EP0641191A4 - Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree. - Google Patents
Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree.Info
- Publication number
- EP0641191A4 EP0641191A4 EP93911349A EP93911349A EP0641191A4 EP 0641191 A4 EP0641191 A4 EP 0641191A4 EP 93911349 A EP93911349 A EP 93911349A EP 93911349 A EP93911349 A EP 93911349A EP 0641191 A4 EP0641191 A4 EP 0641191A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- silica
- therapeutic agent
- fluoride
- compatibility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- compositions such as dentifrices, lozenges, chewing gums, etc.
- constituents such as therapeutic agents, carrier fluids, humectants, abrasives, thickeners, flavorings, fragrances, etc.
- these constituents are typically selected based on various criteria such as cost, efficacy and compatibility.
- Compatibility refers to the interaction between the various constituents when they are put together into a single composition. Compatibility is concerned with how any interaction between the various constituents may affect the efficacy of the individual constituents. While there may be situations where the efficacy of constituents is enhanced by combination in' a single composition, the goal often is to find combinations of constituents which have a minimum adverse interaction. Since the performance of the therapeutic agent(s) is generally most important for the overall performance of the dentifrice composition, the other constituents are often chosen based on their compatibility with the therapeutic agent(s) to be used.
- Fluoride-based agents are most widely known and used for their proven anti-caries effects, however there are numerous other therapeutic agents which have been developed to address other oral care objectives such as fighting calculus, plaque, bacteria, etc.
- U.S. Patent 5,015,467 (Smitherman) gives a good review and discussion of therapeutic agents for oral care.
- non- fluoride agents include pyridinium salts such as cetyl pyridinium chloride (CPC) , guanidines such as chlorhexadine, triclosan, sanguinaria, zinc salts, copper salts, etc.
- Silica particles have been widely used in oral care compositions as abrasives and/or thickeners, silica particles are generally porous, amorphous silicas having fine particle size. Typical silica particles have surface areas of about 50-800 m 2 /g. Silica particles used as abrasives generally have pore volumes of about 0.3-1.0 cc/g whereas silica particles used as thickeners may have pore higher pore volumes up to or greater than 1.5 cc/g. Conventional silicas generally have surface hydroxyl groups which are bonded to silicon atoms on the silica surface as SiOH (silanol) groups. Silicas used in dentifrice compositions generally have about 4-8 SiOH groups per nanometer squared.
- Silica particles are known to exhibit good compatibility fluoride-based therapeutic agents. Although the silica particles have relatively large surface area, only a small amount of the fluoride species is adsorbed on the silica. Thus, most of the fluoride species in the composition remains available in the oral care composition to perform its therapeutic function in the oral cavity.
- Non-fluoride therapeutic agents often contain nonionic or cationic species which tend to be adsorbed onto the silica surface. Thus, less of the therapeutic agent is available to perform its therapeutic function in the oral cavity. The problem is especially acute for high surface area/pore volume silicas which are used as thickeners.
- the present invention solves the compatibility problem between silica and therapeutic agents, especially non-fluoride therapeutic agents.
- the invention involves the modification of conventional silica and use of the modified silica in oral care compositions containing therapeutic agents.
- the invention encompasses oral care compositions containing silica particles and at least one therapeutic agent wherein the improvement comprises using silica particles which have been at least partially
- the thermal treatment embodiment involves heating the silica particles to cause dehydroxylation.
- the heating is preferably performed at about 350°-850°C for a time sufficient to produce some increase in compatibility.
- the invention encompasses oral care compositions containing silica particles and at least one therapeutic agent wherein the improvement comprises using silica particles which have been at least partially dehydroxylated by reacting the silica with a dehydroxylating agent selected from the group consisting of alcohols, silanes, and organosilanes.
- the silica may be subjected to a combination of the thermal and chemical dehydroxylation treatments. While the two treatments may be carried out in any order, preferably the thermal treatment is performed prior to the chemical treatment.
