EP0792161A4 - MICROENCAPSULATED VACCINES BASED ON HYDROGEL - Google Patents

MICROENCAPSULATED VACCINES BASED ON HYDROGEL

Info

Publication number
EP0792161A4
EP0792161A4 EP94923417A EP94923417A EP0792161A4 EP 0792161 A4 EP0792161 A4 EP 0792161A4 EP 94923417 A EP94923417 A EP 94923417A EP 94923417 A EP94923417 A EP 94923417A EP 0792161 A4 EP0792161 A4 EP 0792161A4
Authority
EP
European Patent Office
Prior art keywords
hydrogel
microencapsulated
vaccines
microencapsulated vaccines
hydrogel microencapsulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94923417A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0792161A1 (en
Inventor
Alexander K Andrianov
Sharon A Jenkins
Lendon G Payne
Bryan E Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celldex Therapeutics Inc
Original Assignee
Virus Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/090,841 external-priority patent/US5562909A/en
Application filed by Virus Research Institute Inc filed Critical Virus Research Institute Inc
Publication of EP0792161A1 publication Critical patent/EP0792161A1/en
Publication of EP0792161A4 publication Critical patent/EP0792161A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • C08G79/025—Polyphosphazenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EP94923417A 1993-07-12 1994-07-11 MICROENCAPSULATED VACCINES BASED ON HYDROGEL Withdrawn EP0792161A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90841 1993-07-12
US08/090,841 US5562909A (en) 1993-07-12 1993-07-12 Phosphazene polyelectrolytes as immunoadjuvants
US147781 1993-11-04
US08/147,781 US5529777A (en) 1993-07-12 1993-11-04 Hydrogel microencapsulated vaccines
PCT/US1994/007749 WO1995002416A1 (en) 1993-07-12 1994-07-11 Hydrogel microencapsulated vaccines

Publications (2)

Publication Number Publication Date
EP0792161A1 EP0792161A1 (en) 1997-09-03
EP0792161A4 true EP0792161A4 (en) 1998-04-29

Family

ID=26782696

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94923417A Withdrawn EP0792161A4 (en) 1993-07-12 1994-07-11 MICROENCAPSULATED VACCINES BASED ON HYDROGEL

Country Status (8)

Country Link
EP (1) EP0792161A4 (pt)
JP (1) JPH09500132A (pt)
CN (1) CN1128953A (pt)
AU (1) AU690567B2 (pt)
BR (1) BR9407397A (pt)
CA (1) CA2167081A1 (pt)
NZ (1) NZ269411A (pt)
WO (1) WO1995002416A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM572294A0 (en) * 1994-05-18 1994-06-09 Vaccine Technologies Pty. Ltd. Delivery vehicle for bioactive molecule
US5674495A (en) * 1995-02-27 1997-10-07 Purdue Research Foundation Alginate-based vaccine compositions
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US5807757A (en) * 1996-07-02 1998-09-15 Virus Research Institute, Inc. Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
AU7563798A (en) * 1997-04-30 1998-11-24 Emory University Methods and compositions for administering dna to mucosal surfaces
DE69831421T2 (de) * 1997-12-02 2006-06-22 Archimedes Development Ltd. Zusammensetzungen zur nasalen verabreichung
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
DE60112073T2 (de) 2000-05-12 2006-04-20 Pharmacia & Upjohn Co. Llc, Kalamazoo Impfstoffzusammensetzung und verfahren zur herstellung derselben sowie verfahren zur impfung von wirbeltieren
US20040131631A1 (en) * 2002-11-22 2004-07-08 Alexander Andrianov Polyphosphazene immunostimulants
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
CA2513483C (en) 2003-01-17 2011-11-29 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
ES2360542T3 (es) * 2004-10-25 2011-06-06 Celonova Biosciences Germany Gmbh Partículas poliméricas cargables para aplicaciones terapéuticas y/o diagnósticos y procedimientos para preparar y utilizar las mismas.
KR100784485B1 (ko) 2006-01-18 2007-12-11 한국과학기술연구원 생분해성 온도 감응성 폴리포스파젠계 하이드로젤, 그의제조방법 및 그의 용도
WO2008100142A2 (en) * 2007-02-12 2008-08-21 Octoplus Sciences B.V. Vaccine formulation
EP1985284A1 (en) * 2007-04-25 2008-10-29 OctoPlus Sciences B.V. Vaccine formulation
EP2196196A1 (en) * 2008-12-10 2010-06-16 Medipol S.A. Compound, medicament, vaccine composition and nanocapsules
US8883717B2 (en) * 2012-03-30 2014-11-11 Artificial Cell Technologies, Inc. Antigenic compositions and methods
GB201212010D0 (en) * 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
KR20160095124A (ko) 2013-12-06 2016-08-10 어드밴스드 바이오뉴트리션 코포레이션 생물활성제의 경구 전달을 위한 조성물
WO2017075483A1 (en) * 2015-10-28 2017-05-04 University Of Maryland, College Park Multifunctional biodegradable carriers for drug delivery
CN105214100A (zh) * 2015-11-16 2016-01-06 中国医学科学院生物医学工程研究所 一种pH响应性微囊型蛋白质疫苗载体及制备方法
CN112618709B (zh) * 2019-09-24 2023-11-03 华南理工大学 一种猪口服接种疫苗缓释佐剂及其制备方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880622A (en) * 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
GB8826116D0 (en) * 1988-11-08 1988-12-14 Danbiosyst Ltd Adhesive drug delivery composition
US5032405A (en) * 1989-09-27 1991-07-16 Warner-Lambert Company Oral pharmaceutical composition for acid sensitive proteinaceous agents
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDRIANOV A K ET AL: "Controlled release using ionotropic polyphosphazene hydrogels.", JOURNAL OF CONTROLLED RELEASE 27 (1). 1993. 69-77, XP002055688 *
CHEMICAL ABSTRACTS, vol. 118, no. 16, 19 April 1993, Columbus, Ohio, US; abstract no. 154240, GILLEY, R. M. ET AL: "Microencapsulation and its application to vaccine development" XP002055689 *
CHEMICAL ABSTRACTS, vol. 119, no. 22, 29 November 1993, Columbus, Ohio, US; abstract no. 233952, ANDRIANOV, A. K. ET AL: "Polyphosphazene ionotropic gel microcapsules for controlled drug delivery" XP002055690 *
PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER., 19TH (1992), 110-11. EDITOR(S): KOPECEK, JINDRICH. PUBLISHER: CONTROLLED RELEASE SOC., DEERFIELD, ILL *
PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER., 20TH (1993), 26-7. EDITOR(S): ROSEMAN, THEODORE J.;PEPPAS, NICHOLAS A.; GABELNICK, HENRY L. PUBLISHER: CONTROLLED RELEASE SOC., DEERFIELD, ILL *
See also references of WO9502416A1 *

Also Published As

Publication number Publication date
JPH09500132A (ja) 1997-01-07
CN1128953A (zh) 1996-08-14
EP0792161A1 (en) 1997-09-03
CA2167081A1 (en) 1995-01-26
AU7328694A (en) 1995-02-13
AU690567B2 (en) 1998-04-30
NZ269411A (en) 2001-03-30
BR9407397A (pt) 1996-11-05
WO1995002416A1 (en) 1995-01-26

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