EP0603411A1 - Dispositif ceramique de chauffage et de refroidissement - Google Patents

Dispositif ceramique de chauffage et de refroidissement Download PDF

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Publication number
EP0603411A1
EP0603411A1 EP93913596A EP93913596A EP0603411A1 EP 0603411 A1 EP0603411 A1 EP 0603411A1 EP 93913596 A EP93913596 A EP 93913596A EP 93913596 A EP93913596 A EP 93913596A EP 0603411 A1 EP0603411 A1 EP 0603411A1
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EP
European Patent Office
Prior art keywords
heating
ceramics
cooling apparatus
sintered body
cooling
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Application number
EP93913596A
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German (de)
English (en)
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EP0603411B1 (fr
EP0603411A4 (fr
Inventor
Keiichi Katoh
Syuzi Ueda
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Individual
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Individual
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Priority claimed from JP19155393A external-priority patent/JPH0699085A/ja
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Publication of EP0603411A4 publication Critical patent/EP0603411A4/fr
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    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B3/00—Ohmic-resistance heating
    • H05B3/20—Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater
    • H05B3/22—Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible
    • H05B3/28—Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible heating conductor embedded in insulating material
    • H05B3/283—Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible heating conductor embedded in insulating material the insulating material being an inorganic material, e.g. ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F21/00—Constructions of heat-exchange apparatus characterised by the selection of particular materials
    • F28F21/04—Constructions of heat-exchange apparatus characterised by the selection of particular materials of ceramic; of concrete; of natural stone
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B3/00—Ohmic-resistance heating
    • H05B3/10—Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor
    • H05B3/12—Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material

