel an der Schale und am Block durch das Schwenkmittel befestigt, derartig, daß die Bewegung des Blocks in einer Richtung parallel zur Längsachse des Gefäßes die Bewegung des Schwenkmittels im Schwingmittel verursacht, und
    (v) ein Mittel zur Verzögerung der Bewegung des Blocks,
    bei dem das Verfahren folgendes umfaßt:
    a) Einsetzen der Vorrichtung in den Zentrifugenrotor,
    b) Einsetzen eines Gefäßes in die Schale der Vorrichtung,
    c) Starten des Umlaufs des Rotors der Zentrifuge,
    d) Variieren der Drehzahl des Umlaufs des Rotors, derartig, daß der Block der Vorrichtung bei der Verringerung der Rotordrehzahl zweiseitig gerichtet bewegt wird, um die Schale zu drehen, und
    e) Erreichen der Längsrotation des Gefäßes.
  7. Verfahren nach Anspruch 6, bei dem das Mittel zur Verzögerung der Bewegung des Blocks wenigstens eine Feder ist.
  8. Verfahren nach Anspruch 6, bei dem das Schwingmittel an der Schale eine durchgängige Nut ist, welche die Schale sinusförmig umschließt, und das Schwingmittel die Bewegung sowohl in einer Längs- als auch einer Querrichtung gewährleistet.
  9. Verfahren nach Anspruch 6, bei dem das Schwingmittel eine Kurve oder eine Kurvennut ist.
  10. Verfahren nach Anspruch 6, bei dem das Schwenkmittel ein Kurvenstößel ist.
EP97307161A 1996-09-25 1997-09-15 Zentrifugal betätigter Rotationsmechanismus für Röhrchen Expired - Lifetime EP0838265B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US721782 1985-04-10
US72178296A 1996-09-25 1996-09-25
US91843797A 1997-08-26 1997-08-26
US918437 1997-08-26
2000-02-22

Publications (3)

Publication Number Publication Date
EP0838265A2 EP0838265A2 (de) 1998-04-29
EP0838265A3 EP0838265A3 (de) 1999-03-17
EP0838265B1 true EP0838265B1 (de) 2002-06-05

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Application Number Title Priority Date Filing Date
EP97307161A Expired - Lifetime EP0838265B1 (de) 1996-09-25 1997-09-15 Zentrifugal betätigter Rotationsmechanismus für Röhrchen

Country Status (6)

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EP (1) EP0838265B1 (de)
KR (1) KR19980024909A (de)
CA (1) CA2216056C (de)
DE (1) DE69713025T2 (de)
ES (1) ES2177906T3 (de)
SG (1) SG55488A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080366A (en) * 1998-03-02 2000-06-27 Becton, Dickinson And Company Disposable blood tube holder
GB2349108B (en) * 1999-02-09 2001-03-28 Michael Cole Centrifugal evaporator
FR2797202B1 (fr) * 1999-08-02 2001-10-26 Genomic Equipement pour l'extraction automatique d'acides nucleiques
US10940491B1 (en) * 2018-04-25 2021-03-09 Spherical Holdings, Llc Centrifuge operating with sinusoidal motion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850368A (en) * 1973-02-12 1974-11-26 Kennametal Inc Apparatus for centrifugal compaction
GB2190489A (en) * 1986-02-28 1987-11-18 Automated Diagnostic Systems Specimen processing system

Also Published As

Publication number Publication date
DE69713025D1 (de) 2002-07-11
SG55488A1 (en) 1998-12-21
CA2216056A1 (en) 1998-03-25
DE69713025T2 (de) 2002-12-19
EP0838265A2 (de) 1998-04-29
EP0838265A3 (de) 1999-03-17
ES2177906T3 (es) 2002-12-16
CA2216056C (en) 2000-05-23
KR19980024909A (ko) 1998-07-06

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