EP0618977A4 - Expression-secretion vectors for the production of biologically active fv fragments. - Google Patents

Expression-secretion vectors for the production of biologically active fv fragments.

Info

Publication number
EP0618977A4
EP0618977A4 EP92923150A EP92923150A EP0618977A4 EP 0618977 A4 EP0618977 A4 EP 0618977A4 EP 92923150 A EP92923150 A EP 92923150A EP 92923150 A EP92923150 A EP 92923150A EP 0618977 A4 EP0618977 A4 EP 0618977A4
Authority
EP
European Patent Office
Prior art keywords
fragments
expression
production
biologically active
secretion vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92923150A
Other languages
English (en)
Other versions
EP0618977A1 (fr
Inventor
Shi Chung Ng
James G Anthony
Sui-Lam Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Calgary
Original Assignee
University of Calgary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Calgary filed Critical University of Calgary
Publication of EP0618977A1 publication Critical patent/EP0618977A1/fr
Publication of EP0618977A4 publication Critical patent/EP0618977A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP92923150A 1991-12-18 1991-12-18 Expression-secretion vectors for the production of biologically active fv fragments. Withdrawn EP0618977A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/007625 WO1993012246A1 (fr) 1991-12-18 1991-12-18 Vecteurs d'expression-secretion servant a produire des fragments fv biologiquement actifs

Publications (2)

Publication Number Publication Date
EP0618977A1 EP0618977A1 (fr) 1994-10-12
EP0618977A4 true EP0618977A4 (en) 1997-02-12

Family

ID=22225880

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92923150A Withdrawn EP0618977A4 (en) 1991-12-18 1991-12-18 Expression-secretion vectors for the production of biologically active fv fragments.

Country Status (3)

Country Link
EP (1) EP0618977A4 (fr)
JP (1) JP2000505641A (fr)
WO (1) WO1993012246A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69627685T2 (de) * 1995-10-20 2004-01-29 Novartis Ag Verfahren zur herstellung eines einkettigen fv antikörperfragments

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324162A1 (fr) * 1987-12-31 1989-07-19 Andreas Dr. Plückthun Procédé de préparation d'anticorps par génie génetique
WO1990004026A1 (fr) * 1988-10-11 1990-04-19 The United States Of America, Represented By The Secretary, United States Department Of Commerce Nouvelles structures de plasmide pour la production a haut niveau de proteines d'eucaryotes
EP0416505A2 (fr) * 1989-09-04 1991-03-13 Takeda Chemical Industries, Ltd. Plasmides d'expression et leur utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324162A1 (fr) * 1987-12-31 1989-07-19 Andreas Dr. Plückthun Procédé de préparation d'anticorps par génie génetique
WO1990004026A1 (fr) * 1988-10-11 1990-04-19 The United States Of America, Represented By The Secretary, United States Department Of Commerce Nouvelles structures de plasmide pour la production a haut niveau de proteines d'eucaryotes
EP0416505A2 (fr) * 1989-09-04 1991-03-13 Takeda Chemical Industries, Ltd. Plasmides d'expression et leur utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9312246A1 *

Also Published As

Publication number Publication date
EP0618977A1 (fr) 1994-10-12
WO1993012246A1 (fr) 1993-06-24
JP2000505641A (ja) 2000-05-16

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Legal Events

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