EP0650526A4 - PRODUCTION OF TRIPLE-HELIX COMPLEXES FROM SINGLE-STRANDED NUCLEIC ACIDS BY USE OF NUCLEOTIDOLIGOMERS. - Google Patents
PRODUCTION OF TRIPLE-HELIX COMPLEXES FROM SINGLE-STRANDED NUCLEIC ACIDS BY USE OF NUCLEOTIDOLIGOMERS.Info
- Publication number
- EP0650526A4 EP0650526A4 EP92921942A EP92921942A EP0650526A4 EP 0650526 A4 EP0650526 A4 EP 0650526A4 EP 92921942 A EP92921942 A EP 92921942A EP 92921942 A EP92921942 A EP 92921942A EP 0650526 A4 EP0650526 A4 EP 0650526A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- formation
- nucleic acids
- single stranded
- stranded nucleic
- triple helix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/152—Nucleic acids forming more than 2 strands, e.g. TFOs on a single-stranded target, e.g. fold-back TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77208191A | 1991-10-07 | 1991-10-07 | |
US772081 | 1991-10-07 | ||
PCT/US1992/008458 WO1993007295A1 (en) | 1991-10-07 | 1992-10-05 | Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0650526A1 EP0650526A1 (en) | 1995-05-03 |
EP0650526A4 true EP0650526A4 (en) | 1998-02-04 |
Family
ID=25093855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92921942A Withdrawn EP0650526A4 (en) | 1991-10-07 | 1992-10-05 | PRODUCTION OF TRIPLE-HELIX COMPLEXES FROM SINGLE-STRANDED NUCLEIC ACIDS BY USE OF NUCLEOTIDOLIGOMERS. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0650526A4 (xx) |
JP (1) | JPH07501936A (xx) |
AU (2) | AU2785292A (xx) |
CA (1) | CA2119890A1 (xx) |
IL (1) | IL103311A0 (xx) |
NZ (1) | NZ244606A (xx) |
WO (1) | WO1993007295A1 (xx) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996018732A2 (en) * | 1994-12-15 | 1996-06-20 | Board Of Trustees Of The University Of Illinois | Sequence-specific inhibition of dna synthesis by triplex-forming oligonucleotides |
US6331617B1 (en) | 1996-03-21 | 2001-12-18 | University Of Iowa Research Foundation | Positively charged oligonucleotides as regulators of gene expression |
US5734040A (en) * | 1996-03-21 | 1998-03-31 | University Of Iowa Research Foundation | Positively charged oligonucleotides as regulators of gene expression |
US6274313B1 (en) | 1996-03-21 | 2001-08-14 | Pioneer-Hybrid International, Inc. | Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use |
US5853993A (en) * | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
US7244732B2 (en) | 2003-06-20 | 2007-07-17 | Koronis Pharmaceuticals, Incorporated | Prodrugs of heteroaryl compounds |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
SG2014013395A (en) | 2011-08-30 | 2014-05-29 | Astex Pharmaceuticals Inc | Decitabine derivative formulations |
AU2016287585B2 (en) | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
JP2020529409A (ja) | 2017-08-03 | 2020-10-08 | 大塚製薬株式会社 | 薬物化合物およびその精製方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015884A1 (en) * | 1989-06-19 | 1990-12-27 | The Johns Hopkins University | Formation of triple helix complexes of double stranded dna using nucleoside oligomers |
WO1992010590A1 (en) * | 1990-12-10 | 1992-06-25 | Gilead Sciences, Inc. | Inhibition of transcription by formation of triple helixes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
CA2006008C (en) * | 1988-12-20 | 2000-02-15 | Donald J. Kessler | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
-
1992
- 1992-10-01 IL IL103311A patent/IL103311A0/xx unknown
- 1992-10-02 NZ NZ244606A patent/NZ244606A/en unknown
- 1992-10-05 CA CA002119890A patent/CA2119890A1/en not_active Abandoned
- 1992-10-05 AU AU27852/92A patent/AU2785292A/en not_active Abandoned
- 1992-10-05 EP EP92921942A patent/EP0650526A4/en not_active Withdrawn
- 1992-10-05 JP JP5507113A patent/JPH07501936A/ja active Pending
- 1992-10-05 WO PCT/US1992/008458 patent/WO1993007295A1/en not_active Application Discontinuation
-
1997
- 1997-06-13 AU AU24881/97A patent/AU2488197A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015884A1 (en) * | 1989-06-19 | 1990-12-27 | The Johns Hopkins University | Formation of triple helix complexes of double stranded dna using nucleoside oligomers |
WO1992010590A1 (en) * | 1990-12-10 | 1992-06-25 | Gilead Sciences, Inc. | Inhibition of transcription by formation of triple helixes |
Non-Patent Citations (5)
Title |
---|
HÉLÈNE C: "The anti-gene strategy: Control of gene expression by triplex-forming-oligonucleotides", ANTI-CANCER DRUG DESIGN, vol. 6, 1991, pages 569 - 584, XP002047547 * |
JAYASENA S D ET AL: "OLIGONUCLEOTIDE-DIRECTED TRIPLE HELIX FORMATION AT ADJACENT OLIGOPURINE AND OLIGOPYRIMIDINE DNA TRACTS BY ALTERNATE STRAND RECOGNITION", NUCLEIC ACIDS RESEARCH, vol. 20, no. 20, 1 January 1992 (1992-01-01), pages 5279 - 5288, XP002000132 * |
ONO A ET AL: "Triplex formation of oligonucleotides containing 2'-O-methylpseudoisocytidine in substitution for 2'-deoxycitidine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 113, 1991, pages 4032 - 4033, XP002047549 * |
See also references of WO9307295A1 * |
WELLS RD ET AL: "The chemistry and biology of unusual DNA structures adopted by oligopurine-oligopyrimidine sequences", FASEB JOURNAL, vol. 2, 1988, pages 2939 - 2949, XP002047548 * |
Also Published As
Publication number | Publication date |
---|---|
IL103311A0 (en) | 1993-03-15 |
EP0650526A1 (en) | 1995-05-03 |
AU2488197A (en) | 1997-09-04 |
NZ244606A (en) | 1997-07-27 |
WO1993007295A1 (en) | 1993-04-15 |
JPH07501936A (ja) | 1995-03-02 |
AU2785292A (en) | 1993-05-03 |
CA2119890A1 (en) | 1993-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19940415 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 19971216 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19980227 |
|
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 19971216 |