EP0654997A4 - Compositions of substituted azaspiranes and methods of treating psoriasis therewith. - Google Patents

Compositions of substituted azaspiranes and methods of treating psoriasis therewith.

Info

Publication number
EP0654997A4
EP0654997A4 EP93920102A EP93920102A EP0654997A4 EP 0654997 A4 EP0654997 A4 EP 0654997A4 EP 93920102 A EP93920102 A EP 93920102A EP 93920102 A EP93920102 A EP 93920102A EP 0654997 A4 EP0654997 A4 EP 0654997A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
treating psoriasis
azaspiranes
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93920102A
Other languages
German (de)
French (fr)
Other versions
EP0654997A1 (en
Inventor
Alison Mary Badger
Don Edgar Griswold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0654997A1 publication Critical patent/EP0654997A1/en
Publication of EP0654997A4 publication Critical patent/EP0654997A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP93920102A 1992-08-13 1993-08-12 Compositions of substituted azaspiranes and methods of treating psoriasis therewith. Withdrawn EP0654997A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929217121A GB9217121D0 (en) 1992-08-13 1992-08-13 Methods
GB9217121 1992-08-13
PCT/US1993/007699 WO1994004151A1 (en) 1992-08-13 1993-08-12 Compositions of substituted azaspiranes and methods of treating psoriasis therewith

Publications (2)

Publication Number Publication Date
EP0654997A1 EP0654997A1 (en) 1995-05-31
EP0654997A4 true EP0654997A4 (en) 1997-09-17

Family

ID=10720233

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93920102A Withdrawn EP0654997A4 (en) 1992-08-13 1993-08-12 Compositions of substituted azaspiranes and methods of treating psoriasis therewith.

Country Status (4)

Country Link
EP (1) EP0654997A4 (en)
JP (1) JPH08500593A (en)
GB (1) GB9217121D0 (en)
WO (1) WO1994004151A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002229A1 (en) * 1990-08-10 1992-02-20 Smithkline Beecham Corporation Immunosuppressive compositions
WO1992022294A1 (en) * 1991-06-07 1992-12-23 Smithkline Beecham Corporation Immunomodulatory azaspiranes
WO1994004150A1 (en) * 1992-08-13 1994-03-03 Smithkline Beecham Corporation Methods of treating psoriasis employing substituted azaspiranes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002229A1 (en) * 1990-08-10 1992-02-20 Smithkline Beecham Corporation Immunosuppressive compositions
WO1992022294A1 (en) * 1991-06-07 1992-12-23 Smithkline Beecham Corporation Immunomodulatory azaspiranes
WO1994004150A1 (en) * 1992-08-13 1994-03-03 Smithkline Beecham Corporation Methods of treating psoriasis employing substituted azaspiranes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A.M. BADGER ET AL.: "INHIBITION OF ANIMAL MODELS OF AUTOIMMUNE DISEASE AND THE INDUCTION OF NON-SPECIFIC SUPPRESSOR CELLS BY SK&F 105685 AND RELATED AZASPIRANES", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 11, no. 7, 1989, pages 839 - 846, XP000677549 *
D.N. SAUDER ET AL.: "SUPPRESSOR CELL FUNCTION IN PSORIASIS", ARCHIVES OF DERMATOLOGY, vol. 116, no. 1, 1980, pages 51 - 55, XP000677543 *
J.E.F. REYNOLDS: "MARTINDALE, THE EXTRA PHARMACOPOEIA", 1989, THE PHARMACEUTICAL PRESS, LONDON, XP002034973 *
R. ENGST ET AL.: "EVALUATION OF IMMUNOSUPPRESSIVE ACTING ANTIPSORIATIC AGENTS", Z. HAUTKR., vol. 66, no. S2, 1991, pages 55 - 60, XP000677526 *
See also references of WO9404151A1 *

Also Published As

Publication number Publication date
GB9217121D0 (en) 1992-09-23
WO1994004151A1 (en) 1994-03-03
JPH08500593A (en) 1996-01-23
EP0654997A1 (en) 1995-05-31

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19971201