EP0656900A4 - Kationische 2-heteroarylphenyl-carbapenem-derivate als antibakterielle mittel. - Google Patents

Kationische 2-heteroarylphenyl-carbapenem-derivate als antibakterielle mittel.

Info

Publication number
EP0656900A4
EP0656900A4 EP93920228A EP93920228A EP0656900A4 EP 0656900 A4 EP0656900 A4 EP 0656900A4 EP 93920228 A EP93920228 A EP 93920228A EP 93920228 A EP93920228 A EP 93920228A EP 0656900 A4 EP0656900 A4 EP 0656900A4
Authority
EP
European Patent Office
Prior art keywords
heteroarylphenyl
cationic
antibacterial agents
carbapenem antibacterial
carbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93920228A
Other languages
English (en)
French (fr)
Other versions
EP0656900A1 (de
Inventor
Frank Dininno
Susan M Schmitt
Ravindra N Guthikonda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/937,618 external-priority patent/US5342933A/en
Priority claimed from US07/937,632 external-priority patent/US5292879A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0656900A1 publication Critical patent/EP0656900A1/de
Publication of EP0656900A4 publication Critical patent/EP0656900A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP93920228A 1992-08-28 1993-08-19 Kationische 2-heteroarylphenyl-carbapenem-derivate als antibakterielle mittel. Withdrawn EP0656900A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US937632 1992-08-28
US937618 1992-08-28
US07/937,618 US5342933A (en) 1992-08-28 1992-08-28 Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
US07/937,632 US5292879A (en) 1992-08-28 1992-08-28 Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents
PCT/US1993/007830 WO1994005669A1 (en) 1992-08-28 1993-08-19 Cationic-2-heteroarylphenyl-carbapenem antibacterial agents

Publications (2)

Publication Number Publication Date
EP0656900A1 EP0656900A1 (de) 1995-06-14
EP0656900A4 true EP0656900A4 (de) 1995-09-06

Family

ID=27130104

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93920228A Withdrawn EP0656900A4 (de) 1992-08-28 1993-08-19 Kationische 2-heteroarylphenyl-carbapenem-derivate als antibakterielle mittel.

Country Status (5)

Country Link
EP (1) EP0656900A4 (de)
JP (1) JPH08500835A (de)
AU (1) AU5082993A (de)
CA (1) CA2142708A1 (de)
WO (1) WO1994005669A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
WO1999055668A1 (fr) 1998-04-27 1999-11-04 Kumiai Chemical Industry Co., Ltd. Derives du 3-arylphenyl-sulfure, insecticides et acaricides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4978659A (en) * 1987-02-02 1990-12-18 Merck & Co., Inc. 2-(Heteroaryliumalkyl)phenyl carbapenem antibacterial agents
US5143914A (en) * 1991-06-25 1992-09-01 Merck & Co., Inc. 2-heteroarylphenyl-carbapenem antibacterial agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9405669A1 *

Also Published As

Publication number Publication date
CA2142708A1 (en) 1994-03-17
EP0656900A1 (de) 1995-06-14
JPH08500835A (ja) 1996-01-30
AU5082993A (en) 1994-03-29
WO1994005669A1 (en) 1994-03-17

Similar Documents

Publication Publication Date Title
EP0597463A3 (en) Thermotherapiesonde.
EP0580285A3 (de) Selbsttätige Wiedereinschalter.
EP0598412A3 (de) Hautschutzmittel zum Schutz der menschlichen Haut.
ZA9225B (en) Antibacterial agents.
EP0633771A4 (en) Compounds.
ZA949177B (en) Microbicides.
EP0572808A3 (de) Antiblockierregelsystem.
ZA964512B (en) Triphenylalkyl antimicrobial agents.
EP0668864A4 (de) Substituierte biphenylmethylimidazopyridine.
ZA927999B (en) Thickening agents.
ZA938805B (en) Antimicrobial toothbrush monifilament.
ZA937127B (en) Catch.
HU9400384D0 (en) Novel antimicrobial agents
EP0599191A3 (de) Motordrehzahlregler-Schaltkreis.
ZA93648B (en) Herbicidal N-cyanopyridazinones.
EP0592354A3 (de) Vakuum-Zentrifuge.
EP0663819A4 (de) Ibuprofen-coffein-kombinationen.
GR3034333T3 (en) Antifoaming agents.
EP0656900A4 (de) Kationische 2-heteroarylphenyl-carbapenem-derivate als antibakterielle mittel.
EP0664779A4 (de) Antibiotische mittel.
EP0597049A4 (de) Antimykotika.
ZA935828B (en) New insobutyl-substituted methanesulphonyl-quinolyl-methoxyphenyl-cycloalkylacetamides.
PH31085A (en) Tropone-substituted phenyloxazolidinone antibacterial agents.
EP0592835A3 (de) BU-4803T Antibiotika.
EP0463852A3 (en) 2-phenanthrenyl-carbapenem antibacterial agents

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19950328

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched
AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 19980508

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19980919