Definitions

  • the present invention relates to a heating/cooling apparatus made of a ceramics, which permits a rapid heating and a rapid cooling of various samples in such fields as biotechnology, chemistry, medicine and bioengineering, and achievement of a precise temperature control of the sample and a uniform temperature distribution in the sample.
  • a heating/cooling apparatus of any of these types, a receptacle made of a metal such as aluminum or the like for receiving an object to be heated or cooled, i.e., a sample, and a heating means are configured as two separate components. This results in a poorer heat transfer coefficiency from the heating means to the receptacle for the sample, makes it difficult to rapidly heat the sample, and furthermore, leads to a non-uniform temperature distribution in the sample. It is therefore difficult to achieve a desired heating pattern.
  • the available cooling means of the sample include, on the other hand, a spontaneous cooling, a forced cooling with the use of a coolant such as a gas or a liquid, and a combination thereof. It is however difficult to precisely control a cooling rate by such a cooling means alone. It is thus conceivable to control the cooling rate by using any of the above-mentioned cooling means while supplying a prescribed heat quantity from the heating means to the sample. In this manner of cooling, however, the heat supplied by the heating means cannot be efficiently transferred to the receptacle for the sample. It is therefore difficult to rapidly decrease the sample temperature to a desired temperature, and moreover, the temperature distribution in the sample is non-uniform, resulting in difficulty in achieving a desired cooling pattern.
  • An object of the present invention is therefore to provide a heating/cooling apparatus made of a ceramics, which solves the above-mentioned problems, and permits a rapid heating and a rapid cooling of various samples, allows a precise temperature control of the sample, thereby enabling a temperature control of the sample in accordance with a predetermined temperature pattern, and achieving a uniform temperature distribution in the sample.
  • At least one of a face, at least one hole, at least one recess and at least one groove, the shape of which coincides with that of an object to be heated or cooled, i.e., a sample, for receiving the sample, to increase a contact area with the sample, is formed at an arbitrary position on a sintered body comprising an electrically insulating ceramics having a thermal conductivity of at least 10 W/(m ⁇ k) .
  • An electrically conductive resistance-heating element comprising a metal, an electrically conductive ceramics or carbon is buried into the sintered body.
  • the whole of the above-mentioned sintered body may comprise an electrically conductive ceramics, thereby the sintered body itself forming a resistance-heating element as a heating means.
  • the heating/cooling apparatus made of a ceramics of the present invention further comprises a cooling means.
  • the cooling means comprises a coolant feeder, provided outside the sintered body, for feeding a coolant such as a gas or a liquid to the sintered body, on the one hand, and at least one of part of a surface of the sintered body, a rugged portion formed on part of a surface of the sintered body, at least one cooling through-hole, through which the coolant passes, formed in the sintered body, a heat-radiating plate having fins, provided on the sintered body, and a heat-radiating plate having a honeycomb structure, provided on the sintered body, each for effecting a heat exchange, on the other hand.
  • the heat-radiating plate comprises any one of a metal and a ceramics.
  • the sample is in contact with the face, at least one hole, at least one recess or at least one groove, each for receiving the sample, provided on the sintered body having a satisfactory thermal conductivity, so that the temperature of the sample rapidly becomes equal to the temperature of the sintered body, thus permitting a precise temperature control during the heating and the cooling of the sample.
  • Fig. 1 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a first embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride.
  • Fig. 2 is a schematic sectional view of Fig. 1 cut along the line A-A'.
  • Fig. 3 is a schematic exploded perspective view illustrating a manufacturing process of the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention shown in Fig. 1.
  • Fig. 4 is a schematic descriptive view illustrating a combination of the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention shown in Fig. 1, and a coolant feeder.
  • Fig. 5 is a graph illustrating a predetermined temperature pattern in a performance test of a heating/cooling apparatus made of a ceramics.
  • Fig. 6 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a second embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride.
  • Fig. 7 is a schematic sectional view of Fig. 6 cut along the line A-A'.
  • Fig. 8 is a schematic perspective view illustrating two green blocks for the heating/cooling apparatus made of a ceramics of the second embodiment of the present invention shown in Fig. 6.
  • Fig. 9 is a schematic perspective view illustrating the state in which a resistance-heating element is attached onto one of the two green blocks shown in Fig. 8.
  • Fig. 10 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a third embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride, and a heat-radiating plate having fins, as a cooling means.
