Classifications

• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
  • C08K3/00—Use of inorganic substances as compounding ingredients
  • C08K3/10—Metal compounds
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
  • A01N59/16—Heavy metals; Compounds thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
  • A01N59/16—Heavy metals; Compounds thereof
  • A01N59/20—Copper
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
  • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
  • A61L29/16—Biologically active materials, e.g. therapeutic substances
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
  • C08J3/00—Processes of treating or compounding macromolecular substances
  • C08J3/20—Compounding polymers with additives, e.g. colouring
  • C08J3/203—Solid polymers with solid and/or liquid additives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
  • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
  • A61L2300/104—Silver, e.g. silver sulfadiazine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
  • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
  • A61L2300/606—Coatings

Definitions

• the invention relates to processes for the production of plastic bodies which can be further processed, in particular for the production of objects for medical use, which have an antimicrobially active content of metals or metal compounds (hereinafter referred to as active ingredients).
• metals or their compounds whose oligodynamic effect is known, such as Silver, copper and gold, but also other heavy metals such as Zinc and also lanthanides, which act on bacteria and / or fungi in the sense desired according to the invention, i.e. kill them, prevent their multiplication or their adhesion to or implantation in the plastic or at least greatly reduce it.
• this relates to the costs of the amounts of metal or metal compounds, in particular silver, required for the intended purpose, if these substances are to be incorporated into the plastic in powder form, the lower limit of effectiveness always being the The order of magnitude of 1% by weight of the plastic is mentioned, but larger proportions are always stated as being even more effective.
• this relates to the costs for the ultimately rather complex - and accordingly expediently only to be used for selected cases - wet method of treating the plastics, e.g. according to DE-C-42 26 810, according to which very small amounts of the active ingredient are sufficient.
• Another way of avoiding the high material costs for the antimicrobial finishing of objects is not to provide the plastic as a whole with an antimicrobial, but to subsequently coat the objects made from this plastic with active substances.
• the object of the present invention is therefore to provide ⁇ provision of a method for the preparation of oligodynamically active plastic bodies which After the above ⁇ parts do not have, ie, are simple to produce, only require a small amount of the oligodynamic metal or its compound (s) and are equally effective on all, even inaccessible, surfaces.
• plastic bodies which contain one or more oligodynamically active metals or metal compounds as the active ingredient, which are characterized in that the active ingredient is embedded in the plastic in the form of discrete particles , wherein the amount of active ingredient is not more than 1.0% by weight, preferably not more than 0.5% by weight, based on the total weight of the plastic body, and the maximum of the discrete particle size of the active ingredient is below 500 nm lies.
• Well-handled active substances of all kinds in powder form are only produced and offered with finenesses down to the micron range (ie ⁇ 1 ⁇ m) and submicron range (ie> 0.1 ⁇ m).
• the specific surface area thus achieved is, for example, for the finest commercially available silver powder with a nominal grain size of 2 to 3.5 ⁇ m, which of course also has a certain proportion of coarser and sub-micron particles which is unavoidable due to the process has, according to the manufacturer, about 0.5 to 1 m 2 / g.
• Other, frequently used and also cheaper silver powders have coarser particles and accordingly lower specific surfaces.
• plastic bodies are therefore preferably produced in such a way that the blank is coated with the bactericidally and / or fungicidally (oligodynamically) active substance by means of a chemical or physical process, the coated blank (precursor) obtained is comminuted and / or melted, from which then the desired plastic body is produced by conventional methods.
• the layer thickness is preferably 1 to 50 nm.
• the maximum of the particle size distribution of the active ingredient in at least one dimension is preferably below 100 nm, more preferably 10 nm. In the case of thin layers, the particle size can also be smaller than 1 nm.
• Crystalline materials (PTFE, some polyimides) have to be crushed, for example, by grinding; Melting is included (practically) not applicable. They are then brought into the desired shape by, for example, (pressure) sintering.
• plastics with a low but finely dispersed content of metal particles (or particles from metal compounds) with a correspondingly large specific, active surface are equivalent in effect to plastics that have a much higher, but have less finely dispersed metals (or metal compounds) with a correspondingly smaller specific, active surface.
