EP0623011A1 - Device for spraying therapeutical substances. - Google Patents

Device for spraying therapeutical substances.

Info

Publication number
EP0623011A1
EP0623011A1 EP93901076A EP93901076A EP0623011A1 EP 0623011 A1 EP0623011 A1 EP 0623011A1 EP 93901076 A EP93901076 A EP 93901076A EP 93901076 A EP93901076 A EP 93901076A EP 0623011 A1 EP0623011 A1 EP 0623011A1
Authority
EP
European Patent Office
Prior art keywords
nebulizer
animal
facial mask
seal
nebulization chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP93901076A
Other languages
German (de)
French (fr)
Other versions
EP0623011B1 (en
Inventor
Pierre Lekeux
Luc Mestach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGRITRONICS INTERNATIONAL SA
AGRITRONICS INT SA
Original Assignee
AGRITRONICS INTERNATIONAL SA
AGRITRONICS INT SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AGRITRONICS INTERNATIONAL SA, AGRITRONICS INT SA filed Critical AGRITRONICS INTERNATIONAL SA
Publication of EP0623011A1 publication Critical patent/EP0623011A1/en
Application granted granted Critical
Publication of EP0623011B1 publication Critical patent/EP0623011B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices

Definitions

  • the invention relates to a new device for nebulizing therapeutic substances, intended for the treatment of infections and / or respiratory disorders.
  • aerosol therapy allows rapid obtaining, at the level of the deep respiratory tract, of a maximum concentration of therapeutic substances while avoiding the systemic effects of this substance.
  • the aerosol can be defined as a two-phase system consisting of a continuous gas phase (usually air) and a discontinuous phase (usually liquid) of individual particles.
  • the majority of aerosols are hetero-dispersed or polydispersed aerosols, the size of the particles of which is generally not uniform.
  • the size of the particles generated by this system conditions the penetration and deposition of these particles in the respiratory system. Depending on their size, the particles can reach different sites in the respiratory system.
  • the table below shows the different deposition sites reached depending on the size of the inhaled particles.
  • endotracheal intubation and tracheostomy are techniques which, in human medicine, make it possible to avoid the filtration process carried out by the nasal cavities, but which cannot be easily applied to the veterinary medicine (Brain et al., Aerosols in Medicine, Chapter 5, Moren F., Newhouse M.., Dolovich MB, Elsevier, 1985, 336).
  • the first two types of aerosolizers are known in human medicine, but unusable in rural veterinary medicine.
  • nebulizers a distinction is made between ultrasonic nebulizers and pneumatic nebulizers.
  • the ultrasonic nebulizer comprises a piezoelectric transducer which vibrates at high frequency under the effect of an alternating electric field produced by an electronic oscillator. By successive contiguity, these vibrations are transmitted to the solution to be nebulized. When the vibration intensity is high enough, it will forms a column of liquid, from which a cloud of particles is emitted.
  • ultrasonic nebulizers are most often reserved for hospital environments.
  • Pneumatic nebulizers (such as the type of sor provisionbuli- Hudson ®) all belong to the same principle: a capillary tube immersed in a liquid and the drop beading at the top of the capillary is sprayed (action Venturi) by an air jet or relaxing at high flow.
  • the diameter of the particles generated by the pneumatic nebulizer is inversely proportional to the gas flow. For most pneumatic nebulizers, a minimum flow of 6 l.min -1 is necessary to ensure a high quality / duration of treatment ratio.
  • the flow rate as well as the particle size can also depend on the speed at which the patient inhales.
  • these nebulizers are connected directly and individually to a source of compressed air and allow the inhalation of the treating product only in one nostril of the animal at a time.
  • Patent application GB-A-211,838 describes a device for inhaling therapeutic substances for horses.
  • This device comprises a completely hermetic mask placed on the nostrils of the animal and preventing the latter from breathing through the mouth.
  • An ultrasonic atomizer placed on the mask, projects the therapeutic substance into the animal's nostrils at the rate of its breathing.
  • Such a device has the drawback, by preventing the animal from breathing through the mouth, greatly reducing its comfort and making the administration of therapeutic substances more difficult.
  • this device does not make it possible to adjust certain parameters (particle size, inhalation rate, etc.) adapted to the different types of infections or respiratory disorders to be treated.
  • Such a device is therefore unsuitable for treating animals suffering from serious disorders such as respiratory distress, requiring nebulization in the nostrils of the animal of particles of size less than 1 ⁇ m; or perform treatment by mouth, upper respiratory tract (particles larger than 10 ⁇ m).
  • US Pat. No. 2,843,119 describes a device intended for the administration of oxygen to an animal via a mask placed hermetically around the mouth and the nostrils thereof.
  • This device comprises a nebulization system intended for the post-operative administration of therapeutic substances and connected via a flexible tube to the mask.
  • this nebulization system connected via a long pipe to the mask, does not allow the administration of therapeutic substances into the deep respiratory tract.
  • AIMS OF THE INVENTION The invention aims to provide a simple, quick to set up and inexpensive device allowing optimal nebulization of therapeutic substance (s) directly in the nostrils and / or in the mouth. from animal to treat, while preserving the comfort thereof.
  • the purpose of the device according to the invention is to nebulize optimally at the level of the mouth and / or the nostrils of an animal one or more therapeutic substances in the form of particles whose mean aerodynamic diameter is between 100 and 0.01 ⁇ m.
  • the object of the invention is to provide a device which does not hamper breathing through the mouth and / or the nostrils of the animal during its treatment.
  • the invention also aims to provide a device for using several nebulizers connected together to a single source of compressed air supply.
  • a complementary object of the invention consists in providing a device adaptable to any animal head which it is desired to treat.
  • the invention relates to a device for nebulizing therapeutic substance (s), comprising a facial mask connected by a pneumatic line to a source of compressed air such as a dry and transportable air compressor, characterized in that that a nebulization chamber is disposed in the mask and comprises at least one nebulizer connected to the pneumatic line.
  • the nebulization chamber comprises at least two nebulizers.
  • connection between the pneumatic line and the nebulizer (s) consists of a cover obstructing the nebulization chamber and comprising at least one end piece connected by a seal to the nebulizers, so that by closing the cover or the nebulization chamber, each nebulizer is connected to a nozzle.
