EP0806475A3 - Filter apparatus and method of separating micro-tissues of an organism using said filter apparatus - Google Patents

Filter apparatus and method of separating micro-tissues of an organism using said filter apparatus Download PDF

Info

Publication number
EP0806475A3
EP0806475A3 EP97400715A EP97400715A EP0806475A3 EP 0806475 A3 EP0806475 A3 EP 0806475A3 EP 97400715 A EP97400715 A EP 97400715A EP 97400715 A EP97400715 A EP 97400715A EP 0806475 A3 EP0806475 A3 EP 0806475A3
Authority
EP
European Patent Office
Prior art keywords
filter apparatus
porosity
housing
compressive state
filter member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP97400715A
Other languages
German (de)
French (fr)
Other versions
EP0806475A2 (en
EP0806475B1 (en
Inventor
Yoshitaka c/o Terumo Kabushiki Kaisha Ohmura
Noboru c/o Terumo Kabushiki Kaisha Taguchi
Tadashi c/o Terumo Kabushiki Kaisha Sameshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of EP0806475A2 publication Critical patent/EP0806475A2/en
Publication of EP0806475A3 publication Critical patent/EP0806475A3/en
Application granted granted Critical
Publication of EP0806475B1 publication Critical patent/EP0806475B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1218—Layers having the same chemical composition, but different properties, e.g. pore size, molecular weight or porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Water Supply & Treatment (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Filtration Of Liquid (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)

Abstract

A filter apparatus (1B) is formed by a housing (2), a filter member (5) disposed in the housing (2), flow-passage maintaining members (6a and 6b) disposed on the two sides of the filter member (5), screw thread portions (32) and thread grooves (44) which are a porosity changing unit. The housing (2) is formed by a first housing member (3) having a first port (31) and a second housing member (4) having a second port (41). The filter member (5) is formed by stacking a plurality of porous polymer sheets (51). It is preferable that the porous polymer sheets (51) have gradient of physical or chemical characteristic in a direction of stacking. By operating the porosity changing means, the filter member (5) is set to a compressive state or a non-compressive state. In the compressive state, a first porosity capable of capturing the objective cells is set. In the non-compressive state, a second porosity which is higher than the first porosity is set.
EP97400715A 1996-03-28 1997-03-28 Method of separating cells from blood Expired - Lifetime EP0806475B1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP9919996 1996-03-28
JP9919996 1996-03-28
JP99199/96 1996-03-28
JP26531396 1996-09-13
JP265313/96 1996-09-13
JP26531396 1996-09-13
JP5711597 1997-02-26
JP57115/97 1997-02-26
JP05711597A JP3322595B2 (en) 1996-03-28 1997-02-26 Filter device and method for separating / collecting biological microstructure

Publications (3)

Publication Number Publication Date
EP0806475A2 EP0806475A2 (en) 1997-11-12
EP0806475A3 true EP0806475A3 (en) 2001-01-17
EP0806475B1 EP0806475B1 (en) 2003-05-14

Family

ID=27296151

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97400715A Expired - Lifetime EP0806475B1 (en) 1996-03-28 1997-03-28 Method of separating cells from blood

Country Status (4)

