EP0757553A1 - One-piece dispensing device for the contamination-free administration of medicaments (cytostatica) - Google Patents
One-piece dispensing device for the contamination-free administration of medicaments (cytostatica)Info
- Publication number
- EP0757553A1 EP0757553A1 EP95917950A EP95917950A EP0757553A1 EP 0757553 A1 EP0757553 A1 EP 0757553A1 EP 95917950 A EP95917950 A EP 95917950A EP 95917950 A EP95917950 A EP 95917950A EP 0757553 A1 EP0757553 A1 EP 0757553A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- coupling part
- valve
- piece
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 42
- 230000008878 coupling Effects 0.000 claims abstract description 33
- 238000010168 coupling process Methods 0.000 claims abstract description 33
- 238000005859 coupling reaction Methods 0.000 claims abstract description 33
- 239000000824 cytostatic agent Substances 0.000 claims description 11
- 230000001085 cytostatic effect Effects 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000011109 contamination Methods 0.000 abstract description 6
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000003186 pharmaceutical solution Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 239000003978 infusion fluid Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
Definitions
- the invention relates to a one-piece application device for the contamination-free administration of medicaments (cytostatics), which is used in particular in outpatient treatment.
- medicaments cytostatics
- connection is designed in such a way that the pharmaceutical solution escapes and thus contaminates the surfaces of the containers and thus the medical personnel is avoided.
- Contamination-free transfer and mixing is necessary, particularly with regard to the mixing and transferring of highly toxic cytostatic solutions, which can cause illnesses in the event of uncontrolled release.
- infusion solutions are mixed with solid or liquid substances by means of a syringe and withdrawn or added from or into different containers before the mixed infusion solution can be made available for infusion.
- Contamination cannot be avoided due to possible overpressures in the different containers and the free handling of the syringe.
- it is necessary to work under corresponding fume cupboards, which are extremely disruptive in medical practice.
- specially designed injection openings on infusion containers have been proposed which, although they facilitate the mixing of the substances mentioned, do not solve the contamination problem either.
- a connector for a container for pharmaceutical solutions and a container for infusion solutions (EP 0 330 130) is known from EP 0 363 770 AI.
- the connector described in EP 0 363 770 consists essentially of a tubular coupling part and a shut-off device that closes this.
- the coupling part is composed of a hollow piercing mandrel and a hollow part which can be plugged into a tubular connecting part of a container and is closed by a shut-off device which can be released from the outside.
- the invention is based on the object of specifying a connector for the connection of medicaments (cytostatics) containing containers with administration instruments, which guarantees contamination of the surroundings of the medicament container during its connection up to disposal without great expenditure on equipment.
- medicaments cytostatics
- the object of the invention is achieved by the characterizing features of the claims.
- the invention provides a connector which is used in particular in outpatient treatment and does not place high demands on the medical personnel when using it and which frees it from contamination problems.
- the invention will be explained in more detail with the aid of exemplary embodiments. Show it:
- Fig. 1 shows an embodiment of the invention for the administration of
- FIG. 2 shows an embodiment which serves to dissolve medicinal products (cytostatics) offered in solid form or the mixture of two liquid medicines
- FIG. 3 shows an embodiment which in particular dissolves in firmer
- FIG. 4 shows a more detailed illustration of a coupling part designed in one piece according to the invention.
- a connector which consists of a coupling part 1, which includes a piercing dome 2.
- This coupling part is inseparably connected by means of a hose connection 3, 31 to a flexible container 4 which can be filled with a gas, by adhesive bonding or welding.
- a mechanically actuated shut-off valve 5 is provided within the hose connection.
- the flexible container 4 carries a hose-like drain 6, which is preferably also non-detachably connected to it.
- a further mechanical shut-off valve 7 is integrated into the drain 6.
- Connection tubes (not shown) to the patient, such as conventional catheters, can be connected to the connection 6.
- the coupling part 1 in turn consists of a cup-shaped, inelastic hollow body 11, which has an inner receiving profile 12.
- the hollow body 11 is advantageously additionally lined with elastic sealing means, not shown.
- the receiving profile 12 is conically tapered on the inside and has barbed surfaces 13.
- a medicament cytostatics
- the medicament container schematically indicated in FIG. 3 becomes 100 inserted into the coupling part 1 and pressed.
