US6897044B1
(en)
*
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
GB0030378D0
(en)
|
2000-12-13 |
2001-01-24 |
Cyclacel Ltd |
Compound
|
WO2004021996A2
(en)
*
|
2002-09-06 |
2004-03-18 |
The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services |
Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
CA2545603A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
JPWO2008032833A1
(en)
*
|
2006-09-14 |
2010-01-28 |
株式会社医学生物学研究所 |
Antibody with enhanced ADCC activity and method for producing the same
|
BRPI0907046A2
(en)
*
|
2008-01-18 |
2015-07-28 |
Medimmune Llc |
Engineered cysteine antibody, isolated nucleic acid, vector, host cell, antibody conjugate, pharmaceutical composition, methods of detecting cancer, autoimmune, inflammatory or infectious disorders in an individual and inhibiting proliferation of a target cell
|
US20120003235A1
(en)
|
2008-12-31 |
2012-01-05 |
Biogen Idec Ma Inc. |
Anti-lymphotoxin antibodies
|
WO2011005481A1
(en)
*
|
2009-06-22 |
2011-01-13 |
Medimmune, Llc |
ENGINEERED Fc REGIONS FOR SITE-SPECIFIC CONJUGATION
|
EP2470559B1
(en)
|
2009-08-24 |
2017-03-22 |
Amunix Operating Inc. |
Coagulation factor ix compositions and methods of making and using same
|
HUE041426T2
(en)
|
2009-11-02 |
2019-05-28 |
Univ Washington |
Therapeutic nuclease compositions and methods
|
WO2012006635A1
(en)
|
2010-07-09 |
2012-01-12 |
Biogen Idec Hemophilia Inc. |
Processable single chain molecules and polypeptides made using same
|
KR102161657B1
(en)
|
2011-04-29 |
2020-10-06 |
유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 |
Therapeutic nuclease compositions and methods
|
WO2012170969A2
(en)
|
2011-06-10 |
2012-12-13 |
Biogen Idec Ma Inc. |
Pro-coagulant compounds and methods of use thereof
|
US9738707B2
(en)
|
2011-07-15 |
2017-08-22 |
Biogen Ma Inc. |
Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
|
UY34317A
(en)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
T cell antireceptor antibody (alpha) / ß
|
US20130108641A1
(en)
|
2011-09-14 |
2013-05-02 |
Sanofi |
Anti-gitr antibodies
|
CN104105708B
(en)
|
2011-12-05 |
2018-04-03 |
X博迪生物科学公司 |
Pdgf receptor β Binding peptides
|
LT2804623T
(en)
|
2012-01-12 |
2019-12-10 |
Bioverativ Therapeutics Inc |
Chimeric factor viii polypeptides and uses thereof
|
RS63870B1
(en)
|
2012-02-15 |
2023-01-31 |
Bioverativ Therapeutics Inc |
Factor viii compositions and methods of making and using same
|
WO2013123457A1
(en)
|
2012-02-15 |
2013-08-22 |
Biogen Idec Ma Inc. |
Recombinant factor viii proteins
|
SG10201702396QA
(en)
|
2012-03-28 |
2017-04-27 |
Sanofi Sa |
Antibodies to bradykinin b1 receptor ligands
|
MX2014013637A
(en)
|
2012-05-07 |
2015-02-05 |
Sanofi Sa |
Methods for preventing biofilm formation.
