EP0556276A1 - Dispositif d'injection a jet hypodermique n'utilisant pas d'aiguille - Google Patents

Dispositif d'injection a jet hypodermique n'utilisant pas d'aiguille

Info

Publication number
EP0556276A1
EP0556276A1 EP91920413A EP91920413A EP0556276A1 EP 0556276 A1 EP0556276 A1 EP 0556276A1 EP 91920413 A EP91920413 A EP 91920413A EP 91920413 A EP91920413 A EP 91920413A EP 0556276 A1 EP0556276 A1 EP 0556276A1
Authority
EP
European Patent Office
Prior art keywords
capsule
vial
gas
injector device
jet injector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP91920413A
Other languages
German (de)
English (en)
Other versions
EP0556276A4 (fr
Inventor
Peter Elliott Rosenzweig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sy-Quest International Ltd
Sy Quest International Ltd
Original Assignee
Sy-Quest International Ltd
Sy Quest International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sy-Quest International Ltd, Sy Quest International Ltd filed Critical Sy-Quest International Ltd
Publication of EP0556276A1 publication Critical patent/EP0556276A1/fr
Publication of EP0556276A4 publication Critical patent/EP0556276A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals

Definitions

  • This invention relates to a needleless hypodermic jet injector device and, more particularly, to such a device which includes a disposable gas powered plunger and a disposable medicament vial.
  • a device including a tubular needle connected to a reservoir of medicament incorporating a piston. The needle was inserted through the epidermis into the hypoderma and the medicament was discharged by moving the piston along the reservoir.
  • Such devices have several problems. Firstly, the penetration of the needle is a possible cause for infection and there is patient resistance to the discomfort associated with the insertion of the needle.
  • the diabetes sufferer has to endure the pain and inconvenience of frequent hypodermic needle injections to administer the insulin used in the control of diabetes.
  • the diabetes sufferer In the case of the diabetes sufferer, it is desirable to have a presterilised, disposable device for single and multiple (insulin ) injection use, that has its own power source while being small and light enough for the user to carry during the day.
  • the device should be such that the user can vary the selected dose conveniently and accurately and it should be conveniently and safely operated.
  • the diabetes sufferer needs to inject on at least one and up to three occasions daily, insulin at a dosage varying from less than 0.1 illilitres up to a maximum of 0.3 millilitres.
  • Gas and spring operated jet injection devices have been invented as alternatives to the needle devices.
  • liquid medicament is discharged from a reservoir through a port as a spray by a piston moved along the reservoir by subjecting it to a force created by the sudden release of gas.
  • the common forms of gas device comprise a holder to which is coupled a container of medicament in a manner aligning it with the piston to be gas operated and which provides means to hold a gas filled capsule in the holder. By puncturing the capsule the gas is released into a cylinder and the piston therein is driven into the container to discharge the medicament through a port in the container.
  • the holder is a relatively large member and is complex having to provide securement means for the medicament container and the gas capsule. It has to provide a piston mounting arrangement and means to releasably hold the gas capsule in a gas tight manner and puncture the gas capsule.
  • the device is large and complex and correspondingly expensive.
  • the separate power supply mechanism reduces the portability and convenience of the Parsons device. Consequently it is desirable to have a needleless injection system that overcomes this concern.
  • US Patent No. 4,596,556 describes a hypodermic injection apparatus having a spring-loaded firing mechanism that operates to release carbon dioxide from a capsule. This propels the capsule and a plunger toward a discharge aperture to discharge medication through the aperture.
  • a spring-loaded firing mechanism that operates to release carbon dioxide from a capsule. This propels the capsule and a plunger toward a discharge aperture to discharge medication through the aperture.
  • the device in being self-cocking, reloadable, and reusable the device is somewhat complicated.
  • US Patent No. 3,688,765 describes another device that is intended for portable use. However, it uses a syringe in the form of a prefilled, sealed, ampoule that precludes dosage selection at the time of use.
  • the detachable syringe, disposable carbon dioxide unit and re-usable pressurising unit represent three separate components with which the user must contend.
  • the invention provides a disposable, needleless hypodermic jet injector device for introducing a liquid into a patient, the liquid being contained in a vial which includes a hollow body having an orifice end through which the liquid exits from within the vial, and a vial plug movably mounted within the hollow body and operable to push the liquid out through said orifice end, said device comprising a body portion having a first end including means for adjustably receiving said vial and a second end including means for receiving a gas capsule, the gas capsule having a plurality of independent, pressurised gas-containing chambers, each chamber having an openable exit port in an end of the capsule receivable within the device, the body portion further comprising a first part, adjacent said first end, including a cylinder
