EP0654043A4 - Method for preparing a metal-radionuclide-labelled protein. - Google Patents

Method for preparing a metal-radionuclide-labelled protein.

Info

Publication number
EP0654043A4
EP0654043A4 EP94915454A EP94915454A EP0654043A4 EP 0654043 A4 EP0654043 A4 EP 0654043A4 EP 94915454 A EP94915454 A EP 94915454A EP 94915454 A EP94915454 A EP 94915454A EP 0654043 A4 EP0654043 A4 EP 0654043A4
Authority
EP
European Patent Office
Prior art keywords
radionuclide
preparing
metal
labelled protein
labelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94915454A
Other languages
German (de)
French (fr)
Other versions
EP0654043A1 (en
Inventor
Alfons M Verbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Priority to EP94915454A priority Critical patent/EP0654043A4/en
Publication of EP0654043A1 publication Critical patent/EP0654043A1/en
Publication of EP0654043A4 publication Critical patent/EP0654043A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94915454A 1993-05-03 1994-05-02 Method for preparing a metal-radionuclide-labelled protein. Withdrawn EP0654043A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP94915454A EP0654043A4 (en) 1993-05-03 1994-05-02 Method for preparing a metal-radionuclide-labelled protein.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP93201249 1993-05-03
EP93201249 1993-05-03
EP94915454A EP0654043A4 (en) 1993-05-03 1994-05-02 Method for preparing a metal-radionuclide-labelled protein.
PCT/US1994/005022 WO1994025488A1 (en) 1993-05-03 1994-05-02 Method for preparing a metal-radionuclide-labelled protein

Publications (2)

Publication Number Publication Date
EP0654043A1 EP0654043A1 (en) 1995-05-24
EP0654043A4 true EP0654043A4 (en) 1997-07-16

Family

ID=8213808

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94915454A Withdrawn EP0654043A4 (en) 1993-05-03 1994-05-02 Method for preparing a metal-radionuclide-labelled protein.

Country Status (5)

Country Link
EP (1) EP0654043A4 (en)
AU (1) AU6670894A (en)
CA (1) CA2141739A1 (en)
MX (1) MXPA94003278A (en)
WO (1) WO1994025488A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5746996A (en) * 1994-06-03 1998-05-05 Immunomedics, Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
GB9621137D0 (en) * 1996-10-10 1996-11-27 Chas A Blatchford And Sons Lim An above-knee lower limb prosthesis and a shin component for the prosthesis

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752720A1 (en) * 1976-12-03 1978-06-08 Squibb & Sons Inc SUBSTITUTED AMINO ACIDS
EP0248506A1 (en) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Metal ion labeling of carrier molecules
WO1989007456A1 (en) * 1988-02-09 1989-08-24 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein
WO1989012625A1 (en) * 1988-06-15 1989-12-28 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
WO1991007991A1 (en) * 1989-11-30 1991-06-13 Mallinckrodt Medical, Inc. Method for preparing a metal-radionuclide-labelled protein
WO1992007876A1 (en) * 1990-10-24 1992-05-14 Henning Berlin Gmbh Chemie- Und Pharmawerk Ligand/carrier-protein conjugate
US5162505A (en) * 1989-09-19 1992-11-10 Centocor Proteins modified with positively charged carriers and compositions prepared therefrom

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479930A (en) * 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752720A1 (en) * 1976-12-03 1978-06-08 Squibb & Sons Inc SUBSTITUTED AMINO ACIDS
EP0248506A1 (en) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Metal ion labeling of carrier molecules
WO1989007456A1 (en) * 1988-02-09 1989-08-24 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein
WO1989012625A1 (en) * 1988-06-15 1989-12-28 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5162505A (en) * 1989-09-19 1992-11-10 Centocor Proteins modified with positively charged carriers and compositions prepared therefrom
WO1991007991A1 (en) * 1989-11-30 1991-06-13 Mallinckrodt Medical, Inc. Method for preparing a metal-radionuclide-labelled protein
WO1992007876A1 (en) * 1990-10-24 1992-05-14 Henning Berlin Gmbh Chemie- Und Pharmawerk Ligand/carrier-protein conjugate

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 103, no. 25, 23 December 1985, Columbus, Ohio, US; abstract no. 215767, XP002027314 *
HAYASHI YOSHIO ET AL.: "APPLICATION OF A NEW HETEROBIFUNCTIONAL CONJUGATING REAGENT, DNPVB AND A NEW SH-INTRODUCING REAGENT, MTPTT.", PEPT. CHEM., vol. 22ND, 1985, pages 19 - 22 *
See also references of WO9425488A1 *

Also Published As

Publication number Publication date
CA2141739A1 (en) 1994-11-10
EP0654043A1 (en) 1995-05-24
WO1994025488A1 (en) 1994-11-10
AU6670894A (en) 1994-11-21
MXPA94003278A (en) 2005-04-01

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19950113

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: VERBRUGGEN, ALFONS M.

RHK1 Main classification (correction)

Ipc: C07K 15/00

RHK1 Main classification (correction)

Ipc: A61K 49/02

A4 Supplementary search report drawn up and despatched

Effective date: 19970603

AK Designated contracting states

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STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 19970815