- modified silicas of the invention provide significantly improved compatibility with therapeutic agents, especially non-fluoride therapeutic agents.
- the improved compatibility of the invention does not require highly acidic pH.
- the invention involves the modification of conventional silicas used in oral care compositions by thermal and/or chemical treatment to improve the compatibility between the silica and therapeutic agents.
- the thermal treatment may be performed by simply heating the silica to cause dehydroxylation.
- the heating is performed at about 300°-850°C for about 1 - 3 hours.
- the heating may be performed in air or any other suitable atmosphere.
- the heating may be performed at reduced pressure to facilitate removal of gases evolving from the dehydroxylation (i.e. H0) .
- the extent of thermal dehydroxylation can be measured by determining the loss on ignition (LOI) for the silica.
- the LOI is determined by first predrying the sample at 130°C for about four hours. The predried sample is then calcined for two hours at about 960°C. The LOI is the % weight loss of the calcined sample compared to the weight of the predried sample.
- the thermal dehydroxylation is performed to achieve silica having a loss on ignition of about 2% or less, more preferably about 1% or less.
- Thermal dehydroxylation may be accompanied by reduction in porosity and surface area.
- the thermal treatment is not performed to such an extent as to result in a loss of all porosity.
- the thermally treated particles have a pore volume of at least about 0.3-1.5 cc/g.
- the extent of thermal treatment which the silica particles can withstand may be partly a function of the porosity in the untreated particles.
- Chemical treatment to dehydroxylate the silica may be used instead of or in addition to thermal dehy ⁇ droxylation.
- Chemical dehydroxylation involves reacting surface hydroxyl groups on the silica with a dehydroxy ⁇ lation agent selected from the group consisting of alcohols, silanes, and organosilanes.
- Preferred alcohols are methanol, ethanol, propanol, butanol and glycerol. Glycerol is most preferred since it is non-toxic and is widely used in commercial dentifrice formulae.
- Chemical dehydroxylation may be performed by combining the silica with an excess amount of the dehydroxylation agent, preferably in the absence of water. The mixture is then reacted whereby some or all of the surface hydroxyl groups on the silica are replaced with a radical from the dehydroxylation agent. In the case of alcohols, an ester of the alcohol would be formed at the site where a hydroxyl group was located. The mixture may be heated to promote the reaction. Once the dehydroxylation reaction has occurred, the dehydroxylated silica may be recovered by filtration. The silica is then preferably dried or otherwise treated to remove unreacted dehydroxylation agent. If glycerol is used as the dehydroxylation agent, excess glycerol need not be removed from the silica surface assuming glycerol is to be used in the oral care composition.
- the chemical dehydroxylation is preferably carried out enough to achieve at least some improvement in silica-therapeutic agent compatibility, more preferably at least some improvement in silica-non-fluoride thera ⁇ Commissionic agent compatibility.
- the dehydroxy ⁇ lation reaction may be carried out to virtual completion.
- chemical dehydroxylation generally does not result in loss of porosity. It may be advantageous to use a combination of the dehydroxylation treatments. For example, if substantially complete dehydroxylation is desired with some decrease in porosity, then a combination of thermal dehydroxylation followed by chemical dehydroxylation would be appropriate. Combinations of thermal treatments or combinations of chemical treatments can also be employed if desired. In general, chemical treatment is believed to provide better dehydroxylation of isolated surface hydroxyl groups whereas thermal dehydroxylation may provide more permanent dehydroxylation of adjacent hydroxyl pairs.
- the measurement of extent of chemical dehydroxy- lation by measurement of LOI values may not be accurate because the radicals left at the former hydroxyl sites may also be volatilized during heating to determine LOI.
- the compatibility of the silica with a particular therapeutic agent can be measured by comparing the availability or concentration of the therapeutic agent in a mixture at a reference pH before and after contact with the silica.
- the compatibility of the silica may be expressed as the percentage ratio of concentration of the agent in the mixture after contact with the silica to the concentration of the agent in the mixture before silica addition.