  • the means for receiving the vial comprises a mounting means for receiving and mounting the vial in an adjustable fashion so that the dose delivered therefrom can be adjusted according to volume of liquid to be delivered.
  • the mounting means comprises a threaded recess with which an external thread on the vial can cooperate so that the vial can be threaded longitudinally along the recess to adjust the volume of liquid providing the dose.
  • the mounting means includes one or more detent means for engaging the vial at one or more positions corresponding to particular predetermined doses.
  • the means for receiving the gas capsule comprises a thread for cooperating with a matching thread on the gas capsule.
  • the passage is open at a restricted part of the second end for cooperating with only one of the openable exit ports of the capsule.
  • the means for receiving the gas capsule allows the gas capsule and the passage opening at the second end to be relatively moved, for example rotated, so as to bring each of the openable exit ports, in turn, into cooperation with the passage opening.
  • the passage opening takes up a third of the area of the second end, the gas capsule having three gas chambers, each having an openable exit port in one respective third of the end of the capsule, the capsule being rotatable to bring each exit port into cooperation with the passage opening, in turn.
  • the means for receiving the gas capsule includes detent means at each of the positions at which an exit port is in cooperation with the passage opening.
  • the trigger means preferably comprises a finger portion on the outside of the body portion, a longitudinal trigger portion within the passage and a connecting portion connecting the finger portion and the trigger portion and extending through a longitudinal aperture in the wall of the body portion.
  • the trigger means is preferably longitudinally movable within the aperture such that the trigger portion moves within the passage, an end of trigger portion reaching the second end of the body portion so as to engage and open the openable exit port of the gas capsule when the trigger means has been moved towards the second end.
  • a biasing means preferably biases the trigger means towards the first end of the device.
  • a gas capsule having a plurality of independent, pressurised gas-containing chambers, each chamber having an openable exit port in an end of the capsule for cooperation, in turn, with an opening in an injector device.
  • the end of the capsule is circular and the exit ports are equally circumferentially spaced therein.
  • the chambers are longitudinally extending in the capsule. In one preferred embodiment, three chambers are provided; although any number could be used.
  • the end of the capsule is preferably provided with a thread for cooperating with a matching thread on the injector device.
  • the openable exit ports are preferably provided with valve means which can be opened by a trigger means on the injector device.
  • the trigger means directly releases compressed gas, stored in the capsule, from each capsule chamber, one at a time. By rotating the capsule, each of the three gas charges can be released.
  • the gas pressure acts upon the piston to drive the piston rod which in turn acts upon the plug in the vial to eject the selected dosage of medication through an orifice in the discharge end of the vial section.
  • Figure 1 is a cross-sectional view of an injector device according to the invention with a vial and gas capsule attached thereto;
  • Figure 2 is a cross-sectional view of a trigger used in the injector device along line A-A of Figure 1;
  • Figure 3 is a cross-sectional view of the body portion of the device along line B-B of Figure 1; and Figure 4 is a cross-sectional view of the gas capsule along line C-C of Figure 1.
  • the an injector device 1 comprises a cylindrical body portion 2 having an external thread section 3 at one end, an internal thread section 4 at the other end, and a passage 5 extending longitudinally through the body portion 2 between the two ends.
  • the passageway 5 at the other end is of substantially the same width as the internal diameter of the internal threaded section 4, but, at the first end, is of reduced cross-sectional area, as shown in Figure 3, so as to cover only a third sector of the internal diameter of the body portion 2.
  • Body portion 4 is also provided with a slot 6 in which trigger 7 is assembled into and moves slidably within body portion 2.
  • Trigger 7, as shown in Figure 2 includes finger portion 8 arranged outside body portion 4, trigger plunger 9 arranged within passageway 5 and trigger stem 10 connecting the finger portion 8 and the trigger plunger 9 through slot 6.
  • the slot 6 is longitudinal so as to allow longitudinal movement of the finger portion 8 to cause longitudinal movement of the trigger plunger 9 within passageway 5.
  • Threaded onto the internal thread section 4 of body portion 2 is cylinder portion 11 having a longitudinal bore 12 therein extending from passageway 5 to an internally threaded end section 13.
  • a shoulder 14 is provided in the bore 12 adjacent the internally threaded end section 13. Cylinder portion 11 is attached to body portion 2 by screwing the cylinder portion into the body internal thread section 4 until a shoulder 25 on outside of cylinder portion 11 engages body end face 26.
  • the shoulder 14 serves as a piston stop, as will be described later, and a guide for a plunger 15 having a piston head 16 sealingly slidably mounted in the cylinder bore 12.
  • a gas exhaust port 46 in the wall of the cylinder portion 11 in communication with the bore 12.