  • the seal consists of a rubber membrane disposed between the nebulization chamber and its housing.
  • the seal consists of a plastic or rubber teat fixed on the end of the end piece. preferably by screwing.
  • the seal is held on the nozzle and / or on the lower end of the nebulizer by an O-ring fixing.
  • the facial mask comprises a deformation for housing an interchangeable garni ⁇ ture adapted to the head of the animal.
  • the facial mask according to the invention also includes attachment straps.
  • the pneumatic line of the device according to the invention comprises a flow regulator arranged between the mask and the source of compressed air.
  • This facial mask also has one or more openings for breathing through the nostrils and / or the mouth and / or for the saliva flow from the animal.
  • the therapeutic substances are nebulized by the device according to the invention in the form of particles whose aerodynamic massai median diameter is between 100 and 0.01 ⁇ m.
  • FIG. 1 shows a schematic sectional view of the device of the invention.
  • FIG. 2 shows another partial sectional view of the device of the invention.
  • FIG. 3 shows a partial sectional view of another embodiment of the device of the invention.
  • - Figure 4 shows a sectional view of a seal disposed between the nebulizer and the nozzle in the device according to the invention.
  • - Figures 5 to 8 show the distribution of the size ( ⁇ m) and the speed (m / s) of physiological water particles nebulized by the device according to the invention, depending on the air flow administered (bars). Description of a preferred embodiment of the invention
  • the device according to the invention shown in FIG. 1 comprises a facial mask 1 connected by a pneumatic line 2 to an air compressor 3.
  • facial mask is meant a mask completely covering the mouth and nostrils of the animal to be treated.
  • Several masks can be connected to the same compressor and be easily transported in the same case to their place of use.
  • the arrangement of the nebulization chamber 4 in the facial mask 1 makes it possible to advantageously solve the problems caused by the movements of the animal when the nebulization chamber is connected to the transportable dry air compressor (not lubricated).
  • the device according to the invention allows optimization of the therapeutic effects of the nebulized substance since it is dispersed directly in the nostrils and / or in the mouth of the treated animal and because the size of the particles generated by these nebulizers as well as the flow of these undergo small variations whatever the movements of the animal.
  • This device thus allows the administration of effective and constant doses to the treated animal.
  • nebulizers 5 type Hudson ® can compor- ter deflectors whose presence and position permet ⁇ tent increase the fraction optimal particles in the respiratory tract.
  • the use of two nebulizers is particularly advantageous because it allows the simultaneous administration of different therapeutic substances.
  • the two nebulizers 5 are connected to the pneumatic line 2 and to the air compressor 3 by a hollow cover 6 obstructing the nebulization chamber 4.
  • the cover 6 has two end pieces 7 connected by a seal 8 to the two nebulizers 5 so that by closing the cover 6 or the nebulization chamber
  • each nebulizer 5 is connected to a nozzle 7.
  • the seal according to the invention consists, for example, of a rubber membrane arranged as shown in FIG. 2, between the nebulization chamber 4 and its cover 6.
  • An alternative embodiment of the invention shown in Figure 3 includes a plastic or rubber nipple 10 attached to the end of the nozzle 1, so that when the cover 6 is closed on the chamber nebulization 4, each nebulizer 5 pierces with its lower end 12 the upper part 13 of the teat
  • the seal 8 is advantageously secured on the endpiece by an O-ring for fixing 11.
  • the seal is fixed to the nozzle 7 by screwing and the lower end 12 of the nebulizer 11 is held in the seal 8 by an O-ring of fixing 11.
  • the facial mask 1 made of reinforced polyester, PVC or any other plastic material, is designed to conform to the shape of the head of the animal to be treated.
  • this mask comprises, facing its opening 14, a deformation 15 intended for housing an interchangeable lining 20 adapted to the head of the animal.
  • This closed cell foam filling increases the comfort of the animal and prevents any contamination of the external environment by the nebulized product.
  • the facial mask 1 is quickly placed on the animal thanks to a system of straps 16 attached with the help of mous ⁇ quetons 17 to a chain placed at the neck of the animal.
  • the device according to the invention also includes other elements which contribute to the comfort of the animal and / or which make it possible to facilitate its treatment.
  • the facial mask can in particular be equipped with openings (21, 22) for breathing through the nostrils and / or the mouth and / or for the flow of the animal's saliva and a window (not shown) allowing to check whether the entire liquid phase contained in the nebulizer has been nebulized in the nostrils of the animal.
  • the pneumatic line 2 also comprises placed between the air compressor 3 and the facial mask 1, a flow regulator 18 as well as a pressure gauge 19, making it possible to control the pressure and the air flow supplying the facial mask.
  • a flow regulator 18 as well as a pressure gauge 19, making it possible to control the pressure and the air flow supplying the facial mask.
  • the appended figures represent the particle size distribution ( ⁇ m) and their speed (m / s) following the nebulization of physiological water at the pressure of 6 bars
  • the device according to the invention therefore allows to adapt according to the type of animal and / or the type of infection or respiratory disorders to be treated, the size of the nebulized particles as well as the rate of aspiration of therapeutic substances by the animal.
  • this device also makes it possible to treat serious disorders such as pulmonary distress which require the provision of adapted delivery rates (50 l / minute) in the best conditions of comfort.
  • the air compressor can also be equipped with a heating resistor which advantageously makes it possible to use the device according to the invention in the open air and at low temperatures.
  • the device of the invention can be advantageously used in the treatment of certain respiratory ailments such as chronic obstructive bronchial diseases of the horse or Acute Respiratory Distress Syndrome of cattle.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif de nébulisation de substance(s) thérapeutique(s) destiné à la médecine vétérinaire comportant un masque facial (1) relié par une conduite pneumatique (2) à une source d'air comprimé (3), dans lequel une chambre de nébulisation (4) est disposée dans le masque (1) et comporte au moins un nébuliseur (5).The invention relates to a device for nebulizing therapeutic substance(s) intended for veterinary medicine comprising a face mask (1) connected by a pneumatic line (2) to a source of compressed air (3), in which a nebulization chamber (4) is arranged in the mask (1) and comprises at least one nebulizer (5).

