EP0779872B1 - Blister package with dessicant - Google Patents

Blister package with dessicant Download PDF

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Publication number
EP0779872B1
EP0779872B1 EP95928599A EP95928599A EP0779872B1 EP 0779872 B1 EP0779872 B1 EP 0779872B1 EP 95928599 A EP95928599 A EP 95928599A EP 95928599 A EP95928599 A EP 95928599A EP 0779872 B1 EP0779872 B1 EP 0779872B1
Authority
EP
European Patent Office
Prior art keywords
drying agent
sheet
cavities
blister package
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95928599A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0779872A1 (en
Inventor
Frank-Ulrich Flöther
Hanspeter GÜNTERT
Pedro Lorca
Stefan Merkle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Priority to SI9530204T priority Critical patent/SI0779872T1/xx
Publication of EP0779872A1 publication Critical patent/EP0779872A1/en
Application granted granted Critical
Publication of EP0779872B1 publication Critical patent/EP0779872B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3218—Details with special means for gaining access to the contents
    • B65D2575/3227—Cuts or weakening lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the present invention regards a blister package., particularly a blister package providing preparation cavities and drying agent cavities for packaging moisture sensitive solid or semi-solid pharmaceutical preparations.
  • blister package is used herein in its usual meaning, i.e. for any type of sheet package, preferably made of plastics and aluminum, which have cavities for the uptake of the solid to be packaged in the pan sheet (usually in the plastic sheet) and which are closed by sealing with a second sheet, a so called cover sheet, preferably a coated aluminum foil, whereby the product at its offtake can be pushed through the cover sheet by pressure on the pan sheet.
  • blister packages are a preferred packaging form for solid or semi-solid pharmaceutical preparations, respectively. They have the advantage that the preparations remain cleanly packed until they are used and furthermore - because of the usual labeling on the back side and/or on the top side - the risk of a mix-up is much reduced. Further advantages of the blister package are a reduced abrasion of the product, the possibility to get single units under retention of the primary package, water vapor resistance etc.
  • the moisture permeability with the today generally usual packages can only be improved by the material selection, i.e. as much as possible moisture impermeable laminate sheets.
  • particularly multilayer sheets have turned out to be suitable.
  • a known procedure exclusively uses aluminum composite films as pan sheet and cover sheet.
  • An additional drying effect can be achieved by providing two cavities connected with each other for air exchange, from which one comprises a drying agent and the other one the pharmaceutical preparation.
  • Such a package has the disadvantage that it is relatively expensive and that, particularly because of the lack of transparency, the risk for the erroneous intake of the drying agent instead of the effective substance comprising preparation exists. Besides of the possibly occurring side effects of some drying agents the non-consummation of the effective substance comprising preparation (pharmaceutical preparation) can very badly influence the state of health of the patient.
  • EP-A-0 466 068 describes a blister package in which each cavity for a pharmeceutical preparation is connected with a cavity for a drying agent. Additionally a perforation can be provided enabling the separation of each combination of a pharmaceutical preparation and a drying agent.
  • FR-A-2 593 152 also describes a blister package with drying agent whereby several cavities for a pharmaceutical preparation are connected with one cavity for drying agents.
  • FR-A-2 660 634 discloses a package comprising a drying agent whereby between the drying agent and the cover sheet a membrane is located to keep the drying agent at the desires place.
  • the offtake of the charge is not performed by pushing the charge through the cover sheet but by peeling the cover sheet off. A peeling of the cover sheet from the drying agent is made more difficult by additional sealings.