  • a liquid medicament vial 17 is provided as a fitment for the device.
  • the vial 17 has a vial thread section 18 enabling it to be screwed into the cylinder thread section 13.
  • the vial has an orifice 19 at its fore end and the orifice 19 is sealed by a seal that will yield when pressure is applied to liquid medicament housed in a bore 20 of vial 12. Pressure is applied to the medicament by a plug 21 slidably housed in the vial bore 20.
  • the exterior of the vial 17 is marked in any suitable manner to indicate fractions of the capacity of the vial bore 20. For example there may be external markings on the vial to divide the bore length into five sections each of Y mis.
  • the markings on the vial 17 will pass by a datum mark on the cylinder portion 11, for example an end face 22 of the cylinder portion 11 could be such a mark.
  • Detent means is preferably provided whereby the detent is releasably engaged each time a graduation on the vial 17 is aligned with the datum mark. In this way the vial 17 can be releasably locked in a desired position.
  • the plunger 15 is in its zero position when aligned with the end face 22 of the cylinder portion 11.
  • the stroke of the piston head 16 is limited to the distance "X" and therefore when the vial 17 is threaded fully into the cylinder portion 11 so that the end face 23 of vial 17 engages the end of the threaded section of the cylinder portion 11, the plug 21 will be adjacent the end 24 of the plunger 15.
  • the maximum stroke of the plug 21 is slightly greater than "X”. I follows that when the piston head 16 moves the distance "X”, the plug 21 will move the same distance and substantially the whole of the medicamen in the vial 17 will be ejected. If the vial 17 is moved "out” of the cylinder portion 11, the plunger end 24 will be spaced from the plug 21 and although the plunger 15 will move "X”, the plug 21 will move less than "X”.
  • a gas capsule 27 comprising three longitudinal chambers 28, 29, 30 and three valves 31, 32, 33 arranged at exit ports 43, 44, 45 of the respective longitudinal chambers 28, 29, 30, is attached to body portion 24 by screwing an internal thread section 34 onto the body external thread section 3 until an end face 35 of the capsule 27 approaches an en face 36 of the body external thread section 34 and capsule pins 37, 38, 39 provided on the capsule end face 35 engage detents 40, 41, 42 provided on the body end face 36.
  • the three longitudinal chambers each take up a third sector of the capsule 27 and the detents are arranesd so that only one of the valves 31, 31, 33 is aligned with the end of the passageway 5 in body portion 2.
  • the trigger plunger 9 moves through passageway 5 to operate on the one of the valves 31, 32, 33 which is aligned with the passageway 5 to release the gas pressure from the corresponding one of the chambers 28, 29, 30 and allow gas to travel through passageway 5 in body portion 2 and into cylinder portion 11, driving piston head 16 and plunger 15 into vial 17 and displacing plug 21 and the contents of vial 17 in the form of a high pressure jet through the orifice 19.
  • the gas in the chambers 28, 29, 30 is released by the trigger plunger 9 entering through exit ports 43, 44, 45 and opening valves 31, 32, 33.
  • the three detents 40, 41, 42 on body end face 36 and the three corresponding capsule pins 37, 38, 39 on capsule end face 35 ensure that alignment of trigg. plunger 9 and exit ports 43, 44, 45 is maintained in only three possible positions.
  • the device will be made substantially completely from thermosetting plastic materials, using the injection moulding process.
  • Operational Sequence In an operational sequence, a vial 17 would be fitted to the device 1 and the amount of medicament to be ejected would be chosen by the degree to which the vial 17 is threaded into the cylinder portion 11. The device would be positioned with the orifice 19 over the part of the user where the "injection" is to take place.
  • the trigger plunger 9 would enter one of the exit ports 43, 44, 45, opening the corresponding one of valves 31, 32, 33, and thereby releasing gas from the corresponding one of chambers 28, 29, 30.
  • the plug 21 will move the distance "X" or a fraction of that distance and the amount of medicament ejected will vary accordingly.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention se rapporte à un dispositif d'injection à dose variable (1), à trois jets et n'utilisant pas d'aiguille, qui comprend un corps (2) comportant un passage (5) et une détente (7), un cylindre (11) sur lequel une fiole de médicament (17) peut être vissée de façon à varier la dose à appliquer, ainsi qu'une tête de piston (16) pouvant se déplacer dans le cylindre (11) afin de mouvoir un plongeur (15) jusqu'à le faire pénétrer dans la fiole (17). La fiole (17) comporte un canal (20) contenant le médicament, lequel sort par un orifice (19) sous la pression exercée par un tampon (21) mû par le plongeur (15). La tête de piston (16) est amenée à se déplacer grâce à la libération d'un gaz qui sort de l'une (28) des trois chambres contenues dans une capsule de gaz (27), qui traverse un orifice de sortie (43) et qui pénètre dans le passage (5), grâce à l'ouverture d'un clapet (31) par la détente (7). Le passage (5) est conçu pour s'alligner uniquement sur l'orifice de sortie et le clapet de l'une des trois chambres à la fois, de sorte que, par rotation de la capsule (27), trois jets de gaz sont obtenus avec une seule capsule.
EP91920413A 1990-11-09 1991-11-11 Dispositif d'injection a jet hypodermique n'utilisant pas d'aiguille Withdrawn EP0556276A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU3301/90 1990-11-09
AUPK330190 1990-11-09

Publications (2)

Publication Number Publication Date
EP0556276A1 true EP0556276A1 (fr) 1993-08-25
EP0556276A4 EP0556276A4 (fr) 1994-03-23

Family

ID=3775061

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91920413A Withdrawn EP0556276A1 (fr) 1990-11-09 1991-11-11 Dispositif d'injection a jet hypodermique n'utilisant pas d'aiguille

Country Status (3)

Country Link
EP (1) EP0556276A1 (fr)
CA (1) CA2095858A1 (fr)
WO (1) WO1992008508A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
AU7233194A (en) * 1993-07-31 1995-02-28 Weston Medical Limited Needle-less injector
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
US5542920A (en) * 1994-09-12 1996-08-06 Delab Needle-less parenteral introduction device
DE19820172A1 (de) * 1997-09-30 2005-01-27 Wolfgang Wagner Einrichtung und einrichtungsbezogenes Verfahren zur Einbringung eines Diagnostikträgers oder einer Arznei unter die Haut eines Lebewesens
DE10010123A1 (de) 2000-03-03 2001-09-20 Boehringer Ingelheim Int Nadelloser Injektor in Miniaturausführung
AU2005312301B2 (en) 2004-12-01 2012-02-09 Acushot Inc. Needle-free injector
CA2629300C (fr) 2005-11-17 2014-07-08 Zogenix, Inc. Administration de preparations visqueuses par injection sans aiguille
WO2009042716A2 (fr) 2007-09-24 2009-04-02 Pulse Needlefree Systems, Inc. Injecteur sans aiguille comprenant un ensemble d'ajustement de dose
EP3000462A1 (fr) 2008-04-28 2016-03-30 Zogenix, Inc. Compositions inédites destinées au traitement de la migraine
CN103153370B (zh) 2010-09-15 2015-05-13 周吉尼克斯股份有限公司 无针注射器和优化注射性能的无针注射器设计参数
BR112015022023B1 (pt) 2013-03-11 2022-12-06 Durect Corporation Composição de liberação controlada injetável compreendendo transportador líquido de alta viscosidade
FR3057169B1 (fr) * 2016-10-11 2022-04-01 Crossject Buse d’injection pour dispositif d’injection sans aiguille
DE202018102738U1 (de) * 2018-05-16 2018-09-10 Ira Yasmin Lehmann Nadelfreies Injektionssystem

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317298A2 (fr) * 1987-11-16 1989-05-24 Sy-Quest International Limited Appareil pour l'injection hypodermique de liquides

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US2547099A (en) * 1948-03-11 1951-04-03 Becton Dickinson Co Injection device and ampoule
US2653605A (en) * 1951-03-22 1953-09-29 Jr George N Hein Injection device and ampoule
AT278499B (de) * 1967-04-14 1970-02-10 Orszagos Koolaj Gazipari Patrone zum Aufspeichern von unter Druck stehendem Gas und Verfahren zur Herstellung dieser Patrone
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3714943A (en) * 1970-12-01 1973-02-06 H Yanof Medicament injectors
US3853125A (en) * 1971-10-05 1974-12-10 W Clark Disposable needleless injector
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US4790824A (en) * 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
AU6550990A (en) * 1989-11-09 1991-05-16 Bioject, Inc. Needleless hypodermic injection device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317298A2 (fr) * 1987-11-16 1989-05-24 Sy-Quest International Limited Appareil pour l'injection hypodermique de liquides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9208508A1 *

Also Published As

Publication number Publication date
EP0556276A4 (fr) 1994-03-23
WO1992008508A1 (fr) 1992-05-29
CA2095858A1 (fr) 1992-05-10

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