EP0577593B1 - A filling device for medicine capsules with a rotatable spiral spring means - Google Patents
A filling device for medicine capsules with a rotatable spiral spring means Download PDFInfo
- Publication number
- EP0577593B1 EP0577593B1 EP91906873A EP91906873A EP0577593B1 EP 0577593 B1 EP0577593 B1 EP 0577593B1 EP 91906873 A EP91906873 A EP 91906873A EP 91906873 A EP91906873 A EP 91906873A EP 0577593 B1 EP0577593 B1 EP 0577593B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- capsule
- capsules
- spiral spring
- filling
- blanks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 56
- 239000003814 drug Substances 0.000 title claims abstract description 6
- 239000000463 material Substances 0.000 abstract description 12
- 229920001296 polysiloxane Polymers 0.000 abstract description 2
- 239000000126 substance Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 238000007789 sealing Methods 0.000 description 7
- 210000000078 claw Anatomy 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
Definitions
- the present invention relates to an equipment for filling a medical substance essentially in powder form into capsules.
- the capsules are intended to be implanted under the skin, and from which the medical substance diffuses to the blood circulation through the capsule wall. Intended uses are for instance dosing of contraceptive hormones, as well as in dosing antabus agents.
- the medical substance for each capsule is metered using an aperture plate glidable on a smooth surface.
- the equipment includes a mandrel for compressing the powder medicine substance into the metering apertures, and a second mandrel for feeding the medical substance from the metering apertures into capsules.
- the equipment in the French publication 2 306 679 discloses a tubular madrel for metering of the medical substance for each capsule.
- the medical substance dose is cut by means of this madrel from a medical substance mat of a certain thickness into a "rod" of certain length and diameter.
- the mandrel includes a piston device glidably moovable in the hollow mandrel in order to push the metered medical substance dose from the mandrel into a capsule.
- Both of the aforementioned equipments have at least some compressing effect to the powder medical substance.
- the starting point is a tube for forming the casing of the capsule, and for which a suitable material is a silicone plastic.
- the diameter of the tube under the manufacturing of hormone capsules is 1.5 mm.
- the tube is fed to the capsule manufacturing line as continuous lengths from a suitable apparatus.
- the tube is cut into capsule blanks of a suitable length, e.g. to lengths of about 34 mm.
- the said capsule blanks are then arranged into rows formed by several blanks.
- One row may comprise e.g. 12 blanks.
- One of such rows is advantageously joined together and it forms a handling unit for the next stages of the process.
- the said means can advantageously be a cassette of a clamping claw structure where the claws are in a mutual spring loaded clamping contact and where mutually co-operating indentation slots have been formed on the contact faces of the claws in order to form through holes for receiving the capsule blanks.
- the dosed quantity of the material is dropped from each dosing means to its respective transportation groove made in the surface of a disc, operating as a vibrating conveyor.
- the dosed material quantities proceed in the grooves of the vibrating conveyor further to feeding funnels, below which the capsule blanks to be filled have been transferred, carried by the clamping claw cassette.
- a special spiral feeder is used.
- the said feeder comprises a spiral spring that has a diameter less than the inner diameter of the capsule blank, and a straight guiding wire therein. This spring is rotatable in the forward direction of its spiral.
- the procedure is carried out so that the spiral spring is inserted into the capsule blank and made to rotate. Simultaneously with the activation of the rotative movement raising of the spiral spring from the capsule blank is initiated.
- the spring acts as a feeder screw.
- the spiral spring is extracted, still in rotation, from the capsule blank.
- the feeding funnels are kept under vibration.
- the spiral spring determines the height of the material column fed to the capsule.
- the capsule ends of the capsule blanks are sealed by using similar procedures as in connection with the sealing of the first ends of the capsule blanks described above. After the glue used in the sealing process has hardened, the capsule ends may be similarly finished by cutting parts away from their sealed portions.
- the completed capsules are conveyed through as such known process stages, whereby the capsules are washed, dried, inspected, packaged and sterilized to ready-to-use products.
- the material batches dosed on the groove disc 21 are transferred to filling funnels 23 placed in a transverse row below the tail edge of the groove disc 21. Beneath these filling funnels, a row of capsule blanks 7 carried by a clamping claw cassettes 6 has been conveyed the lower ends of which capsules have been sealed and advantageously trimmed.
