WO1994004151A1

WO1994004151A1 - Compositions of substituted azaspiranes and methods of treating psoriasis therewith

Info

Publication number: WO1994004151A1
Application number: PCT/US1993/007699
Authority: WO
Inventors: Alison Mary Badger; Don Edgar Griswold
Original assignee: Smithkline Beecham Corporation
Priority date: 1992-08-13
Filing date: 1993-08-12
Publication date: 1994-03-03
Also published as: GB9217121D0; EP0654997A4; JPH08500593A; EP0654997A1

Abstract

Invented is a method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a substituted azaspirane.

Description

Compositions of Substituted Azaspiranes and Methods of Treating Psoriasis therewith

This invention relates to a method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a substituted azaspirane.

Background of the Invention Badger et al. U.S. Patent Application No. 4,963,557 discloses a class of suppressor cell inducing immunomodoulatory azaspirane compounds.

Badger does not disclose or claim said compounds for the treatment of psoriasis.

SUMMARY OF THE INVENTION This invention relates to a method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a compound of the formula

(I) in which: m is 1 or 2;

R! and R2 are the same or different and are selected from hydrogen or straight or branched chain alkyl, provided that the total number of carbon atoms contained by Rl and R^ when taken together is 4-10; or R* and R^ together form a cyclic alkyl group containing 3-7 carbon atoms; A is absent or present as C -C- alkyl; and

R3 is a heterocyclic or heterobicyclic ring, said heterocyclic or heterobicyclic ring thereby containing up to 10 carbon atoms and from 1-3 heteroatoms of the formula^NR^, where R^ is absent or present as hydrogen, or a straight chain alkyl containing 1-3 carbon atoms; or a pharmaceutically acceptable salt, hydrate or solvate thereof.

DETAILED DESCRIPTION OF THE INVENTION The term "treatment" and derivatives thereof as used in the specification and in the claims is meant that a mammal in need of antipsoriatic activity is cured of or provided with acceptable symptomatic relief from the disease.

The term "effective amount" as used herein is meant the amount needed to effect treatment as defined above.

The term "mammal" as used herein is meant warm-blooded vertebrate animals, including all that possess hair and suckle their young. Preferably said mammal is a human.

This invention relates to a method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a compound of the formula

in which: m is 1 or 2; 4/04151

- 3

R! and R^ are the same or different and are selected from hydrogen or straight or branched chain alkyl, provided that the total number of carbon atoms contained by R and R^ when taken together is 4-10; or R^ and R^ together form a cyclic alkyl group containing 3-7 carbon atoms; A is absent or present as C1-C7 alkyl; and

Preferred compounds of the invention for use in the presently invented method include:

or a p armaceut cal y accepta e salt, hy rate or so vate t ereo .

The compounds of this invention are prepared by procedures described here below and illustrated by the examples. Reagents, protecting groups and functionality of the molecule must be consistent with the proposed chemical transformations. Steps in the synthesis must be compatible with the functional groups and the protecting groups. _ _Δ _

- 4 -

Formula (I) compounds (i.e. active ingredient) are prepared as described in Scheme I where Rl, R2, R and A are as defined in Formula I and the definition of R3 additionally comprises protecting groups, preferably benzyl protecting groups, which are dissociated to prepare the substituents of R^ as defined in Formula (I) or are dissociated and further reacted to prepare the substituents of R^ as defined in Formula (I).

SCHEME I

a)

LiALH₄

Scheme I depicts formation of Formula (I) compounds. The starting anhydride compounds are known and are synthesized from available precursors using known procedures. According to Scheme I, a solution of an anhydride compound (a) and a substituted primary amine compound are added to an appropriate organic solvent, preferably xylene or toluene, to form a reaction mixture. This reaction mixture is stirred at reflux with constant water removal, and evaporated to form formula (b) compounds.

