EP0648151A1 - Method and device for grading capsules. - Google Patents
Method and device for grading capsules.Info
- Publication number
- EP0648151A1 EP0648151A1 EP93912997A EP93912997A EP0648151A1 EP 0648151 A1 EP0648151 A1 EP 0648151A1 EP 93912997 A EP93912997 A EP 93912997A EP 93912997 A EP93912997 A EP 93912997A EP 0648151 A1 EP0648151 A1 EP 0648151A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- capsules
- control
- capsule
- sorting device
- control position
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 216
- 238000000034 method Methods 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 claims abstract description 13
- 239000007903 gelatin capsule Substances 0.000 claims description 20
- 230000002950 deficient Effects 0.000 claims description 16
- 238000004590 computer program Methods 0.000 claims description 14
- 238000003860 storage Methods 0.000 claims description 14
- 238000011156 evaluation Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000007664 blowing Methods 0.000 claims 1
- 238000002594 fluoroscopy Methods 0.000 claims 1
- 238000001454 recorded image Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 5
- 108010010803 Gelatin Proteins 0.000 abstract description 4
- 229920000159 gelatin Polymers 0.000 abstract description 4
- 239000008273 gelatin Substances 0.000 abstract description 4
- 235000019322 gelatine Nutrition 0.000 abstract description 4
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 4
- 229920002472 Starch Polymers 0.000 abstract description 3
- 235000019698 starch Nutrition 0.000 abstract description 3
- 239000008107 starch Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 239000003086 colorant Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
- B07C5/342—Sorting according to other particular properties according to optical properties, e.g. colour
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/36—Sorting apparatus characterised by the means used for distribution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
- B07C5/342—Sorting according to other particular properties according to optical properties, e.g. colour
- B07C5/3422—Sorting according to other particular properties according to optical properties, e.g. colour using video scanning devices, e.g. TV-cameras
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S209/00—Classifying, separating, and assorting solids
- Y10S209/919—Rotary feed conveyor
Definitions
- the invention relates to a method and an apparatus for sorting capsules for defect-free and defective capsules, e.g. B. capsules for orally used medicament.
- Such capsules mainly serve as a casing or container for a powdered or granulated medicament and are taken together with it.
- These capsules are made of a physiologically safe material, e.g. B. hard or soft gelatin, starch or another material that does not contain the active ingredient of the drug itself.
- B. hard or soft gelatin e.g. hard or soft gelatin, starch or another material that does not contain the active ingredient of the drug itself.
- gelatin capsules are mass-produced in high-performance production processes from gelatin or gelatin solution. A distinction is made between hard gelatin capsules and soft gelatin capsules.
- Hard gelatin capsules consist of a hollow upper part (cap) and a hollow lower part (body), which are produced simultaneously on one machine.
- the capsule parts are temporarily assembled without a filling material to form a finished capsule, as a result of which a small, empty oblong container is obtained.
- Hard gelatin capsules are produced in various colors and color combinations, transparent and opaque.
- the empty hard capsule has a weight of approx. 30 to 130 mg depending on the size.
- the dimensional accuracy of the hard gelatin capsules is of particular importance. They are passed on to the pharmaceutical industry as empty capsules and are filled here with the medicament. The empty capsules are separated into upper and lower parts, the lower part holding the contents and the empty upper part then being put back on. Both capsule halves are firmly and permanently joined together by pressure, so that the contents can no longer escape.
- the hard gelatin capsules produced on conventional production machines can have defects, such as holes, deformations or bubbles, which can cause considerable problems during filling.
- the resulting stoppages of the filling machines should be avoided. Therefore defective capsules have to be sorted out by the manufacturer.
- This sorting process is currently accomplished by manually reading the capsules.
- the capsules to be sorted fall from a container mounted on a vibrator onto a transparent conveyor belt.
- the capsules on this conveyor or sorting belt are illuminated from below or from above.
- One or more persons carry out a visual inspection of the capsules and remove the defective capsules from the passing conveyor belt by hand.
- Each control person sees only about 30 to 40% of the surface of a capsule on a sorting belt.
- a complete control of the quality of the capsule is therefore not possible.
- the result of this quality control is significantly influenced by the attention of the respective control person and by their subjective assessment.
- the sorting of the capsules should be carried out without control persons and should therefore be automated.
- the invention describes a method and a device for sorting out defective capsules, wherein the capsules can be viewed all around in a control station in individual control positions by means of cameras.