Description

DISPOSITIF DE NEBULISATION DE SUBSTANCES THERAPEUTIQUES Objet de l'invention DEVICE FOR NEBULIZING THERAPEUTIC SUBSTANCES Subject of the invention
L'invention concerne un nouveau dispositif de nébulisation de substances thérapeutiques, destiné au traite¬ ment des infections et/ou des troubles respiratoires. Arrière-plan technologiqueThe invention relates to a new device for nebulizing therapeutic substances, intended for the treatment of infections and / or respiratory disorders. Technological background
Les animaux d'élevage, en particulier les bovins, souffrent de nombreuses affections respiratoires induites par toute une série d'agents infectieux.Farm animals, particularly cattle, suffer from many respiratory conditions induced by a variety of infectious agents.
Dans les cheptels bovins, ces affections induisent des pertes économiques très importantes. Ainsi en Grande- Bretagne, les pertes annuelles causées par ces affections excèdent £ 50 millions et constituent une des premières sources de mortalité de ces animaux. En effet, les bovins surtout ceux du type viandeux, sont défavorisés sur le plan de leurs fonctions pulmonaires et les jeunes bovins, en raison de l'immaturité fonctionnelle de leur système respira¬ toire et les animaux de type culard, se caractérisent par une fonction pulmonaire particulièrement vulnérable.In cattle herds, these conditions cause very significant economic losses. Thus in Great Britain, the annual losses caused by these diseases exceed £ 50 million and constitute one of the first sources of mortality of these animals. Cattle, especially those of the meat type, are disadvantaged in terms of their pulmonary functions and young cattle, due to the functional immaturity of their respiratory system and animals of the cheek type, are characterized by a function particularly vulnerable lung.
Dans le traitement des obstructions réversibles des voies respiratoires profondes, l'inhalation de substances thérapeutiques aérosolisées, donne de bons résultats thérapeutiques.In the treatment of reversible obstructions of the deep respiratory tract, the inhalation of aerosolized therapeutic substances, gives good therapeutic results.
En effet, l'aérosolthérapie permet l'obtention rapide, au niveau des voies respiratoires profondes, d'une concentration maximale de substances thérapeutiques tout en évitant les effets systémiques de cette substance.In fact, aerosol therapy allows rapid obtaining, at the level of the deep respiratory tract, of a maximum concentration of therapeutic substances while avoiding the systemic effects of this substance.
Cependant, pour l'obtention de résultats thérapeu¬ tiques optimaux, l'aptitude des particules à gagner les voies respiratoires profondes doit être prise en considération.However, in order to obtain optimal therapeutic results, the ability of the particles to gain deep breathing should be considered.
En effet, la plupart des substances déposées au niveau de l'oropharynx sont dégluties. De plus, étant métabo- lisées lors de leur passage au travers de la paroi intesti- nale et du foie, ces substances sont souvent inactivées. Par ailleurs, lorsque les meilleures conditions sont réunies, 10% des particules inhalées sont efficaces pour assurer une réponse clinique.In fact, most of the substances deposited in the oropharynx are swallowed. In addition, being metabolized during their passage through the intestinal wall and the liver, these substances are often inactivated. Furthermore, when the best conditions are met, 10% of the inhaled particles are effective in ensuring a clinical response.
L'aérosol peut se définir comme un système biphasi- que constitué d'une phase gazeuse continue (habituellement de l'air) et d'une phase discontinue (habituellement liquide) de particules individuelles.The aerosol can be defined as a two-phase system consisting of a continuous gas phase (usually air) and a discontinuous phase (usually liquid) of individual particles.
La majorité des aérosols sont des aérosols hétéro- dispersés ou polydispersés dont la taille des particules générées n'est généralement pas uniforme.The majority of aerosols are hetero-dispersed or polydispersed aerosols, the size of the particles of which is generally not uniform.
La taille des particules générées par ce système conditionne la pénétration et le dépôt de ces particules dans l'appareil respiratoire. En fonction de leur taille, les particules peuvent atteindre des sites différents dans le système respiratoire.The size of the particles generated by this system conditions the penetration and deposition of these particles in the respiratory system. Depending on their size, the particles can reach different sites in the respiratory system.
Le tableau ci-dessous reprend les différents sites de dépôt atteints en fonction de la taille des particules inhalées.The table below shows the different deposition sites reached depending on the size of the inhaled particles.
Ce tableau montre que le site au niveau duquel les particules se déposent est d'autant plus profond que la taille de ces particules est faible. Par ailleurs, la fonc¬ tion de filtration réalisée par les cavités nasales est à ce point marquée qu'elle s'exerce sur toute particule d'un diamètre supérieur à 10 μm. Dès lors, chez un animal en respiration buccale, cette fonction de filtration est par¬ tiellement anéantie. Etat de la techniqueThis table shows that the site at which the particles are deposited is deeper than the size of these particles is small. Furthermore, the filtration function performed by the nasal cavities is so marked that it is exerted on any particle with a diameter greater than 10 μm. Consequently, in an animal in buccal respiration, this filtration function is partially destroyed. State of the art
Si plusieurs millénaires se sont écoulés depuis l'introduction de l'aérosolthérapie dans les affections respiratoires humaines, l'intérêt que la médecine vétérinaire porte à cette technique est beaucoup plus récent.If several millennia have passed since the introduction of aerosol therapy in human respiratory diseases, the interest that veterinary medicine has in this technique is much more recent.
Pour que celle-ci soit d'une efficacité maximale dans le traitement des affections en médecine vétérinaire, certaines exigences techniques doivent être remplies par l'aérosoliseur utilisé.For this to be of maximum effectiveness in the treatment of diseases in veterinary medicine, certain technical requirements must be met by the aerosolizer used.
De plus, certains facteurs, nécessitant la collabo¬ ration du patient, ne peuvent être appliqués qu'en médecine humaine.In addition, certain factors, requiring the patient's collaboration, can only be applied in human medicine.
L'inspiration par voie buccale, l'intubation endo- trachéale et la trachéotomie sont des techniques qui, en médecine humaine, permettent d'éviter le processus de filtra¬ tion que réalisent les cavités nasales, mais qui ne peuvent être facilement appliquées à la médecine vétérinaire (Brain et al., Aérosols in Médecine, Chapter 5, Moren F., Newhouse M. ., Dolovich M.B. , Elsevier, 1985, 336).Oral inspiration, endotracheal intubation and tracheostomy are techniques which, in human medicine, make it possible to avoid the filtration process carried out by the nasal cavities, but which cannot be easily applied to the veterinary medicine (Brain et al., Aerosols in Medicine, Chapter 5, Moren F., Newhouse M.., Dolovich MB, Elsevier, 1985, 336).