  • DE-OS-24 04 232 discloses a children-resistant package, however without any means to keep the pharmaceutical preparation dry. Besides of a removable tear resistant sheet on the cover sheet preventing pushing of the charge through the cover sheet, the cavities are thus formed, that a child cannot open them by biting on the blister.
  • US-5 172 812 discloses a children-resistant package with a rupturable cover sheet and with a paperboard material peelably laminated to the sheet of rupturable material. Furthermore a die cut is provided "misregistered" with the opening so that only a part of the paperboard material is peeled off from the opening so that the tablet can only be removed if pressure is applied in a specific manner. This document does not disclose a drying agent comprising package.
  • US-A-3 780 856 and US-A-3 835 995 both disclose blister packages with a cover sheet that is to be peeled off. In both packages a tear-off strip is provided where the cover sheet is not sealed to the carrier layer.
  • the problem of the present invention thus was to provide a blister package for the dry storage of pharmaceutical preparations, for which the accidental intake of the drying agent is prevented.
  • a blister package with a pan sheet with preparation cavities and drying agent cavities as well as a cover sheet characterized in that the blister package in the region of the drying agent cavities is enforced thus, that the withdrawing of the charge with the usual finger pressure is prevented, and that the reinforcement over the drying agent cavities cannot be removed by applying usual finger means.
  • the inventive blister package at least the cover sheet is reinforced in the region of the drying agent thus that the reinforcement over the drying agent cavities cannot be removed by usual application of usual finger means as for example pressing, pushing or peeling off with the fingers or the finger nails.
  • each cavity comprising a pharmaceutical preparation is connected to at least one cavity comprising a drying agent.
  • the inventive blister package has a pan sheet 4 with cavities 1 for the uptake of effective substance comprising preparations and cavities 2 for the uptake of drying agents as well as a cover sheet 5 sealed to said pan sheet 4, characterized in that the blister package in the region of the drying agent cavities 2 is reinforced thus, that the withdrawing of a drying agent carried by said drying agent cavity 2 with usual finger pressure is prevented, and that the reinforcement over the drying agent cavities 2 cannot be removed by applying usual means.
  • each cavity 1 is connected with at least one cavity 2 by a connecting means 3, thus that an air exchange is of course possible, but not a direct contact of the effective substance comprising preparation with the drying agent.
  • said connecting means 3 is a connecting passage-like cavity in the formed pan sheet 4 of the blister package, which is particularly a plastic sheet.
  • the lifetime of the package can be controlled by the amount of drying agent used, dependent on the environmental conditions.
  • the amount of drying agent results from its water absorbing capacity, the blister design, the used foil quality, the provided storage conditions and the desired shelf life of the product.
  • drying agent advantageously is also applied in the form of tablets whereby the dosage as well as the introduction into the cavities 2 is facilitated and additionally a clogging up of the passages by loose particles is diminished or avoided, respectively, for such an embodiment possibly larger drying agent tablets are used.
  • Suitable as drying agent are all solid, preferably pharmaceutically harmless substances such as molecular sieves and silica gel.
  • the package comprises additional security elements preventing the accidental intake of the drying agent instead of the effective substance comprising preparation.
  • a security measure can for example be the sealing of an additional plastic sheet in the drying agent region, particularly onto the cover sheet 5.
  • This additional sheet prevents a pushing through of the drying agent through the cover sheet 5.
