EP0560270A2 - Pompe peristaltique linéaire - Google Patents

Pompe peristaltique linéaire Download PDF

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Publication number
EP0560270A2
EP0560270A2 EP93103714A EP93103714A EP0560270A2 EP 0560270 A2 EP0560270 A2 EP 0560270A2 EP 93103714 A EP93103714 A EP 93103714A EP 93103714 A EP93103714 A EP 93103714A EP 0560270 A2 EP0560270 A2 EP 0560270A2
Authority
EP
European Patent Office
Prior art keywords
cam
peristaltic pump
flexible tube
cams
linear peristaltic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP93103714A
Other languages
German (de)
English (en)
Other versions
EP0560270B1 (fr
EP0560270A3 (en
Inventor
Alexandre Tsoukalis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micrel Microelectronic Applications Center Ltd
Original Assignee
Micrel Microelectronic Applications Center Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micrel Microelectronic Applications Center Ltd filed Critical Micrel Microelectronic Applications Center Ltd
Publication of EP0560270A2 publication Critical patent/EP0560270A2/fr
Publication of EP0560270A3 publication Critical patent/EP0560270A3/en
Application granted granted Critical
Publication of EP0560270B1 publication Critical patent/EP0560270B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14228—Pumping with an aspiration and an expulsion action with linear peristaltic action, i.e. comprising at least three pressurising members or a helical member
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/082—Machines, pumps, or pumping installations having flexible working members having tubular flexible members the tubular flexible member being pressed against a wall by a number of elements, each having an alternating movement in a direction perpendicular to the axes of the tubular member and each having its own driving mechanism
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B9/00—Piston machines or pumps characterised by the driving or driven means to or from their working members
    • F04B9/02—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical
    • F04B9/04—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical the means being cams, eccentrics or pin-and-slot mechanisms
    • F04B9/042—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical the means being cams, eccentrics or pin-and-slot mechanisms the means being cams