|
WO2013175276A1
(en)
|
2012-05-23 |
2013-11-28 |
Argen-X B.V |
Il-6 binding molecules
|
US10202595B2
(en)
|
2012-06-08 |
2019-02-12 |
Bioverativ Therapeutics Inc. |
Chimeric clotting factors
|
CN104519897A
(en)
|
2012-06-08 |
2015-04-15 |
比奥根艾迪克Ma公司 |
Procoagulant compounds
|
EP3404105A1
(en)
|
2012-07-06 |
2018-11-21 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
ES2770501T3
(en)
|
2012-07-11 |
2020-07-01 |
Bioverativ Therapeutics Inc |
Factor VIII complex with XTEN and Von Willebrand factor protein and its uses
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
PT2895513T
(en)
|
2012-09-12 |
2018-10-08 |
Genzyme Corp |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
CN115925957A
(en)
|
2013-02-08 |
2023-04-07 |
Irm责任有限公司 |
Specific sites for modifying antibodies to make immunoconjugates
|
HRP20231183T1
(en)
|
2013-02-15 |
2024-01-05 |
Bioverativ Therapeutics Inc. |
Optimized factor viii gene
|
SG11201506088RA
(en)
|
2013-03-11 |
2015-09-29 |
Genzyme Corp |
Hyperglycosylated binding polypeptides
|
TWI683666B
(en)
|
2013-03-15 |
2020-02-01 |
美商百歐維拉提夫治療公司 |
Factor ix polypeptide formulations
|
EP3875106A1
(en)
|
2013-08-08 |
2021-09-08 |
Bioverativ Therapeutics Inc. |
Purification of chimeric fviii molecules
|
TW201722994A
(en)
|
2013-08-13 |
2017-07-01 |
賽諾菲公司 |
Antibodies to Plasminogen Activator Inhibitor-1 (PAI-1) and uses thereof
|
EA033403B1
(en)
|
2013-08-13 |
2019-10-31 |
Sanofi Sa |
Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof
|
TWI667255B
(en)
|
2013-08-14 |
2019-08-01 |
美商生物化學醫療公司 |
Factor viii-xten fusions and uses thereof
|
WO2015048330A2
(en)
|
2013-09-25 |
2015-04-02 |
Biogen Idec Ma Inc. |
On-column viral inactivation methods
|
US10988745B2
(en)
|
2013-10-31 |
2021-04-27 |
Resolve Therapeutics, Llc |
Therapeutic nuclease-albumin fusions and methods
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
SG11201605242YA
(en)
|
2014-01-10 |
2016-07-28 |
Biogen Ma Inc |
Factor viii chimeric proteins and uses thereof
|
US10464997B2
(en)
*
|
2014-02-11 |
2019-11-05 |
Seattle Genetics, Inc. |
Selective reduction of proteins
|
HUE061339T2
(en)
|
2014-03-19 |
2023-06-28 |
Genzyme Corp |
Site-specific glycoengineering of targeting moieties
|
EP3712176A1
(en)
|
2014-03-21 |
2020-09-23 |
X-Body, Inc. |
Bi-specific antigen-binding polypeptides
|
BR112016022910A2
(en)
|
2014-04-11 |
2017-10-17 |
Medimmune Llc |
bispecific her2 antibodies
|
US11008561B2
(en)
|
2014-06-30 |
2021-05-18 |
Bioverativ Therapeutics Inc. |
Optimized factor IX gene
|
CU20170038A7
(en)
|
2014-09-26 |
2017-10-05 |
Bayer Pharma AG |
DERIVATIVES OF ADRENOMEDULIN STABILIZED ESPECIALLY USEFUL IN THE TREATMENT AND / OR PREVENTION OF CARDIOVASCULAR, EDEMATOS AND / OR INFLAMMATORY DISORDERS
|
AU2015330869B2
(en)
|
2014-10-09 |
2021-07-08 |
Genzyme Corporation |
Glycoengineered antibody drug conjugates
|
CA3203273A1
(en)
|
2014-10-14 |
2016-04-21 |
Halozyme, Inc. |
Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
|
KR20180021176A
(en)
*
|
2015-06-29 |
2018-02-28 |
이뮤노젠 아이엔씨 |
Conjugate of cysteine engineered antibody
|
UA126016C2
(en)
|
2015-08-03 |
2022-08-03 |
Біовератів Терапеутікс Інк. |
Factor ix fusion proteins and methods of making and using same
|
WO2017046746A1
(en)
|
2015-09-15 |
2017-03-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
|
EP3411478B1
(en)
|
2016-02-01 |
2022-06-08 |
Bioverativ Therapeutics Inc. |
Optimized factor viii genes
|
EP4410378A3
(en)
|
2016-07-01 |
2024-10-09 |
Resolve Therapeutics, LLC |
Optimized binuclease fusions and methods
|
TWI788307B
(en)
|
2016-10-31 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
|