- the relative height of the penetration depth of the Piercing mandrel 2 to the barbed surfaces 13 is set such that when the piercing mandrel 2 has penetrated the puncture base of the medicament container 100, the barbed surfaces 13 engage directly in corresponding counter-surfaces of the bottle neck of the medicament container 100 and thus inseparably connect it to the coupling part 1.
- the path to, for example, air-filled, sterile, flexible container 4 is opened via a mechanically actuated shut-off valve 5.
- the air can be pressed into the medicament container 100 and then the required, meterable amount of the liquid medicament can be sucked off or discharged into the container 4. Only then is the route of the drug to the patient via the hose-like drain 6, which is revealed by the mechanical shut-off valve 7, released.
- the guide means adjoining the drain 6, which are connected in the usual way to a plug adapter 61 connected to the drain 6, are not shown in detail.
- FIG. 2 shows a further embodiment of the invention, which differs from the embodiment according to FIG. 1 by a different design above the hose connection fitting 31 along a line X-X.
- Two hose connections 32 each of which contains a mechanically actuated shut-off valve 5, 51, branch off from the hose connection 31, which is permanently connected to it.
- the two hose connections 32 are each provided with a coupling part 1, which are designed analogously to that described under FIG. 1.
- This version is used in particular for the administration of medicaments (cytostatics) which are available in solid form, such as powders.
- the procedure is as follows: first, the first coupling part 1 is connected to a container that contains a corresponding solvent and then the second coupling part 1 is connected to a container that contains the drug to be dissolved. After opening the shut-off valve 51, a predeterminable amount of the solvent gets into the flexible container 4, The shut-off valves 7 and 5 are in the closed position. The shut-off valve 51 is then closed and the shut-off valve 5 is opened in order to clear the way to the container with the medicament to be dissolved (cytostatics), the flexible container 4 being pressurized. After the dissolving process, the dissolved medicament can return to the container 4. The shut-off valves 5 and 51 are moved into the closed position and the administration of the dissolved medicament can take place analogously, as described under FIG. 1. Of course, an embodiment according to FIG. 2 can also be used for the metered mixing of two liquid medicaments, the containers of which can be connected to the first and second coupling parts 1.
- FIG. 3 shows a particularly advantageous application device according to the invention, which consists of a coupling part 1, which also contains a piercing mandrel 2.
- This coupling part 1 is inseparably connected by means of a hose connection 31 to a flexible, self-supporting container 41 based on a gas by gluing or welding.
- a mechanically actuated shut-off valve 5 is provided within the hose connection.
- the aforementioned container 41 carries, analogously to FIG. 1, a hose-like drain 6, preferably also inseparably connected to it, within which a further mechanical shut-off valve 7 is integrated.
- a second hose connection 32 which is also non-detachably connected to it, branches off from the hose connection 31, to which a check valve 52 is connected as a mechanical shut-off valve, which, contrary to the direction towards the flexible container 41, has a blocking effect.
- the check valve 52 is provided with a connecting piece 521 for receiving a conical connecting piece 9.
- This connecting piece 521 is preferably designed as a Luer lock connection, which is used in particular for receiving a conical outlet end of a conventional syringe.
- an analog shut-off valve 5 can be provided between the check valve 52 and the hose connection 3.
- the Luer lock connection is preferably designed such that it engages in the check valve itself in such a way that it opens the same causes in connection with the conical syringe outlet end 9.
- the proposed embodiment is used in particular for the administration of medicaments (cytostatics) which are available in solid form, such as powders.
- the procedure is as follows: first, the coupling part 1 is used to connect the container 100, which contains the medicament to be dissolved, by pressing in the direction of the arrow. The path to the hose connection 31 is kept closed by the shut-off valve 5. Thereafter, a syringe, usually with saline solution, which can be filled depending on the amount to be dissolved, of the drug present in solid form, is connected with its conical outlet end 9 to the Luer lock connection 521, the check valve 52 is opened. The solvent can now be introduced into the flexible, self-supporting container 41 filled with a gas, preferably air.
- a gas preferably air.
- shut-off valve 5 is designed as a three-way valve which is introduced into the container 41 immediately before the hose connection 31 occurs. The released medicament is released to the patient by opening the shut-off valve 7.