• plastics produced according to the above-mentioned process that these plastics are suitable for particularly critical applications by suitable process control in the production of the layer of metal (or of metal compounds) it can be equipped with particles whose size can be influenced from the outset for an optimal long-term effect.
• the coating can be done on foils (see example), which can then be shredded and further processed. However, it can also be applied to fibers or to granules, with the same result of producing the desired final concentration of the active ingredient in the plastic.
• plastic blanks Those in which fillers have already been mixed can also be used as plastic blanks. Preference is given to plastic blanks whose fillers do not significantly change the chemical or physiological properties of the plastic used as a preliminary product.
• Plastic blanks with fillers also have a larger surface area, which has a favorable effect on the coating according to the invention (better dispersion).
• plastics in the form of foils, tapes (a special case of foils), fibers or granules with one or more active substances in thin layers, preferably with layer thicknesses between 10 and 100 nm, is possible in a variety of ways with chemical and above all, possible with physical processes.
• the coating is only carried out with metals in the elementary state, and that the metal layer formed during the coating process is generally very dense and therefore in periods of time relevant for processing considerations, e.g. has a barrier effect for water vapor.
• thermoplastic polyurethane is a preferred plastic raw material Novel plastics similar to common polyurethanes (eg "carbothanes”) are also mentioned here.
• the aim of the process variants listed below is to bring the plastic, which has been coated with active ingredient, into a shape such that its further processing into intermediate products in mixers, kneaders, extruders or other machines or its final processing either in extruders, in Injection molding machines or in other facilities, such as (Hot) pressing becomes possible.
• thermoplastic used in all of these machine types, however, the processing of the thermoplastic used is carried out under the influence of temperatures which are relatively high for plastics.
• temperatures which are relatively high for plastics.
• care must be taken to ensure that the plastic to be processed takes this temperature into account - either since the coating, which was generally carried out in a vacuum, could no longer absorb moisture,
• plastic that has already been coated may have admixed with uncoated films or fibers (or also uncoated granules) for processing in the extruder.
• foils or foil packs which are coated on one or two sides, under certain circumstances may also be layered or packaged in multiple layers and may also contain uncoated (intermediate) foils,
• the active ingredient area per unit volume of plastic after further processing depends only on the number of layers of active ingredient per layer that has been achieved in the state after coating Thickness unit plastic, ie it only depends on the thickness of the films and whether they are coated on one or two sides.
• the thickness of the coating is only used to determine the active ingredient supply, i.e. the time how long the system remains in effect.
• the selected coating process and the parameters used here in particular also the parameters used within the coating process for the pretreatment of the surface (for example in the case of glowing or sputter etching), have large flows on whether a layer produced is only apparently (optically) or really tight against water vapor.
• uncoated intermediate films can be used. These uncoated intermediate foils must of course be included in the "layer coating per unit thickness plastic" balance.
• the chopped product would be with suitable feeding devices, e.g. "StopfSchnecken", quite well suited for loading processing machines.
• Films can be economically produced in large quantities in any width and, above all, in almost any required thickness. The latter possibility gives a very wide variation possibility for the content of active substance area per unit volume, which ultimately determines the effectiveness of the finished plastic.
• the use of foils as a raw material should always be considered when the average size is large Active substance areas per unit volume of plastic are to be generated. The difficulties of further processing are limited, given a correspondingly large production.
• the plastic containing 2 active ingredients initially preferably receives ions of the less noble element on the surface before a final state gradually stabilizes
• Granules can be economically produced in large quantities, but only in a very limited diameter range.
• the ratio of surface area to volume is defined strictly (linearly) as a function of the granule diameter. This property results in a very small variation possibility for the content of active substance area per unit volume, which ultimately determines the effectiveness of the finished plastic.
• the technology for coating bulk material for example electrical resistances
• the method according to the invention does not depend on a very uniform coating
• its use as a raw material should always be considered when small active substance areas per unit volume of plastic are sufficient.