Formula (c) compounds are prepared by adding to a formula (b) compound dissolved in a suitable organic solvent, such as tetrahydrofuran (THF), a suitable reducing agent, preferably, lithium aluminum hydride. Pharmaceutically acceptable salts and their preparation are well known to those of skill in the art. Preferred pharmaceutically acceptable salts for basic compounds of Formula (I) include, but are not limited to, hydrochloride, citrate, maleate, lactate, hydrobromide, and sulfate.

The compounds of Formula (I) may form hydrates or solvates. It is known to those of skill in the art that charged compounds form hydrated species when lyophilized with water, or form solvated species when concentrated in a solution with an appropriate organic solvent.

A preferred compound of Formula (I), as used herein, is the compound where R* and R^ are propyl, m is 1, A is absent, and R^ is 4-piperidine which is 8,8-dipropyl-2-azaspiro[4.5]decane-2-(4-piperidine).

This invention discloses compounds of Formula (I) and pharmaceutically acceptable salts or hydrates or solvates thereof as being useful for treatment of psoriasis in a mammal in need of such treatment.

This invention relates to a method of treatment of psoriasis in a mammal in need thereof which comprises administering an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt or hydrate or solvate thereof. A compound of Formula (I) or a pharmaceutically acceptable salt or hydrate or solvate thereof can be administered to such mammal in a conventional dosage form prepared by combining a compound of Formula (I) or a pharmaceutically acceptable salt or hydrate or solvate thereof, with a conventional pharmaceutically acceptable carrier or diluent according to known techniques.

It will be recognized by one of skill in the art that the form and character of the pharmaceutically acceptable carrier or diluent is dictated by the amount of active ingredient with which it is to be combined, the route of administration and other well-known variables. A compound of Formula (I) or a pharmaceutically acceptable salt or hydrate or solvate thereof is administered to a mammal in need of antipsoriatic activity in an amount sufficient to cure or provide acceptable symptomatic relief from the disease.

The route of administration of the Formula (I) compound is not critical but is usually oral, parenteral or topical, preferably topical. The present invention is 4/04151

thus also concerned with providing suitable topical and systmeic pharmaceutical formulations for use in the novel methods of treatment of the present invention. The term parenteral as used herein includes intravenous, intramuscular, subcutaneous, intranasal, intrarectal, transdermal, intravaginal or intraperitoneal administration. The subcutaneous and intramuscular forms of parenteral administration are generally preferred. The daily parenteral dosage regimen will preferably be from about 0.01 mg/kg to about 10 mg/kg of total body weight, most preferably from about 0.1 mg/kg to about 1 mg/kg. The daily oral dosage regimen will preferably be from about 0.01 mg/kg to about 10 mg kg of total body weight. The daily topical dosage regiment will preferably be from about 0.01 mg/kg to about 10 mg kg.

Preferably, each parenteral dosage unit will contain the active ingredient in an amount of from about 0.1 mg to about 100 mg. Preferably each oral dosage unit will contain the active ingredient in an amount of from about 0.1 mg to about 100 mg. Preferably, each topical dosage unit will contain the active ingredient in an amount of from about 0.1 mg to about 100 mg.

The compounds of Formula (I) which are active when given orally can be formulated as liquids, for example syrups, suspensions or emulsions, tablets, capsules and lozenges.

A liquid formulation will generally consist of a suspension or solution of the compound or pharmaceutically acceptable salt in a suitable liquid carrier(s) for example, ethanol, glycerine, non-aqueous solvent, for example polyethylene glycol, oils, or water with a suspending agent, preservative, flavoring or coloring agent.

A composition in the form of a tablet can be prepared using any suitable pharmaceutical carrier(s) routinely used for preparing solid formulations. Examples of such carriers include magnesium stearate, starch, lactose, sucrose and cellulose.

