EP0759976A4 - Isolement et production d'anticorps catalytiques par une technologie faisant appel a des phages - Google Patents

Isolement et production d'anticorps catalytiques par une technologie faisant appel a des phages

Info

Publication number
EP0759976A4
EP0759976A4 EP94919078A EP94919078A EP0759976A4 EP 0759976 A4 EP0759976 A4 EP 0759976A4 EP 94919078 A EP94919078 A EP 94919078A EP 94919078 A EP94919078 A EP 94919078A EP 0759976 A4 EP0759976 A4 EP 0759976A4
Authority
EP
European Patent Office
Prior art keywords
isolation
production
catalytic antibodies
phage technology
phage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94919078A
Other languages
German (de)
English (en)
Other versions
EP0759976A1 (fr
Inventor
Rodger G Smith
John Mccafferty
David Chiswell
Michael J Darsley
Kevin Fitzgerald
John H Kenten
Mark T Martin
Richard C Titmas
Richard O Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IGEN International Inc
Original Assignee
IGEN International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN International Inc filed Critical IGEN International Inc
Publication of EP0759976A1 publication Critical patent/EP0759976A1/fr
Publication of EP0759976A4 publication Critical patent/EP0759976A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP94919078A 1994-03-30 1994-03-30 Isolement et production d'anticorps catalytiques par une technologie faisant appel a des phages Withdrawn EP0759976A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/003420 WO1995027045A1 (fr) 1994-03-30 1994-03-30 Isolement et production d'anticorps catalytiques par une technologie faisant appel a des phages

Publications (2)

Publication Number Publication Date
EP0759976A1 EP0759976A1 (fr) 1997-03-05
EP0759976A4 true EP0759976A4 (fr) 2001-02-07

Family

ID=22242396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94919078A Withdrawn EP0759976A4 (fr) 1994-03-30 1994-03-30 Isolement et production d'anticorps catalytiques par une technologie faisant appel a des phages

Country Status (4)

Country Link
EP (1) EP0759976A4 (fr)
JP (1) JPH10507341A (fr)
AU (1) AU695406B2 (fr)
WO (1) WO1995027045A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0985039B1 (fr) 1997-06-12 2008-02-20 Novartis International Pharmaceutical Ltd. Polypeptides d'anticorps artificiels
JP2002522029A (ja) 1998-07-27 2002-07-23 ジェネンテック・インコーポレーテッド コートタンパク質の改変によるファージ提示における改良した形質転換効率
ES2564161T3 (es) 2000-07-11 2016-03-18 Research Corporation Technologies, Inc Polipéptidos de anticuerpos artificiales
US8178320B2 (en) 2001-11-22 2012-05-15 Keio University Artificial antibody library with super-repertory
WO2003104418A2 (fr) 2002-06-06 2003-12-18 Research Corporation Technologies, Inc. Polypeptides reconstitues
FI20022048A0 (fi) 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014430A1 (fr) * 1989-05-16 1990-11-29 Scripps Clinic And Research Foundation Nouveau procede d'exploitation du repertoire immunologique
WO1993012232A1 (fr) * 1991-12-10 1993-06-24 Dana Farber Cancer Institute Anticorps recombine humain anti-gp120 neutralisant le reactif, adn codant celui-ci et son utilisation
US5258289A (en) * 1990-09-05 1993-11-02 Davis Claude G Method for the selecting of genes encoding catalytic antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014430A1 (fr) * 1989-05-16 1990-11-29 Scripps Clinic And Research Foundation Nouveau procede d'exploitation du repertoire immunologique
US5258289A (en) * 1990-09-05 1993-11-02 Davis Claude G Method for the selecting of genes encoding catalytic antibodies
WO1993012232A1 (fr) * 1991-12-10 1993-06-24 Dana Farber Cancer Institute Anticorps recombine humain anti-gp120 neutralisant le reactif, adn codant celui-ci et son utilisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MCCAFFERTY J ET AL: "SELECTION AND RAPID PURIFICATION OF MURINE ANTIBODY FRAGMENTS THAT BIND A TRANSITION-STATE ANALOG BY PHAGE DISPLAY", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,US,CLIFTON, NJ, vol. 47, 1994, pages 157 - 173, XP002913520, ISSN: 0273-2289 *
See also references of WO9527045A1 *

Also Published As

Publication number Publication date
WO1995027045A1 (fr) 1995-10-12
JPH10507341A (ja) 1998-07-21
AU7014194A (en) 1995-10-23
EP0759976A1 (fr) 1997-03-05
AU695406B2 (en) 1998-08-13

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Free format text: THE ISOLATION AND PRODUCTION OF CATALYTIC ANTIBODIES USING PHAGE TECHNOLOGY

RTI1 Title (correction)

Free format text: ISOLATION AND PRODUCTION OF CATALYTIC ANTIBODIES USING TWO AFFINITY PEPTIDES IN TANDEM

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