- the images recorded by the cameras are evaluated by means of computer programs to determine production errors.
- the defective capsules are finally sorted out according to the result of the evaluation.
- a method according to the invention for sorting capsules is described in claim 1. Claims 2 to 8 characterize further developments of this method. A device according to the invention for sorting capsules is described in claim 9. Further developments of this sorting device are described in claims 10 to 25.
- the automated, electronic sorting method according to the invention and the associated device enable complete control of the capsules on the basis of the all-round observation. Since human inadequacies are eliminated, the result of the sorting process is considerably improved. Capsule producers can thus meet the quality requirements of the pharmaceutical industry as buyers of capsules.
- the sorting method and the sorting device according to the invention can be used, for example, for sorting out defective, empty, pre-closed or filled, closed hard gelatin capsules. Furthermore, can the invention can also be used for sorting out soft gelatin capsules, capsules made of starch or other materials as well as tablets, coated tablets and lozenges.
- FIG. 1 is a schematic view of a sorting device with a control station from above;
- Fig. 2 is a side view, partly in section, of a control position of the sorting device
- Fig. 3 is a sectional side view of the control position of Fig. 2;
- Fig. 4 is a sectional view taken along line A-A of Fig. 3;
- Fig. 5 is a top view of another control position of the sorter
- FIG. 6 is a side view in section along line B-B of FIG. 5.
- the device for sorting gelatin capsules according to defect-free capsules 2 and defective capsules 3 consists of at least one control station 5, which has various control positions 10, 20, 30, 40, 50, 60 for recording and evaluating the properties of the capsules 2 , 3 has.
- the capsules 2, 3 are held by capsule holders 70.
- the sorting device has feed devices 90, through which the capsules 2, 3 get from a storage container 80 into the capsule holders 70, and ejection devices, 51, 61, through which the error-free capsules 2 are separated from the defective capsules 3 from the Control station 5 are ejected.
- One capsule 2, 3 is held in a capsule holder 70 and is conveyed through six control positions 10, 20, 30, 40, 50, 60 in the control station 5.
- the capsules 2, 3 are provided in the capsule holders 70.
- the capsules are removed from the storage container 80 and arranged in the feed device 90 on a guide track 7 in rows of capsules lying one behind the other in the traffic jam.
- the feed device 90 consists of a downward-pointing tube 91 which is fastened at its upper end to a base plate 81 of the storage container 80.
- the base plate 81 rotates relative to the fixed housing 83 of the storage container 80, as a result of which the capsules 2, 3 reach the tube 91 from the storage container via holes 82 in the base plate 81.
- the feed device 90 has two locking bolts 92, 93 connected in series, which are mechanically controlled via guides in such a way that they are lifted one after the other.
- the first locking pin 92 serves to form the capsules 2, 3 in the tube 91, while the second locking pin 93 separates the capsules 2, 3 from the jam into the capsule holder 70.
- the locking pin thus making it possible that 'each only one capsule in the capsule holder can be found be ⁇ . If several capsules were located in a capsule holder at the same time, problems would arise in the further course of the control process. In particular, the capsules could jam at the end of the control station 5 when ejected.
- the capsule holder 70 is attached to the outer, lower end of the feeder 90. It consists of a U-shaped, trapezoidal open rail 71, which has on its underside a slot 72 with pointed edges running in the conveying direction of the capsules 2, 3, capsules. At its outer end, the capsule holder 70 has a tip, for example in the form of a grub screw, for supporting the capsules.
- the capsules in the capsule holders 70 are conveyed through the following control positions 20, 30, 40, 50, 60.
- 5 cameras 21, 31, 32, 33 and light sources 22, 34 are arranged at the second and third control positions 20, 30 in the control station for a complete all-round observation of the capsules.
- a separate image processing computer program is provided for each camera 21, 31, 32, 33, which electronically evaluates the captured image and uses this to determine the nature of the capsules. Since capsules of different colors are to be checked, a color recognition is contained in the computer program.
- the light sources 22, 34 in the control positions 20, 30 consist of light-emitting diodes which emit light in a region which is visible to the cameras and which is suitable for illuminating the capsules 2, 3.
- the cameras in the control stations are essentially arranged on the other side of the capsule, opposite the light source. If a transparent or opaque capsule is checked, the light from the light source shines through it, essentially in the direction of the cameras.
- any errors that may occur with capsules can be recognized. For example, it can be determined whether the capsule has holes, bubbles, deformations or contaminants at any point.