Definitions

  • the invention relates to a linear peristaltic pump comprising a flexible tube supported on a support plate and having an input end connected to a fluid reservoir as well as an output end; a motor-driven cam shaft rotatably supported in a stationary frame and arranged in parallel to the flexible tube and having at least three cams, which are displaced angularly to each other; a cam follower for each cam, guided between parallel guide faces for straight reciprocable movement in a direction normal to the axis of the cam shaft, having end faces for squeezing the flexible tube in an operation sequence travelling along the tube from the input end to the output end; and ball bearings for reducing friction between the cam and the cam followers.
  • the invention particularly relates to a portable linear peristaltic pump operated on batteries for delivering drugs to patients.
  • Linear peristaltic pumps are an improvement over the older type of rotary peristaltic pumps, and in their portable form, linear peristaltic pumps have the advantage that disposable parts of the mechanism are less expensive to replace than in reciprocally moving piston pumps in which the pumping mechanism is installed on the disposable parts like syringes.
  • linear peristaltic pumps the drug is contained in a reservoir of soft material connected to a small flexible silicone tube which is consecutively compressed along its length by a set of fingers driven by a cam mechanism, thereby pumping the drug from the reservoir into a catheter.
  • Large size bedside volumetric linear peristaltic pumps as used in hospitals are reliable long-life devices which are suitable for intensive care units.
  • EP-A-214 443 shows a transfusion pump having a flexible tube supported on a support plate and having an input end connected to a fluid reservoir, and an output end connected, for instance, to a catheter.
  • the mechanism comprises a motor-driven cam shaft arranged in parallel to the flexible tube and having a plurality of cams.
  • these cams directly operate on cam fingers which squeeze the flexible tube in an operation sequence travelling along the tube from its input end to the output end. It is clear that between the cams and the cam followers large friction exists which would be a disadvantage in case of portable pumps operating on batteries.
  • EP-A-214 443 also discloses a pump mechanism (Figs. 7 and 8) which uses ball bearings which are fixed excentrically on a shaft, and the outer circumferences of these ball bearings directly operate on the flexible tube. Although in this construction friction and wear is reduced, rather large ball bearings are necessary in order to obtain sufficiently large strokes for squeezing the flexible tube. Such large ball bearings need larger space in a direction normal to the squeezing direction of the flexible tube, so that this principle is more suitable for large bedside pumps than for portable pumps. Moreover, excentric pump mechanisms have the disadvantage that the operation curves can only be made sinusodial but not in any shape as would be possible with shaped cam surfaces.
  • a linear peristaltic pump as defined above is characterized in that the inner parts of the ball bearings are supported on the cam followers whereas the cams operate on the outer circumferential surfaces of the ball bearings; that the cams, cam followers and ball bearings are substantially in the same plane; and that the overall diameter of the ball bearings is smaller than that of the outer surfaces of the cams.
  • the straight reciprocable movement of the cam followers is guided between parallel guide faces, and the dimensions normal to the direction of movement can be kept small in spite of the use of ball bearings reducing friction on the cams, because smaller ball bearings can be used compared with ball bearings mounted excentrically on a shaft in the prior art pumps.
  • a stationary frame is provided with parallel side walls with guide grooves for guiding side faces of the cam followers.
  • the ball bearings are preferably supported on projections extending parallel to the axis of the cam shaft from the cam followers.
  • the flexible tube In order to avoid movements of the flexible tube in transversal direction normal to the operating direction of the cam followers, the flexible tube is preferably held in position under the cam followers by stationary shoulders limiting sideward movement, the height of the shoulders being less than twice the wall thickness of the tube.
  • a protective sheet is placed between the flexible tube and the end faces of the cam followers for sealing the drive mechanism against the tube.
  • the cam shaft with its cams is preferably a one-piece metal part, preferably made by powder injection molding or powder metal sintering.
  • each cam has three curve portions:
  • the flexible tube With such a curvature of the cams the flexible tube is squeezed over a rather long angle of rotation, and released and expanded over a rather short angle of rotation, so that the tube has sufficient expansion time to reach its full and expanded form to allow its filling with fluid to the full volume.
  • the cams are displaced at even angles around a full circle.
  • the second portion of the curvature is made slightly longer than said angle to provide overlapping of the second portions of the individual cams, so that the volume of fluid to be pumped is safely trapped between the closed sections of the tube without any back flow.
  • the duration of the first portion is about 200°
  • the duration of the second portion about 65°
  • the duration of the third portion about 95° of a full revolution of 360°.
  • an additional cam and cam follower are provided at the output end of the flexible tube for linearizing the output flow, the maximum radius of this cam being less than necessary to close the tube.
  • This additional cam has the function to increase the output flow for the short period of time when the last regular cam is in its closed position, i.e. the additional cam has a first portion of depression during the second portion of the last regular cam, and a second portion of release of pressure to the flexible tube during the remaining part of the revolution.
  • the duration of the first portion of the additional cam is about 65° and the duration of the second portion is about 295°.
  • Another important aspect of the present invention is a special construction of placing the fluid reservoir and the flexible tube within a compartment of a housing of the peristaltic pump.
  • This preferable embodiment is characterized by an exchangeable unit comprising the fluid reservoir, preferably made from soft elastomer material, and the flexible tube having its input end connected to the fluid reservoir.
  • the exchangeable unit is placed in a compartment of the housing which is closed by a lid constituting the support plate to the flexible tube.
  • registration means are provided at a frame of the exchangeable unit and within the compartment, which registration means only permit insertion of the exchangeable unit in proper orientation but not in reverse orientation.
  • clamping means are provided at the output end of the flexible tube, the clamping means opening the output if the exchangeable unit is within the compartment and the lid is properly closed.
  • the clamping means are preferably spring-biased into the closed position and opened by a projection of the lid.
  • a pressure sensor for sensing the output pressure of the peristaltic pump.
  • the pressure sensor in a preferred embodiment, is operated by a flexible, soft membrane covering an opening of a housing connected to the output end of the flexible tube.
  • the soft membrane has a rather large area, so that the overall sensitivity of the pressure sensor is increased.