A composition in the form of a capsule can be prepared using routine encapsulation procedures. For example, pellets containing the active ingredient can be prepared using standard carriers and then filled into a hard gelatin capsule; alternatively, a dispersion or suspension can be prepared using any suitable pharmaceutical carrier(s), for example aqueous gums, celluloses, silicates or oils and the dispersion or suspension then filled into a soft gelatin capsule. The compounds of the present invention are also administered in the form of a pharmaceutical composition- comprising the active compound in combination with a pharmacologically acceptable carrier adapted for topical administration. These topical pharmaceutical compositions may be in the form of a solution, cream, ointment, gel, lotion, shampoo or aerosol formulation adapted for application to the skin. These topical pharmaceutical compositions containing the compounds of the present invention ordinarily include above 0.1% to 15%, preferably about 0.1 to 5%, and more preferably about 0.1% to 2%, of the active compound, in a mixture with a pharmaceutically acceptable carrier.

While it is possible for an active ingredient to be administered alone, it is preferable to present it as a pharmaceutical formulation.

It will be recognized by one of skill in the art that the optimal quantity and spacing of individual dosages of a compound of Formula (I) or a pharmaceutically acceptable salt or hydrate or solvate thereof will be determined by the nature and extent of the condition being treated, the form, route and site of administration, and the particular patient being treated, and that such optimums can be determined by conventional techniques. It will also be appreciated by one of skill in the art that the optimal course of treatment, i.e., the number of doses of a compound of

Formula (I) or a pharmaceutically acceptable salt or hydrate or solvate thereof given per day and duration of therapy can be ascertained by those skilled in the art using conventional course of treatment determination tests.

In addition, the compounds of the present invention can be co-administered with further active ingredients or therapies known for the treatment of psoriasis such as; keratinolytics, topical corticosteroids, coal tar and ultraviolet light or cyclosporine A.

Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following examples are, therefore, to be construed as merely illustrative and not a limitation of the scope of the present invention in any way. I. SYNTHETIC EXAMPLES

In the following Examples, temperature is in degrees Centigrade (°C). 4,4-Dipropylcyclohexane-l-carboxy-l -acetic acid anhydride, 4,4- diethylcyclohexane-1-carboxy-l-acetic acid anhydride, 4,4-dipropylcyclohexane-l,l-diacetic acid anhydride, and

4,4-diethylcyclohexane-l,l-diacetic acid anhydride were synthesized as described in U.S. Patent 4,963,557.

4-Amino-l-benzylpiperidine, lithium aluminum hydride and tropinone were purchased from the Aldrich Chemical Co. (Milwaukee, WI). 3R-Pyrrolidine and 3S-pyrrolidine were purchased from CTC Organics (Atlanta, GA).

EXAMPLE 1 2-r4-Piperidinyn-8.8-dipropyl-2-azaspiror4.51-decane dihydrochloride

(i) 2-r4-fN-BenzyDpiperidinyll-8.8-dipropyl-2-azaspiror4.51-decane-1.3- decant?

To a solution of 4,4-dipropylcyclohexane-l-carboxy-l -acetic acid anhydride ^■ (1 molar equivalent) in xylene was added 4-amino-l-benzylpiperidine (1 molar equivalent). The reaction mixture was heated at reflux with a Dean-Stark trap until 1 equivalent of water was collected in the trap. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to give a white solid. The crude imide was dissolved in excess ethyl acetate followed by two washes with saturated aqueous sodium bicarbonate solution to remove any residual acid-amide from the product. The organic phase was dried over sodium sulfate, filtered, and concentrated to give the desired imide as a white solid; mp 148-149 C; 90-95% yield.

