EP0799243A4 - PROTEINES p53 A DOMAINES DE TETRAMERISATION MODIFIES - Google Patents

PROTEINES p53 A DOMAINES DE TETRAMERISATION MODIFIES

Info

Publication number
EP0799243A4
EP0799243A4 EP95941474A EP95941474A EP0799243A4 EP 0799243 A4 EP0799243 A4 EP 0799243A4 EP 95941474 A EP95941474 A EP 95941474A EP 95941474 A EP95941474 A EP 95941474A EP 0799243 A4 EP0799243 A4 EP 0799243A4
Authority
EP
European Patent Office
Prior art keywords
proteins
tetramerization domains
altered
altered tetramerization
domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95941474A
Other languages
German (de)
English (en)
Other versions
EP0799243A1 (fr
Inventor
Thanos D Halazonetis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wistar Institute of Anatomy and Biology
Original Assignee
Wistar Institute of Anatomy and Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/347,792 external-priority patent/US5573925A/en
Priority claimed from US08/431,357 external-priority patent/US5721340A/en
Application filed by Wistar Institute of Anatomy and Biology filed Critical Wistar Institute of Anatomy and Biology
Publication of EP0799243A1 publication Critical patent/EP0799243A1/fr
Publication of EP0799243A4 publication Critical patent/EP0799243A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP95941474A 1994-11-28 1995-11-27 PROTEINES p53 A DOMAINES DE TETRAMERISATION MODIFIES Withdrawn EP0799243A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/347,792 US5573925A (en) 1994-11-28 1994-11-28 P53 proteins with altered tetramerization domains
US347792 1994-11-28
US431357 1995-04-28
US08/431,357 US5721340A (en) 1994-11-28 1995-04-28 p53 proteins with altered tetramerization domains
US45662395A 1995-06-01 1995-06-01
US456623 1995-06-01
PCT/US1995/015353 WO1996016989A1 (fr) 1994-11-28 1995-11-27 PROTEINES p53 A DOMAINES DE TETRAMERISATION MODIFIES

Publications (2)

Publication Number Publication Date
EP0799243A1 EP0799243A1 (fr) 1997-10-08
EP0799243A4 true EP0799243A4 (fr) 1998-08-19

Family

ID=27407795

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95941474A Withdrawn EP0799243A4 (fr) 1994-11-28 1995-11-27 PROTEINES p53 A DOMAINES DE TETRAMERISATION MODIFIES

Country Status (3)

Country Link
EP (1) EP0799243A4 (fr)
AU (1) AU4288496A (fr)
WO (1) WO1996016989A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736915B1 (fr) 1995-07-19 1997-08-22 Rhone Poulenc Rorer Sa Variants de la proteine p53 et utilisations therapeutiques
US5847083A (en) * 1996-08-21 1998-12-08 The Wistar Institute Of Anatomy And Biology Modified p53 constructs which enhance DNA binding
WO1998006753A2 (fr) * 1996-08-13 1998-02-19 Trustees Of Princeton University Mutant de p53
CN1261803A (zh) 1997-07-01 2000-08-02 埃瑟若詹尼克斯公司 抗氧化剂增强对细胞过度增生性疾病的治疗
US6388062B1 (en) 1998-05-08 2002-05-14 The Wistar Institute Of Anatomy And Biology Modified p53 tetramerization domains having hydrophobic amino acid substitutions
EP1179062A2 (fr) * 1999-05-12 2002-02-13 Xencor, Inc. Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies
WO2001009325A2 (fr) * 1999-07-30 2001-02-08 The Government Of The United States Of America, Asrepresented By The Secretary, Dept. Of Health And Human Services Mutations du gene p53 humain, et systeme genetique de levures utilise pour l'identification fonctionnelle des mutations du gene p53 humain
US7256260B1 (en) 1999-07-30 2007-08-14 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, Nih Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations
US7081443B2 (en) 2002-05-21 2006-07-25 Korea Advanced Institutes Of Science And Technology (Kaist) Chimeric comp-ang1 molecule
FR2941230B1 (fr) * 2009-01-19 2011-03-18 Centre Nat Rech Scient Polypeptides d'adressage specifique a des cellules-cibles d'otx2
EP2970371B1 (fr) 2013-03-14 2019-07-31 Agrivida, Inc. Utilisation de domaines de dimérisation à des fins de régulation par la température de l'activité enzymatique

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HALAZONETIS T. D. ET AL.: "CONFORMATIONAL SHIFTS PROPAGATE FROM THE OLIGOMERIZATION DOMAIN OF P53 TO ITS TETRAMERIC DNA BINDING DOMAIN AND RESTORE DNA BINDING TO SELECT P53 MUTANTS", EMBO JOURNAL, vol. 12, no. 13, 1 January 1993 (1993-01-01), pages 5057 - 5064, XP002003078 *
PIETENPOL J. A. ET AL.: "SEQUENCE-SPECIFIC TRANSCRIPTIONAL ACTIVATION IS ESSENTIAL FOR GROWTH SUPPRESSION BY P53", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 91, March 1994 (1994-03-01), pages 1998 - 2002, XP002019922 *
See also references of WO9616989A1 *
WATERMAN J.L.F. ET AL.: "The dihedral symmetry of the p53 tetramerization domain mandates a conformational swith upon DNA binding.", EMBO JOURNAL, vol. 14, no. 3, 3 February 1995 (1995-02-03), pages 512 - 519, XP002067901 *

Also Published As

Publication number Publication date
WO1996016989A1 (fr) 1996-06-06
EP0799243A1 (fr) 1997-10-08
AU4288496A (en) 1996-06-19

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Legal Events

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