EP0804235A4 - ANTIBODIES AGAINST SELECTIN P AND USES THEREOF - Google Patents

ANTIBODIES AGAINST SELECTIN P AND USES THEREOF

Info

Publication number
EP0804235A4
EP0804235A4 EP94917301A EP94917301A EP0804235A4 EP 0804235 A4 EP0804235 A4 EP 0804235A4 EP 94917301 A EP94917301 A EP 94917301A EP 94917301 A EP94917301 A EP 94917301A EP 0804235 A4 EP0804235 A4 EP 0804235A4
Authority
EP
European Patent Office
Prior art keywords
selectin
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94917301A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0804235A1 (en
Inventor
Robert W Chesnut
Margaret J Polley
James C Paulson
S Tarran Jones
Jose W Saldanha
Mary M Bendig
Michael Kriegler
Carl Perez
Robert Bayer
Michael Nunn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeres Biomedical Ltd
Original Assignee
Aeres Biomedical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/004274 external-priority patent/WO1993021956A1/en
Priority claimed from US08/202,047 external-priority patent/US5800815A/en
Application filed by Aeres Biomedical Ltd filed Critical Aeres Biomedical Ltd
Publication of EP0804235A1 publication Critical patent/EP0804235A1/en
Publication of EP0804235A4 publication Critical patent/EP0804235A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP94917301A 1993-05-04 1994-05-04 ANTIBODIES AGAINST SELECTIN P AND USES THEREOF Withdrawn EP0804235A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
WOPCT/US93/04274 1993-05-04
PCT/US1993/004274 WO1993021956A1 (en) 1992-05-05 1993-05-04 Antibodies to p-selectin and their uses
US5729293A 1993-05-05 1993-05-05
US57292 1993-05-05
US08/202,047 US5800815A (en) 1903-05-05 1994-02-25 Antibodies to P-selectin and their uses
US202047 1994-02-25
PCT/US1994/004935 WO1994025067A1 (en) 1993-05-04 1994-05-04 Antibodies to p-selectin and their uses

Publications (2)

Publication Number Publication Date
EP0804235A1 EP0804235A1 (en) 1997-11-05
EP0804235A4 true EP0804235A4 (en) 2001-09-19

Family

ID=27369213

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94917301A Withdrawn EP0804235A4 (en) 1993-05-04 1994-05-04 ANTIBODIES AGAINST SELECTIN P AND USES THEREOF

Country Status (3)

Country Link
EP (1) EP0804235A4 (sv)
FI (1) FI955261A (sv)
WO (1) WO1994025067A1 (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6155896A (en) * 1995-06-07 1996-12-30 Cytel Corporation Humanized antibodies to e-selectin
AU6390696A (en) * 1995-06-20 1997-01-22 Trustees Of Boston University Hypoxia-responsive adhesion molecules, specific antibodies, nd their uses
WO1999018442A1 (en) * 1997-10-07 1999-04-15 Centocor, Inc. Diagnosis of thrombotic events by detecting p-selectin
AU2012200852B2 (en) * 2004-04-13 2012-10-18 F. Hoffmann-La Roche Ag Anti-P-selectin antibodies
PL1737891T3 (pl) * 2004-04-13 2013-08-30 Hoffmann La Roche Przeciwciała przeciw selektynie p
US8945565B2 (en) 2006-12-01 2015-02-03 Selexys Pharmaceuticals Corporation Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
US20110212096A1 (en) 2006-12-01 2011-09-01 Scott Rollins Anti-p-selectin antibodies and methods of their use and identification
PT2662091T (pt) 2006-12-01 2018-12-03 Novartis Ag Anticorpos anti-p-selectina e métodos para os utilizar no tratamento de doenças inflamatórias
WO2009046978A1 (en) * 2007-10-12 2009-04-16 F. Hoffmann-La Roche Ag Protein expression from multiple nucleic acids
WO2019025847A1 (en) 2017-08-04 2019-02-07 Novartis Ag TREATMENT DIAGRAMS
KR20210003086A (ko) 2018-03-08 2021-01-11 노파르티스 아게 항-p-셀렉틴 항체의 용도
WO2020247698A1 (en) 2019-06-07 2020-12-10 Novartis Ag Use of an anti-p-selectin antibody
EP4010019A1 (en) 2019-08-08 2022-06-15 Novartis AG Use of the anti-p-selectin antibody crizanlizumab for treating sickle cell nephropathy and chronic kidney disease associated with sickle cell disease
EP4213878A4 (en) * 2020-09-16 2024-07-03 Univ Ramot METHODS OF TREATMENT OF GLIOBLASTOMA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021956A1 (en) * 1992-05-05 1993-11-11 Cytel Corporation Antibodies to p-selectin and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
CA2067250C (en) * 1989-10-20 2008-06-17 Bruce Furie Inhibition of padgem-mediated cell binding
EP1400536A1 (en) * 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021956A1 (en) * 1992-05-05 1993-11-11 Cytel Corporation Antibodies to p-selectin and their uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CARLOS T M ET AL: "Membrane proteins involved in phagocyte adherence to endothelium.", IMMUNOLOGICAL REVIEWS, (1990 APR) 114 5-28. REF: 122, XP001008136 *
See also references of WO9425067A1 *
SHARAR S R ET AL: "P - selectin blockade does not impair leukocyte host defense against bacterial peritonitis and soft tissue infection in rabbits.", JOURNAL OF IMMUNOLOGY, (1993 NOV 1) 151 (9) 4982-8., XP000999480 *

Also Published As

Publication number Publication date
WO1994025067A1 (en) 1994-11-10
FI955261A0 (sv) 1995-11-02
FI955261A (sv) 1996-01-03
EP0804235A1 (en) 1997-11-05

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Legal Events

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