  • Fig. 11 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a fourth embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride, and at least one cooling through-hole as a cooling means, formed in the sintered body.
  • Fig. 12 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a fifth embodiment of the present invention, which comprises a sintered body made of a ceramics comprising silicon carbide.
  • Fig. 13 is a schematic perspective view illustrating a green block for the heating/cooling apparatus made of a ceramics of the fifth embodiment of the present invention shown in Fig. 12.
  • Fig. 14 is a schematic perspective view illustrating a green block having holes formed therein for receiving objects to be heated or cooled, i.e., samples, for the heating/cooling apparatus made of a ceramics of the fifth embodiment of the present invention shown in Fig. 12.
  • Fig. 15 is a schematic descriptive view illustrating a combination of the heating/cooling apparatus made of a ceramics of the fifth embodiment of the present invention shown in Fig. 12, and a coolant feeder.
  • Fig. 16 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a sixth embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride, provided with at least one peephole.
  • Fig. 17 is a schematic sectional view of Fig. 16 cut along the line A-A'.
  • Fig. 18 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a seventh embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride.
  • Fig. 19 is a schematic sectional view of Fig. 18 cut along the line A-A'.
  • Fig. 20 is a schematic sectional view of Fig. 18 cut along the line B-B', illustrating the heating/cooling apparatus made of a ceramics of the seventh embodiment of the present invention shown in Fig. 18, which is attached with a sample receptacle.
  • Fig. 1 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a first embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride
  • Fig. 2 is a schematic sectional view of Fig. 1 cut along the line A-A'.
  • the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention is manufactured as follows. As shown in Fig. 3, holes 2 and 3 for receiving samples are formed in each of green sheets 7, 8 and 10 made of a ceramics comprising aluminum nitride.
  • a resistance-heating element 5 is formed on the surface of the green sheet 8 by a method such as a screen printing. Then, the green sheets 7, 8 and 10 are piled one upon another, and a sintered body 1 is formed by sintering these green sheets 7, 8 and 10 thus piled up.
  • the sintered body 1 thus formed has a shape as shown in Fig. 1, and the side surfaces opposite to each other have electrodes 4 and 4', respectively, connected to the resistance-heating element 5.
  • FIG. 4 is a schematic descriptive view illustrating a combination of the above-mentioned heating/cooling apparatus of the first embodiment of the present invention, and a coolant feeder.
  • a cooling gas was supplied to the heating/cooling apparatus by means of a blower 11 as a coolant feeder.
  • test tubes having a thermocouple received therein was inserted into each of the holes 2 and 3 to investigate the performance of the heating/cooling apparatus.
  • Temperature of each test tube was subjected to a PID (abbreviation of proportional-plus-integral-plus-derivative) control on the basis of the temperature measured by the thermocouple, so that the temperature of the test tube coincide with a target temperature.
  • Electric power of the resistance-heating element 5 was controlled with the use of a thyristor.
  • the performance test was carried out as follows. Two test tubes filled with objects to be heated or cooled, i.e., samples, were inserted respectively into the holes 2 and 3 for receiving samples of the heating/cooling apparatus, and the samples were heated or cooled with the use of the above-mentioned heating/cooling apparatus in accordance with a predetermined temperature pattern as shown in Fig. 5, thereby precisely controlling the temperature of the samples. More specifically, the test tubes each receiving 1.5 ml of pure water were inserted respectively into the holes 2 and 3, each having an inside diameter agreeing with the outside diameter of the test tubes, of the heating/cooling apparatus shown in Fig. 1. A thermocouple for measuring temperature was immersed into the middle of pure water received in each of the test tubes. Pure water in each of the two test tubes showed an initial temperature of 17 °C, as measured by the thermocouple.
  • a program regarding set temperatures and set periods for heating and cooling pure water was input into a controller for controlling the operation of the heating/cooling apparatus.
  • the above-mentioned program comprised, as shown in Fig. 5: increasing the temperature of pure water to 95°C (hereinafter referred to as the "first set temperature”), then keeping this temperature for ten minutes (hereinafter referred to as the "first set period”), then decreasing the temperature of pure water to 4°C (hereinafter referred to as the "second set temperature”), then keeping this temperature for 60 minutes (hereinafter referred to as the "second set period”), then increasing again the temperature of pure water to 25°C (hereinafter referred to as the "third set temperature”), then keeping this temperature for 20 minutes (hereinafter referred to as the "third set period” ), and then discontinuing the operation of the heating/cooling apparatus.