(ii) 2-r4-fN-BenzyDpiperidinyll-8.8-dipropyl-2-azaspiro[4.51-decane To a mixture of lithium aluminum hydride (3.2 molar equivalents) in tetrahydrofuran was added dropwise a solution of 2-[4-(N-benzyl)piperidinyl]-8,8- dipropyl-2-azaspiro[4.5]-decane -1,3-dione (1 molar equivalent) in tetrahydrofuran. The reaction mixture was stirred for 2-6 h following completion of addition. The excess hydride was quenched with sodium sulfate-decahydrate and the resulting mixture was filtered and the filtrate was concentrated to give the desired diamine as a viscous, colorless oil. The oil was used directly without further purification; yield 90-95%. (iii) 2-f4-Piperidinyl)-8.8-dipropyl-2-azaspiror4.51-decane To a suspension of 10% palladium-on-carbon (0.1 molar equivalents) in a 7.5% formic acid in methanol solution was added 2-[4-(N-benzyl)piperidinyl]-8,8- dipropyl-2-azaspiro[4.5]-decane (1 molar equivalent). The reaction mixture was hydrogenated at 60 psi hydrogen pressure in a Parr hydrogenation apparatus at room temperature until hydrogen uptake had ceased (48-96h). The catalyst was removed by filtration through celite and the filtrate concentrated under reduced pressure. The residue was dissolved in water and then basified with 10% NaOH. The resulting aqueous emulsion was extracted with ethyl ether. The organic phase was dried over sodium sulfate, filtered and concentrated to give the debenzylated diamine product as a colorless oil; 90-95% yield.

(iv) 2-f4-PiperidinyD-8.8-dipropyl-2-azaspiror4.51-decane dihydrochloride 2-(4-Piperidinyl)-8,8-dipropyl-2-azaspiro[4.5]-decane was dissolved in a minimum of anhydrous ethanol and added to a cooled solution of hydrogen chloride in ethanol. On addition of a large volume of ether, a white precipitate formed which was isolated by filtration. The white solid was recrystallized from ethanol or methanol; mp 298-300°C; yield 85-90%.

EXAMPLE 2 2-f4-fN-MethyDpiperidinyD-8.8-dipropyl-2-azaspiro-f4.51-decane dihydrochloride

(i) 2-f4-fN-MethyDpiperidinyl-8.8-dipropyl-2-azaspiror4.51-decane To a solution of 2-(4-piperidinyl)-8,8-dipropyl-2- azaspiro[4.5]-decane (1 molar equivalent prepared according to Example 1 (iii)) in acetonitrile was added 37% aqueous formaldehyde (5 molar equivalents) and sodium cyanoborohydride (1.6 molar equivalents). The reaction mixture was stirred overnight at room temperature. Added 2 N KOH and extracted the reaction mixture twice with ethyl acetate. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to give a yellow viscous oil. The residue was purified by chromatography on silica gel using MeOH/ethyl acetate/cone, ammonium hydroxide (74/24/1.5) as eluant. The product was isolated as a colorless oil; yield 60%.

(ii) 2-f4-N-MethvDpiperidinyl-8.8-dipropyl-2-azaspiror4.51-decane dihydrochloride The title compound is prepared according to Example 1 (iv) by substituting 2-(4-(N-Methyl)piperidinyl-8,8-dipropyl-2-azaspiro[4.5]-decane for 2-(4- Piperidinyl)-8,8-dipropyl-2-azaspiro[4.5]-decane; mp 332-334°C.

EXAMPLE 3

2-f4-Piperidinyl)-8.8-diethyl-2-azaspiror4.51-decane dihvdrochloride

The title compound is prepared according to Example 1 (i-iv) by substituting 4,4-diethylcyclohexane-l-carboxy-l -acetic acid anhydride for 4,4-dipropylcyclo- hexane-l-carboxy-1 -acetic acid anhydride; mp 331-332°C.

EXAMPLE 4 2-f2-f4-ImidazolyPethyI)-8.8-dipropyI-2-azaspiror4.51decane dihydrochloride

(i) 2-f2-f4-Imidazolyl)ethyl)-8.8-dipropyl-2-azaspiror4.51decane

The title compound is prepared according to Example 1 (i-iii) by substituting histamine for 4-amino-l-benzylpiperidine.