  • the general view of the linear peristaltic pump, Figure 1 shows a housing 3 containing the mechanical parts of the pump including a motor, a reduction gear, an electric battery and the movement mechanism in the area of the rear part, whereas in a lower front part of the housing the electronics are installed using a microprocessor and SMD technology for reducing size.
  • the housing 3 is provided with a lid 5 at the bottom hinged at 5a for access to a compartment into which an exchangeable unit comprising a fluid reservoir 4 can be inserted.
  • a display 1 and operation keys 2 are provided at the top of the housing.
  • a cam shaft 9 having a plurality of cams 30a-30f is rotatably supported by journals 8 within a stationary frame 26.
  • the cam shaft 9 is driven by a low inertia motor 6 having a reduction gear 6a.
  • a magnetic drum 7 having angularly spaced magnets is operating on hall sensors 17 which are angularly displaced to each other in order to detect the direction of rotation as well as the speed of rotation.
  • the signals of the hall sensors 17 are used in a microprocessor controlling the operation of the peristaltic pump.
  • each of the cams 30a-30f there is provided a plurality of cam followers 11 each having a small ball bearing 10 supported with is inner part 10a on a projection 11c formed at the cam followers 11.
  • the outer circumference 10b of each ball bearing 10 touches the cam surface of each cam 30a-30f, so that only small friction is present between the cam followers 11 and the cams 30a-30f.
  • End faces 11b of the cam followers 11 operate on a flexible tube 16 supported on a support plate 5, being the lid for the housing 3 as already described.
  • the cam followers 11 are guided for movement in a straight line in vertical direction (as seen in the drawings) by side faces 11a moving in guide faces 26a in the form of grooves present in side walls of the stationary frame 26.
  • the flexible tube 16 is made of elastic material, preferably of silicone material.
  • a protective sheet 15 of plastic material is placed between the tube 16 and the end faces 11b of the cam followers 11 (only shown in Figure 3 but not in Figure 2 for the sake of clarity).
  • the cam 30a as shown in Figure 2 has three portions of curvature, i.e.
  • cam followers 11 are pushed upwards by the elasticity of the tube 16 upon release by the cam followers 11. It is, however, also possible to assist the upward movement by return springs.
  • FIG. 4 now shows an exchangeable unit comprising the fluid reservoir 4 and the flexible tube 16 supported on a frame 28 made of hard plastic material and connected to the fluid reservoir.
  • the fluid reservoir 4 is in the form of a small bag preferably made from soft elastomer material, and the flexible tube 16 is connected through a pump connector 24 and an input tube 27 to the fluid reservoir.
  • the frame 28 comprises registration means 25 in the form of holes, into which complementary projections within the compartment of the housing 3 would fit in order to safeguard proper orientation of the exchangeable unit within the compartment.
  • the output end 16b of the flexible tube 16 is connected to a small housing 23 which is only shown schematically in Figure 3. An opening at the upper side (as seen in the drawing) is closed by a membrane 23a glued to the walls of the housing at the opening.
  • the output pressure at the output end 16b of the flexible tube 16 is present in the housing 23 and operates the membrane 23a having a rather large area for operating a pressure sensor 14 which can be an analog pressure sensor or a switch.
  • the pressure sensor 14 is used for sensing overpressure at the output, so that either the operation of the peristaltic pump can be stopped and/or an alarm signal be given.
  • the housing 23 is connected to an output tube 29, and from there to an output connector 22, in the present case a Luer Lock connector (particularly see Figure 4).
  • the frame 28 also has projections 21 which safeguard that the flexible tube 16 does not move transversely under the squeezing pressure of the cam followers 11. These projections or shoulders 21 are also shown in Figure 2. Their height in squeezing direction is slightly less than twice the wall thickness of the tube 16, so that the tube can be fully compressed by the end faces 11b of the cam followers 11.
  • the exchangeable unit comprising the fluid reservoir 4 and the flexible tube 16
  • the exchangeable unit can be inserted into a compartment of the housing 3 by opening the hinged lid 5 at the bottom of the housing 1.
  • a spring clamp 12 is provided at the output tube (29). This spring clamp 12 is spring-biased into its closed position.
  • a projection (not shown) at the lid 5 operates the spring clamp 12 into its open position, so that the output is opened and the peristaltic pump can be used.
  • a switch 13 is provided which is operated by the lid 5 in such a way that operation of the peristaltic pump is only permitted when the lid 5 is properly closed.
  • each of the six cams 30a-30f has a first portion 18 having a continuously increasing radius of calculated curvature, and in the present embodiment, this portion extends over an angle of 200°.
  • the radius of the cam surface preferably increases linearly with the rotation angle in the direction of an arrow 32.
  • the subsequent second portion 19 has a constant radius, i.e. the maximum radius R30. In the present embodiment, the constant radius in portion 19 lasts for 65°.
  • a sharp decrease from the maximum radius R30 to the minimum radius takes place, in the present embodiment during a rotation angle of about 95°.
  • the maximum radius R30 and the length of the cam followers 11 are such that the flexible tube 16 is completely closed.
  • the end faces 11b of some of the cam followers 11 are shown at a distance from the flexible tube 16, this distance or gap is smaller or zero in practice.
  • FIG. 6 now shows an additional cam 31 which is placed behind the sixth regular cam 30f (Figure 3) for the purpose of smoothing variations of the output pressure during the pumping action.
  • This additional cam is not shown in Figure 3 but only in Figure 6.
  • the additional cam 31 has a first portion 33 during which the radius increases from a minimum value to a maximum radius R31. From this maximum value R31 the radius decreases during a second portion 34 to the minimum value.
  • the maximum radius R31 is smaller than the maximum radius R30 of the regular cams 30 because the flexible tube 16 shall only be pressed but not closed.
  • the angular duration of the first portion 33 is about 65°, whereas the remaining portion 34 is about 295°.
  • Figure 5 now shows the angular position of the last and sixth regular cam 30f, and the additional cam 31 is fixed to the cam shaft 9 at the same angular position as shown for the sixth cam 30f in Figure 5, i.e. when cam 30f has its maximum radius R30, the additional cam 31 also has it maximum radius R31. From this follows that when the sixth cam 30f rotates from point A to point B during its second portion 19 during which the flexible tube 16 is held fully closed, the additional cam 31 runs from point A to point B through its first portion 33 during which the pressure to the end portion 16b of the flexible tube 16 is gradually increased without closing the tube 16. This means that while no fluid is pumped beyond the closed cam 30f the additional cam 31 provides a pumping action to the output during the same time. Accordingly, pressure variations at the output are greatly reduced.
EP19930103714 1992-03-10 1993-03-09 Pompe peristaltique linéaire Expired - Lifetime EP0560270B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR92100089 1992-03-10
GR92010089 1992-03-10