EP3544983A2
(en)
|
2016-11-23 |
2019-10-02 |
Immunogen, Inc. |
Selective sulfonation of benzodiazepine derivatives
|
EP3548066A1
(en)
|
2016-12-02 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
US20200085915A1
(en)
|
2016-12-02 |
2020-03-19 |
Bioverativ Therapeutics Inc. |
Methods of inducing immune tolerance to clotting factors
|
AU2018205234B2
(en)
|
2017-01-06 |
2024-09-19 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists
|
EP3565586A1
(en)
|
2017-01-06 |
2019-11-13 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
|
US20200224161A1
(en)
|
2017-05-10 |
2020-07-16 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
KR20200035130A
(en)
|
2017-08-09 |
2020-04-01 |
바이오버라티브 테라퓨틱스 인크. |
Nucleic acid molecules and uses thereof
|
JP7374091B2
(en)
|
2017-08-22 |
2023-11-06 |
サナバイオ, エルエルシー |
Soluble interferon receptors and their uses
|
JP2021503885A
(en)
|
2017-11-22 |
2021-02-15 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Expanded culture of peripheral blood lymphocytes (PBL) from peripheral blood
|
CA3085765A1
(en)
|
2017-12-15 |
2019-06-20 |
Iovance Biotherapeutics, Inc. |
Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof
|
CA3090136A1
(en)
|
2018-02-01 |
2019-08-08 |
Bioverativ Therapeutics, Inc. |
Use of lentiviral vectors expressing factor viii
|
EP3752600A1
(en)
|
2018-02-13 |
2020-12-23 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists
|
CN112154153A
(en)
|
2018-03-28 |
2020-12-29 |
百时美施贵宝公司 |
Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
|
TW202015723A
(en)
|
2018-05-18 |
2020-05-01 |
美商百歐維拉提夫治療公司 |
Methods of treating hemophilia a
|
CN112867394B
(en)
|
2018-06-04 |
2024-09-13 |
马萨诸塞州渤健公司 |
Anti-VLA-4 antibodies with reduced effector function
|
JP7492463B2
(en)
|
2018-07-03 |
2024-05-29 |
ブリストル-マイヤーズ スクイブ カンパニー |
FGF-21 preparation
|
MX2021001599A
(en)
|
2018-08-09 |
2021-07-02 |
Bioverativ Therapeutics Inc |
Nucleic acid molecules and uses thereof for non-viral gene therapy.
|
TW202031273A
(en)
|
2018-08-31 |
2020-09-01 |
美商艾歐凡斯生物治療公司 |
Treatment of nsclc patients refractory for anti-pd-1 antibody
|
JP2022512899A
(en)
|
2018-11-05 |
2022-02-07 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Treatment of NSCLC patients refractory to anti-PD-1 antibody
|
AU2020204992A1
(en)
|
2019-01-04 |
2021-07-15 |
Resolve Therapeutics, Llc |
Treatment of sjogren's disease with nuclease fusion proteins
|
US20220133795A1
(en)
|
2019-03-01 |
2022-05-05 |
Iovance Biotherapeutics, Inc. |
Expansion of Tumor Infiltrating Lymphocytes From Liquid Tumors and Therapeutic Uses Thereof
|
CA3135032A1
(en)
|
2019-04-03 |
2020-10-08 |
Genzyme Corporation |
Anti-alpha beta tcr binding polypeptides with reduced fragmentation
|
WO2020254197A1
(en)
|
2019-06-18 |
2020-12-24 |
Bayer Aktiengesellschaft |
Adrenomedullin-analogues for long-term stabilization and their use
|
US20210113634A1
(en)
|
2019-09-30 |
2021-04-22 |
Bioverativ Therapeutics Inc. |
Lentiviral vector formulations
|
JP2023514152A
(en)
|
2020-02-06 |
2023-04-05 |
ブリストル-マイヤーズ スクイブ カンパニー |
IL-10 and its uses
|
CN115515643A
(en)
|
2020-02-28 |
2022-12-23 |
建新公司 |
Modified binding polypeptides for optimized drug conjugation
|
EP4171614A1
(en)
|
2020-06-29 |
2023-05-03 |
Resolve Therapeutics, LLC |
Treatment of sjogren's syndrome with nuclease fusion proteins
|
US20230372397A1
(en)
|
2020-10-06 |
2023-11-23 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
EP4259164A1
(en)
|
2020-12-11 |
2023-10-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
|
JP2023554395A
(en)
|
2020-12-17 |
2023-12-27 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Treatment with tumor-infiltrating lymphocyte therapy in combination with CTLA-4 and PD-1 inhibitors
