EP0639075A4 - Specific inhibition of dihydrofolate reductase and compounds therefor. - Google Patents

Specific inhibition of dihydrofolate reductase and compounds therefor.

Info

Publication number
EP0639075A4
EP0639075A4 EP19920900837 EP92900837A EP0639075A4 EP 0639075 A4 EP0639075 A4 EP 0639075A4 EP 19920900837 EP19920900837 EP 19920900837 EP 92900837 A EP92900837 A EP 92900837A EP 0639075 A4 EP0639075 A4 EP 0639075A4
Authority
EP
European Patent Office
Prior art keywords
dihydrofolate reductase
specific inhibition
compounds therefor
therefor
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19920900837
Other languages
German (de)
French (fr)
Other versions
EP0639075A1 (en
Inventor
Ivan Kompis
Jeffrey M Blaney
Charles K Marlow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of EP0639075A4 publication Critical patent/EP0639075A4/en
Publication of EP0639075A1 publication Critical patent/EP0639075A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP92900837A 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor Ceased EP0639075A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US730691 1985-05-02
US61361990A 1990-11-14 1990-11-14
US613619 1990-11-14
US73069191A 1991-07-16 1991-07-16
PCT/US1991/008515 WO1992008461A1 (en) 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor

Publications (2)

Publication Number Publication Date
EP0639075A4 true EP0639075A4 (en) 1993-09-29
EP0639075A1 EP0639075A1 (en) 1995-02-22

Family

ID=27087063

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92900837A Ceased EP0639075A1 (en) 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor

Country Status (7)

Country Link
EP (1) EP0639075A1 (en)
JP (1) JPH07509215A (en)
AU (1) AU657348B2 (en)
CA (1) CA2095518A1 (en)
IE (1) IE913974A1 (en)
PT (1) PT99514B (en)
WO (1) WO1992008461A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721242A (en) * 1993-06-17 1998-02-24 Hoffmann-La Roche Inc. Antibiotic combination
AU704911B2 (en) * 1994-11-24 1999-05-06 Basilea Pharmaceutica Ag Novel benzyl pyrimidines
TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same
AU6203098A (en) * 1997-02-24 1998-09-18 Barry J. Barclay Synergistically acting anti-fungal agents that are inhibitors of folate metabolism, especially methotrexate and sulfamethoxazole
CN1191861C (en) 1999-05-24 2005-03-09 三共株式会社 Medicinal compositions containing anti-Fas antibody
US8853228B2 (en) * 2007-06-04 2014-10-07 University Of Connecticut Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658897A (en) * 1951-06-27 1953-11-10 Burroughs Wellcome Co 2, 4-diamino-5-benzyl pyrimidines
FR1090394A (en) * 1953-03-11 1955-03-30 Wellcome Found Pyrimidine derivatives and their manufacture
FR1292920A (en) * 1959-04-18 1962-05-11 Wellcome Found Pyrimidine derivatives and their preparation
US3671564A (en) * 1965-10-28 1972-06-20 Burroughs Wellcome Co Benzylidene cyano-acetals
DE1720031A1 (en) * 1966-02-19 1972-08-03 Wellcome Found Biologically active 5-benzylpyrimidine derivatives and processes for their preparation
US4024145A (en) * 1973-11-08 1977-05-17 Hoffmann-La Roche Inc. Benzylpyrimidine derivatives
DE2617967A1 (en) * 1976-04-24 1977-11-03 Nordmark Werke Gmbh PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES
FR2357563A1 (en) * 1976-07-09 1978-02-03 American Home Prod NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM
LU77268A1 (en) * 1977-05-05 1979-01-18
LU77269A1 (en) * 1977-05-05 1979-01-18
EP0003212A1 (en) * 1977-11-10 1979-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2.4-Diamino-5-benzylpyrimidines, pharmaceutical compositions containing them and their preparation
US4233445A (en) * 1979-07-05 1980-11-11 American Home Products Corporation 7-(Substituted)-7H-pyrrolo[3.2-F]-quinazoline-1,3-diamines
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
EP0054756A2 (en) * 1980-11-27 1982-06-30 The Wellcome Foundation Limited Antibacterial benzylpyrimidines
US4451466A (en) * 1982-07-02 1984-05-29 Shell Oil Company Use of pyrroloquinazolinediamines as pesticides
EP0122580A1 (en) * 1983-04-14 1984-10-24 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrimidine derivatives, their preparation and pharmaceutical compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852450A (en) * 1954-06-10 1958-09-16 Donnelley & Sons Co Method of copper plating
GB1181657A (en) * 1966-03-31 1970-02-18 Ici Ltd Pyrimidine Derivatives and Compositions Containing them
BE793253A (en) * 1971-12-23 1973-04-16 Lepetit Spa NEW BACTERICIDE COMPOSITIONS AND THEIR USE
OA07362A (en) * 1980-10-27 1984-06-30 May & Baker Ltd Pyrimidine derivatives, process for their preparation and compositions containing them.
EP0139613A1 (en) * 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-nitrophenyl)-4-aminopyrimidine derivatives, their preparation and use
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
DE3417264A1 (en) * 1984-05-10 1985-11-14 Bayer Ag, 5090 Leverkusen NEW 2,4-DIAMINO-6-HALOGEN-5-ALKYLTHIO-PYRIMIDINE
DE3701277A1 (en) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh NEW TRICYCLIC BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS
US4996198A (en) * 1988-07-11 1991-02-26 Hoffmann-La Roche Inc. Anticoccidial composition