Trois types d'aérosoliseurs sont connus dans la littérature: les aérosols doseurs, les inhalateurs de poudre sèche et les nébuliseurs.Three types of aerosolizers are known in the literature: metered dose inhalers, dry powder inhalers and nebulizers.
Les deux premiers types d'aérosoliseurs sont connus en médecine humaine, mais inutilisables en médecine vétéri¬ naire rurale. Parmi les nébuliseurs, on distingue les nébuli¬ seurs ultrasoniques et les nébuliseurs pneumatiques.The first two types of aerosolizers are known in human medicine, but unusable in rural veterinary medicine. Among the nebulizers, a distinction is made between ultrasonic nebulizers and pneumatic nebulizers.
Le nébuliseur ultrasonique comporte un transducteur piézo-électrique qui vibre à haute fréquence sous 1'effet d'un champ électrique alternatif produit par un oscillateur électronique. Par contiguïté successive, ces vibrations sont transmises à la solution devant être nébulisée. Lorsque l'intensité des vibrations est suffisamment élevée, il se forme une colonne de liquide, de laquelle un nuage de parti¬ cules est émis.The ultrasonic nebulizer comprises a piezoelectric transducer which vibrates at high frequency under the effect of an alternating electric field produced by an electronic oscillator. By successive contiguity, these vibrations are transmitted to the solution to be nebulized. When the vibration intensity is high enough, it will forms a column of liquid, from which a cloud of particles is emitted.
Cependant la taille des particules générées par ces nébuliseurs ainsi que le débit de ceux-ci peuvent subir d'importantes variations (Boguslavsky et al., PhysicalHowever the size of the particles generated by these nebulizers as well as the flow of these can undergo important variations (Boguslavsky et al., Physical
Mechanism of the acoustic atomization of a liquid, AcousticMechanism of the acoustic atomization of a liquid, Acoustic
J. (USSR), 1969, 15, 17-24).J. (USSR), 1969, 15, 17-24).
Par ailleurs, étant donné leur coût et leur fragi¬ lité, les nébuliseurs ultrasoniques sont le plus souvent réservés aux milieux hospitaliers.Furthermore, given their cost and their fragility, ultrasonic nebulizers are most often reserved for hospital environments.
Les nébuliseurs pneumatiques (tels que le nébuli- seur de type Hudson®) relèvent tous du même principe: un tube capillaire plonge dans un liquide et la goutte perlant au sommet du capillaire est pulvérisée (action Venturi) par un jet d'air ou d'oxygène se détendant à débit élevé. Le diamè¬ tre des particules générées par le nébuliseur pneumatique est inversement proportionnel au débit gazeux. Pour la plupart des nébuliseurs pneumatiques, un débit minimal de 6 l.min-1 est nécessaire pour assurer un rapport qualité/durée de traitement élevé. Le débit ainsi que la taille particulaire peuvent également dépendre de la vitesse à laquelle le pa¬ tient inhale.Pneumatic nebulizers (such as the type of sor nébuli- Hudson ®) all belong to the same principle: a capillary tube immersed in a liquid and the drop beading at the top of the capillary is sprayed (action Venturi) by an air jet or relaxing at high flow. The diameter of the particles generated by the pneumatic nebulizer is inversely proportional to the gas flow. For most pneumatic nebulizers, a minimum flow of 6 l.min -1 is necessary to ensure a high quality / duration of treatment ratio. The flow rate as well as the particle size can also depend on the speed at which the patient inhales.
Cependant, l'utilisation manuelle de ces nébuli¬ seurs pour le traitement thérapeutique des animaux présente encore des difficultés. En effet, ces nébuliseurs sont rac¬ cordés directement et individuellement à une source d'air comprimé et ne permettent l'inhalation du produit traitant que dans une seule narine de l'animal à la fois.However, the manual use of these nebulizers for the therapeutic treatment of animals still presents difficulties. Indeed, these nebulizers are connected directly and individually to a source of compressed air and allow the inhalation of the treating product only in one nostril of the animal at a time.
De plus, les mouvements effectués par l'animal au cours du traitement augmentent les risques de contamination de l'environnement et réduisent 1'optimalisation des effets thérapeutiques souhaités.In addition, the movements made by the animal during treatment increase the risk of contamination of the environment and reduce the optimization of the desired therapeutic effects.
La demande de brevet GB-A-211 838 décrit un dispo¬ sitif d'inhalation de substances thérapeutiques pour les chevaux.Patent application GB-A-211,838 describes a device for inhaling therapeutic substances for horses.
Ce dispositif comprend un masque totalement hermé¬ tique disposé sur les naseaux de l'animal et empêchant celui- ci de respirer par la bouche. Un atomiseur ultrasonique, disposé sur le masque, projette la substance thérapeutique dans les naseaux de l'animal au rythme de sa respiration.This device comprises a completely hermetic mask placed on the nostrils of the animal and preventing the latter from breathing through the mouth. An ultrasonic atomizer, placed on the mask, projects the therapeutic substance into the animal's nostrils at the rate of its breathing.
Un tel dispositif présente l'inconvénient, en empêchant l'animal de respirer par la bouche, de réduire fortement son confort et de rendre plus difficile l'adminis¬ tration de substances thérapeutiques.Such a device has the drawback, by preventing the animal from breathing through the mouth, greatly reducing its comfort and making the administration of therapeutic substances more difficult.
En outre, ce dispositif ne permet pas de régler certains paramètres (taille des particules, vitesse d'inhala- tion, etc.) adaptés aux différents types d'infections ou de troubles respiratoires à traiter. Un tel dispositif est donc inadapté pour traiter des animaux souffrant de troubles graves tels que la détresse respiratoire, nécessitant la nébulisation dans les narines de l'animal de particules de taille inférieure à 1 μm; ou d'effectuer le traitement par la bouche, des voies respiratoires supérieures (particules de taille supérieure à 10 μm) .In addition, this device does not make it possible to adjust certain parameters (particle size, inhalation rate, etc.) adapted to the different types of infections or respiratory disorders to be treated. Such a device is therefore unsuitable for treating animals suffering from serious disorders such as respiratory distress, requiring nebulization in the nostrils of the animal of particles of size less than 1 μm; or perform treatment by mouth, upper respiratory tract (particles larger than 10 μm).