  • the heating/cooling apparatus was operated under the control by means of the controller, and actual changes in temperature with time of pure water received in each of the two test tubes, were measured by the thermocouple.
  • the results of measurement were as follows. Upon the lapse of eight seconds after the start of operation of the heating/cooling apparatus, the temperature of pure water in each of the test tubes increased to 95 °C which was the first set temperature. Thereafter, during ten minutes which were the first set period, the temperature of pure water in each of the test tubes was kept at a temperature of 95 ⁇ 0.1°C. Then, upon the lapse of 20 seconds after the first set period, the temperature of pure water in each of the test tubes decreased to 4°C which was the second set temperature.
  • the temperature of pure water in each of the test tubes was kept at a temperature of 4 ⁇ 0.1°C. Subsequently, upon the lapse of two seconds after the second set period, the temperature of pure water in each of the test tubes increased to 25°C which was the third set temperature. Then, during 20 minutes which were the third set period, the temperature of pure water in each of the test tubes was kept at a temperature of 25 ⁇ 0.1°C, and thereafter, the operation of the heating/cooling apparatus was discontinued.
  • the sintered body 1 of the heating/cooling apparatus made of a ceramics of the above-mentioned first embodiment of the present invention has been described above as comprising an electrically insulating ceramics comprising aluminum nitride.
  • the sintered body 1 may however comprise an electrically insulating ceramics comprising at least one of silicon carbide, silicon nitride, aluminum oxide and beryllium oxide, other than aluminum nitride.
  • the material for forming the resistance-heating element 5 is not limited to at least one metal selected from the group consisting of tungsten, molybdenum and rhenium, but may be carbon, and furthermore, may be at least one electrically conductive ceramics selected from the group consisting of silicon carbide, titanium nitride, molybdenum silicide, zirconium boride, tungsten carbide and tantalum carbide.
  • the resistance-heating element 5 is buried in the form of a single layer into the sintered body 1.
  • a resistance-heating element comprising a plurality of layers may be buried into the sintered body 1.
  • the holes 2 and 3 for receiving the samples may have any shape in any number.
  • Fig. 6 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a second embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride
  • Fig. 7 is a schematic sectional view of Fig. 6 cut along the line A-A'.
  • the heating-cooling apparatus made of a ceramics of the second embodiment of the present invention is manufactured as follows. A powdery raw material comprising aluminum nitride is charged into a metallic mold not shown to form two green blocks 21 and 22 as shown in Fig. 8.
  • resistance-heating elements 19 and 20 each comprising a coiled wire made of at least one metal selected from the group consisting of tungsten, molybdenum and rhenium, are arranged on the surface of the green block 22 as shown in Fig. 9.
  • the other green block 21 is placed upon the green block 22, and as shown in Figs. 6 and 7, holes 13, 14, 15 and 16 for receiving samples are formed by means of a cutting.
  • the two green blocks thus provided with the holes are sintered by a hot press method, thereby preparing a sintered body 12 made of a ceramics comprising aluminum nitride having the resistance-heating elements 19 and 20 buried therein.
  • the side surfaces of the sintered body 12 are ground to expose ends of the coiled wires as the resistance-heating elements 19 and 20.
  • electrodes 17 and 18 are brazed onto the ends of the coiled wires thus exposed.
  • a performance test of the heating/cooling apparatus made of a ceramics of the above-mentioned second embodiment of the present invention was carried out in the same manner as in that of the heating/cooling apparatus made of the ceramics of the first embodiment of the present invention.
  • a blower as a coolant feeder was arranged below the heating/cooling apparatus, thereby blowing a cooling gas toward the heating-cooling apparatus to cool same.
  • the temperature of the sample was controlled also in the same manner as in the performance test of the heating/cooling apparatus of the first embodiment of the present invention.
  • the heating/cooling apparatus of the second embodiment of the present invention there were obtained excellent results of the performance test as in the heating/cooling apparatus of the first embodiment of the present invention. Furthermore, the heating/cooling apparatus of the second embodiment of the present invention was improved by providing a rugged portion or fins by means of a grinding on part of the surface of the sintered body 12, and the same performance test as described above was carried out for each of such improvements. There were obtained excellent results of the performance test as in the heating/cooling apparatus of the second embodiment of the present invention. Particularly within a range of temperature of from 100 to 600°C, there was available a cooling rate higher than that in the heating/cooling apparatus of the first embodiment of the present invention.
  • the holes 13, 14, 15 and 16 for receiving samples may be of any shape in any number, and the resistance-heating elements 19 and 20 may be in any number.
