EP0608215A4 - Antineoplastische wirkstoffe auf der basis von chinobenzoxazinen, chinobenzothiazinen und pyrido-acridinen. - Google Patents

Antineoplastische wirkstoffe auf der basis von chinobenzoxazinen, chinobenzothiazinen und pyrido-acridinen.

Info

Publication number
EP0608215A4
EP0608215A4 EP19910918185 EP91918185A EP0608215A4 EP 0608215 A4 EP0608215 A4 EP 0608215A4 EP 19910918185 EP19910918185 EP 19910918185 EP 91918185 A EP91918185 A EP 91918185A EP 0608215 A4 EP0608215 A4 EP 0608215A4
Authority
EP
European Patent Office
Prior art keywords
quinobenzothiazine
quinobenzoxazine
pyrido
acridine
antineoplastic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910918185
Other languages
English (en)
French (fr)
Other versions
EP0608215A1 (de
Inventor
Daniel T Chu
Jacob J Plattner
Robert Hallas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0608215A4 publication Critical patent/EP0608215A4/de
Publication of EP0608215A1 publication Critical patent/EP0608215A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP91918185A 1990-08-24 1991-08-23 Antineoplastische wirkstoffe auf der basis von chinobenzoxazinen, chinobenzothiazinen und pyrido-acridinen Withdrawn EP0608215A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57310290A 1990-08-24 1990-08-24
US573102 1990-08-24
PCT/US1991/006040 WO1992003136A1 (en) 1990-08-24 1991-08-23 Quinobenzoxazine, quinobenzothiazine, and pyrido-acridine antineoplastic agents

Publications (2)

Publication Number Publication Date
EP0608215A4 true EP0608215A4 (de) 1993-11-11
EP0608215A1 EP0608215A1 (de) 1994-08-03

Family

ID=24290672

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91918185A Withdrawn EP0608215A1 (de) 1990-08-24 1991-08-23 Antineoplastische wirkstoffe auf der basis von chinobenzoxazinen, chinobenzothiazinen und pyrido-acridinen

Country Status (5)

Country Link
EP (1) EP0608215A1 (de)
CA (1) CA2099609A1 (de)
IE (1) IE912902A1 (de)
PT (1) PT98766B (de)
WO (1) WO1992003136A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0604181A1 (de) * 1992-12-21 1994-06-29 Eli Lilly And Company Antitumorpräparate und Behandlungsmethoden
US7354916B2 (en) 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US7507727B2 (en) 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
EP1610795A4 (de) 2003-04-07 2007-10-24 Cylene Pharmaceuticals Inc Heterocyclische substituierte 1,4-dihydro-4-oxo-1,8-naphthpyridin-analoga
JP2006522827A (ja) 2003-04-07 2006-10-05 サイリーン ファーマシューティカルズ インコーポレーティッド 置換キノベンゾオキサジン類似体
US7652134B2 (en) 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
KR100989029B1 (ko) 2004-09-17 2010-10-25 사일린 파마슈티칼스, 인크 세포 증식 억제제로서의 퀴놀론 동족체

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA853071B (en) * 1984-04-26 1985-12-24 Abbott Lab Quino-quinoline antibacterial compounds
EP0324298A1 (de) * 1987-12-29 1989-07-19 Laboratorios Del Dr. Esteve, S.A. 7-(1-Azetidinyl)-1,4-dihydro-4-oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung als Arzneimittel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542133A (en) * 1984-04-26 1985-09-17 Abbott Laboratories Methylenedioxy quino-benoxazine derivatives and antibacterial use
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4540694A (en) * 1984-04-26 1985-09-10 Abbott Laboratories 1-Pyridine substituted quino-benoxazines and antibacterial use
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA853071B (en) * 1984-04-26 1985-12-24 Abbott Lab Quino-quinoline antibacterial compounds
EP0324298A1 (de) * 1987-12-29 1989-07-19 Laboratorios Del Dr. Esteve, S.A. 7-(1-Azetidinyl)-1,4-dihydro-4-oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung als Arzneimittel

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHU D.T.W. ET AL.: "SYNTHESIS AND ANTITUMOUR ACTIVITIES OF QUINOLONE ANTINEOPLASTIC AGENTS", DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, vol. XVIII, no. 7, 1992, pages 275 - 282 *
D.T.W.CHU ET AL.: "SYNTHESIS OF 4-OXO-4H-QUINO(2,3,4-i,j)(1,4)-BENOXAZINE-5-CARBOXYLIC ACID DERIVATIVES", J. HETEROCYCLIC CHEM., vol. 24, 1987, pages 453 - 456 *
P. HUSSY ET AL.: "EFFECT OF 4-QUINOLONES AND NOVOBIOCIN ON CALF THYMUS DNA POLYMERASE ALPHA PRIMASE COMPLEX, TOPOISOMERASE I AND II, AND GROWTH OF MAMMALIAN LYMPHOBLASTS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 29, no. 6, 1986, pages 1073 - 1078 *
S. RADL ET AL.: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 3-OXO-3H-PYRIDO(3,2,1-kl)PHENOXAZINE-2-CARBOXYLIC ACIDS", COLLECT. CZECH. CHEM. COMMUN., vol. 54, 1989, pages 506 - 515, XP001013437 *
See also references of WO9203136A1 *

Also Published As

Publication number Publication date
IE912902A1 (en) 1992-02-26
CA2099609A1 (en) 1992-02-25
EP0608215A1 (de) 1994-08-03
WO1992003136A1 (en) 1992-03-05
PT98766B (pt) 1999-01-29
PT98766A (pt) 1992-07-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19930609

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19970527

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19971007