Le brevet US-2 843 119 décrit un dispositif destiné à l'administration d'oxygène à un animal via un masque dis- posé de manière hermétique autour de la bouche et des naseaux de celui-ci. Ce dispositif comprend un système de nébulisa¬ tion destiné à l'administration post-opératoire de substances thérapeutiques et relié via un tube flexible au masque.US Pat. No. 2,843,119 describes a device intended for the administration of oxygen to an animal via a mask placed hermetically around the mouth and the nostrils thereof. This device comprises a nebulization system intended for the post-operative administration of therapeutic substances and connected via a flexible tube to the mask.
Cependant, ce système de nébulisation relié via un tuyau de longue taille au masque, ne permet pas l'administra¬ tion des substances thérapeutiques dans les voies respiratoi¬ res profondes.However, this nebulization system connected via a long pipe to the mask, does not allow the administration of therapeutic substances into the deep respiratory tract.
Il est également connu de réaliser un local pour les animaux à traiter dans lequel une substance thérapeutique est mise en suspension sous forme de particules aérosolisées. Cependant, cette technique coûteuse d'administration est surtout réservée au traitement des pathologies respiratoires aviaires ou pour la désinfection des locaux. Buts de 1'invention L'invention vise à fournir un dispositif simple, rapide à mettre en place et peu coûteux permettant une nébu¬ lisation optimale de substance(s) thérapeutique(s) directe¬ ment dans les naseaux et/ou dans la bouche d'un animal à traiter, tout en préservant le confort de celui-ci.It is also known to produce a room for the animals to be treated in which a therapeutic substance is suspended in the form of aerosolized particles. However, this expensive technique of administration is especially reserved for the treatment of avian respiratory pathologies or for the disinfection of premises. AIMS OF THE INVENTION The invention aims to provide a simple, quick to set up and inexpensive device allowing optimal nebulization of therapeutic substance (s) directly in the nostrils and / or in the mouth. from animal to treat, while preserving the comfort thereof.
Le dispositif selon l'invention a pour but de nébuliser de manière optimale au niveau de la bouche et/ou des naseaux d'un animal une ou plusieurs substances thérapeu- tiques sous forme de particules dont le diamètre aérodynami¬ que nasal moyen est compris entre 100 et 0,01 μm.The purpose of the device according to the invention is to nebulize optimally at the level of the mouth and / or the nostrils of an animal one or more therapeutic substances in the form of particles whose mean aerodynamic diameter is between 100 and 0.01 μm.
L'invention a pour but de fournir un dispositif qui n'entrave pas la respiration par la bouche et/ou les naseaux de l'animal lors de son traitement. L'invention a également pour but de fournir un dispositif permettant d'utiliser plusieurs nébuliseurs reliés ensemble à une seule source d'alimentation en air comprimé.The object of the invention is to provide a device which does not hamper breathing through the mouth and / or the nostrils of the animal during its treatment. The invention also aims to provide a device for using several nebulizers connected together to a single source of compressed air supply.
Un but complémentaire de l'invention consiste à fournir un dispositif adaptable à n'importe quelle tête d'animal que l'on désire traiter.A complementary object of the invention consists in providing a device adaptable to any animal head which it is desired to treat.
Eléments caractéristiques de l'inventionCharacter-defining elements of the invention
L'invention concerne un dispositif de nébulisation de substance(s) thérapeutique(s) , comportant un masque facial relié par une conduite pneumatique à une source d'air com- primé telle qu'un compresseur à air sec et transportable, caractérisé en ce qu'une chambre de nébulisation est disposée dans le masque et comporte au moins un nébuliseur relié à la conduite pneumatique.The invention relates to a device for nebulizing therapeutic substance (s), comprising a facial mask connected by a pneumatic line to a source of compressed air such as a dry and transportable air compressor, characterized in that that a nebulization chamber is disposed in the mask and comprises at least one nebulizer connected to the pneumatic line.
De préférence, la chambre de nébulisation comporte au moins deux nébuliseurs.Preferably, the nebulization chamber comprises at least two nebulizers.
La liaison entre la conduite pneumatique et le ou les nébuliseurs consiste en un couvercle obstruant la chambre de nébulisation et comportant au moins un embout relié par un joint d'étanchéité aux nébuliseurs, de manière qu'en fermant le couvercle ou la chambre de nébulisation, chaque nébuliseur soit relié à un embout.The connection between the pneumatic line and the nebulizer (s) consists of a cover obstructing the nebulization chamber and comprising at least one end piece connected by a seal to the nebulizers, so that by closing the cover or the nebulization chamber, each nebulizer is connected to a nozzle.
Selon une première forme d'exécution de l'inven¬ tion, le joint d'étanchéité consiste en une membrane en caoutchouc disposée entre la chambre de nébulisation et son boîtier.According to a first embodiment of the invention, the seal consists of a rubber membrane disposed between the nebulization chamber and its housing.
Selon une autre forme d'exécution préférée de l'invention, le joint d'étanchéité consiste en une tétine en plastique ou en caoutchouc fixée sur l'extrémité de l'embout. de préférence par vissage.According to another preferred embodiment of the invention, the seal consists of a plastic or rubber teat fixed on the end of the end piece. preferably by screwing.
De préférence le joint d'étanchéité est maintenu sur l'embout et/ou sur l'extrémité inférieure du nébuliseur par un joint torique de fixation. Afin d'assurer le confort de l'animal, le masque facial comporte une déformation pour le logement d'une garni¬ ture interchangeable et adaptée à la tête de l'animal.Preferably, the seal is held on the nozzle and / or on the lower end of the nebulizer by an O-ring fixing. In order to ensure the comfort of the animal, the facial mask comprises a deformation for housing an interchangeable garni¬ ture adapted to the head of the animal.
Le masque facial selon l'invention comporte égale¬ ment des sangles d'attache. Avantageusement, la conduite pneumatique du dispo¬ sitif selon l'invention comporte un régulateur de débit disposé entre le masque et la source d'air comprimé. Ce masque facial comporte également une ou plusieurs ouvertures pour la respiration par les naseaux et/ou la bouche et/ou pour l'écoulement de la salive de l'animal.The facial mask according to the invention also includes attachment straps. Advantageously, the pneumatic line of the device according to the invention comprises a flow regulator arranged between the mask and the source of compressed air. This facial mask also has one or more openings for breathing through the nostrils and / or the mouth and / or for the saliva flow from the animal.