  • Fig. 10 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a third embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride, and a heat-radiating plate having fins, as a cooling means.
  • the heating/cooling apparatus of the third embodiment of the present invention is configured by forming a metallic layer comprising at least one metal of copper, nickel, molybdenum and manganese on the lower surface of the heating/cooling apparatus of the above-mentioned second embodiment of the present invention, and then brazing a metallic heat-radiating plate 30 having fins, as a cooling means, onto the metallic layer.
  • 23 is a sintered body; 24, 25, 26 and 27 are holes for receiving samples; and 28 and 29 are electrodes.
  • a performance test of the heating/cooling apparatus made of a ceramics of the above-mentioned third embodiment of the present invention was carried out in the same manner as in that of the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention. Also in the performance test of the heating/cooling apparatus of the third embodiment of the present invention, there were obtained excellent results of the performance test as in the heating/cooling apparatus of the first embodiment of the present invention. Particularly within a range of temperature of from 100 to 600°C, there was available a cooling rate higher than that of the heating/cooling apparatus of the first embodiment of the present invention.
  • the metallic heat-radiating plate 30 having fins, as a cooling means has been described as being provided on the lower surface of the sintered body 23.
  • the above-mentioned heat-radiating plate 30 may be provided on a surface other than the lower surface of the sintered body 23, for example, on a side surface thereof.
  • the above-mentioned heat-radiating plate 30 may have a honeycomb structure in place of the fins.
  • Fig. 11 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a fourth embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride, and at least one cooling through-hole as a cooling means, formed in the sintered body.
  • the heating/cooling apparatus of the fourth embodiment of the present invention is configured by forming cooling through-holes 38 and 39 as cooling means, as shown in Fig. 11, by means of an ultrasonic working, a diamond grinding or the like, in the sintered body of the heating/cooling apparatus of the second embodiment of the present invention.
  • 31 is a sintered body; 32, 33, 34 and 35 are holes for receiving samples; and 36 and 37 are electrodes.
  • a cooling gas is supplied into the cooling through-holes 38 and 39.
  • a performance test of the heating/cooling apparatus made of a ceramics of the above-mentioned fourth embodiment of the present invention was carried out in the same manner as in that of the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention. Also in the performance test of the heating/cooling apparatus of the fourth embodiment of the present invention, there were obtained excellent results of the performance test as in the heating/cooling apparatus of the first embodiment of the present invention. Particularly within a range of temperature of from 100 to 600 °C, there was available a cooling rate higher than that of the heating/cooling apparatus of the first embodiment of the present invention.
  • a cooling gas has been described as being supplied into the cooling through-holes 38 and 39 as the cooling means.
  • a liquid coolant may be supplied into the cooling through-holes 38 and 39.
  • a partition having a honeycomb structure may be provided as required in each of the cooling through-holes 38 and 39.
  • Fig. 12 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a fifth embodiment of the present invention, which comprises a sintered body made of a ceramics comprising silicon carbide.
  • 40 is a sintered body made of an electrically conductive ceramics comprising silicon carbide; and 41 and 42 are holes for receiving samples.
  • the heating/cooling apparatus made of a ceramics of the fifth embodiment of the present invention is manufactured as follows. A powdery raw material comprising an electrically conductive ceramics comprising silicon carbide is charged into a metallic mold not shown to form a green block 45 as shown in Fig. 13. Then, as shown in Fig. 14, holes 41 and 42 for receiving samples are formed in the green block 45 by means of a cutting.
  • the green block 45 thus provided with the holes 41 and 42 is sintered under the known sintering conditions.
  • metallic layers as electrodes 43 and 44 are attached, as shown in Fig. 12, onto the opposing side surfaces of the resultant sintered body 40, respectively.
  • the sintered body 40 itself forms a resistance-heating element serving as a heating means. There is no need therefore to specifically provide resistance-heating element in the sintered body 40.
  • a performance test of the heating/cooling apparatus made of a ceramics of the above-mentioned fifth embodiment of the present invention was carried out in the same manner as in that of the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention.
  • a blower 50 as a coolant feeder was arranged, as shown in Fig. 15, below the heating/cooling apparatus, thereby blowing a cooling gas toward the heating/cooling apparatus to cooling same.