- the dome on the upper and lower part of the capsule is also checked for damage.
- the position of the capsule eg upper part above or below
- the length and the diameter of the upper part and lower part of the capsule are determined, and the cutting edge of the upper part is checked for irregularities.
- the points at which the capsule is supported in the capsule holder 70 are dimensioned and arranged in such a way that all areas of the capsule are covered by the Light sources 22, 34 shine through or are illuminated and can be detected by cameras 21, 31, 32, 33.
- the capsules 2, 3 are viewed by a first camera 21.
- the camera 21 is arranged under the capsule holder 70, that is, under the feed path 7 of the capsules, so that it sees the capsules from below / behind.
- a light source 22 is arranged above the capsule holder 70, ie above the feed path 7 and thus opposite the camera 21, which illuminates the capsules 2, 3 from above / in front.
- a further light source 34 is provided for illuminating the capsules.
- the cameras 31, 32 are arranged obliquely above, to the side of the capsule holder 70, that is to say above and to the side of the feed path 7 of the capsules 2, 3, one camera 31 seeing the capsules from the right front and the other camera 32 seeing the capsules from the left front.
- a third camera 33 can optionally be arranged directly above the capsule holder, ie above the feed path 7 of the capsules, which is inclined to the other two cameras 31, 32 and the capsules directly from looks up / front.
- the light source 34 is arranged under the capsule holder, ie under the feed path 7, and illuminates the capsules from below / behind.
- the capsules 2, 3 are conveyed through the control positions 10, 20, 30, 40, 50, 60 in the capsule holders 70, but do not move in relation to the capsule holders 70 themselves. In the control positions 20 and 30 they are moved through the stationary cameras 21, 31, 32, 33 are considered. Thus, the capsule 2, 3 neither rotates relative to the cameras nor do the cameras move around the capsule.
- the fourth control position 40 is a waiting position, during which the computer program evaluates the images taken in order to determine production errors in the capsules.
- the result of the evaluation is converted in the fifth or sixth control position into a separation of the defect-free capsules 2 from the defect capsules 3.
- a compressed air valve 51 is provided in the fifth control position, which is controlled and activated by the computer program if the corresponding capsule has no errors.
- the defect-free capsule 2 is thus blown out of the capsule holder 70 by the compressed air valve 51 and taken up by a collecting container.
- the compressed air valve is not activated in the fifth control position 50. Rather, the capsule passes through this control position and finally reaches the sixth control position 60.
- a further compressed air valve 61 is provided, which is controlled and activated by the computer program if the capsule has a fault. Defective capsules 3 are therefore blown out of the capsule holder 70 at the sixth control position 60 by the compressed air valve 61 and taken up by a collecting container.
- the stepper motor runs, which rotates the base plate 81 of the storage container 80 relative to its housing 83, where be moved through the six control positions by the feed devices 90 with the capsule holders 70 thereon, synchronously with the cameras at the control positions 20 and 30.
- Each camera must therefore take a picture of a capsule exactly when it is in the corresponding control position. While the capsule holder moves with the capsule into the next control position, the camera should not take a picture.
- the first capsule reaches the third control position 30, where it is viewed by the cameras 31, 32, 33, while the second capsule is in the second con Roll position 20 arrives and is viewed here by the camera 21.
- a third capsule is already provided in the first control position 10.
- the first capsule comes into the control position 40, the second capsule into the control position 30, the third capsule into the control position 20, while a further capsule is provided in the first control position 10.
- the computer program While the first capsule is in the waiting position in the control position 40, the computer program evaluates the images of the first capsule recorded by the cameras in the preceding steps, although the subsequent capsules already in the corresponding control positions 20 and 30 of are viewed by the cameras.
- the computer program thus enables parallel observation and evaluation of successive capsules.
- FIG. 1 schematically shows six feed devices 90 with the associated control positions 10, 20, 30, 40, 50, 60 only in one quadrant of the circular base plate 81 of the storage container 80. Analogously, this arrangement can be repeated in the other three quadrants of the circular base plate, so that a total of four troll stations 5 with six control positions each are arranged around a storage container 80. If the base plate is dimensioned differently, more or fewer control stations 5 with the respectively associated control positions can be arranged around the storage container 80.
- approximately 70,000 capsules per hour can be checked, which corresponds to a typical performance of a gelatin capsule production machine. Accordingly, approximately 17,000 to 18,000 control steps are carried out per hour in each of the four control stations. The number of capsules checked can be increased accordingly by multiplying the control stations.