(ii) 2-(2-(4-ImidazolyPethyP-8.8-dipropyl-2-azaspiror4.51decane dihydrochloride

2-(2-(4-Imidazolyl)ethyl)-8,8-dipropyl-2-azaspiro-[4.5]decane was dissolved in a minimum amount of ethanol and a solution of HCl(g)/EtOH was added. The dihydrochloride did not precipitate. The solution was concentrated to dryness and placed in a vacuum oven overnight at 60 / 5 mm to give the desired dihydrochloride salt as a white solid: yield 72%; m.p. 258-262 C.

EXAMPLE 5 2-f3R-pyrrolidinyD-8.8-dipropyl-2-azaspiror4.51-decane dimaleate

(i) 2-f3R-pyrrolidinyD-8.8-dipropyl-2-azaspiror4.51-decane-1.3-dione

To a solution of 4,4-dipropylcyclohexane-l-carboxy-l -acetic acid anhydride (1 molar equivalent) in xylene was added 3R-aminopyrrolidine (1 molar equivalent). The reaction mixture was heated at reflux with a Dean-Stark trap until 1 equivalent of water was collected in the trap. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to give a viscous, dark brown oil. The crude product was dissolved in methanol and a methanol solution containing maleic acid (1 molar equivalent) was added. The volatiles were stripped off under reduced pressure from the product-maleate solution to yield a dark brown solid. The solid was recrystallized from dichloromethane/ethyl acetate to afford the pure salt as a white crystalline solid. The product salt was solubilized in a minimum of water and the resulting solution basified with 1 M sodium hydroxide and extracted with ethyl ether. The ether extracts were combined, dried over sodium sulfate, filtered, and concentrated to give the desired imide as a viscous oil; 70-75% yield.

(ii) 2-f3R-pyrrolidinyD-8.8-dipropyl-2-azaspiror4.51-decane To a mixture of lithium aluminum hydride (3.2 molar equivalents) in ethyl ether was added dropwise a solution of 2-(3R-pyrrolidinyl)-8,8-dipropyl-2- azaspiro[4.5]-decane-l,3-dione (1 molar equivalent) in ethyl ether. The reaction mixture was stirred for 2-6 h after addition was completed. The excess hydride was quenched with sodium sulfate-decahydrate and the resulting mixture was filtered. The filtrate was concentrated under reduced pressure to give the diamine as a viscous, colorless oil; 80-85% yield.

(iii) 2-f3R-pyrrolidinvD-8.8-dipropyl-2-azaspiror4.51-decane dimaleate 2-(3R-pyrrolidinyl)-8,8-dipropyl-2-azaspiro[4.5]-decane was dissolved in methanol and a methanol solution containing maleic acid (2 molar equivalents) was added. The solvent volume was reduced under vacuum. A 10% hexane in ethyl acetate solution was carefully added to the product-methanol solution to form a white precipitate which was isolated by filtration. The white solid product required no further purification; mp 168.5-170°C; 70-80% yield.

EXAMPLE 6 2-f3S-pyrrolidinyl)-8.8-dipropyl-2-azaspiror4,51-decane dimaleate The title compound is prepared according to Example 5 (i-iii) by substituting 3S-aminopyrrolidine for 3R-aminopyrroldine; mp 169.5-170.5°C.

EXAMPLE 7 2-f3'-OuinuclidinyD-8.8-dipropyl-2-azaspiror4.51-decanedihydrochIoride

(i) 2-f3'-Ouinuclidinyl)-8.8-dipropyl-2-azaspiror4.51decane-1.3-dione To a solution of 4,4-dipropylcyclohexane- 1 -carboxy- 1 -acetic acid anhydride

(1 molar equivalent) in toluene was added 3-aminoquinuclidine (1 molar equivalent). The reaction mixture was heated to reflux with stirring using a Dean- Stark trap until the volume of water collected was unchanged (approximately five hours), and then allowed to cool. The toluene was evaporated under reduced pressure and the residue partitioned between ethyl acetate and IN sodium hydroxide solution. The organic phase was separated, washed with water, dried (MgSO_. ) and evaporated to give 2-(3-quinuclidinyl)-8,8-dipropyl-2-azaspiro[4.5]decane-l,3- dione ( 94%) as a yellow oil which solidified on standing. This was used without further purification.