  • the sintered body 40 of the heating/cooling apparatus of the fifth embodiment of the present invention has been described above as comprising an electrically conductive ceramics comprising silicon carbide, but the sintered body 40 may comprise any one electrically conductive ceramics selected from the group consisting of titanium nitride, a mixture of aluminum nitride and carbon and a mixture of silicon nitride and molybdenum silicide, other than silicon carbide.
  • the heating/cooling apparatus of the fifth embodiment of the present invention has been described above as having the two holes 41 and 42 for receiving samples. It is not however limited to this structure, but the holes may be of any shape in any number. It is also possible, as required, to provide the sintered body 40 with a heat-radiating plate having fins, a heat-radiating plate having a honeycomb structure, or at least one cooling through-hole, as a cooling means.
  • Fig. 16 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramics of a sixth embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride, provided with at least one peephole.
  • 51 is a sintered body
  • 52 and 53 are holes for receiving samples
  • 54 is an electrode
  • 55 and 56 are peepholes for visually and optically observing samples in test tubes, for example
  • 57, 58 and 59 are cooling through-holes, as cooling means, through which a coolant passes.
  • Fig. 17 is a schematic sectional view of Fig. 16 cut along the line A-A'.
  • Fig. 17, 63 is a resistance-heating element.
  • the heating/cooling apparatus of the sixth embodiment of the present invention it is possible to observe, through the peepholes 55 and 56, the state of samples while appropriately controlling the temperature of the samples.
  • the peepholes 55 and 56 may be of any shape in any number. It is possible to form optical paths for observation by filling the peepholes 55 and 56 with any one of an optically permeable ceramics, an optically permeable glass and an optically permeable resin.
  • the heating/cooling apparatus of the sixth embodiment of the present invention there is used a combination of: (1) any one of the several kinds of the chemical composition of the sintered body, and (2) any one of the several kinds of the chemical composition of the resistance-heating element, as described above in relation to the above-mentioned first to fifth embodiments of the present invention.
  • the holes 52 and 53 for receiving samples may be of any shape in any number.
  • Fig. 18 is a schematic perspective view illustrating a heating/cooling apparatus made of a ceramic of a seventh embodiment of the present invention, which comprises a sintered body made of a ceramics comprising aluminum nitride.
  • 60 is a sintered body made of a ceramics comprising aluminum nitride;
  • 61 is an electrode;
  • 62 are a plurality of cooling through-holes as cooling means, through which a coolant passes.
  • Fig. 19 is a schematic sectional view of Fig. 18 cut along the line A-A'.
  • 66 is a resistance-heating element comprising tungsten, connected to the electrode 61.
  • Fig. 20 is a schematic sectional view of Fig.
  • FIG. 18 cut along the line B-B', illustrating the heating/cooling apparatus of the seventh embodiment of the present invention shown in Fig. 18, which is attached with a sample receptacle 64.
  • Fig. 20 65 are a plurality of recesses for samples; and 62 is a cooling through-hole as a cooling means.
  • a performance test of the heating/cooling apparatus made of a ceramics of the above-mentioned seventh embodiment of the present invention was carried out in the same manner as in that of the heating/cooling apparatus made of a ceramics of the first embodiment of the present invention. Pure water identical with that in the performance test of the heating/cooling apparatus of the first embodiment of the present invention, was poured into each of the recesses for samples 65. Also in the performance test of the heating/cooling apparatus of the seventh embodiment of the present invention, there was employed the same temperature controlling method as that in the performance test of the heating/cooling apparatus of the first embodiment of the present invention.
  • control of temperature was effected on the basis of the temperatures of pure water measured by means of the thermocouple immersed into pure water received in each of the recesses for samples 65. Satisfactory results of the performance test were obtained in the performance test of the heating/cooling apparatus of the seventh embodiment of the present invention. An error between the temperature of pure water in each of the recesses for samples 65 and the target temperature was within ⁇ 1°C.
  • heating/cooling apparatus of the seventh embodiment of the present invention there is used a combination of: (1) any one of the several kinds of the chemical composition of the sintered body, (2) any one of the several kinds of the chemical composition of the resistance-heating element, and (3) any one of the several kinds of the cooling means, as described above in relation to the above-mentioned first to fifth embodiments of the present invention.
  • the heating/cooling apparatus made of a ceramics of the present invention it is possible to rapidly heat and cool various samples, to precisely control the temperature of the sample, to keep a uniform temperature distribution in the sample, and to conduct a precise temperature control in accordance with a predetermined complicated temperature program, which was impossible by any of the conventional technologies, thus providing useful effects in such fields as biotechnology, chemistry, medicine and bioengineering, and providing industrially useful effects.