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658897A (en) * 1951-06-27 1953-11-10 Burroughs Wellcome Co 2, 4-diamino-5-benzyl pyrimidines
FR1090394A (en) * 1953-03-11 1955-03-30 Wellcome Found Pyrimidine derivatives and their manufacture
FR1292920A (en) * 1959-04-18 1962-05-11 Wellcome Found Pyrimidine derivatives and their preparation
US3671564A (en) * 1965-10-28 1972-06-20 Burroughs Wellcome Co Benzylidene cyano-acetals
DE1720031A1 (en) * 1966-02-19 1972-08-03 Wellcome Found Biologically active 5-benzylpyrimidine derivatives and processes for their preparation
US4024145A (en) * 1973-11-08 1977-05-17 Hoffmann-La Roche Inc. Benzylpyrimidine derivatives
DE2617967A1 (en) * 1976-04-24 1977-11-03 Nordmark Werke Gmbh PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES
FR2357563A1 (en) * 1976-07-09 1978-02-03 American Home Prod NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM
LU77268A1 (en) * 1977-05-05 1979-01-18
LU77269A1 (en) * 1977-05-05 1979-01-18
EP0003212A1 (en) * 1977-11-10 1979-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2.4-Diamino-5-benzylpyrimidines, pharmaceutical compositions containing them and their preparation
US4233445A (en) * 1979-07-05 1980-11-11 American Home Products Corporation 7-(Substituted)-7H-pyrrolo[3.2-F]-quinazoline-1,3-diamines
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
EP0054756A2 (en) * 1980-11-27 1982-06-30 The Wellcome Foundation Limited Antibacterial benzylpyrimidines
US4451466A (en) * 1982-07-02 1984-05-29 Shell Oil Company Use of pyrroloquinazolinediamines as pesticides
EP0122580A1 (en) * 1983-04-14 1984-10-24 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrimidine derivatives, their preparation and pharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9208461A1 *

Also Published As

Publication number Publication date
WO1992008461A1 (en) 1992-05-29
PT99514B (en) 1999-04-30
AU2202792A (en) 1994-04-28
EP0639075A1 (en) 1995-02-22
PT99514A (en) 1992-10-30
IE913974A1 (en) 1992-05-20
CA2095518A1 (en) 1992-05-15
AU657348B2 (en) 1995-03-09
JPH07509215A (en) 1995-10-12

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Legal Events

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