- a filling device 24 comprises feeding devices, the number of which corresponds to the number of the filling funnels 23.
- Each feeding device comprises a rotating motor 25, a spindle 26, and a feeder screw 27 attached to the the lower end of the spindle.
- the feeder screw 27 is formed by a thin spiral spring.
- another thin straight guiding wire is placed inside the spring, extending substantially along the whole length of the spiral spring.
- the feeder screw 27 formed by the spiral spring is directed through each feeding funnel 23 to the capsule blank below it and is made to rotate.
- the rotative movement is naturally chosen in the feeding direction of the spiral spring.
- the feeder screw rotating in the capsule blank feeds the material fed into the feeder funnel efficiently into the capsule blank.
- the feeder screw is raised as filling is advancing.
- the feeder screw is removed completely from the capsule blank and the blanks are transferred to be sealed. Before sealing it is possible to clean the inside of their mouth areas to remove any remaining filling material. The sealing is carried out by glueing in the same way as sealing of the opposite end of the blanks before the filling stage.
- the ends of the filled capsules can be trimmed by cutting. After trimming, the completed capsules will be removed from their respective clamping claw cassettes after which operation they will be processed individually according to prior technology discussed briefly above.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Basic Packing Technique (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Formation And Processing Of Food Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Endoscopes (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/FI1991/000091 WO1992017149A1 (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
CA002106986A CA2106986A1 (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
HU9302744A HUT68494A (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0577593A1 EP0577593A1 (en) | 1994-01-12 |
EP0577593B1 true EP0577593B1 (en) | 1996-06-26 |
Family
ID=27169609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91906873A Expired - Lifetime EP0577593B1 (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0577593B1 (lv) |
JP (1) | JPH06505885A (lv) |
CN (1) | CN1028151C (lv) |
AT (1) | ATE139686T1 (lv) |
AU (1) | AU656317B2 (lv) |
BR (1) | BR9201188A (lv) |
CA (1) | CA2106986A1 (lv) |
DE (1) | DE69120547T2 (lv) |
DK (1) | DK0577593T3 (lv) |
EE (1) | EE02956B1 (lv) |
ES (1) | ES2090321T3 (lv) |
FI (1) | FI934210A0 (lv) |
GR (1) | GR3021181T3 (lv) |
HU (1) | HUT68494A (lv) |
LV (1) | LV10177B (lv) |
MX (1) | MX9201401A (lv) |
NO (1) | NO933408L (lv) |
RU (1) | RU2103988C1 (lv) |
WO (1) | WO1992017149A1 (lv) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9400462D0 (sv) * | 1994-02-11 | 1994-02-11 | Astra Ab | Filling device |
GB0616448D0 (en) * | 2006-08-18 | 2006-09-27 | Ici Plc | Methods of and apparatus for dispensing powder samples |
IT1397610B1 (it) * | 2009-12-22 | 2013-01-18 | Mg 2 Srl | Macchina rotativa intermittente per il riempimento di capsule con prodotti farmaceutici. |
JP5718766B2 (ja) * | 2011-08-12 | 2015-05-13 | 東洋自動機株式会社 | 被包装物充填装置及び方法 |
CN104257274B (zh) * | 2014-09-23 | 2016-07-06 | 黄龙国 | 一种塑封胶囊机 |
CN108455095B (zh) * | 2017-02-21 | 2023-07-14 | 李和伟 | 一种旋转式给药器 |