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Abstract

Le but de l'invention est de permettre la maîtrise précise et variée de la température et d'obtenir une gestion et une commande de la température programmée, ce qui était impossible avec l'état antérieur de la technique. Grâce à la présente invention, il est donc possible de développer une technique scientifique qui marquera son époque, ainsi que de nouvelles utilisations et applications de ladite technique dans le domaine de la biotechnologie et dans les domaines associés à la chimie, la médecine et l'ingéniérie. Le dispositif selon l'invention est constitué d'un matériau fritté présentant une bonne conductibilité de la chaleur. Ledit matériau fritté comporte des trous ou des rainures sur lesquels sont placés un objet, sur une quelconque de ses faces, une résistance enterrée produisant de la chaleur, et une surface de refroidissement. Le dispositif est en contact avec l'objet par l'intermédiaire d'une surface suffisamment grande pour permettre une conduction efficace de la chaleur dudit dispositif à l'objet. Il est donc possible d'opérer des élévations et des chutes rapides de température, pour atteindre une température prédéterminée, et d'assurer une haute précision de répartition de la température, et ainsi d'avoir une maîtrise précise de la tempéraure.
EP93913596A 1992-07-01 1993-06-28 Dispositif ceramique de chauffage et de refroidissement Expired - Lifetime EP0603411B1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP21193792 1992-07-01
JP211937/92 1992-07-01
JP213144/92 1992-07-02
JP21314592 1992-07-02
JP21314492 1992-07-02
JP213145/92 1992-07-02
JP191553/93 1993-06-23
JP19155393A JPH0699085A (ja) 1992-07-01 1993-06-23 セラミック加熱冷却器
PCT/JP1993/000881 WO1994001529A1 (fr) 1992-07-01 1993-06-28 Dispositif ceramique de chauffage et de refroidissement

Publications (3)

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EP0603411A1 true EP0603411A1 (fr) 1994-06-29
EP0603411A4 EP0603411A4 (fr) 1995-02-22
EP0603411B1 EP0603411B1 (fr) 1998-08-19

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EP (1) EP0603411B1 (fr)
KR (1) KR100346861B1 (fr)
CA (1) CA2115360A1 (fr)
DE (1) DE69320449T2 (fr)
WO (1) WO1994001529A1 (fr)

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DE4409436A1 (de) * 1994-03-19 1995-09-21 Boehringer Mannheim Gmbh Verfahren zur Bearbeitung von Nukleinsäuren
WO1997026993A1 (fr) * 1996-01-25 1997-07-31 Bjs Company Ltd. Chauffage
WO1998039479A1 (fr) * 1997-03-03 1998-09-11 Regents Of The University Of Minnesota Dispositif de cyclage thermique ou de regulation de temperature et procede recourant a un plateau d'alumine
WO1998047442A1 (fr) * 1997-04-24 1998-10-29 Jouvin Jean Luc Module conditionneur d'hydrocolloide
WO1998038487A3 (fr) * 1997-02-28 1998-11-19 Cepheid Ensemble pour reaction chimique avec echange thermique et interrogee optiquement
WO1998058524A1 (fr) * 1997-06-17 1998-12-23 Delta Theta Limited Elements chauffants
US6300149B1 (en) * 1996-08-06 2001-10-09 Cavendish Kinetics Limited Integrated circuit device manufacture
EP1191361A1 (fr) * 2000-09-25 2002-03-27 Sumitomo Electric Industries, Ltd. Module de chauffage pour un dispositif de guide d'ondes
US7255833B2 (en) 2000-07-25 2007-08-14 Cepheid Apparatus and reaction vessel for controlling the temperature of a sample
US7462323B1 (en) 1999-12-21 2008-12-09 Cepheid Apparatus for performing heat-exchanging chemical reactions
CN105536903A (zh) * 2015-12-24 2016-05-04 青岛顺昕电子科技有限公司 一种扩展加热装置使用范围的方法
WO2016083301A1 (fr) * 2014-11-24 2016-06-02 Ceramtec Gmbh Gestion de la température dans le domaine de l'e-mobilité