- FIG. 4 shows a coupling part 1, partly in section, in more detail.
- all designated parts are: piercing mandrel 2, hollow body 11, receiving profile 12 and a connecting piece 8, which preferably consists of a plastic, are formed in one piece according to the invention, i.e. the piercing mandrel 2 is also an integral part of the coupling part 1.
- the entire coupling part 1 can preferably be produced as a uniform molded part.
- the incisions 21 shown which are also produced at the same time during the production of the coupling part 1 by means of plastic injection, are used for the elastic reception of the corresponding counterpart of the medicament container.
- a flexible container 4, 41 which can be filled with a gas, which is provided with at least two, optionally open and closable connecting lines to defined coupling means or in the direction of drug delivery is.
- the entire application device which contains the container already filled with a gas (preferably air), can be provided in sterilized form, or the container can also be filled with a gas before it is used.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE9407022U | 1994-04-28 | ||
DE9407022U DE9407022U1 (en) | 1994-04-28 | 1994-04-28 | Connector for contamination-free administration of drugs (cytostatics) |
DE4422960 | 1994-06-29 | ||
DE19944422960 DE4422960C2 (en) | 1994-04-28 | 1994-06-29 | One-piece application device for contamination-free administration of drugs, especially cytostatics |
DE19944433669 DE4433669C2 (en) | 1994-04-28 | 1994-09-21 | One-piece application device for the contamination-free administration of pharmaceuticals in solid starting form, in particular cytostatics |
DE4433669 | 1994-09-21 | ||
PCT/EP1995/001547 WO1995029661A1 (en) | 1994-04-28 | 1995-04-25 | One-piece dispensing device for the contamination-free administration of medicaments (cytostatica) |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0757553A1 true EP0757553A1 (en) | 1997-02-12 |
EP0757553B1 EP0757553B1 (en) | 2000-08-02 |
Family
ID=27206544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95917950A Expired - Lifetime EP0757553B1 (en) | 1994-04-28 | 1995-04-25 | One-piece dispensing device for the contamination-free administration of medicaments (cytostatica) |
Country Status (6)
Country | Link |
---|---|
US (1) | US5899877A (en) |
EP (1) | EP0757553B1 (en) |
AT (1) | ATE195071T1 (en) |
CA (1) | CA2188953A1 (en) |
FI (1) | FI964252A0 (en) |
WO (1) | WO1995029661A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030032935A1 (en) * | 2001-08-10 | 2003-02-13 | Scimed Life Systems, Inc. | Packages facilitating convenient mixing and delivery of liquids |
US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
US7053134B2 (en) * | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
AU2003240000A1 (en) | 2002-06-12 | 2003-12-31 | Boston Scientific Limited | Bulking agents |
US7842377B2 (en) | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
US7976823B2 (en) * | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
US7736671B2 (en) * | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
US7311861B2 (en) * | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
US8425550B2 (en) | 2004-12-01 | 2013-04-23 | Boston Scientific Scimed, Inc. | Embolic coils |
US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
US7858183B2 (en) | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
US8007509B2 (en) | 2005-10-12 | 2011-08-30 | Boston Scientific Scimed, Inc. | Coil assemblies, components and methods |
US8101197B2 (en) | 2005-12-19 | 2012-01-24 | Stryker Corporation | Forming coils |
US8152839B2 (en) | 2005-12-19 | 2012-04-10 | Boston Scientific Scimed, Inc. | Embolic coils |
US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
DK2043585T3 (en) * | 2006-07-21 | 2010-08-16 | Polimoon Medical Packaging As | Connecting device and method for sterile mixing |