  • Preferably one additional sheet simultaneously covers several drying agent comprising cavities 2, resulting in an improved adhesion thereof.
  • This foil can be clear or colored. Measures on the side of the pan sheet 4 such as local coloring, local reinforcement of the sheet or covering hood, respectively, etc. are possible but technically much more expansive.
  • drying agent cavities 2 are situated adjacently, particularly in one or several adjacent rows.
  • the preferred inventive blister packages with enhanced security against withdrawing of the drying agents provide on the cover sheet side at least in the region of the cavities 2 for the uptake of drying agent a protection sheet 6.
  • the protection sheet 6 can be of any shape, provided that the withdrawing of the drying agent is effectively prevented. Suitable are e.g. plastic foils which, due to their toughness prohibit a pushing through. Because of their toughness polyethylene (PE) sheets or polyethylene composite films, respectively, for example a laminate of polyethylene (PE) and polyethyleneterephthalate (PET) sheet (PET/PE sheet) are preferred.
  • PE polyethylene
  • PET polyethyleneterephthalate
  • cover sheets 5 of a multilayer laminate with the protection sheet 6 being already comprised (cf. Fig. 3).
  • sheets which are commercially available, inside (contact to the pan sheet 4) have a hot-melt layer, e.g. a thermoplastic lacquer.
  • a hot-melt layer e.g. a thermoplastic lacquer.
  • an aluminum foil an adhesive
  • a polyester sheet e.g. polyethyleneterephthalate (PET)
  • PET polyethyleneterephthalate
  • an adhesion enhancer e.g. another solid adhesive layer
  • a paper layer e.g. another solid adhesive layer
  • a sheet with e.g. 20 ⁇ m thickness of the Al-layer and 12 ⁇ m thickness of the polyester sheet and an adhesive with restricted adhesion in the laminate is e.g. available from Neher, Kreuzlingen, Switzerland, under the name Peel-Push foil.
  • the adhesive can either be thus construed that it only provides restricted laminate adhesion so that a separation between the cover sheet 5 and the protection sheet 6 is possible by hand, or it is thus that the adhesion of the laminate is so strong that the multilayer laminate is peeled off as such, i.e. cover sheet 5 and protection sheet 6 together.
  • the protection sheet part of the multilayer laminate can only be peeled off from the effective substance comprising preparations but not from the drying agent.
  • seal free zones 7 are provided in the effective substance comprising preparation part opening aids, e.g. seal free zones 7, as well as a perforation or a cross section 8 to the drying agent region.
  • seal free zones 7 are preferably located directly at the perforation or the cross section 8, or at the intersection of the perforation or the cross section 8 and the perforation or the cross section 9, so that the peel off direction necessarily leads away from the drying agent.
  • the seal free zone 7 is e.g.
  • the sealing tool e.g. a stamp
  • the sealing tool provides respective "cold” parts, and/or by deep drawing of the package form in the respective region, so that no contact can be made and at the same time the seizing of the loose sheet part is facilitated, or by punching out the respective zone from the pan sheet prior to sealing it with the cover sheet.
  • a perforation or cross section 9 is provided between two pharmaceutical preparation cavities and/or between two drying agent cavities.
  • the perforation or the cross section 8, respectively, as well as the perforation or cross section 9 preferably concern at least the protection foil part of the multilayer laminate.
  • a perforation 9 through the whole blister package can be provided so that single units can be separated. Since the drying agent region because of the protection foil is secured against withdrawing also for a 1:1 combination (one effective substance comprising preparation per drying agent tablet) no risk of withdrawing exists.
  • the paper + PET complex can only be peeled off from the region of the preparation. This is achieved in that the opening aids 7 are exclusively present in the preparation field. If a sheet with an adhesive providing strong laminate adhesion between cover sheet 5 and protection sheet 6 is used, a perforation or cross section 8 as well as a perforation or cross section 9 must be provided to ensure that the multilayer laminate is only peeled off from one effective substance preparation, which then is laid open.
