EP0674705A4 - Oligonucleotides antisens utilises pour inhiber l'expression de genes de collagene ayant subis une mutation et de type sauvage. - Google Patents
Oligonucleotides antisens utilises pour inhiber l'expression de genes de collagene ayant subis une mutation et de type sauvage.Info
- Publication number
- EP0674705A4 EP0674705A4 EP94901327A EP94901327A EP0674705A4 EP 0674705 A4 EP0674705 A4 EP 0674705A4 EP 94901327 A EP94901327 A EP 94901327A EP 94901327 A EP94901327 A EP 94901327A EP 0674705 A4 EP0674705 A4 EP 0674705A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- mutated
- collagen
- wild type
- antisense oligonucleotides
- inhibit expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97333292A | 1992-11-09 | 1992-11-09 | |
US973332 | 1992-11-09 | ||
PCT/US1993/010756 WO1994011494A1 (fr) | 1992-11-09 | 1993-11-09 | Oligonucleotides antisens utilises pour inhiber l'expression de genes de collagene ayant subis une mutation et de type sauvage |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0674705A1 EP0674705A1 (fr) | 1995-10-04 |
EP0674705A4 true EP0674705A4 (fr) | 1997-11-26 |
Family
ID=25520770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94901327A Withdrawn EP0674705A4 (fr) | 1992-11-09 | 1993-11-09 | Oligonucleotides antisens utilises pour inhiber l'expression de genes de collagene ayant subis une mutation et de type sauvage. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0674705A4 (fr) |
JP (1) | JPH08503366A (fr) |
CA (1) | CA2148687A1 (fr) |
WO (1) | WO1994011494A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6156513A (en) * | 1995-09-15 | 2000-12-05 | Ramareddy V. Guntaka | Oligmers which inhibit expression of collagen genes |
US5780611A (en) * | 1995-09-15 | 1998-07-14 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
US5808037A (en) * | 1995-09-15 | 1998-09-15 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
GB9519299D0 (en) | 1995-09-21 | 1995-11-22 | Farrar Gwyneth J | Genetic strategy |
GB9604449D0 (en) * | 1996-03-01 | 1996-05-01 | Farrar Gwyneth J | Genetic strategy ii |
US8551970B2 (en) | 1996-04-02 | 2013-10-08 | Optigen Patents Limited | Genetic suppression and replacement |
GB9606961D0 (en) * | 1996-04-02 | 1996-06-05 | Farrar Gwyneth J | Genetic strategy III |
US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
AU6764398A (en) * | 1997-03-20 | 1998-10-12 | Variagenics, Inc. | Target genes for allele-specific drugs |
US6200754B1 (en) | 1998-03-19 | 2001-03-13 | Variagenics, Inc. | Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes |
US6939712B1 (en) * | 1998-12-29 | 2005-09-06 | Impedagen, Llc | Muting gene activity using a transgenic nucleic acid |
GB9929487D0 (en) * | 1999-12-15 | 2000-02-09 | Zeneca Ltd | Antisense oligonucleotides |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990006934A1 (fr) * | 1988-12-20 | 1990-06-28 | Baylor College Of Medicine | Acide nucleique a triple brin et procedes d'utilisation |
WO1993004701A1 (fr) * | 1991-09-05 | 1993-03-18 | University Of Connecticut | Apport cible de polynucleotides ou d'oligonucleotides a des cellules |
-
1993
- 1993-11-09 EP EP94901327A patent/EP0674705A4/fr not_active Withdrawn
- 1993-11-09 CA CA002148687A patent/CA2148687A1/fr not_active Abandoned
- 1993-11-09 WO PCT/US1993/010756 patent/WO1994011494A1/fr not_active Application Discontinuation
- 1993-11-09 JP JP6512264A patent/JPH08503366A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990006934A1 (fr) * | 1988-12-20 | 1990-06-28 | Baylor College Of Medicine | Acide nucleique a triple brin et procedes d'utilisation |
WO1993004701A1 (fr) * | 1991-09-05 | 1993-03-18 | University Of Connecticut | Apport cible de polynucleotides ou d'oligonucleotides a des cellules |
Non-Patent Citations (4)
Title |
---|
COLIGE, A. ET AL.: "Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene ( COL1A1 ) in transfected mouse 3T3 cells.", BIOCHEMISTRY, (1993 JAN 12) 32 (1) 7-11., XP002032408 * |
COLIGE, A. ET AL.: "USE OF AN ANTISENSE OLIGONUCLEOTIDE TO INHIBIT EXPRESSION OF A MUTATED HUMAN PROCOLLAGEN GENE (COL1A1) IN TRANSFECTED MOUSE 3T3 CELLS.", MATRIX 13 (1). 1993. 30., XP002032407 * |
FOURTH INTERNATIONAL CONFERENCE ON THE MOLECULAR BIOLOGY AND PATHOLOGY OF MATRIX, JUNE 10-13, 1992. * |
See also references of WO9411494A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0674705A1 (fr) | 1995-10-04 |
CA2148687A1 (fr) | 1994-05-26 |
JPH08503366A (ja) | 1996-04-16 |
WO1994011494A1 (fr) | 1994-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5446137B1 (en) | Oligonucleotides containing 4'-substituted nucleotides | |
GR3015085T3 (en) | Anti-sense regulation of gene expression in plant cells. | |
GB2187462B (en) | Root-nodule specific expression of genes in root-nodule tissue and plants comprising root-nodules using promoters from root-nodule specific genes. | |
IL104536A0 (en) | Gene transfer in birds by introduction of dna into muscle in ovo | |
EP0666923A4 (fr) | Apport cible de polynucleotides ou d'oligonucleotides a des cellules. | |
EP0674705A4 (fr) | Oligonucleotides antisens utilises pour inhiber l'expression de genes de collagene ayant subis une mutation et de type sauvage. | |
AU4944396A (en) | Antisense transcript expressed in b lymphocytes and synthetic oligonucleotides useful to inhibit the activity thereof | |
GB9524350D0 (en) | Enhancer-increased gene expression in plants | |
IL108367A0 (en) | Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells | |
AU7572096A (en) | Chimeric oligomers having an rna-cleavage activity | |
GB9514437D0 (en) | Inhibition of gene expression | |
GB9224640D0 (en) | Stable oligonucleotides | |
IL104537A0 (en) | Gene transfer in birds by introduction of dna into muscle in ovo | |
AU6601690A (en) | Selective inhibition of gene expression by photoactivatable oligonucleotides | |
EP0353290A4 (en) | Selective inhibition of gene expression by photoactivatable oligonucleotides | |
GB9225427D0 (en) | Oligonucleotides with rna cleavage activity | |
EP0672153A4 (fr) | Vecteur transportant et exprimant un gene etranger. | |
ZA896423B (en) | Factor regulating gene expression | |
HU9500979D0 (en) | Antisense oligonucleotide inhibition of the ras gene | |
GB8901674D0 (en) | Regulation of plant gene expression | |
ZA958381B (en) | Regulated genes by stimulation of chondrocytes with 1l-1beta | |
EP0489846A4 (en) | Antisense oligonucleotides to c-abl proto-oncogene | |
AU6548396A (en) | Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene | |
EP0975650A4 (fr) | Oligomeres inhibant l'expression de genes de collagene | |
HU9202483D0 (en) | Multigen having self-splitting activity for expression of rna |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950609 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19971009 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19991206 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000418 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1010394 Country of ref document: HK |