- the described method and the device for sorting empty, pre-sealed hard gelatin capsules can, for example, be connected directly to the capsule production machine.
- an arrangement in other production steps is also conceivable, e.g. B. where strongly opaque or filled hard gelatin capsules or soft gelatin capsules, which are filled and closed immediately during production, are to be checked and sorted out.
- the capsule is no longer transparent and can therefore no longer be illuminated by the light sources and the cameras.
- the cameras and the light sources are then arranged in the control positions such that the capsule body can only be illuminated and viewed from the outside, but that a complete all-round view of the capsule is nevertheless possible.
Landscapes
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
- Sorting Of Articles (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4221107A DE4221107A1 (en) | 1992-06-26 | 1992-06-26 | Method and device for sorting capsules |
DE4221107 | 1992-06-26 | ||
PCT/EP1993/001534 WO1994000249A1 (en) | 1992-06-26 | 1993-06-16 | Method and device for grading capsules |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0648151A1 true EP0648151A1 (en) | 1995-04-19 |
EP0648151B1 EP0648151B1 (en) | 1996-08-28 |
Family
ID=6461944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93912997A Expired - Lifetime EP0648151B1 (en) | 1992-06-26 | 1993-06-16 | Method and device for grading capsules |
Country Status (9)
Country | Link |
---|---|
US (1) | US5819953A (en) |
EP (1) | EP0648151B1 (en) |
JP (1) | JPH07508458A (en) |
KR (1) | KR100265082B1 (en) |
AT (1) | ATE141834T1 (en) |
CA (1) | CA2139110A1 (en) |
DE (2) | DE4221107A1 (en) |
ES (1) | ES2093432T3 (en) |
WO (1) | WO1994000249A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4417015A1 (en) * | 1994-05-14 | 1995-11-16 | Maschimpex Gmbh | Sorting machine for sorting or classifying small products of the pharmaceutical and confectionery industries by shape and color |
DE4419461B4 (en) * | 1994-06-05 | 2004-08-05 | Massen, Robert, Prof. Dr.-Ing. | Automatic sorting of used batteries |
FR2775204A1 (en) * | 1998-02-25 | 1999-08-27 | Pellenc Sa | Sorting of fruit and vegetables based on at least one of their characteristics |
US20070000939A1 (en) * | 2002-10-29 | 2007-01-04 | Vasilios Vasiadis | Device for handling and orientating pills or tablets in a precise manner |
US20050092660A1 (en) * | 2003-10-29 | 2005-05-05 | Vasilios Vasiadis | Device for handling and orientating pills or tablets in a precise manner |
AU2003287727A1 (en) * | 2002-11-13 | 2004-06-03 | Ackley Machine Corporation | Laser unit, inspection unit, method for inspecting pellet-shaped articles and pharmaceutical article |
US7285061B2 (en) * | 2003-08-04 | 2007-10-23 | Ervin Wagner | Sports skills training method and apparatus |
US20050242304A1 (en) * | 2004-04-29 | 2005-11-03 | Armbuster Lynn E | Diffuse light pharmaceutical inspection system and process |
US8121392B2 (en) * | 2004-10-25 | 2012-02-21 | Parata Systems, Llc | Embedded imaging and control system |
DE102005049958A1 (en) * | 2005-10-19 | 2007-04-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 100% optical semiquantitative filling control of pharmaceutical capsules on capsule filling machines |
US20070194034A1 (en) * | 2006-02-17 | 2007-08-23 | Vasilios Vasiadis | Device for printing pills, tablets or caplets in a precise manner |
US8078329B2 (en) * | 2006-09-29 | 2011-12-13 | Courtoy Nv | System for rejection of tablets produced in a rotary tablet press and a method of rejection of tablets |
US20080149541A1 (en) * | 2006-12-05 | 2008-06-26 | Bigney Nicholas D | Apparatus, system, and method for detecting and removing flawed capsules |