  • the paper layer particularly in the region over the drying agent, can be colored or provided with a warning imprint.
  • a label in the product region e.g. specification of the weekdays etc., on which the respective tablet shall be consumed.
  • Such a label additionally diminishes the probability that the sequence of the intake is thus that - e.g. for packages with several units for which one unit comprises more than one preparation cavity 1 per drying agent cavity 2 - all but one tablet of one unit are consumed at the beginning of the consumption, the one remaining tablet, however, is consumed as the last one of all units, so that the drying agent - because of the enhanced humidity access through the ruptured area of the cover sheet 6 over the tablet cavities 1 - is extremely strained.
  • a monitoring device can be provided indicating the complete consumption of the drying agent or the enhancement of the humidity, respectively.
  • a monitoring device can be provided indicating the complete consumption of the drying agent or the enhancement of the humidity, respectively.
  • a monitoring device can be provided indicating the complete consumption of the drying agent or the enhancement of the humidity, respectively.
  • the silica gel with indicator e.g. the silica gel with indicator, a silica gel colored with CoCl 2 to show the water absorption.
  • silica gel with indicator preferably should only be used in inventive blister packages providing the additional protection to prevent the intake of the drying agent.
  • the pan sheet itself should - as already mentioned above - be as little moisture permeable as possible. Furthermore it should be sealable as well as also having a good compatibility with the product.
  • a today usual sheet for such applications is a combination sheet of PVC (polyvinylchloride),PE (polyethylene) and PVDC (polyvinylidenechloride). Such a sheet is e.g. sold under the name Alfoil®, Tristar®, Aclar®, etc. and extensively used for pharmaceuticals.
  • cover sheet a usual sheet can be used, particularly one comprising an aluminium layer or an aluminium foil such as a usually used polymer coated aluminium foil or the above mentioned multilayer laminate, respectively.
  • the pan sheet is formed according to the blister design with usual methods and after the introduction of the drying agent and the product conneted with the cover foil in a manner usual for blister packages , particularly sealed.
  • a protection sheet of PET/PE thickness about 60 ⁇ m is sealed at about 120-130°C. Due to the toughness of the PET/PE sheet a pushing through of the drying agent is not possible.
  • the thus secured blister package then can be perforated as desired, preferably between each unit.
  • Example 2 Protection against withdrawing by a multilayer laminate
  • the filled pan sheet is sealed at about 200°C with a multilayer laminate (Peel-Push-Folie from Neher, Buchlingen, Switzerland) according to Figure 3 as cover sheet and protection sheet instead of an aluminum sheet thus, that, in the product region at the perforation line to the drying agent region and at the perforation line between the units, for each unit at least one seal free zone is formed. If the seal is made by a stamp, this is achieved by "cold" zones on the stamp itself.
  • a multilayer laminate Peel-Push-Folie from Neher, Buchlingen, Switzerland
  • the withdrawing of the product is made in several steps:
  • the protection sheet part of the multilayer laminate can exclusively be peeled off in the product region. This is not possible in the region of the drying agents since any opening aid such as a seal free zone is lacking.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Composite Materials (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Die Bonding (AREA)
EP95928599A 1994-09-07 1995-09-05 Blister package with dessicant Expired - Lifetime EP0779872B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9530204T SI0779872T1 (en) 1994-09-07 1995-09-05 Blister package with desiccant