US8414927B2 (en) | 2006-11-03 | 2013-04-09 | Boston Scientific Scimed, Inc. | Cross-linked polymer particles |
US9138552B2 (en) * | 2007-06-05 | 2015-09-22 | Cedars-Sinai Medical Center | Closed suctioning and rinsing methods and tracheal devices |
US20090270832A1 (en) * | 2008-04-23 | 2009-10-29 | Baxter International Inc. | Needleless port assembly for a container |
US9084864B1 (en) | 2010-03-04 | 2015-07-21 | Barthel LLC | Adaptor for breathing tube and method |
IT1400708B1 (en) | 2010-06-25 | 2013-06-28 | Frattini Paolo Giuseppe Gobbi | DEVICE FOR DOSED RECONSTITUTION AND ADMINISTRATION OF LIQUID SOLUTIONS CONTAINING ACTIVE SUBSTANCES AVAILABLE IN SEPARATE FORM, IN POWDER OR GEL IN PARTICULAR. |
WO2012117409A1 (en) | 2011-02-28 | 2012-09-07 | Vhb Pharmaceuticals Private Limited | A needle-free dispending pin for safe drug administration |
US20130046153A1 (en) | 2011-08-16 | 2013-02-21 | Elwha LLC, a limited liability company of the State of Delaware | Systematic distillation of status data relating to regimen compliance |
WO2023126699A1 (en) * | 2021-12-30 | 2023-07-06 | Paolo Gobbi Frattini S.R.L. | Pressure compensation device for reconstitution, withdrawal and transfer of a drug from a vial or other vacuum container, and apparatus comprising the above said device |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4114617A (en) * | 1977-02-28 | 1978-09-19 | Turner Thomas D | Apparatus for infusion of a measured volume of blood |
US4200095A (en) * | 1977-08-15 | 1980-04-29 | Millipore Corporation | Arrangement for intravenous administration or the like |
FR2468059A1 (en) * | 1979-10-16 | 1981-04-30 | Aguettant Lab | DEVICE FOR MEDICAL USE OF CONNECTION WITH SEALING BETWEEN TWO BITS FOR THE COMMUNICATION OF TWO VOLUMES |
US4705505A (en) * | 1984-09-28 | 1987-11-10 | Fried Steven J | Rapid solution administration set with integral heat exchanger |
US4675020A (en) * | 1985-10-09 | 1987-06-23 | Kendall Mcgaw Laboratories, Inc. | Connector |
EP0273015A3 (en) * | 1986-12-24 | 1988-10-05 | Vifor S.A. | Container with a receiving device for a vial |
US4863454A (en) * | 1987-10-16 | 1989-09-05 | Labove Larry D | Dual bag intravenous preparation system |
SE8800337L (en) * | 1988-02-03 | 1989-08-04 | Astra Ab | DEVICE FOR MIXING AND / OR TRANSFER OF A SUBSTANCE |
DE8802443U1 (en) * | 1988-02-25 | 1988-09-01 | Schiwa GmbH, 4519 Glandorf | Containers for infusion solutions |
DE8812460U1 (en) * | 1988-10-03 | 1988-12-22 | Schiwa GmbH, 4519 Glandorf | Connector for a container for pharmaceutical solutions |
US4997430A (en) * | 1989-09-06 | 1991-03-05 | Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. | Method of and apparatus for administering medicament to a patient |
US4973328A (en) * | 1989-11-20 | 1990-11-27 | Gerard Smith | Closed system administering assembly |
US5368586A (en) * | 1991-06-21 | 1994-11-29 | Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. | Closure for a drug-vial |
US5242392A (en) * | 1992-02-13 | 1993-09-07 | Vaughn Dale T | Intravenous piggyback flush apparatus |
-
1995
- 1995-04-25 CA CA 2188953 patent/CA2188953A1/en not_active Abandoned
- 1995-04-25 US US08/732,480 patent/US5899877A/en not_active Expired - Fee Related
- 1995-04-25 WO PCT/EP1995/001547 patent/WO1995029661A1/en active IP Right Grant
- 1995-04-25 AT AT95917950T patent/ATE195071T1/en not_active IP Right Cessation
- 1995-04-25 EP EP95917950A patent/EP0757553B1/en not_active Expired - Lifetime
-
1996
- 1996-10-22 FI FI964252A patent/FI964252A0/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9529661A1 * |
Also Published As
Publication number | Publication date |
---|---|
ATE195071T1 (en) | 2000-08-15 |
FI964252A (en) | 1996-10-22 |
US5899877A (en) | 1999-05-04 |
WO1995029661A1 (en) | 1995-11-09 |
EP0757553B1 (en) | 2000-08-02 |
CA2188953A1 (en) | 1995-11-09 |
FI964252A0 (en) | 1996-10-22 |
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