Country Link
US (1) US6139757A (en)
EP (1) EP0806475B1 (en)
JP (1) JP3322595B2 (en)
DE (1) DE69721893T2 (en)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69834809T2 (en) * 1997-04-08 2007-05-16 Pall Corp. METHOD FOR OBTAINING RARE CELLS FROM BLOOD PRODUCTS
EP0919249B1 (en) * 1997-11-20 2005-01-12 Nipro Corporation A blood filter set and a method of recovering blood components by use of the same
US6120474A (en) * 1997-12-15 2000-09-19 Nissho Corporation Blood component-recovering apparatus and a method for recovering blood components using the same
FR2782730B1 (en) * 1998-08-25 2002-05-17 Biocom Sa CELL SEPARATION PROCESS FOR THE ISOLATION OF PATHOGENIC CELLS, PARTICULARLY RARE CANCERES, EQUIPMENT AND REAGENT FOR IMPLEMENTING THE PROCESS AND APPLICATION OF THE PROCESS
JP3517359B2 (en) 1998-09-14 2004-04-12 テルモ株式会社 Cell separation / collection apparatus and cell separation / collection method
JP2000179616A (en) * 1998-12-11 2000-06-27 Daido Metal Co Ltd Sliding member
US6331246B1 (en) * 2000-05-08 2001-12-18 Stryker Corporation Waste filter and manifold system
WO2002005934A2 (en) * 2000-05-31 2002-01-24 Pall Corporation Membrane packets, methods for making membrane packets, and membrane packet assemblies
DE10036174B4 (en) * 2000-07-25 2006-12-07 Axaron Bioscience Ag Method and apparatus for analyzing chemical or biological samples
JP4792662B2 (en) * 2001-05-31 2011-10-12 Ｊｎｃ株式会社 Production method of porous sheet
US6623959B2 (en) * 2001-06-13 2003-09-23 Ethicon, Inc. Devices and methods for cell harvesting
EP1436405A4 (en) * 2001-08-20 2006-01-04 Whatman Inc Dna purification and recovery from high particulate and solids samples
JP4531310B2 (en) * 2001-09-07 2010-08-25 旭化成メディカル株式会社 Biological component separation filter holder, filter unit, and blood filtration filter performance evaluation method using the same
US7595043B2 (en) * 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
KR100930139B1 (en) 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. Systems and Methods for treating Patients with Processed Lipoaspirate Cells
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US20050095228A1 (en) * 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US9597395B2 (en) * 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US8404229B2 (en) * 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
DE60300826T2 (en) * 2002-01-25 2006-05-18 Inoac Corp., Nagoya fluid filter
ITTO20020736A1 (en) * 2002-08-21 2004-02-22 Fresenius Hemocare Italia Srl LEukocyte filter and its use for the depletion of leukocyte blood products.
EP1580551B1 (en) * 2002-11-19 2013-02-20 Sekisui Medical Co., Ltd. Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane
ATE498680T1 (en) * 2003-10-10 2011-03-15 Asahi Kasei Kuraray Medical Co METHOD FOR PRODUCING A CELL CONCENTRATE AND A CELL COMPOSITION
US7497340B2 (en) * 2004-02-19 2009-03-03 Stryker Corporation Manifold and filter assembly with filter basket
US20100099112A1 (en) * 2004-06-02 2010-04-22 Siliang Zhou Quantitative lateral flow system and assay
US20050279695A1 (en) * 2004-06-17 2005-12-22 Millipore Corporation Disposable integral filter unit
ATE479096T1 (en) 2004-07-29 2010-09-15 Relia Diagnostic Systems Llc CROSS-FLOW SYSTEM AND ASSAY
EP1844434A4 (en) * 2005-01-10 2013-11-13 Cytori Therapeutics Inc Devices and methods for monitoring, managing, and servicing medical devices
EP1924306A2 (en) * 2005-09-16 2008-05-28 BG Implant, Inc. Glaucoma treatment devices and methods
JP4855119B2 (en) 2006-03-28 2012-01-18 テルモ株式会社 Filter member and artificial lung
JP5103003B2 (en) * 2006-11-09 2012-12-19 シスメックス株式会社 Cell processing equipment
US20070278154A1 (en) * 2006-05-30 2007-12-06 Sysmex Corporation Cell processing method and cell processing apparatus
US20090304644A1 (en) * 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
US20100015104A1 (en) * 2006-07-26 2010-01-21 Cytori Therapeutics, Inc Generation of adipose tissue and adipocytes
JP5243456B2 (en) * 2007-03-02 2013-07-24 スミス アンド ネフュー ピーエルシー Filter cleaning apparatus and method with ultrasonic, backwash and filter motion during biological sample filtration
WO2009073724A1 (en) * 2007-12-04 2009-06-11 Ingeneron, Inc. Apparatus and methods for cell isolation
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
JP5629683B2 (en) 2008-07-25 2014-11-26 スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ Separator controller
JP5077141B2 (en) * 2008-08-18 2012-11-21 京三電機株式会社 filter
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US8865199B2 (en) * 2008-11-17 2014-10-21 Ingeneron, Inc. Biomatrix composition and methods of biomatrix seeding
AU2010242780B2 (en) 2009-05-01 2016-04-21 Puregraft Llc Systems, methods and compositions for optimizing tissue and cell enriched grafts
CN102260628A (en) * 2010-05-31 2011-11-30 上海康德莱企业发展集团医疗器械有限公司 Device for filtering, screening, enriching and quick-compositing stem cells
KR101254675B1 (en) 2010-10-25 2013-04-15 주식회사 싸이토젠 Cells collection apparatus
US9204868B2 (en) 2011-12-02 2015-12-08 Interscope, Inc. Methods and apparatus for removing material from within a mammalian cavity using an insertable endoscopic instrument
US8882680B2 (en) 2011-12-02 2014-11-11 Interscope, Inc. Insertable endoscopic instrument for tissue removal
CN104023968B (en) * 2011-12-22 2017-05-24 帝斯曼知识产权资产管理有限公司 Multilayered woven manufacture and use of the multilayer woven manufacture as carriers for dried matrix spot applications
KR101404507B1 (en) * 2012-04-12 2014-06-10 한국과학기술원 Particle processing device using combination of multiple membrane structures
CN104321130B (en) 2012-05-30 2017-11-17 通用电气健康护理生物科学股份公司 Filter cartridge and filter cartridge stack
US20150017715A1 (en) * 2013-07-11 2015-01-15 Celltraffix, Inc. Cell collection device and method
WO2015019889A1 (en) * 2013-08-09 2015-02-12 日立化成株式会社 Cell trapping device, cell trapping system, and production method for cell trapping device
JP6165574B2 (en) * 2013-09-26 2017-07-19 シスメックス株式会社 Filter member and cell acquisition method
US9067172B1 (en) * 2014-01-28 2015-06-30 Air Products And Chemicals, Inc. Solid-state membrane module
US20150209721A1 (en) * 2014-01-28 2015-07-30 Air Products And Chemicals, Inc. Solid-State Membrane Module
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9764323B2 (en) * 2014-09-18 2017-09-19 Waters Technologies Corporation Device and methods using porous media in fluidic devices
KR20170066540A (en) 2014-10-09 2017-06-14 일루미나, 인코포레이티드 Method and device for separating immiscible liquids to effectively isolate at least one of the liquids
AU2015374033B2 (en) 2014-12-31 2020-07-02 Microoptx Inc. Glaucoma treatment devices and methods
CN116206744A (en) 2015-06-25 2023-06-02 甘布罗伦迪亚股份公司 Medical device systems and methods with distributed databases
AU2016331925B2 (en) 2015-09-30 2021-04-22 Microoptx Inc. Dry eye treatment devices and methods
US20170128934A1 (en) * 2015-11-10 2017-05-11 Neoteryx, Llc Plasma extraction device
EP3429453B1 (en) * 2016-03-15 2022-04-06 Interscope, Inc. Surgical console, specimen receiver, and insertable endoscopic instrument for tissue removal
KR102476516B1 (en) 2016-12-21 2022-12-09 감브로 룬디아 아베 A medical device system that includes an information technology infrastructure with secure cluster domains supporting external domains.
WO2019050251A1 (en) 2017-09-05 2019-03-14 이준석 Device for reducing size of biological tissue
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DE102018004521A1 (en) * 2018-06-07 2019-12-12 Sartorius Stedim Biotech Gmbh Serial arrangement with multiple layers of asymmetric filter media, manufacturing process, filtration unit, use of the array, and characterization procedures
EP3906986B1 (en) * 2019-03-12 2023-05-10 Terumo Kabushiki Kaisha Filtration device
KR20200119443A (en) 2019-04-09 2020-10-20 이준석 Method for separating target material from biological tissue
KR102202861B1 (en) * 2019-04-09 2021-01-18 이준석 Apparatus for changing screen, system for reducing size of biological tissue comprising the same, method of using the same and method of separating target material from biological tissue associated therewith
KR102066590B1 (en) * 2019-06-21 2020-01-15 주식회사 한국바이오 셀프 Particle processing device and using method thereof
US11471711B2 (en) * 2020-04-30 2022-10-18 Medibotics Llc Smart mask with a transparent mouth-covering portion and impellor- driven air filtration
DE102020216578B4 (en) * 2020-12-28 2023-02-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Device and method for separating differently sized particles in a liquid and uses of the device
JP2024037475A (en) * 2022-09-07 2024-03-19 株式会社日立ハイテク Filtering device, filter fixing fixture and filtering method
WO2024063175A1 (en) * 2022-09-22 2024-03-28 연세대학교 원주산학협력단 Microplastic sampling and size distribution device