JP2012501824A (en) * | 2008-09-05 | 2012-01-26 | ソルドファ エス.エイ.アール.エル. | Capsule automatic sorter |
CN103210296B (en) | 2010-06-01 | 2016-08-10 | 阿克莱机械公司 | Inspection system |
DE102011007269A1 (en) * | 2011-04-13 | 2012-10-18 | Robert Bosch Gmbh | control device |
CN105834127B (en) * | 2016-06-02 | 2020-04-28 | 浙江汇力胶囊有限公司 | Platform is examined to full-automatic capsule lamp |
KR102022302B1 (en) * | 2016-10-25 | 2019-11-04 | 태영산업 주식회사 | apparatus for manufacturing cigarette filter |
KR101967763B1 (en) * | 2017-03-28 | 2019-04-10 | 태영산업 주식회사 | sorting apparatus for cigarette capsule |
US10892048B2 (en) * | 2017-09-28 | 2021-01-12 | Puli Pravin Reddy | Machine learning pill identification |
CN109622392B (en) * | 2018-12-28 | 2024-05-03 | 浙江天瑞制药机械有限公司 | Automatic soft capsule video sorting device |
WO2020202039A1 (en) | 2019-04-05 | 2020-10-08 | Blue Sky Ventures (Ontario) Inc. | Vibratory conveyor for conveying items and related filling machine and methods |
CA3134804A1 (en) | 2019-04-05 | 2020-10-08 | Blue Sky Ventures (Ontario) Inc. | Sensor assembly for moving items and related filling machine and methods |
KR102150970B1 (en) * | 2019-07-12 | 2020-09-02 | (주)엔에프에이 | Device for inspecting drugs with backlihgt source |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2617527A (en) * | 1948-08-20 | 1952-11-11 | Western Electric Co | Apparatus for loading and selectively unloading |
US4144970A (en) * | 1977-08-10 | 1979-03-20 | Eli Lilly And Company | Inspection apparatus for filled capsule |
US4300689A (en) * | 1978-01-16 | 1981-11-17 | Hoffmann-La Roche Inc. | Dual wavelength spectrophotometer for ampoule leak detection and content inspection |
JPS5571937A (en) * | 1978-11-24 | 1980-05-30 | Kanebo Ltd | Method of and device for inspecting surface |
DE3608989A1 (en) * | 1986-03-18 | 1987-09-24 | Lorenz Ing Grad Bohle | DEVICE FOR CLASSIFYING PIECE PRODUCTS BY LENGTH |
SU1388112A1 (en) * | 1986-07-18 | 1988-04-15 | Предприятие П/Я В-8906 | Rotor for sorting articles |
DE8706655U1 (en) * | 1987-05-08 | 1988-06-09 | Maschimpex GmbH, 7990 Friedrichshafen | Sorting machine for sorting small objects |
JPH01249181A (en) * | 1988-03-31 | 1989-10-04 | Tdk Corp | Parts sorting method for automatic appearance screening machine for chip parts |
DE4011965A1 (en) * | 1990-04-12 | 1991-10-17 | Zedete Ges Fuer Qualitaetssich | Quality control device for axi-symmetrical parts - uses photocomparison techniques to gauge size with computer processing image |
-
1992
- 1992-06-26 DE DE4221107A patent/DE4221107A1/en not_active Withdrawn
-
1993
- 1993-06-16 ES ES93912997T patent/ES2093432T3/en not_active Expired - Lifetime
- 1993-06-16 EP EP93912997A patent/EP0648151B1/en not_active Expired - Lifetime
- 1993-06-16 DE DE59303591T patent/DE59303591D1/en not_active Expired - Lifetime
- 1993-06-16 AT AT93912997T patent/ATE141834T1/en not_active IP Right Cessation
- 1993-06-16 KR KR1019940704711A patent/KR100265082B1/en not_active IP Right Cessation
- 1993-06-16 CA CA002139110A patent/CA2139110A1/en not_active Abandoned
- 1993-06-16 US US08/362,588 patent/US5819953A/en not_active Expired - Lifetime
- 1993-06-16 WO PCT/EP1993/001534 patent/WO1994000249A1/en active IP Right Grant
- 1993-06-16 JP JP6502010A patent/JPH07508458A/en active Pending
Non-Patent Citations (1)
Title |
---|
See references of WO9400249A1 * |
Also Published As
Publication number | Publication date |
---|---|
ATE141834T1 (en) | 1996-09-15 |
EP0648151B1 (en) | 1996-08-28 |
DE4221107A1 (en) | 1994-01-05 |
ES2093432T3 (en) | 1996-12-16 |
US5819953A (en) | 1998-10-13 |
DE59303591D1 (en) | 1996-10-02 |
JPH07508458A (en) | 1995-09-21 |
CA2139110A1 (en) | 1994-01-06 |
KR950702091A (en) | 1995-06-19 |
KR100265082B1 (en) | 2000-09-01 |
WO1994000249A1 (en) | 1994-01-06 |
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