Avantageusement, les substances thérapeutiques sont nébulisées par le dispositif selon l'invention sous la forme de particules dont le diamètre aérodynamique massai médian est compris entre 100 et 0,01 μm. D'autres détails et avantages de l'invention appa¬ raîtront à la lecture d'une forme d'exécution préférée de l'invention en référence aux figures annexées. Brève description des dessinsAdvantageously, the therapeutic substances are nebulized by the device according to the invention in the form of particles whose aerodynamic massai median diameter is between 100 and 0.01 μm. Other details and advantages of the invention will become apparent on reading a preferred embodiment of the invention with reference to the appended figures. Brief description of the drawings
- La figure 1 représente une vue schématique en coupe du dispositif de l'invention.- Figure 1 shows a schematic sectional view of the device of the invention.
- La figure 2 représente une autre vue partielle en coupe du dispositif de l'invention.- Figure 2 shows another partial sectional view of the device of the invention.
- La figure 3 représente une vue partielle en coupe d'une autre forme d'exécution du dispo- sitif de l'invention.- Figure 3 shows a partial sectional view of another embodiment of the device of the invention.
- La figure 4 représente une vue en coupe d'un joint d'étanchéité disposé entre le nébuliseur et l'embout dans le dispositif selon l'invention. - Les figures 5 à 8 représentent la distribution de la taille (μm) et de la vitesse (m/s) de particules d'eau physiologique nébuli¬ sées par le dispositif selon l'invention, en fonction du débit d'air administré (bars) . Description d'un mode d'exécution préféré de l'invention- Figure 4 shows a sectional view of a seal disposed between the nebulizer and the nozzle in the device according to the invention. - Figures 5 to 8 show the distribution of the size (μm) and the speed (m / s) of physiological water particles nebulized by the device according to the invention, depending on the air flow administered (bars). Description of a preferred embodiment of the invention
Le dispositif selon l'invention représenté à la figure 1 comporte un masque facial 1 relié par une conduite pneumatique 2 à un compresseur à air 3.The device according to the invention shown in FIG. 1 comprises a facial mask 1 connected by a pneumatic line 2 to an air compressor 3.
On entend par masque facial, un masque recouvrant totalement la bouche et les naseaux de l'animal à traiter. Plusieurs masques peuvent être reliés à un même compresseur et être aisément transportés dans un même coffret sur leur lieu d'utilisation.By facial mask is meant a mask completely covering the mouth and nostrils of the animal to be treated. Several masks can be connected to the same compressor and be easily transported in the same case to their place of use.
Une chambre de nébulisation 4, comportant deux nébuliseurs 5 reliés à une conduite pneumatique 2, est dispo¬ sée dans le masque facial 1. La disposition de la chambre de nébulisation 4 dans le masque facial 1 permet de résoudre avantageusement les problèmes occasionnés par les mouvements de l'animal lorsque la chambre de nébulisation se trouve raccordée au compresseur à air sec transportable (non lubrifié) . Le dispositif selon l'invention permet une optima- lisation des effets thérapeutiques de la substance nébulisée puisqu'elle est dispersée directement dans les narines et/ou dans la bouche de l'animal traité et que la taille des parti¬ cules générées par ces nébuliseurs ainsi que le débit de ceux-ci subissent de faibles variations quelles que soient les mouvements de l'animal.A nebulization chamber 4, comprising two nebulizers 5 connected to a pneumatic pipe 2, is available in the facial mask 1. The arrangement of the nebulization chamber 4 in the facial mask 1 makes it possible to advantageously solve the problems caused by the movements of the animal when the nebulization chamber is connected to the transportable dry air compressor (not lubricated). The device according to the invention allows optimization of the therapeutic effects of the nebulized substance since it is dispersed directly in the nostrils and / or in the mouth of the treated animal and because the size of the particles generated by these nebulizers as well as the flow of these undergo small variations whatever the movements of the animal.
Ce dispositif permet ainsi l'administration de doses efficaces et constantes à l'animal traité.This device thus allows the administration of effective and constant doses to the treated animal.
Ces nébuliseurs 5 de type Hudson®, peuvent compor- ter des déflecteurs dont la présence et la position permet¬ tent d'accroître la fraction des particules optimales dans les voies respiratoires.These nebulizers 5 type Hudson ® can compor- ter deflectors whose presence and position permet¬ tent increase the fraction optimal particles in the respiratory tract.
L'utilisation de deux nébuliseurs est particulière¬ ment avantageuse car elle permet l'administration simultanée de substances thérapeutiques différentes.The use of two nebulizers is particularly advantageous because it allows the simultaneous administration of different therapeutic substances.
Le tableau ci-dessous indique que l'administration simultanée par le dispositif selon l'invention de hydrochlo¬ rure de clenbutérol (un β2 agoniste) et de bromure d'Iprotropium (un antagoniste choligermique) à des veaux de type Bleu-Blanc Belge (67 animaux testés) souffrant de dé¬ tresse respiratoire, est plus efficace que l'administration séparée de chacune des deux drogues.The table below indicates that the simultaneous administration by the device according to the invention of clenbuterol hydrochloride (a β 2 agonist) and bromide Iprotropium (a choligermic antagonist) to Belgian Blue-White type calves (67 animals tested) suffering from respiratory distress, is more effective than the separate administration of each of the two drugs.
Les deux nébuliseurs 5 sont reliés à la conduite pneumatique 2 et au compresseur d'air 3 par un couvercle creux 6 obstruant la chambre de nébulisation 4. The two nebulizers 5 are connected to the pneumatic line 2 and to the air compressor 3 by a hollow cover 6 obstructing the nebulization chamber 4.
Le couvercle 6 comporte deux embouts 7 reliés par un joint d'étanchéité 8 aux deux nébuliseurs 5 de manière qu'en fermant le couvercle 6 ou la chambre de nébulisationThe cover 6 has two end pieces 7 connected by a seal 8 to the two nebulizers 5 so that by closing the cover 6 or the nebulization chamber
4 s'ouvrant selon une charnière 23, chaque nébuliseur 5 est relié à un embout 7.4 opening according to a hinge 23, each nebulizer 5 is connected to a nozzle 7.
Le joint d'étanchéité selon l'invention consiste par exemple, en une membrane en caoutchouc disposée comme représenté à la figure 2, entre la chambre de nébulisation 4 et son couvercle 6.The seal according to the invention consists, for example, of a rubber membrane arranged as shown in FIG. 2, between the nebulization chamber 4 and its cover 6.