- the pH of the silica-containing mixture is preferably adjusted to the reference pH on addition of the silica.
- the concentration after contact with silica is preferably measured after separation of the silica from the mixture.
- the method of determining the concentration of the therapeutic agent may be any conventional method suitable for the particular agent (e.g. ultraviolet light absorption) .
- the improvement in compatibility would simply in- volve comparison of the compatibility values for the untreated and treated silicas.
- the compatibility test may be applied to all dehydroxylated silicas regardless of method of dehydroxylation. While any degree of im ⁇ provement in compatibility would be encompassed by the invention, preferably the thermal and/or chemical treat ⁇ ment of the invention results in at least about 5% improvement in compatibility in comparison with the untreated silica.
- the silica treated in accordance with the invention may be any silica conventionally used in dentifrices or other oral care compositions.
- the silica is an amorphous silica gel (e.g. a xerogel) or an amorphous precipitated silica.
- Amorphous silica gels and precipitated silicas are typically used in dentifrices or other oral care compositions as abrasives and/or thickeners.
- the treatments of the invention provide improved compatibility of the silica with therapeutic agents in general at pH values commonly used in dentifrice and other oral care compositions (e.g. about 6-7) .
- the treatments also result in improved compatibility at more acidic or basic pH levels.
- the invention is further illustrated by the following examples. The invention is not limited to the details of the examples.
- Example 1 A 200g sample of silica xerogel (620 m 2 /g surface area, 0.35 cc/g pore volume, 8 ⁇ median particle size) was thermally treated for two hours in a muffle furnace at 760°C.
- Loss on ignition (LOI) defined as the % weight loss during a two hour, 960°C calcination of a predried sample (130°C) , was used to estimate the extent of dehydroxylation of the silica gel.
- the LOI value dropped from approximately 7% for the untreated silica to less than 2% for the 760°C treated sample indicating substantial dehydroxylation.
- the thermally treated sample was then compared to the silica xerogel starting material for CPC compatibility (availability) using the following procedure: o
- a stock solution of 1.2 wt.% CPC in deionized water was prepared.
- Two 1.75 gram samples of the thermally treated and of untreated silica gel were slurried (i.e. four slurries total) into 42 ml aliquots of the stock solution.
- the pH of one thermally treated silica gel slurry and one untreated silica gel slurry was adjusted to 6 pH using a small amount of 10% NaOH solution.
- the pH of the remaining two slurries was adjusted to 7 pH using the same NaOH solution.
- Example 2 A thermally treated xerogel similar to that described in Example 1 except calcined at 800°C was evaluated for chlorhexidine (ChlX) availability.
- the testing procedure was analogous to that used for determination of CPC availability except that the stock solution consisted of a 1.0 wt.% chlorhexidine digluconate in deionized water, and the UV absorbance measurement used for to determine % ChlX remaining was performed using 254 nm wavelength radiation.
- Example 3 A glycerol-reacted silica xerogel was prepared by slurrying 100 grams of the same xerogel starting material as Example 1 into 350 mis of glycerol and boiling the slurry under vacuum for 2 hours during which time the temperature of the slurry rose to approximately 200°C. 600 mis of anhydrous roethanol were then added to the viscous slurry, and the reacted silica was removed by centrifugation and decantation. The reacted silica was then reslurried in another 600 is of anhydrous methanol, to further wash the product free of unreacted glycerol, and then filtered.
- the reacted silica product was then dried in a vacuum oven for 16 hours at 165°C in order to remove any remaining methanol solvent.
- An LOI value of 24.5% confirmed the substantial reaction of glycerol with the silica xerogel surface.
- Example 4 A sample of the glycerol-reacted silica xerogel prepared according to Example 3 was also evaluated for ChlX availability using the method given in Example 2. Results given in the table below again show a superior availability with the glycerol-reacted silica gel compared to the untreated silica gel from which it was prepared.