CN107776920A (zh) * | 2017-11-23 | 2018-03-09 | 无锡鼎加弘思饮品科技有限公司 | 一种饮品胶囊灌装机构以及饮品胶囊的灌装方法 |
CN112224545A (zh) * | 2020-10-09 | 2021-01-15 | 崔宝月 | 临床药学药剂调剂装置 |
CN112722432A (zh) * | 2020-12-28 | 2021-04-30 | 广州水琴贸易有限公司 | 一种颗粒罐装机 |
CN113335619B (zh) * | 2021-06-15 | 2022-10-14 | 重庆宏南科技股份有限公司 | 用于制药设备的药品自动定量分配装置 |
CN113682506A (zh) * | 2021-08-18 | 2021-11-23 | 广州珐玛珈智能设备股份有限公司 | 多列条包机颗粒度量模块 |
CN113955165A (zh) * | 2021-11-15 | 2022-01-21 | 江苏仅一联合智造有限公司 | 一种高速螺杆充填包装机 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1033874B (it) * | 1975-04-07 | 1979-08-10 | Zanasi Nigris Spa | Procedimento e dispositivo per il dosaggio di prodotti pastosi piu o meno densi,da immettere in un qualsivoglia contenitore |
CA1259966A (en) * | 1985-02-27 | 1989-09-26 | Taizo Yamamoto | Capsule filling apparatus |
GB2237258B (en) * | 1989-10-26 | 1993-10-20 | American Cyanamid Co | Apparatus and method for manufacturing soft shell capsules |
-
1991
- 1991-03-28 AT AT91906873T patent/ATE139686T1/de not_active IP Right Cessation
- 1991-03-28 DK DK91906873.4T patent/DK0577593T3/da active
- 1991-03-28 AU AU75690/91A patent/AU656317B2/en not_active Ceased
- 1991-03-28 RU RU93057752A patent/RU2103988C1/ru active
- 1991-03-28 WO PCT/FI1991/000091 patent/WO1992017149A1/en active IP Right Grant
- 1991-03-28 DE DE69120547T patent/DE69120547T2/de not_active Expired - Fee Related
- 1991-03-28 MX MX9201401A patent/MX9201401A/es not_active IP Right Cessation
- 1991-03-28 ES ES91906873T patent/ES2090321T3/es not_active Expired - Lifetime
- 1991-03-28 CA CA002106986A patent/CA2106986A1/en not_active Abandoned
- 1991-03-28 EP EP91906873A patent/EP0577593B1/en not_active Expired - Lifetime
- 1991-03-28 JP JP3506898A patent/JPH06505885A/ja active Pending
- 1991-03-28 HU HU9302744A patent/HUT68494A/hu unknown
-
1992
- 1992-02-12 CN CN92101007.9A patent/CN1028151C/zh not_active Expired - Fee Related
- 1992-03-27 BR BR929201188A patent/BR9201188A/pt not_active Application Discontinuation
-
1993
- 1993-09-10 LV LVP-93-1066A patent/LV10177B/en unknown
- 1993-09-24 NO NO93933408A patent/NO933408L/no unknown
- 1993-09-24 FI FI934210A patent/FI934210A0/fi not_active Application Discontinuation
-
1994
- 1994-10-13 EE EE9400113A patent/EE02956B1/xx unknown
-
1996
- 1996-09-26 GR GR960402533T patent/GR3021181T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
Also Published As
Publication number | Publication date |
---|---|
CN1065200A (zh) | 1992-10-14 |
HUT68494A (en) | 1995-06-28 |
DK0577593T3 (da) | 1996-10-14 |
BR9201188A (pt) | 1992-09-15 |
LV10177B (en) | 1995-04-20 |
NO933408D0 (no) | 1993-09-24 |
FI934210A (fi) | 1993-09-24 |
CA2106986A1 (en) | 1992-09-29 |
EE02956B1 (et) | 1997-02-17 |
AU7569091A (en) | 1992-11-02 |
RU2103988C1 (ru) | 1998-02-10 |
ES2090321T3 (es) | 1996-10-16 |
NO933408L (no) | 1993-09-24 |
EP0577593A1 (en) | 1994-01-12 |
FI934210A0 (fi) | 1993-09-24 |
DE69120547D1 (de) | 1996-08-01 |
WO1992017149A1 (en) | 1992-10-15 |
GR3021181T3 (en) | 1996-12-31 |
MX9201401A (es) | 1993-01-01 |
JPH06505885A (ja) | 1994-07-07 |
CN1028151C (zh) | 1995-04-12 |
AU656317B2 (en) | 1995-02-02 |
ATE139686T1 (de) | 1996-07-15 |
LV10177A (lv) | 1994-10-20 |
DE69120547T2 (de) | 1997-02-13 |
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EP1553910B1 (en) | A capsule filling machine | |
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TW200403B (lv) |
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