(ii) 2-f3'-OuinuclidinvD-8.8-dipropyl-2-azaspiror4.51decane To a stirred suspension of lithium aluminum hydride (3.5 molar equivalents) in the THF (80 ml) at 0°C under argon was added a solution of 2-(3'-quinuclidinyl)- 8,8-dipropyl-2-azaspiro [4.5]decane-l,3-dione (1 molar equivalent) in THF dropwise over 45 minutes. The reaction mixture was allowed to warm to room temperature then stirred overnight. Sodium sulfate decahydrate was added slowly in portions to quench the unreacted LAH and the resulting suspension of solids was filtered and the filtrate evaporated under reduced pressure to yield a residual colorless oil.

(iii) 2-f3'-OuinuclidinyD-8.8-dipropyl-2-azaspiror4.51decane dihydrochloride

2-(3'-Quinuclidinyl)-8,8-dipropyl-2-azaspiro[4.5]decane was dissolved in a small volume of ethanol and a solution of saturated hydrogen chloride in ethanol was added. Upon addition of a large volume of ether a white precipitate formed which was filtered and dried giving the title compound (yield 70%) as a white amorphous solid; mp 277-278°C. Elemental analysis suggest that the title compound was isolated as the monohydrate.

EXAMPLE 8 2-f3'-α-f8'-Methyl-8-azabicvclof3.2.1)-8.8-dipropyl-2-azaspiror4.51decane dihydrochloride

(i) 3-α-Amino-8-methyl-8-azabicyclo(3.2.1)octane (3-a-aminotropane) A solution of tropinone (5.0 g) in ethanol containing palladium on activated carbon (10%, 2.0 g) was saturated with ammonia at 0° C then hydrogenated on a Parr apparatus at 50 psi for 24 hours. The mixture was filtered through celite and evaporated under reduced pressure. The colorless residual oil was used without further purification.

EXAMPLE 6 - CLEANSING CREAM

, _ ₁₇ _

EXAMPLE 9 - SHAMPOO GEL

While the above descriptions and examples fully describe the invention and the preferred embodiments thereof, it is understood that the invention is not limited to the particular disclosed embodiments coming within the scope of the following claims.

Claims

/04151

What is claimed is: 18

1. A method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a compound of the formula

in which: m is 1 or 2;

R! and R^ are the same or different and are selected from hydrogen or straight or branched chain alkyl, provided that the total number of carbon atoms contained by R^ and R^ when taken together is 4-10; or R^ and R^ together form a cyclic alkyl group containing 3-7 carbon atoms;

A is absent or present as C1-C7 alkyl; and

R3 is a heterocyclic or heterobicyclic ring, said heterocyclic or heterobicyclic ring thereby containing up to 10 carbon atoms and from 1-3 heteroatoms of the formula NR^, where R^ is absent or present as hydrogen, or a straight chain alkyl containing 1-3 carbon atoms; or a pharmaceutically acceptable salt, hydrate or solvate thereof.

The method of claim 1 wherein the mammal being treated is a human.

3. The method of claim 1 wherein the compound is selected from:

and

or a pharmaceutically acceptable salt, hydrate or solvate thereof.

4. The method of claim 1 wherein the compound is 8,8-dipropyl-2- azaspiro[4.5]decane-2-(4-piperidine); or a pharmaceutically acceptable salt, hydrate or solvate thereof.