|
JP2024500403A
(en)
|
2020-12-17 |
2024-01-09 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Treatment of cancer with tumor-infiltrating lymphocytes
|
CA3203382A1
(en)
|
2020-12-31 |
2022-07-07 |
Adrian Emanual Wells |
Devices and processes for automated production of tumor infiltrating lymphocytes
|
TW202241508A
(en)
|
2021-01-29 |
2022-11-01 |
美商艾歐凡斯生物治療公司 |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
EP4301138A2
(en)
|
2021-03-05 |
2024-01-10 |
Iovance Biotherapeutics, Inc. |
Tumor storage and cell culture compositions
|
WO2022198141A1
(en)
|
2021-03-19 |
2022-09-22 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
TW202305118A
(en)
|
2021-03-23 |
2023-02-01 |
美商艾歐凡斯生物治療公司 |
Cish gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
EP4314253A2
(en)
|
2021-03-25 |
2024-02-07 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for t-cell coculture potency assays and use with cell therapy products
|
EP4326287A2
(en)
|
2021-04-19 |
2024-02-28 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
JP2024519029A
(en)
|
2021-05-17 |
2024-05-08 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
PD-1 gene-edited tumor-infiltrating lymphocytes and their use in immunotherapy
|
WO2023004074A2
(en)
|
2021-07-22 |
2023-01-26 |
Iovance Biotherapeutics, Inc. |
Method for cryopreservation of solid tumor fragments
|
TW202327631A
(en)
|
2021-07-28 |
2023-07-16 |
美商艾歐凡斯生物治療公司 |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
JP2024535002A
(en)
|
2021-09-09 |
2024-09-26 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Process for generating TIL products using PD-1 TALEN knockdown
|
JP2024534581A
(en)
|
2021-09-24 |
2024-09-20 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Expansion process and agents for tumor-infiltrating lymphocytes
|
EP4166569A1
(en)
*
|
2021-10-18 |
2023-04-19 |
Fondazione IRCCS Istituto Nazionale dei Tumori |
Antibodies directed against alpha-folate receptor
|
AR127482A1
(en)
|
2021-10-27 |
2024-01-31 |
Iovance Biotherapeutics Inc |
SYSTEMS AND METHODS TO COORDINATE THE MANUFACTURE OF CELLS FOR PATIENT-SPECIFIC IMMUNOTHERAPY
|
AU2022388729A1
(en)
|
2021-11-10 |
2024-05-16 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
WO2023147488A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
WO2023147486A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Tumor infiltrating lymphocytes engineered to express payloads
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023220608A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
WO2024011114A1
(en)
|
2022-07-06 |
2024-01-11 |
Iovance Biotherapeutics, Inc. |
Devices and processes for automated production of tumor infiltrating lymphocytes
|
WO2024030758A1
(en)
|
2022-08-01 |
2024-02-08 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
WO2024062074A1
(en)
|
2022-09-21 |
2024-03-28 |
Sanofi Biotechnology |
Humanized anti-il-1r3 antibody and methods of use
|
WO2024089609A1
(en)
|
2022-10-25 |
2024-05-02 |
Ablynx N.V. |
Glycoengineered fc variant polypeptides with enhanced effector function
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
WO2024098027A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
WO2024112711A2
(en)
|
2022-11-21 |
2024-05-30 |
Iovance Biotherapeutics, Inc. |
Methods for assessing proliferation potency of gene-edited t cells
|
WO2024112571A2
(en)
|
2022-11-21 |
2024-05-30 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
|
WO2024151885A1
(en)
|
2023-01-13 |
2024-07-18 |
Iovance Biotherapeutics, Inc. |
Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
|