Une variante d'exécution de l'invention représentée à la figure 3, comprend une tétine en matière plastique ou en caoutchoux 10 fixée sur l'extrémité de l'embout 1 , de telle manière que lorsque le couvercle 6 est refermé sur la chambre de nébulisation 4, chaque nébuliseur 5 perce avec son extrémité inférieure 12 la partie supérieure 13 de la tétineAn alternative embodiment of the invention shown in Figure 3, includes a plastic or rubber nipple 10 attached to the end of the nozzle 1, so that when the cover 6 is closed on the chamber nebulization 4, each nebulizer 5 pierces with its lower end 12 the upper part 13 of the teat
10 et assure ainsi l'étanchéité du conduit d'air comprimé.10 and thus seals the compressed air duct.
Le joint d'étanchéité 8 est avantageusement ainte- nu sur l'embout par un joint torique de fixation 11.The seal 8 is advantageously secured on the endpiece by an O-ring for fixing 11.
Selon une autre forme d'exécution représentée à la figure 4, le joint d'étanchéité est fixé à l'embout 7 par vissage et l'extrémité inférieure 12 du nébuliseur 11 est maintenu dans le joint d'étanchéité 8 par un joint torique de fixation 11.According to another embodiment shown in Figure 4, the seal is fixed to the nozzle 7 by screwing and the lower end 12 of the nebulizer 11 is held in the seal 8 by an O-ring of fixing 11.
Une telle disposition permet avantageusement l'administration de substance(s) thérapeutique(s) en minimi¬ sant les risques de contamination de l'environnement, en particulier en ne dispersant pas de manière inutile et nuisi¬ ble les agents thérapeutiques sur des animaux sains. Le masque facial 1, réalisé en polyester renforcé, en PVC ou en toute autre matière plastique, est conçu pour épouser la forme de la tête de l'animal à traiter. Pour cela, ce masque comporte face à son ouverture 14, une déformation 15 destinée au logement d'une garniture 20 interchangeable et adaptée à la tête de l'animal.Such an arrangement advantageously allows the administration of therapeutic substance (s) by minimizing the risks of contamination of the environment, in particular by not dispersing the therapeutic agents in a useless and harmful manner on healthy animals. The facial mask 1, made of reinforced polyester, PVC or any other plastic material, is designed to conform to the shape of the head of the animal to be treated. For this, this mask comprises, facing its opening 14, a deformation 15 intended for housing an interchangeable lining 20 adapted to the head of the animal.
Cette garniture en mousse de cellules fermées augmente le confort de l'animal et évite toute contamination du milieu extérieur par le produit nébulisé.This closed cell foam filling increases the comfort of the animal and prevents any contamination of the external environment by the nebulized product.
Le masque facial 1 se pose rapidement sur l'animal grâce à un système de sangles 16 attachées à l'aide de mous¬ quetons 17 à une chaîne placée au cou de l'animal.The facial mask 1 is quickly placed on the animal thanks to a system of straps 16 attached with the help of mous¬ quetons 17 to a chain placed at the neck of the animal.
Le dispositif selon l'invention comporte également d'autres éléments qui participent au confort de l'animal et/ou qui permettent de faciliter son traitement. Le masque facial peut notamment être équipé d'ouvertures (21, 22) pour la respiration par les naseaux et/ou la bouche et/ou pour l'écoulement de la salive de l'animal et d'une fenêtre (non représentée) permettant de vérifier si toute la phase liquide contenue dans le nébuli- seur a été nébulisée dans les narines de l'animal.The device according to the invention also includes other elements which contribute to the comfort of the animal and / or which make it possible to facilitate its treatment. The facial mask can in particular be equipped with openings (21, 22) for breathing through the nostrils and / or the mouth and / or for the flow of the animal's saliva and a window (not shown) allowing to check whether the entire liquid phase contained in the nebulizer has been nebulized in the nostrils of the animal.
La conduite pneumatique 2 comprend également dis¬ posé entre le compresseur d'air 3 et le masque facial 1, un régulateur de débit 18 ainsi qu'un manomètre 19, permettant de contrôler la pression et le débit d'air alimentant le masque facial. En modifiant la pression d'admission de l'air comprimé, la taille des particules nébulisées et leur vitesse de propagation se trouvent modifiées.The pneumatic line 2 also comprises placed between the air compressor 3 and the facial mask 1, a flow regulator 18 as well as a pressure gauge 19, making it possible to control the pressure and the air flow supplying the facial mask. By modifying the inlet pressure of the compressed air, the size of the nebulized particles and their speed of propagation are modified.
Les figures annexées représentent la distribution des tailles des particules (μm) et leur vitesse (m/s) suite à la nébulisation d'eau physiologiopie à la pression de 6 barsThe appended figures represent the particle size distribution (μm) and their speed (m / s) following the nebulization of physiological water at the pressure of 6 bars
(12 litres par minute [figures 5 et 6]) et de 2 bars (4,5 litres par minute [figures 7 et 8]).(12 liters per minute [Figures 5 and 6]) and 2 bars (4.5 liters per minute [Figures 7 and 8]).
Le dispositif selon l'invention permet donc d'adapter en fonction du type d'animal et/ou du type d'infec¬ tion ou de troubles respiratoires à traiter, la taille des particules nébulisées ainsi que le débit d'aspiration des substances thérapeutiques par l'animal. Ainsi, ce dispositif permet également de traiter des troubles graves comme la détresse pulmonaire qui néces¬ site de fournir des débits d'administration adaptés (50 1/minute) dans les meilleures conditions de confort.The device according to the invention therefore allows to adapt according to the type of animal and / or the type of infection or respiratory disorders to be treated, the size of the nebulized particles as well as the rate of aspiration of therapeutic substances by the animal. Thus, this device also makes it possible to treat serious disorders such as pulmonary distress which require the provision of adapted delivery rates (50 l / minute) in the best conditions of comfort.
Le compresseur d'air peut également être équipé d'une résistance chauffante qui permet avantageusement d'uti¬ liser le dispositif selon l'invention en plein air et à des températures peu élevées.The air compressor can also be equipped with a heating resistor which advantageously makes it possible to use the device according to the invention in the open air and at low temperatures.
Le dispositif de l'invention peut être avantageuse¬ ment utilisé dans le traitement de certaines affections respiratoires telles que les maladies bronchiques obstructi- ves chroniques du cheval ou le Syndrome de Détresse Respira¬ toire Aiguë des bovins. The device of the invention can be advantageously used in the treatment of certain respiratory ailments such as chronic obstructive bronchial diseases of the horse or Acute Respiratory Distress Syndrome of cattle.