5. The method of claim 1 wherein the compound is administered orally.

6. The method of claim 5 wherein from about 0.01 mg/kg to about 10 mg/kg of compound is administered per day.

7. The method of claim 1 wherein the compound is administered parenterally.

8. The method of claim 7 wherein from about 0.01 mg/kg to about 10 mg/kg of compound is administered per day.

9. The method of claim 1 wherein the compound is administered topically.

10. The method of claim 9 wherein from about 0.01 mg/kg of about 10 mg/kg of compound is administered per day.

11. A pharmaceutical composition for use in treatment of psoriasis in a mammal in need thereof comprising a

in which: m is 1 or 2;

R! and R^ are the same or different and are selected from hydrogen or straight or branched chain alkyl, provided that the total number of carbon atoms contained by R¹ and R^ when taken together is 4-10; or R* and R^ together form a cyclic alkyl group containing 3-7 carbon atoms; /04151

20

A is absent or present as C\-Cη alkyl; and

R3 is a heterocyclic or heterobicyclic ring, said heterocyclic or heterobicyclic ring thereby containing up to 10 carbon atoms and from 1-3 heteroatoms of the formula NR^, where R^ is absent or present as hydrogen, or a straight chain alkyl containing 1-3 carbon atoms; or a pharmaceutically acceptable salt, hydrate or solvate thereof and a pharmaceutically acceptable carrier.

12. A composition according to claim 11 wherein the mammal being treated is a human.

13. A composition according to claim 11 wherein the compound is selected from:

or a pharmaceutically acceptable salt, hydrate or solvate thereof.

14. A composition according to claim 11 wherein the compound is 8,8-dipropyl-

2-azaspiro[4.5]decane-2-(4-piperidine); or a pharmaceutically acceptable salt, hydrate or solvate thereof. 15. A composition according to claim 11 wherein the compound is administered orally.

16. A composition according to claim 15 wherein from about 0.01 mg/kg to about 10 mg/kg of compound is administered per day.

17. A composition according to claim 11 wherein the compound is administered parenterally.

18. A composition according to claim 17 wherein from about 0.01 mg/kg to about 10 mg/kg of compound is administered per day.

19. A composition according to claim 11 wherein the compound is administered topically.

20. A composition according to claim 19 wherein from about 0.01 mg/kg of about 10 mg/kg of compound is administered per day.

21. Use of a compound of the formula

in which: m is 1 or 2;

R! and R^ are the same or different and are selected from hydrogen or straight or branched chain alkyl, provided that the total number of carbon atoms contained by R^ and R^ when taken together is 4-10; or R* and R^ together form a cyclic alkyl group containing 3-7 carbon atoms;

A is absent or present as Cj-Cγ alkyl; and

R3 is a heterocyclic or heterobicyclic ring, said heterocyclic or heterobicyclic ring thereby containing up to 10 carbon atoms and from 1-3 heteroatoms of the formula NR^, where R^ is absent or present as hydrogen, or a straight chain alkyl containing 1-3 carbon atoms; or a pharmaceutically acceptable salt, hydrate or solvate thereof in the manufacture of a medicament for use in the treatment of psoriasis in a mammal in need thereof.

22. A use according to claim 21 wherein the mammal being treated is a human. 22

23. A use according to claim 21 wherein the compound is selected from:

or a pharmaceutically acceptable salt, hydrate or solvate thereof.

24. A use according to claim 21 wherein the compound is 8,8-dipropyl-2- azaspiro[4.5]decane-2-(4-piperidine); or a pharmaceutically acceptable salt, hydrate or solvate thereof.

25. A use according to claim 21 wherein the compound is administered orally.

26. A use according to claim 25 wherein from about 0.01 mg/kg to about 10 mg/kg of compound is administered per day.

27. A use according to claim 21 wherein the compound is administered parenterally. 28. A use according to claim 27 wherein from about 0.01 mg/kg to about 10 mg/kg of compound is administered per day.

29. A use according to claim 21 wherein the compound is administered topically.

30. A use according to claim 29 wherein from about 0.01 mg/kg of about 10 mg/kg of compound is administered per day.