EP0750632A1 - Ionenkanäle bildende amphiphile Peptide mit N - thermischen Modifikationen - Google Patents

Ionenkanäle bildende amphiphile Peptide mit N - thermischen Modifikationen

Info

Publication number
EP0750632A1
EP0750632A1 EP95909267A EP95909267A EP0750632A1 EP 0750632 A1 EP0750632 A1 EP 0750632A1 EP 95909267 A EP95909267 A EP 95909267A EP 95909267 A EP95909267 A EP 95909267A EP 0750632 A1 EP0750632 A1 EP 0750632A1
Authority
EP
European Patent Office
Prior art keywords
peptide
amino acid
lys
ala
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95909267A
Other languages
English (en)
French (fr)
Inventor
U. Prasad Kari
Taffy J. Williams
Michael Mclane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Magainin Pharmaceuticals Inc
Original Assignee
Magainin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magainin Pharmaceuticals Inc filed Critical Magainin Pharmaceuticals Inc
Publication of EP0750632A1 publication Critical patent/EP0750632A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP95909267A 1994-01-18 1995-01-18 Ionenkanäle bildende amphiphile Peptide mit N - thermischen Modifikationen Withdrawn EP0750632A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18446294A 1994-01-18 1994-01-18
US184462 1994-01-18
PCT/US1995/000714 WO1995019370A1 (en) 1994-01-18 1995-01-18 Ion-channel forming amphiphilic peptides having n-terminal modifications

Publications (1)

Publication Number Publication Date
EP0750632A1 true EP0750632A1 (de) 1997-01-02

Family

ID=22676966

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95909267A Withdrawn EP0750632A1 (de) 1994-01-18 1995-01-18 Ionenkanäle bildende amphiphile Peptide mit N - thermischen Modifikationen

Country Status (5)

Country Link
EP (1) EP0750632A1 (de)
JP (1) JPH09507669A (de)
AU (1) AU693518B2 (de)
CA (1) CA2180748A1 (de)
WO (1) WO1995019370A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1001800A2 (de) * 1997-07-15 2000-05-24 Magainin Pharmaceuticals Inc. Biologisch aktive peptide mit verminderter toxizität in tieren und ein verfahren zu deren herstellung
KR100314721B1 (ko) * 1998-01-22 2001-11-23 김일웅 생물학적 활성이 있는 신규한 펩타이드
NL1008745C2 (nl) * 1998-03-30 1999-10-01 Stichting Tech Wetenschapp Therapeutisch werkzame verbinding voor behandeling van gist- en/of schimmelinfecties in de mondholte.
WO2001060162A2 (en) * 2000-02-15 2001-08-23 Ohio University Cationic, amphipathic beta-sheet peptides and uses thereof
WO2001098362A2 (en) * 2000-06-16 2001-12-27 Hercules Incorporated Chemically-modified antimicrobial peptides, compositions and methods of production and use
GB0024428D0 (en) * 2000-10-05 2000-11-22 King S College Absorption enhancers
CN101155825B (zh) * 2005-02-09 2014-11-26 赫里克斯生物医疗公司 抗微生物六肽

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504152A (ja) * 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
EP0667871A1 (de) * 1991-09-13 1995-08-23 Magainin Pharmaceuticals Inc. Biologisch aktive amphiphile peptidzusammensetzungen und ihre verwendungen
AU674525B2 (en) * 1992-06-01 1997-01-02 Magainin Pharmaceuticals, Inc. Biologically active peptides having N-terminal substitutions
EP0672053A1 (de) * 1992-12-07 1995-09-20 Magainin Pharmaceuticals Inc. Behandlung von septisch-toxischem schock

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9519370A1 *

Also Published As

Publication number Publication date
JPH09507669A (ja) 1997-08-05
AU693518B2 (en) 1998-07-02
WO1995019370A1 (en) 1995-07-20
AU1728895A (en) 1995-08-01
CA2180748A1 (en) 1995-07-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19960806

AK Designated contracting states

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17Q First examination report despatched

Effective date: 19971013

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18D Application deemed to be withdrawn

Effective date: 20000801