EP0593452A4 - Method for preparing a metal-radionuclide-labelled protein. - Google Patents
Method for preparing a metal-radionuclide-labelled protein.Info
- Publication number
- EP0593452A4 EP0593452A4 EP19910902555 EP91902555A EP0593452A4 EP 0593452 A4 EP0593452 A4 EP 0593452A4 EP 19910902555 EP19910902555 EP 19910902555 EP 91902555 A EP91902555 A EP 91902555A EP 0593452 A4 EP0593452 A4 EP 0593452A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- radionuclide
- preparing
- metal
- labelled protein
- labelled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8902956 | 1989-11-30 | ||
NL8902956 | 1989-11-30 | ||
PCT/US1990/006977 WO1991007991A1 (en) | 1989-11-30 | 1990-11-28 | Method for preparing a metal-radionuclide-labelled protein |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0593452A4 true EP0593452A4 (en) | 1992-08-31 |
EP0593452A1 EP0593452A1 (en) | 1994-04-27 |
Family
ID=19855723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91902555A Withdrawn EP0593452A1 (en) | 1989-11-30 | 1990-11-28 | Method for preparing a metal-radionuclide-labelled protein |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0593452A1 (en) |
JP (1) | JPH05504763A (en) |
AU (1) | AU654663B2 (en) |
CA (1) | CA2069868A1 (en) |
WO (1) | WO1991007991A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
CA2141739A1 (en) * | 1993-05-03 | 1994-11-10 | Alfons M. Verbruggen | Method for preparing a metal-radionuclide-labelled protein |
AU730388B2 (en) * | 1996-01-11 | 2001-03-08 | Peregrine Pharmaceuticals, Inc. | Antibodies with reduced net positive charge |
US5990286A (en) * | 1996-12-18 | 1999-11-23 | Techniclone, Inc. | Antibodies with reduced net positive charge |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247866A1 (en) * | 1986-05-29 | 1987-12-02 | Mallinckrodt, Inc. (a Delaware corporation) | Coupling agents for radiolabeling proteins |
WO1989007456A1 (en) * | 1988-02-09 | 1989-08-24 | Mallinckrodt, Inc. | Method of preparing a metal-radionuclide-labelled protein |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59116232A (en) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | Cell toxicity complex and its preparation |
US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US4732974A (en) * | 1986-03-05 | 1988-03-22 | Mallinckrodt, Inc. | Metal ion labeling of carrier molecules |
US4970303A (en) * | 1988-02-03 | 1990-11-13 | Xoma Corporation | Linking agents and methods |
GB8809616D0 (en) * | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
DE68921982D1 (en) * | 1988-06-14 | 1995-05-04 | Cetus Oncology Corp | COUPLING AGENTS AND STERICALLY DISABLED CONJUGATES THEREOF. |
US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
-
1990
- 1990-11-28 AU AU71566/91A patent/AU654663B2/en not_active Ceased
- 1990-11-28 EP EP91902555A patent/EP0593452A1/en not_active Withdrawn
- 1990-11-28 WO PCT/US1990/006977 patent/WO1991007991A1/en not_active Application Discontinuation
- 1990-11-28 JP JP50268291A patent/JPH05504763A/en active Pending
- 1990-11-28 CA CA002069868A patent/CA2069868A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247866A1 (en) * | 1986-05-29 | 1987-12-02 | Mallinckrodt, Inc. (a Delaware corporation) | Coupling agents for radiolabeling proteins |
WO1989007456A1 (en) * | 1988-02-09 | 1989-08-24 | Mallinckrodt, Inc. | Method of preparing a metal-radionuclide-labelled protein |
Non-Patent Citations (5)
Also Published As
Publication number | Publication date |
---|---|
EP0593452A1 (en) | 1994-04-27 |
AU654663B2 (en) | 1994-11-17 |
JPH05504763A (en) | 1993-07-22 |
AU7156691A (en) | 1991-06-26 |
CA2069868A1 (en) | 1991-05-31 |
WO1991007991A1 (en) | 1991-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19920601 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19950405 |