- Example 2 A sample of the same silica xerogel starting material of Example 1 was treated by thermal dehydroxylation followed by glycerol reaction. The thermal treatment was identical to that described in Example 1 except that the temperature of the treatment was 705°C. It was followed by a glycerol reaction step identical to that described in Example 3. The resulting sample was tested for ChlX availability using the method described in Example 2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88541292A | 1992-05-19 | 1992-05-19 | |
US885412 | 1992-05-19 | ||
PCT/US1993/004716 WO1993023007A1 (fr) | 1992-05-19 | 1993-05-17 | Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0641191A1 EP0641191A1 (fr) | 1995-03-08 |
EP0641191A4 true EP0641191A4 (fr) | 1996-08-21 |
Family
ID=25386847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93911349A Withdrawn EP0641191A4 (fr) | 1992-05-19 | 1993-05-17 | Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0641191A4 (fr) |
JP (1) | JPH08502034A (fr) |
AU (1) | AU4251693A (fr) |
WO (1) | WO1993023007A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751635B1 (fr) * | 1996-07-23 | 1998-10-02 | Rhone Poulenc Chimie | Silice compatible avec les aromes, son procede de preparation et compositions dentifrices la contenant |
US6946119B2 (en) * | 2003-02-14 | 2005-09-20 | J.M. Huber Corporation | Precipitated silica product with low surface area, dentifrices containing same, and processes |
US8551457B2 (en) | 2008-11-25 | 2013-10-08 | The Procter & Gamble Company | Oral care compositions comprising spherical fused silica |
JP5717644B2 (ja) | 2008-11-25 | 2015-05-13 | ザ プロクター アンド ギャンブルカンパニー | 改善された審美性及び溶融シリカを有する、口腔ケア組成物 |
TW201103566A (en) * | 2009-06-16 | 2011-02-01 | Grace W R & Co | Cation compatible metal oxides and oral care compositions containing the metal oxides |
US11052029B2 (en) | 2009-06-16 | 2021-07-06 | W. R. Grace & Co.-Conn. | Cation compatible metal oxides and oral care compositions containing the metal oxides |
US20110293541A1 (en) | 2010-05-25 | 2011-12-01 | John Christian Haught | Oral Care Compositions And Methods Of Making Oral Care Compositions Comprising Silica From Plant Materials |
AU2013337356B2 (en) | 2012-11-05 | 2016-12-08 | The Procter & Gamble Company | Heat treated precipitated silica |
US9186307B2 (en) * | 2012-11-19 | 2015-11-17 | J.M. Huber Corporation | Treated silicas and metal silicates for improved cleaning in dentifrice |
US20140271900A1 (en) * | 2013-03-15 | 2014-09-18 | J.M. Huber Corporation | High Cleaning Silica with Low Abrasion and Method for Making Same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1442395A (en) * | 1973-04-11 | 1976-07-14 | Unilever Ltd | Dentifrice |
FR2622439B1 (fr) * | 1987-11-04 | 1991-07-12 | Rhone Poulenc Chimie | Silice pour compositions dentifrices compatible notamment avec la chlorhexidine |
FR2622565B1 (fr) * | 1987-11-04 | 1990-11-09 | Rhone Poulenc Chimie | Silice pour compositions dentifrices compatible notamment avec le zinc |
-
1993
- 1993-05-17 JP JP6503818A patent/JPH08502034A/ja active Pending
- 1993-05-17 WO PCT/US1993/004716 patent/WO1993023007A1/fr not_active Application Discontinuation
- 1993-05-17 EP EP93911349A patent/EP0641191A4/fr not_active Withdrawn
- 1993-05-17 AU AU42516/93A patent/AU4251693A/en not_active Abandoned
Non-Patent Citations (2)
Title |
---|
No further relevant documents disclosed * |
See also references of WO9323007A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU4251693A (en) | 1993-12-13 |
EP0641191A1 (fr) | 1995-03-08 |
WO1993023007A1 (fr) | 1993-11-25 |
JPH08502034A (ja) | 1996-03-05 |
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