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH02741/94A CH687615A5 (de) 1994-09-07 1994-09-07 Tropen-Verpackung.
CH2741/94 1994-09-07
PCT/IB1995/000728 WO1996007601A1 (en) 1994-09-07 1995-09-05 Childproof blister package with dessicant

Publications (2)

Publication Number Publication Date
EP0779872A1 EP0779872A1 (en) 1997-06-25
EP0779872B1 true EP0779872B1 (en) 1998-11-25

Family

ID=4240569

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95928599A Expired - Lifetime EP0779872B1 (en) 1994-09-07 1995-09-05 Blister package with dessicant

Country Status (14)

Country Link
EP (1) EP0779872B1 (es)
JP (1) JPH10505047A (es)
AT (1) ATE173710T1 (es)
AU (1) AU700873B2 (es)
CA (1) CA2199263C (es)
CH (1) CH687615A5 (es)
DE (1) DE69506267T2 (es)
DK (1) DK0779872T3 (es)
ES (1) ES2125643T3 (es)
IL (1) IL115202A (es)
MX (1) MX9701821A (es)
TW (1) TW308577B (es)
WO (1) WO1996007601A1 (es)
ZA (1) ZA957530B (es)

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AU739587B2 (en) * 1997-12-22 2001-10-18 Astrazeneca Ab Inhalation device
CA2348024C (en) * 1998-10-30 2008-02-19 Mcneil-Ppc, Inc. Granular, free-flowing pharmaceutical composition, and straw-like dosage form for oral administration thereof
AU779458B2 (en) 2000-12-28 2005-01-27 Manrex Pty. Limited Improvements in blister sheets
US6592978B1 (en) * 2002-02-01 2003-07-15 Kloeckner Pentaplast Of America, Inc. Three part high moisture barrier for packages
GB0225621D0 (en) 2002-11-02 2002-12-11 Glaxo Group Ltd Medicament carrier
US20050284789A1 (en) * 2004-06-29 2005-12-29 Carespodi Dennis L Laser-scored push-through blister backing and methods of making same
BRPI0617477A2 (pt) 2005-10-19 2011-07-26 Teva Pharma mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica
JP2007178376A (ja) * 2005-12-28 2007-07-12 Sysmex Corp 試験片収容体、その製造方法
EP2035001B1 (en) 2006-06-12 2011-11-09 Teva Pharmaceutical Industries Limited Stable laquinimod preparations
EP1902708A1 (de) 2006-09-25 2008-03-26 Losan Pharma GmbH Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung
PL2682120T3 (pl) 2007-12-20 2017-02-28 Teva Pharmaceutical Industries, Ltd. Stabilne preparaty lakwinimodu
EP2127628A1 (en) * 2008-05-27 2009-12-02 Ranbaxy Laboratories Limited Unit dose pack
BRPI0913518A2 (pt) 2008-09-03 2016-07-26 Teva Pharma composto, composição farmacêutica, e, método de tratamento de um distúrbio mediado por função imune
AU2009100522A4 (en) * 2009-05-28 2009-08-06 Manrex Pty. Ltd. Blister Package Stiffening
PT2256061E (pt) * 2009-05-30 2012-05-07 Bayer Innovation Gmbh Produto com materiais de suporte bioabsorvível e embalamento
FR2968083B1 (fr) * 2010-11-25 2015-03-06 Biomerieux Sa Article pour l'analyse biologique
WO2012084017A1 (de) * 2010-12-21 2012-06-28 Boehringer Ingelheim International Gmbh Verpackungen mit adsorbens für arzneimittel
BR112015010193A2 (pt) 2012-11-07 2017-07-11 Teva Pharma sais de amina de laquinimod
WO2017184584A1 (en) * 2016-04-19 2017-10-26 Ascent Pharmaceuticals, Inc. Stable packaging system for moisture and oxygen sensitive pharmaceutical dosage forms
EP3599176B1 (de) 2018-07-26 2020-12-30 Uhlmann Pac-Systeme GmbH & Co. KG Verfahren zur herstellung von blisterverpackungen für medizinische produkte und blisterverpackung
EP4206089A1 (en) 2021-12-30 2023-07-05 Airnov, Inc. Blister pack

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US3780856A (en) * 1971-07-26 1973-12-25 Medi Dose Inc Medicinal dispensing device
US3835995A (en) * 1972-07-12 1974-09-17 Paco Packaging Tamperproof package
DE2404232A1 (de) * 1974-01-30 1975-08-07 Aluminium Walzwerke Singen Verpackung fuer tablettenartiges fuellgut mit einer durchdrueckpackung
FR2593152B1 (fr) * 1986-01-22 1988-12-23 Adir Conditionnement etanche sous forme de plaquettes alveolaire permettant des echanges gazeux entre les alveoles.
FR2660634B1 (fr) * 1990-04-06 1992-10-16 Airsec Ind Sa Conditionnement pour produits necessitant l'usage d'un agent deshydratant.
JPH0471560A (ja) * 1990-07-10 1992-03-06 Mect Corp 包装体
US5172812A (en) * 1992-01-23 1992-12-22 Rexham Corporation Child-resistant paperboard blister package and method of making the same

Also Published As

Publication number Publication date
DE69506267D1 (de) 1999-01-07
JPH10505047A (ja) 1998-05-19
DE69506267T2 (de) 1999-05-06
AU3230795A (en) 1996-03-27
EP0779872A1 (en) 1997-06-25
IL115202A (en) 1999-03-12
CA2199263C (en) 2007-11-06
CH687615A5 (de) 1997-01-15
MX9701821A (es) 1997-06-28
DK0779872T3 (da) 1999-08-09
TW308577B (es) 1997-06-21
IL115202A0 (en) 1995-12-31
CA2199263A1 (en) 1996-03-14
AU700873B2 (en) 1999-01-14
ES2125643T3 (es) 1999-03-01
ATE173710T1 (de) 1998-12-15
ZA957530B (en) 1997-03-07
WO1996007601A1 (en) 1996-03-14

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