Claims

REVENDICATIONS
1. Dispositif de nébulisation de substance(s) thérapeutique(s) comportant un masque facial (1) relié par une conduite pneumatique (2) à une source d'air comprimé (3)1. Device for nebulizing therapeutic substance (s) comprising a facial mask (1) connected by a pneumatic line (2) to a source of compressed air (3)
5 caractérisé en ce qu'une chambre de nébulisation (4) est disposée dans le masque (1) et comporte au moins un nébuli¬ seur (5) lié à la conduite pneumatique.5 characterized in that a nebulization chamber (4) is arranged in the mask (1) and comprises at least one nebulizer (5) linked to the pneumatic line.
2. Dispositif selon la revendication 1 caractérisé en ce que la chambre de nébulisation (4) comporte au moins ljO deux nébuliseurs (5) .2. Device according to claim 1 characterized in that the nebulization chamber (4) comprises at least ljO two nebulizers (5).
3. Dispositif selon la revendication 1 ou 2 carac¬ térisé en ce que la liaison entre la conduite pneumatique (2) et le ou les nébuliseur(s) (5) consiste en un couvercle (6) obstruant la chambre de nébulisation (4) et comportant au3. Device according to claim 1 or 2 carac¬ terized in that the connection between the pneumatic line (2) and the nebulizer (s) (5) consists of a cover (6) obstructing the nebulization chamber (4) and comprising at
15 moins un embout (7) relié par un joint d'étanchéité (8) au(x) nébuliseur(s) (5) de manière qu'en fermant le couvercle (6) ou la chambre de nébulisation (4), chaque nébuliseur (5) soit relié à un embout (7) .15 minus one end piece (7) connected by a seal (8) to the nebulizer (s) (5) so that by closing the cover (6) or the nebulization chamber (4), each nebulizer (5) is connected to a nozzle (7).
4. Dispositif selon la revendication 3 caractérisé 20 en ce que le joint d'étanchéité (8) consiste en une membrane en caoutchouc (9) disposée entre la chambre de nébulisation (4) et son boîtier (6).4. Device according to claim 3 characterized in that the seal (8) consists of a rubber membrane (9) disposed between the nebulization chamber (4) and its housing (6).
5. Dispositif selon la revendication 3 caractérisé en ce que le joint d'étanchéité (8) consiste en une tétine 5 (10) fixée sur l'extrémité de l'embout (7).5. Device according to claim 3 characterized in that the seal (8) consists of a nipple 5 (10) fixed on the end of the nozzle (7).
6. Dispositif selon la revendication 5 caractérisé en ce que la tétine (10) est fixée sur l'extrémité de l'em¬ bout (7) par vissage.6. Device according to claim 5 characterized in that the nipple (10) is fixed to the end of the tip em¬ (7) by screwing.
7. Dispositif selon l'une quelconque des revendica- 0 tions 3 à 6 caractérisé en ce que le joint d'étanchéité (8) est maintenu sur l'embout (7) et/ou sur l'extrémité infé¬ rieure (12) du nébuliseur par un joint torique de fixation (11).7. Device according to any one of the claims 0 to 3 to 6 characterized in that the seal (8) is held on the end piece (7) and / or on the lower end (12) of the nebulizer by a fixing O-ring (11).
8. Dispositif selon l'une quelconque des revendica- 5 tions précédentes caractérisé en ce que le masque facial (1) comporte une déformation (15) pour le logement d'une garni¬ ture interchangeable (20) et adaptée à la tête de l'animal.8. Device according to any one of the preceding claims, characterized in that the facial mask (1) comprises a deformation (15) for housing an interchangeable garni¬ ture (20) and adapted to the head of the 'animal.
9. Dispositif selon l'une quelconque des revendications précédentes caractérisé en ce que le masque facial (1) comporte des sangles d'attache (16).9. Device according to any one of previous claims characterized in that the facial mask (1) comprises attachment straps (16).
10. Dispositif selon l'une quelconque des revendi¬ cations précédentes caractérisé en ce que la conduite pneuma- tique comporte un régulateur de débit (18) disposé entre le masque facial (1) et la source d'air comprimé (3).10. Device according to any one of the preceding claims, characterized in that the pneumatic line comprises a flow regulator (18) disposed between the facial mask (1) and the source of compressed air (3).
11. Dispositif selon l'une quelconque des revendi¬ cations précédentes caractérisé en ce que le masque facial 1) comporte une ou plusieurs ouvertures (20, 21) pour la respiration par les naseaux et/ou la bouche et/ou pour l'écoulement de la salive de l'animal.11. Device according to any one of the preceding revendi¬ cations characterized in that the facial mask 1) has one or more openings (20, 21) for breathing through the nostrils and / or the mouth and / or for the flow saliva from the animal.
12. Dispositif selon l'une quelconque des revendi¬ cations précédentes caractérisé en ce que les substances thérapeutiques sont nébulisées sous la forme de particules dont le diamètre aérodynamique massai médian est compris 100 et 0,01 μm.12. Device according to any one of the preceding claims, characterized in that the therapeutic substances are nebulized in the form of particles whose aerodynamic massai median diameter is between 100 and 0.01 μm.
13. Dispositif selon l'une quelconque des revendi¬ cations précédentes caractérisé en ce que la source d'air comprimé est un compresseur à air sec transportable. 13. Device according to any one of the preceding revendi¬ cations characterized in that the source of compressed air is a transportable dry air compressor.
EP93901076A 1992-01-21 1993-01-21 Device for spraying therapeutical substances Expired - Lifetime EP0623011B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BE9200057 1992-01-21
BE9200057A BE1006103A3 (en) 1992-01-21 1992-01-21 Substance of mist device (s) therapeutic.
PCT/BE1993/000004 WO1993013730A1 (en) 1992-01-21 1993-01-21 Device for spraying therapeutical substances

Publications (2)

Publication Number Publication Date
EP0623011A1 true EP0623011A1 (en) 1994-11-09
EP0623011B1 EP0623011B1 (en) 1997-07-23

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BE (1) BE1006103A3 (en)
DE (1) DE69312473T2 (en)
DK (1) DK0623011T3 (en)
WO (1) WO1993013730A1 (en)

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WO1995001137A1 (en) * 1993-06-29 1995-01-12 Voges Innovation Pty. Ltd. Dispenser
DE10260636A1 (en) * 2002-12-19 2004-07-08 Nagel, Jochen Medical inhaler has mask with blinkers and on-demand inhaler atomizer controlled by batteries
DE10322505B4 (en) 2003-05-19 2009-11-05 Pari GmbH Spezialisten für effektive Inhalation Inhalation therapy mask and device for animals
DE102017008459A1 (en) * 2017-06-20 2018-12-20 Stefan Marx Inhaler for horses
FR3104381B1 (en) 2019-12-16 2021-11-05 Ab7 Innovation Piezoelectric device for the targeted diffusion of active material in animals
FR3104382B1 (en) 2019-12-16 2022-07-22 Ab7 Innovation Piezoelectric device for the targeted diffusion of active material

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US2843119A (en) * 1955-09-14 1958-07-15 Max E Glasser Respirators for animals
CH653244A5 (en) * 1981-12-22 1985-12-31 Georg Feierabend INHALATION DEVICE FOR ANIMALS.

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Also Published As

Publication number Publication date
WO1993013730A1 (en) 1993-07-22
DE69312473T2 (en) 1998-02-05
DE69312473D1 (en) 1997-09-04
DK0623011T3 (en) 1998-02-16
BE1006103A3 (en) 1994-05-10
EP0623011B1 (en) 1997-07-23

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