Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/68—Plantaginaceae (Plantain Family)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
  • A61K36/738—Rosa (rose)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/75—Rutaceae (Rue family)
  • A61K36/752—Citrus, e.g. lime, orange or lemon

Definitions

• the present invention relates to therapeutic compositions for topical use for the treatment of psoriasis, based on the combination of distilled aqueous extracts of vegetables, and a procedure for obtaining them.
• Psoriasis is a common, chronic and recurring disease, characterized by the formation of dry and well-defined patches and silvery peeling scales of different sizes on certain areas of the epidermis. It characteristically affects the scalp, the extensor surfaces of the extremities, in particular the elbows and knees, the back and the buttocks, as well as the nails, eyebrows, axillae, naval and anogenital region. Occasionally the disease is generalized.
• An effective treatment is therefore considered to be one which achieves a high percentage of remission of the lesions over a relatively long period without the reappearance of said lesions.
• the use of extracts of natural origin is also known in the topical treatment of the disease.
• the PCT patent application number 89/05651 proposes the use of oily extracts of a collection of plants such as garlic, the common nettle and veronica, etc.
• the European patent application number 367103 describes the use of ointments made with jojoba and beeswax or spermaceti.
• the Spanish patent number 2.006.474 describes the use of extracts of plants belonging to the family of the zygophyllaceae together with an aqueous solution of a non-alkali metal halide.
• the object of the present invention is to provide aqueous compositions of vegetable extracts which can be used for the effective topical treatment of psoriasis without the need to use mercury salts, and therefore with a very low degree of toxicity, which reduce as much as possible the occurrence of relapses.
• compositions for the topical treatment of psoriasis which form the object of the present invention consist essentially of the combination of distilled aqueous extracts of the leaves and spikes of plantain (Plantago major L.), the petals of wild rose (Rosa canina L.) and the flowers of bitter orange (Citrus aurantium L.).
• Said extracts commonly known as plantain water, rose water and orange flower water, are obtained separately by soaking the parts of the plants mentioned above in water and then distilling the extract, collecting the distillate as a useful substance for the purposes of the present invention.
• the plantain water, rose water and orange flower water can be prepared in situ or can be purchased.
• compositions that form the object of the present invention must contain the three types of vegetable extract: plantain water, rose water and orange flower water.
• the procedure may consist of mixing the three distilled aqueous extracts of plantain, rose and orange flower, eliminating between 5 and 20% of the volume by distillation at atmospheric pressure, compensating the volume distilled with 96° ethanol and filtering until the desired composition is obtained.
• compositions of the present invention are highly effective in the topical treatment of psoriasis, without exhibiting the toxicity associated with said salts.
• compositions of the present invention onto the psoriatic scales of different types of patient causes said scales to fall away by returning to normal the cell renewal cycle of the skin, which recovers its natural elasticity.
• compositions that form the object of the present invention are innocuous, have a pleasant smell of roses and are non-irritant, and as such are readily accepted by the patient.
• the plantain, rose and orange flower waters are obtained by soaking the plant powder at room temperature for 10-24 hours in 600-800 ml of distilled water for every 100 g of plant powder.
• the resulting liquid is subjected to a simple distillation to obtain a distillate which has 60% of the original volume.
• the volume is then made up to three litres with distilled water.
• the solution obtained is distilled at 100°C for 15 minutes, giving a resulting volume of about 2.7 litres which are left to cool. 300 ml of 96° ethanol are added and the solution is filtered.
• the volume is then made up to three litres with distilled water.
• the solution obtained is distilled at 100°C for 15 minutes, giving a resulting volume of about 2.7 litres which are left to cool. 300 ml of 96° ethanol are added and the solution is filtered.
• the volume is then made up to three litres with distilled water.
• the solution obtained is distilled at 100°C for 15 minutes, giving a resulting volume of about 2.7 litres which are left to cool. 300 ml of 96° ethanol are added and the solution is filtered.
• the volume is then made up to three litres with distilled water.
• the solution obtained is distilled at 100°C for 15 minutes, giving a resulting volume of about 2.7 litres which are left to cool. 300 ml of 96° ethanol are added and the solution is filtered.
• 50 patients are treated by means of applications every 12 hours, preferably in the mornings and at night, until the whole whitening.
• Table 1 Composition Effectiveness Tolerance Example 1 ++++ ++++++ Example 2 +++ ++++ Example 3 +++ ++++ Example 4 ++ ++++ Each composition is evaluated by assigning crosses according to the results observed.
• compositions are effective and have an excellent level of tolerance but, as can be seen in the table, the behaviour of the composition obtained in example 1 is particularly noteworthy due its greater effectiveness.
• Table 2 shows in more detail the results obtained with a composition similar to that of example 1.
• General 39 1-17 5-85 1-4 Palm/sole 3 4-25 3-5 2-4
• Guttate 5 3-19 15-99 2-5
• Pustular 3 2-7 10-99 2-5 Total range 50 ⁇ 1-25 ⁇ 3-99 ⁇ 1-5 ⁇

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• Health & Medical Sciences (AREA)
• Natural Medicines & Medicinal Plants (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Alternative & Traditional Medicine (AREA)
• Biotechnology (AREA)
• Botany (AREA)
• Medical Informatics (AREA)
• Medicinal Chemistry (AREA)
• Microbiology (AREA)
• Mycology (AREA)
• Pharmacology & Pharmacy (AREA)
• Epidemiology (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Medicines Containing Plant Substances (AREA)

Applications Claiming Priority (2)

Publications (1)

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Cited By (1)

Citations (2)

Family Cites Families (8)

• 1993
  • 1993-07-30 ES ES9301798A patent/ES2065292B1/es not_active Expired - Lifetime
• 1994
  • 1994-07-19 EP EP94500127A patent/EP0636373A1/de not_active Withdrawn

Patent Citations (2)

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