EP0778835A4 - Derives de 7-azabicyclo 2.2.1]-heptane et -heptene utilises comme ligands des recepteurs cholinergiques - Google Patents

Derives de 7-azabicyclo 2.2.1]-heptane et -heptene utilises comme ligands des recepteurs cholinergiques

Info

Publication number
EP0778835A4
EP0778835A4 EP95932333A EP95932333A EP0778835A4 EP 0778835 A4 EP0778835 A4 EP 0778835A4 EP 95932333 A EP95932333 A EP 95932333A EP 95932333 A EP95932333 A EP 95932333A EP 0778835 A4 EP0778835 A4 EP 0778835A4
Authority
EP
European Patent Office
Prior art keywords
azabicyclo
heptane
receptor ligands
cholinergic receptor
heptene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95932333A
Other languages
German (de)
English (en)
Other versions
EP0778835A1 (fr
Inventor
T Y Shen
W Dean Harman
Dao Fei Huang
Javier Gonzalez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
Original Assignee
University of Virginia UVA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/296,463 external-priority patent/US5817679A/en
Application filed by University of Virginia UVA filed Critical University of Virginia UVA
Publication of EP0778835A1 publication Critical patent/EP0778835A1/fr
Publication of EP0778835A4 publication Critical patent/EP0778835A4/fr
Withdrawn legal-status Critical Current

Links

EP95932333A 1994-08-25 1995-08-25 Derives de 7-azabicyclo 2.2.1]-heptane et -heptene utilises comme ligands des recepteurs cholinergiques Withdrawn EP0778835A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/296,463 US5817679A (en) 1993-04-01 1994-08-25 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US296463 1994-08-25
US255195P 1995-08-21 1995-08-21
US2551 1995-08-21
PCT/US1995/010884 WO1996006093A1 (fr) 1994-08-25 1995-08-25 Derives de 7-azabicyclo[2.2.1]-heptane et -heptene utilises comme ligands des recepteurs cholinergiques

Publications (2)

Publication Number Publication Date
EP0778835A1 EP0778835A1 (fr) 1997-06-18
EP0778835A4 true EP0778835A4 (fr) 1999-02-03

Family

ID=26670536

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95932333A Withdrawn EP0778835A4 (fr) 1994-08-25 1995-08-25 Derives de 7-azabicyclo 2.2.1]-heptane et -heptene utilises comme ligands des recepteurs cholinergiques

Country Status (5)

Country Link
EP (1) EP0778835A4 (fr)
JP (1) JP2002504883A (fr)
CN (1) CN1071753C (fr)
AU (1) AU708112B2 (fr)
CA (1) CA2196979A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522161A (ja) * 2003-04-07 2006-09-28 グラクソ　グループ　リミテッド Ｍ３ムスカリン性アセチルコリン受容体拮抗剤
JP2006335737A (ja) * 2005-06-03 2006-12-14 Ihara Nikkei Kagaku Kogyo Kk ベンゾ［ｃ］ヘテロ５員環化合物の製造方法
CN105143213B (zh) * 2013-04-26 2018-07-24 赛诺菲 5-氯-噻吩-2-甲酸[(s)-2-[甲基-3-(2-氧代-吡咯烷-1-基)-苯磺酰基氨基]-3-(4-甲基-哌嗪-1-基)-3-氧代-丙基]酰胺的酒石酸盐
CN114409669B (zh) * 2022-01-24 2023-06-23 云南民族大学 一种氧杂降冰片烯环上c-5位炔基取代的斑蝥素衍生物及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445377A1 (de) * 1983-12-23 1985-07-04 Sandoz-Patent-GmbH, 7850 Lörrach Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen
EP0382687A2 (fr) * 1989-02-06 1990-08-16 BOEHRINGER INGELHEIM ITALIA S.p.A. Dérivés hétérocycliques benzo-condensés contenant de l'azote
WO1994022868A1 (fr) * 1993-04-01 1994-10-13 University Of Virginia DERIVES DE 7-AZABICYCLO[2.2.1]-HEPTANE et -HEPTENE UTILISES COMME ANALGESIQUES ET AGENTS ANTI-INFLAMMATOIRES
JPH0761940A (ja) * 1993-06-17 1995-03-07 Eisai Co Ltd アザビシクロヘプタン誘導体
EP0657455A1 (fr) * 1993-12-09 1995-06-14 Egis Gyogyszergyar Dérivés d'épi-épibatidine, un procédé et intermédiares pour leur préparation et épi-épibatidine et médicaments contenant les dérivés d'épi-épibatidine et/ou épi-épibatidine et leur utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314899A (en) * 1992-03-03 1994-05-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Epibatidine and derivatives, compositions and methods of treating pain

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445377A1 (de) * 1983-12-23 1985-07-04 Sandoz-Patent-GmbH, 7850 Lörrach Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen
EP0382687A2 (fr) * 1989-02-06 1990-08-16 BOEHRINGER INGELHEIM ITALIA S.p.A. Dérivés hétérocycliques benzo-condensés contenant de l'azote
WO1994022868A1 (fr) * 1993-04-01 1994-10-13 University Of Virginia DERIVES DE 7-AZABICYCLO[2.2.1]-HEPTANE et -HEPTENE UTILISES COMME ANALGESIQUES ET AGENTS ANTI-INFLAMMATOIRES
JPH0761940A (ja) * 1993-06-17 1995-03-07 Eisai Co Ltd アザビシクロヘプタン誘導体
EP0657455A1 (fr) * 1993-12-09 1995-06-14 Egis Gyogyszergyar Dérivés d'épi-épibatidine, un procédé et intermédiares pour leur préparation et épi-épibatidine et médicaments contenant les dérivés d'épi-épibatidine et/ou épi-épibatidine et leur utilisation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. HASSNER ET AL: "A simple method of preparation of 7-alkyl-7-azabicyclo(2.2.1)heptanes", TETRAHEDRON LETTERS, vol. 36, no. 10, 1995, OXFORD GB, pages 1709 - 1712, XP002086470 *
A. P. KRAPCHO ET AL: "The synthesis of a cocaine intermediate via a sodium-liquid ammonia carbon-carbon sigma-bond cleavage of an azabicyclic succinate-type ester", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, 1985, LETCHWORTH GB, pages 233 - 234, XP002086468 *
DATABASE WPI Week 9518, Derwent World Patents Index; AN 95-136801, XP002086471, "Novel aza-bicycloheptane deriv(s). - useful for treating Alzheimer's disease, Parkinson's disease, hypertension, tobacco dependence etc." *
S. F. NELSEN ET AL: "The nitrogen inversion barrier of 7-methyl-7-azabicyclo(2.2.1)heptane and the "bicyclic effect"", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, DC US, pages 1776 - 1781, XP002086467 *
S. R. FLETCHER ET AL: "Total synthesis and determination of the absolute configuration of epibatidine", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 7, 1994, EASTON US, pages 1771 - 1778, XP002086469 *
See also references of WO9606093A1 *

Also Published As

Publication number Publication date
JP2002504883A (ja) 2002-02-12
CN1163613A (zh) 1997-10-29
AU3540695A (en) 1996-03-14
EP0778835A1 (fr) 1997-06-18
CA2196979A1 (fr) 1996-02-29
AU708112B2 (en) 1999-07-29
CN1071753C (zh) 2001-09-26

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