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US6524532B1 (en) 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
US6635492B2 (en) 1996-01-25 2003-10-21 Bjs Company Ltd. Heating specimen carriers
JPH10117765A (ja) * 1996-10-18 1998-05-12 Ngk Insulators Ltd 試料容器及びその製造方法
US5958349A (en) * 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
US6300124B1 (en) 1999-11-02 2001-10-09 Regents Of The University Of Minnesota Device and method to directly control the temperature of microscope slides
KR100416993B1 (ko) 2001-07-21 2004-02-05 삼성전자주식회사 평면 광도파로 소자 모듈의 일체형 열전달 장치

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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4409436A1 (de) * 1994-03-19 1995-09-21 Boehringer Mannheim Gmbh Verfahren zur Bearbeitung von Nukleinsäuren
WO1997026993A1 (fr) * 1996-01-25 1997-07-31 Bjs Company Ltd. Chauffage
US6300149B1 (en) * 1996-08-06 2001-10-09 Cavendish Kinetics Limited Integrated circuit device manufacture
US8029733B2 (en) 1997-02-28 2011-10-04 Cepheid Thermal cycler with optical detector
WO1998038487A3 (fr) * 1997-02-28 1998-11-19 Cepheid Ensemble pour reaction chimique avec echange thermique et interrogee optiquement
US9316590B2 (en) 1997-02-28 2016-04-19 Cepheid Apparatus for controlling and monitoring reactions
WO1998039479A1 (fr) * 1997-03-03 1998-09-11 Regents Of The University Of Minnesota Dispositif de cyclage thermique ou de regulation de temperature et procede recourant a un plateau d'alumine
WO1998047442A1 (fr) * 1997-04-24 1998-10-29 Jouvin Jean Luc Module conditionneur d'hydrocolloide
FR2762505A1 (fr) * 1997-04-24 1998-10-30 Jean Luc Jouvin Module conditionneur d'hydrocolloide pour la prise d'empreintes dentaires
WO1998058524A1 (fr) * 1997-06-17 1998-12-23 Delta Theta Limited Elements chauffants
US8293064B2 (en) 1998-03-02 2012-10-23 Cepheid Method for fabricating a reaction vessel
US7462323B1 (en) 1999-12-21 2008-12-09 Cepheid Apparatus for performing heat-exchanging chemical reactions
US7255833B2 (en) 2000-07-25 2007-08-14 Cepheid Apparatus and reaction vessel for controlling the temperature of a sample
EP1191361A1 (fr) * 2000-09-25 2002-03-27 Sumitomo Electric Industries, Ltd. Module de chauffage pour un dispositif de guide d'ondes
WO2016083301A1 (fr) * 2014-11-24 2016-06-02 Ceramtec Gmbh Gestion de la température dans le domaine de l'e-mobilité
JP2018503217A (ja) * 2014-11-24 2018-02-01 セラムテック ゲゼルシャフト ミット ベシュレンクテル ハフツングＣｅｒａｍＴｅｃ ＧｍｂＨ Ｅモビリティ分野における熱管理
CN105536903A (zh) * 2015-12-24 2016-05-04 青岛顺昕电子科技有限公司 一种扩展加热装置使用范围的方法

Also Published As

Publication number Publication date
CA2115360A1 (fr) 1994-01-20
EP0603411B1 (fr) 1998-08-19
KR100346861B1 (ko) 2003-01-08
WO1994001529A1 (fr) 1994-01-20
DE69320449T2 (de) 1999-02-18
DE69320449D1 (de) 1998-09-24
EP0603411A4 (fr) 1995-02-22

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