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3747769A (en) * 1971-08-02 1973-07-24 R Brumfield Compressible disposable filter press for blood
FR2328498A1 (en) * 1975-10-23 1977-05-20 Bauakademie Ddr Filters made of perforated elastic sheet - which is stretched to vary aperture size, esp. for removing water from concrete mixts.
US4828705A (en) * 1986-10-31 1989-05-09 Kingston Technologies, Inc. Pressure-dependent anisotropic-transport membrane system
US4889626A (en) * 1988-11-17 1989-12-26 Memron, Inc. Filter cartridge having a tunable asymmetric fluoropolymer alloy filter membrane
WO1992000798A1 (en) * 1990-07-13 1992-01-23 Lanmark Consultants Limited Improvements in or relating to flow control
US5160616A (en) * 1988-12-12 1992-11-03 Public Health Laboratory Service Board Filtering apparatus
WO1995017238A1 (en) * 1993-12-21 1995-06-29 Genera Technologies Limited Filtration method and apparatus
DE19519804A1 (en) * 1995-05-31 1996-12-05 Juergen Dr Schrezenmeir Bioactive capsule has multi-layered sheath of variable porosity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0553288T3 (en) * 1990-10-18 1997-12-29 Cellpro Inc Apparatus and method for separating particles using a resilient container
US5498336A (en) * 1991-02-22 1996-03-12 Terumo Kabushiki Kaisha Leukocyte-removing filter and leukocyte-removing apparatus furnished therewith
EP0598909B1 (en) * 1992-02-12 1998-01-14 Mitsubishi Rayon Co., Ltd. Hollow yarn membrane module
WO1993024649A1 (en) * 1992-05-29 1993-12-09 The Regents Of The University Of California Cryptosporidium polypeptides, nucleic acid, vectors and methods of use
US5616457A (en) * 1995-02-08 1997-04-01 University Of South Florida Method and apparatus for the detection and classification of microorganisms in water