Publications (3)

Publication Number Publication Date
EP0560270A2 true EP0560270A2 (fr) 1993-09-15
EP0560270A3 EP0560270A3 (en) 1993-11-24
EP0560270B1 EP0560270B1 (fr) 1996-07-10

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ID=10941054

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19930103714 Expired - Lifetime EP0560270B1 (fr) 1992-03-10 1993-03-09 Pompe peristaltique linéaire

Country Status (3)

Country Link
EP (1) EP0560270B1 (fr)
DE (1) DE69303516T2 (fr)
GR (1) GR1001179B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037703A1 (fr) * 1996-04-10 1997-10-16 Baxter International Inc. Pompe a perfusion volumetrique
EP0858812A2 (fr) * 1997-02-17 1998-08-19 Micrel, Microelectronic Applications Center Ltd. Pompe péristaltique linéaire
EP0881388A1 (fr) * 1995-11-28 1998-12-02 Terumo Kabushiki Kaisha Procédé d'infusion et pompe de perfusion
AU727479B2 (en) * 1996-04-10 2000-12-14 Baxter International Inc. Method of manufacturing an infusion pump
US7955060B2 (en) 2002-10-04 2011-06-07 Pfm Medical Tpm Gmbh Peristaltic pump
US8961155B2 (en) 2011-02-19 2015-02-24 Douglas Shipman Peristaltic linear pump and method of operation
CN104582752A (zh) * 2012-09-27 2015-04-29 泰尔茂株式会社 输液泵
CN106730126A (zh) * 2015-11-19 2017-05-31 张家港合升进出口有限公司 一种自动输液装置
US9937289B2 (en) 2002-06-14 2018-04-10 Baxter International Inc. Method of operating an infusion pump with a multiple orientation display
US20220241499A1 (en) * 2021-02-04 2022-08-04 Micrel Medica Devices S.A. Peristaltic infusion pump tube segment and infusion pump device with such a tube segment

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10330984B4 (de) * 2003-07-09 2009-12-10 Tecpharma Licensing Ag Injektionsgerät mit Positionssensor
US8105269B2 (en) 2008-10-24 2012-01-31 Baxter International Inc. In situ tubing measurements for infusion pumps
US8137083B2 (en) 2009-03-11 2012-03-20 Baxter International Inc. Infusion pump actuators, system and method for controlling medical fluid flowrate
US8382447B2 (en) 2009-12-31 2013-02-26 Baxter International, Inc. Shuttle pump with controlled geometry
US8567235B2 (en) 2010-06-29 2013-10-29 Baxter International Inc. Tube measurement technique using linear actuator and pressure sensor
CN103212133B (zh) 2013-04-10 2014-10-15 中国人民解放军第四军医大学 一种微型便携式多功能输液装置
CN111257759B (zh) * 2020-02-20 2022-04-15 北京纳米能源与系统研究所 液流电池监测装置和液流电池监测及调控系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2020735A (en) * 1978-05-10 1979-11-21 Fresenius Chem Pharm Ind Hose pump having a high dosing accuracy
WO1984000690A1 (fr) * 1982-08-12 1984-03-01 American Hospital Supply Corp Appareil de pompage d'un fluide peristaltique
US4909710A (en) * 1989-10-23 1990-03-20 Fisher Scientific Company Linear peristaltic pump
EP0422855A1 (fr) * 1989-10-10 1991-04-17 Imed Corporation Pompe peristaltique à deux temps
EP0426273A1 (fr) * 1989-11-02 1991-05-08 Baxter International Inc. Dispositif de pompage