• the desired ratio of the different active ingredients can be set by the ratio of the proportion of each of the two active ingredient components of the coating.
• the ratio of the release of ions of these two active substances does not remain stable during the period of use.
• Fibers can be produced economically in large quantities.
• the desired ratio of the active substance concentrations can be set by the ratio of the proportion of each of the two active substance components in the coating.
• the desired area of each active ingredient in the plastic volume unit and thus also the area ratio of the two active ingredients to one another can be set by the number of the respective coating processes with the subsequent spinning.
• Tapes are a special form of film. These can be economically produced in large quantities in any width and thickness required. The latter possibility is a very wide variation possibility for the active substance content area per unit volume, which ultimately determines the effective ⁇ ness of the finished plastic.
• tapes In view of the low manufacturing costs per unit of weight and the relatively low outlay for the two-part Coating of tapes, in which the highly automated technology which has been developed in the case of foils can be used, the use of tapes as a raw material must always be considered when an average large active ingredient area per unit volume of plastic is to be produced. Tapes can also be coated sufficiently on the narrow sides so that they can subsequently be considered coated all around.
• tapes can be drawn directly into many extrusion machines without further comminution (and the subsequent intermediate steps that normally follow), which results in a decisive simplification of the entire manufacturing process for plastics according to the invention, which, of course, involves an increased use of active ingredient must be bought.
• the two-sided coating of the film with only one active substance makes it possible to save drying again before further processing or final processing in the case of a water vapor-tight coating, but in the course of this further or final processing leads to a loss of active active ingredient area in the final product , because it inevitably directly presses active substance surfaces together.
• Another embodiment is characterized in that a coated plastic blank is first produced by one of the processes described above, but with a higher concentration of one or more antimicrobially active metal (s) and / or metal compound (s); this coated plastic blank is then comminuted and / or melted together with uncoated plastic blanks and finally brought into the desired shape by a conventional method.
• the same and / or different plastic (s) can be used for the uncoated plastic blanks than for the coated plastic blank. example
• test specimens were found to be fully effective against the colonization with the Staphylococcus epidermidis bacterium. This investigation was carried out according to the method described in DE-C-42 26 810.
• the plastic samples used are melt by hand by a ⁇ and stirring was manufactured ratios under controlled Temperaturver ⁇ .
• thermoplastic polyurethane films "Platilon U 073" (polyether type) 0.18 mm thick, which were used in a system that was actually intended for coating optical parts
• Silver 10 nm on one side b) Silver 30 nm on one side, c) Silver 60 nm on one side, d) Silver 30 nm on both sides, e) Silver 30 nm on one side and silver 60 nm on the other side f) Silver 30 nm on one side and copper 30 nm on the other side g) copper 30 nm double-sided,
• test plates a) and c) were produced in duplicate for control purposes.
• Staphylococcus epidermidis 5 x 10 germs / ml
• Staphylococcus aureus 5 x 10 germs / ml
• Streptococcus faecalis 5 x 10 germs / ml
• Escherichia coli 5 x 10 germs / ml
• Pseudomonas aeruginosa 5 x 10 germs / ml
• Candida albicans 5 x 10 germs / ml
• the plates were removed from the incubator and the wells were filled up again with physiological saline solution. After a further 15 minutes, the newly formed suspension was removed and placed in nutrient broth.

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• Life Sciences & Earth Sciences (AREA)
• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Engineering & Computer Science (AREA)
• General Health & Medical Sciences (AREA)
• Organic Chemistry (AREA)
• Polymers & Plastics (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
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• Materials For Medical Uses (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

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• 1995
  • 1995-02-01 EP EP95906894A patent/EP0711113B1/fr not_active Expired - Lifetime
  • 1995-02-01 AT AT95906894T patent/ATE155649T1/de active
  • 1995-02-01 ES ES95906894T patent/ES2107913T3/es not_active Expired - Lifetime
  • 1995-02-01 DE DE59500419T patent/DE59500419D1/de not_active Expired - Lifetime
  • 1995-02-01 US US08/663,161 patent/US5976562A/en not_active Expired - Lifetime
  • 1995-02-01 WO PCT/DE1995/000122 patent/WO1995020878A1/fr active IP Right Grant
  • 1995-02-01 CA CA002182390A patent/CA2182390C/fr not_active Expired - Lifetime
  • 1995-02-01 DK DK95906894.1T patent/DK0711113T3/da active
• 1999
  • 1999-11-01 US US09/431,199 patent/US6544536B1/en not_active Expired - Lifetime

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