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3747769A (en) * 1971-08-02 1973-07-24 R Brumfield Compressible disposable filter press for blood
FR2328498A1 (en) * 1975-10-23 1977-05-20 Bauakademie Ddr Filters made of perforated elastic sheet - which is stretched to vary aperture size, esp. for removing water from concrete mixts.
US4828705A (en) * 1986-10-31 1989-05-09 Kingston Technologies, Inc. Pressure-dependent anisotropic-transport membrane system
US4889626A (en) * 1988-11-17 1989-12-26 Memron, Inc. Filter cartridge having a tunable asymmetric fluoropolymer alloy filter membrane
US5160616A (en) * 1988-12-12 1992-11-03 Public Health Laboratory Service Board Filtering apparatus
WO1992000798A1 (en) * 1990-07-13 1992-01-23 Lanmark Consultants Limited Improvements in or relating to flow control
WO1995017238A1 (en) * 1993-12-21 1995-06-29 Genera Technologies Limited Filtration method and apparatus
DE19519804A1 (en) * 1995-05-31 1996-12-05 Juergen Dr Schrezenmeir Bioactive capsule has multi-layered sheath of variable porosity

Also Published As

Publication number Publication date
EP0806475A2 (en) 1997-11-12
DE69721893D1 (en) 2003-06-18
EP0806475B1 (en) 2003-05-14
JPH10137557A (en) 1998-05-26
JP3322595B2 (en) 2002-09-09
US6139757A (en) 2000-10-31
DE69721893T2 (en) 2004-02-19

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