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7277391A (en) * 1990-03-15 1991-09-19 Abbott Laboratories A spring-biased valve for use in a positive displacement volumetric pump
DE4035182C1 (fr) * 1990-11-06 1992-01-02 B. Braun Melsungen Ag, 3508 Melsungen, De

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2020735A (en) * 1978-05-10 1979-11-21 Fresenius Chem Pharm Ind Hose pump having a high dosing accuracy
WO1984000690A1 (fr) * 1982-08-12 1984-03-01 American Hospital Supply Corp Appareil de pompage d'un fluide peristaltique
EP0422855A1 (fr) * 1989-10-10 1991-04-17 Imed Corporation Pompe peristaltique à deux temps
US4909710A (en) * 1989-10-23 1990-03-20 Fisher Scientific Company Linear peristaltic pump
EP0426273A1 (fr) * 1989-11-02 1991-05-08 Baxter International Inc. Dispositif de pompage

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0881388A1 (fr) * 1995-11-28 1998-12-02 Terumo Kabushiki Kaisha Procédé d'infusion et pompe de perfusion
US5988983A (en) * 1995-11-28 1999-11-23 Terumo Kabushiki Kaisha Infusion method and infusion pump
AU728493B2 (en) * 1996-04-10 2001-01-11 Baxter International Inc. An infusion pump with a shuttle for deforming and reforming a tube
EP0931555A2 (fr) * 1996-04-10 1999-07-28 Baxter International Inc. Pompe de perfusion volumétrique
EP0931555A3 (fr) * 1996-04-10 1999-10-27 Baxter International Inc. Pompe de perfusion volumétrique
AU727479B2 (en) * 1996-04-10 2000-12-14 Baxter International Inc. Method of manufacturing an infusion pump
WO1997037703A1 (fr) * 1996-04-10 1997-10-16 Baxter International Inc. Pompe a perfusion volumetrique
US5842841A (en) * 1996-04-10 1998-12-01 Baxter International, Inc. Volumetric infusion pump with transverse tube loader
EP0858812A3 (fr) * 1997-02-17 1998-11-11 Micrel, Microelectronic Applications Center Ltd. Pompe péristaltique linéaire
US5980490A (en) * 1997-02-17 1999-11-09 Micrel, Microelectronic Applications Center Ltd. Linear peristaltic pump
EP0858812A2 (fr) * 1997-02-17 1998-08-19 Micrel, Microelectronic Applications Center Ltd. Pompe péristaltique linéaire
US9937289B2 (en) 2002-06-14 2018-04-10 Baxter International Inc. Method of operating an infusion pump with a multiple orientation display
US10092690B2 (en) 2002-06-14 2018-10-09 Baxter International Inc. Infusion pump including syringe sensing
US7955060B2 (en) 2002-10-04 2011-06-07 Pfm Medical Tpm Gmbh Peristaltic pump
US8961155B2 (en) 2011-02-19 2015-02-24 Douglas Shipman Peristaltic linear pump and method of operation
EP2902047A4 (fr) * 2012-09-27 2016-05-18 Terumo Corp Pompe à perfusion
CN104582752A (zh) * 2012-09-27 2015-04-29 泰尔茂株式会社 输液泵
EP3323447A1 (fr) * 2012-09-27 2018-05-23 Terumo Kabushiki Kaisha Pompe à perfusion
US10549033B2 (en) 2012-09-27 2020-02-04 Terumo Kabushiki Kaisha Infusion pump
CN106730126A (zh) * 2015-11-19 2017-05-31 张家港合升进出口有限公司 一种自动输液装置
US20220241499A1 (en) * 2021-02-04 2022-08-04 Micrel Medica Devices S.A. Peristaltic infusion pump tube segment and infusion pump device with such a tube segment

Also Published As

Publication number Publication date
EP0560270B1 (fr) 1996-07-10
GR1001179B (el) 1993-06-07
EP0560270A3 (en) 1993-11-24
DE69303516T2 (de) 1996-10-31
DE69303516D1 (de) 1996-08-14

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