EP0778835A4 - 7-azabicyclo 2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands - Google Patents
7-azabicyclo 2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligandsInfo
- Publication number
- EP0778835A4 EP0778835A4 EP95932333A EP95932333A EP0778835A4 EP 0778835 A4 EP0778835 A4 EP 0778835A4 EP 95932333 A EP95932333 A EP 95932333A EP 95932333 A EP95932333 A EP 95932333A EP 0778835 A4 EP0778835 A4 EP 0778835A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- azabicyclo
- heptane
- receptor ligands
- cholinergic receptor
- heptene derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US296463 | 1994-08-25 | ||
US08/296,463 US5817679A (en) | 1993-04-01 | 1994-08-25 | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
US255195P | 1995-08-21 | 1995-08-21 | |
US2551 | 1995-08-21 | ||
PCT/US1995/010884 WO1996006093A1 (en) | 1994-08-25 | 1995-08-25 | 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0778835A1 EP0778835A1 (en) | 1997-06-18 |
EP0778835A4 true EP0778835A4 (en) | 1999-02-03 |
Family
ID=26670536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95932333A Withdrawn EP0778835A4 (en) | 1994-08-25 | 1995-08-25 | 7-azabicyclo 2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0778835A4 (en) |
JP (1) | JP2002504883A (en) |
CN (1) | CN1071753C (en) |
AU (1) | AU708112B2 (en) |
CA (1) | CA2196979A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1613307A4 (en) * | 2003-04-07 | 2008-03-12 | Glaxo Group Ltd | M sb 3 /sb muscarinic acetylcholine receptor antagonists |
JP2006335737A (en) * | 2005-06-03 | 2006-12-14 | Ihara Nikkei Kagaku Kogyo Kk | METHOD FOR PRODUCING BENZO[c]HETEROCYCLIC 5-MEMBERED RING COMPOUND |
TWI615390B (en) * | 2013-04-26 | 2018-02-21 | 賽諾菲公司 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(s)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propryl]amide |
CN114409669B (en) * | 2022-01-24 | 2023-06-23 | 云南民族大学 | C-5 alkynyl substituted cantharidin derivative on oxanorbornene ring and preparation method and application thereof |
WO2024106529A1 (en) * | 2022-11-18 | 2024-05-23 | 国立大学法人 東京大学 | Novel compound having anti-obesity activity |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3445377A1 (en) * | 1983-12-23 | 1985-07-04 | Sandoz-Patent-GmbH, 7850 Lörrach | CARBOCYLIC AND HETEROCYCLIC CARBONIC ACID ESTERS AND AMIDES OF BRIDGED AND NON-BRIDGED CYCLIC NITROCYLINE AMINES OR ALCOHOLS |
EP0382687A2 (en) * | 1989-02-06 | 1990-08-16 | BOEHRINGER INGELHEIM ITALIA S.p.A. | Benzofused-N-containing heterocycle derivatives |
WO1994022868A1 (en) * | 1993-04-01 | 1994-10-13 | University Of Virginia | 7-azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents |
JPH0761940A (en) * | 1993-06-17 | 1995-03-07 | Eisai Co Ltd | Azabicycloheptane derivative |
EP0657455A1 (en) * | 1993-12-09 | 1995-06-14 | Egis Gyogyszergyar | Epi-epibatidine derivatives, a process and intermediates for preparing them and epi-epibatidine and medicaments containing the epi-epibatidine derivatives and/or epi-epibatidine and the use of them |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5314899A (en) * | 1992-03-03 | 1994-05-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Epibatidine and derivatives, compositions and methods of treating pain |
-
1995
- 1995-08-25 EP EP95932333A patent/EP0778835A4/en not_active Withdrawn
- 1995-08-25 CN CN95195674A patent/CN1071753C/en not_active Expired - Fee Related
- 1995-08-25 JP JP50831096A patent/JP2002504883A/en active Pending
- 1995-08-25 CA CA 2196979 patent/CA2196979A1/en not_active Abandoned
- 1995-08-25 AU AU35406/95A patent/AU708112B2/en not_active Ceased
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3445377A1 (en) * | 1983-12-23 | 1985-07-04 | Sandoz-Patent-GmbH, 7850 Lörrach | CARBOCYLIC AND HETEROCYCLIC CARBONIC ACID ESTERS AND AMIDES OF BRIDGED AND NON-BRIDGED CYCLIC NITROCYLINE AMINES OR ALCOHOLS |
EP0382687A2 (en) * | 1989-02-06 | 1990-08-16 | BOEHRINGER INGELHEIM ITALIA S.p.A. | Benzofused-N-containing heterocycle derivatives |
WO1994022868A1 (en) * | 1993-04-01 | 1994-10-13 | University Of Virginia | 7-azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents |
JPH0761940A (en) * | 1993-06-17 | 1995-03-07 | Eisai Co Ltd | Azabicycloheptane derivative |
EP0657455A1 (en) * | 1993-12-09 | 1995-06-14 | Egis Gyogyszergyar | Epi-epibatidine derivatives, a process and intermediates for preparing them and epi-epibatidine and medicaments containing the epi-epibatidine derivatives and/or epi-epibatidine and the use of them |
Non-Patent Citations (6)
Title |
---|
A. HASSNER ET AL: "A simple method of preparation of 7-alkyl-7-azabicyclo(2.2.1)heptanes", TETRAHEDRON LETTERS, vol. 36, no. 10, 1995, OXFORD GB, pages 1709 - 1712, XP002086470 * |
A. P. KRAPCHO ET AL: "The synthesis of a cocaine intermediate via a sodium-liquid ammonia carbon-carbon sigma-bond cleavage of an azabicyclic succinate-type ester", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, 1985, LETCHWORTH GB, pages 233 - 234, XP002086468 * |
DATABASE WPI Week 9518, Derwent World Patents Index; AN 95-136801, XP002086471, "Novel aza-bicycloheptane deriv(s). - useful for treating Alzheimer's disease, Parkinson's disease, hypertension, tobacco dependence etc." * |
S. F. NELSEN ET AL: "The nitrogen inversion barrier of 7-methyl-7-azabicyclo(2.2.1)heptane and the "bicyclic effect"", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, DC US, pages 1776 - 1781, XP002086467 * |
S. R. FLETCHER ET AL: "Total synthesis and determination of the absolute configuration of epibatidine", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 7, 1994, EASTON US, pages 1771 - 1778, XP002086469 * |
See also references of WO9606093A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN1163613A (en) | 1997-10-29 |
CA2196979A1 (en) | 1996-02-29 |
EP0778835A1 (en) | 1997-06-18 |
CN1071753C (en) | 2001-09-26 |
AU708112B2 (en) | 1999-07-29 |
JP2002504883A (en) | 2002-02-12 |
AU3540695A (en) | 1996-03-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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17P | Request for examination filed |
Effective date: 19970324 |
|
RHK1 | Main classification (correction) |
Ipc: C07D487/08 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19981221 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20000915 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020101 |
|
RTI1 | Title (correction) |
Free format text: 7-AZABICYCLO 2.2.1 -HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS |