EP0551294A4 - Ribozyme inhibition of bcr-abl gene expression - Google Patents

Ribozyme inhibition of bcr-abl gene expression

Info

Publication number
EP0551294A4
EP0551294A4 EP19910915940 EP91915940A EP0551294A4 EP 0551294 A4 EP0551294 A4 EP 0551294A4 EP 19910915940 EP19910915940 EP 19910915940 EP 91915940 A EP91915940 A EP 91915940A EP 0551294 A4 EP0551294 A4 EP 0551294A4
Authority
EP
European Patent Office
Prior art keywords
bcr
gene expression
abl gene
ribozyme inhibition
ribozyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910915940
Other languages
English (en)
Other versions
EP0551294A1 (en
Inventor
David S. Snyder
John J. Rossi
Stephen J. Forman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
City of Hope
Original Assignee
City of Hope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by City of Hope filed Critical City of Hope
Priority claimed from PCT/US1991/005443 external-priority patent/WO1993003141A1/en
Publication of EP0551294A1 publication Critical patent/EP0551294A1/en
Publication of EP0551294A4 publication Critical patent/EP0551294A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP19910915940 1991-08-01 1991-08-01 Ribozyme inhibition of bcr-abl gene expression Withdrawn EP0551294A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1991/005443 WO1993003141A1 (en) 1991-08-01 1991-08-01 Ribozyme inhibition of bcr-abl gene expression
CA002092571A CA2092571A1 (en) 1991-08-01 1991-08-01 Ribozyme inhibition of bcr-abl gene expression

Publications (2)

Publication Number Publication Date
EP0551294A1 EP0551294A1 (en) 1993-07-21
EP0551294A4 true EP0551294A4 (en) 1993-12-29

Family

ID=4151351

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910915940 Withdrawn EP0551294A4 (en) 1991-08-01 1991-08-01 Ribozyme inhibition of bcr-abl gene expression

Country Status (3)

Country Link
EP (1) EP0551294A4 (ja)
JP (1) JPH06501610A (ja)
CA (1) CA2092571A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK500652015A3 (sk) * 2015-10-15 2017-05-03 Ústav Polymérov Sav Spôsob úpravy funkčného stavu ľubovoľnej mRNA umožňujúci jej selektívne a špecifické rozpoznanie

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004753A1 (en) * 1989-10-02 1991-04-18 Cetus Corporation Conjugates of antisense oligonucleotides and therapeutic uses thereof
WO1992000080A1 (en) * 1990-06-26 1992-01-09 The Wistar Institute Of Anatomy & Biology Method for treating leukemias

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004753A1 (en) * 1989-10-02 1991-04-18 Cetus Corporation Conjugates of antisense oligonucleotides and therapeutic uses thereof
WO1992000080A1 (en) * 1990-06-26 1992-01-09 The Wistar Institute Of Anatomy & Biology Method for treating leukemias

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SCIENCE vol. 245, 8 September 1989, LANCASTER, PA US pages 1107 - 1110 CARACCIOLO, D. ET AL. 'Lineage-specific requirement of c-abl function in normal hematopoiesis' *
See also references of WO9303141A1 *
TRENDS IN BIOTECHNOLOGY vol. 8, no. 7, July 1990, CAMBRIDGE GB pages 174 - 178 COTTEN, M. 'The in vivo application of ribozymes' *

Also Published As

Publication number Publication date
CA2092571A1 (en) 1993-02-02
JPH06501610A (ja) 1994-02-24
EP0551294A1 (en) 1993-07-21

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19930430

AK Designated contracting states

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RHK1 Main classification (correction)

Ipc: C12N 15/52

A4 Supplementary search report drawn up and despatched

Effective date: 19931111

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18W Application withdrawn

Withdrawal date: 19940308

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Effective date: 19940308