EP0546174A4 - Monodisperse single and double emulsions and production thereof - Google Patents

Monodisperse single and double emulsions and production thereof

Info

Publication number
EP0546174A4
EP0546174A4 EP19910911947 EP91911947A EP0546174A4 EP 0546174 A4 EP0546174 A4 EP 0546174A4 EP 19910911947 EP19910911947 EP 19910911947 EP 91911947 A EP91911947 A EP 91911947A EP 0546174 A4 EP0546174 A4 EP 0546174A4
Authority
EP
European Patent Office
Prior art keywords
production
range
double emulsions
monodisperse single
monodisperse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19910911947
Other versions
EP0546174A1 (en
EP0546174B1 (en
Inventor
Tadao 501 Oaza-Shioji Nakashima
Masataka 11074 Oaza-Shimanouchi Shimizu
Masato Ken-Kyosai-Juutaku Kukizaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MIYAZAKI-KEN
Original Assignee
MIYAZAKI-KEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MIYAZAKI-KEN filed Critical MIYAZAKI-KEN
Priority claimed from PCT/JP1991/000882 external-priority patent/WO1993000156A1/en
Publication of EP0546174A1 publication Critical patent/EP0546174A1/en
Publication of EP0546174A4 publication Critical patent/EP0546174A4/en
Application granted granted Critical
Publication of EP0546174B1 publication Critical patent/EP0546174B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
    • B01F25/31421—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction the conduit being porous
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
    • B01F25/53—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle in which the mixture is discharged from and reintroduced into a receptacle through a recirculation tube, into which an additional component is introduced

Abstract

A monodisperse single emulsion containing particles with a mean diameter within the range of 0.3 to 40 mu m and being substantially free from particles with a diameter as small as 50 % of the mean diameter or less; and a monodisperse double emulsion containing particles with a mean diameter within the range of 0.3 to 40 mu m and an internal phase concentration which is substantially uniformly regulated to be within the range of 1 to 70 %.
EP91911947A 1991-06-29 1991-06-29 Monodisperse single and double emulsions and production thereof Expired - Lifetime EP0546174B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1991/000882 WO1993000156A1 (en) 1991-06-29 1991-06-29 Monodisperse single and double emulsions and production thereof
US07/906,282 US5326484A (en) 1991-06-29 1992-06-29 Monodisperse single and double emulsions and method of producing same

Publications (3)

Publication Number Publication Date
EP0546174A1 EP0546174A1 (en) 1993-06-16
EP0546174A4 true EP0546174A4 (en) 1993-09-15
EP0546174B1 EP0546174B1 (en) 1997-10-29

Family

ID=25422192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91911947A Expired - Lifetime EP0546174B1 (en) 1991-06-29 1991-06-29 Monodisperse single and double emulsions and production thereof

Country Status (2)

Country Link
EP (1) EP0546174B1 (en)
JP (1) JP2733729B2 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9414318D0 (en) * 1994-07-15 1994-09-07 Dowelanco Ltd Preparation of aqueous emulsions
JP2975943B2 (en) * 1996-02-20 1999-11-10 農林水産省食品総合研究所長 Emulsion manufacturing method and emulsion manufacturing apparatus
GB9606738D0 (en) * 1996-03-29 1996-06-05 Disperse Tech Ltd Dispersion of immiscible phases
JP3081880B2 (en) 1998-03-30 2000-08-28 農林水産省食品総合研究所長 Microsphere continuous manufacturing equipment
FR2808703B1 (en) * 2000-05-09 2002-08-02 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF A DOUBLE MONODISPERSE EMULSION
JP3511238B2 (en) 2000-10-13 2004-03-29 独立行政法人食品総合研究所 Microsphere manufacturing method and manufacturing apparatus
JP4659253B2 (en) * 2001-03-30 2011-03-30 サンスター株式会社 Method for producing emulsion composition
EP1412418A1 (en) * 2001-08-03 2004-04-28 Akzo Nobel N.V. Process to make dispersions
JP4038585B2 (en) * 2002-06-03 2008-01-30 宮崎県 Solid fat microcapsule and method for producing the same
DE10351644A1 (en) * 2003-11-05 2005-06-09 Bayer Technology Services Gmbh Process for the preparation of storage-stable multiple emulsions
JP4616602B2 (en) * 2004-09-16 2011-01-19 大日本塗料株式会社 Method for producing monodisperse particles
JP5079977B2 (en) * 2004-09-16 2012-11-21 大日本塗料株式会社 Method for producing monodisperse particles
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP4580801B2 (en) 2005-03-29 2010-11-17 株式会社東芝 Composite type fine particle manufacturing method and composite type fine particle manufacturing apparatus
JP2007106975A (en) * 2005-10-11 2007-04-26 Spg Trading Kk Device for manufacturing spg (shirasu porous glass) emulsion fuel
JP4713397B2 (en) 2006-01-18 2011-06-29 株式会社リコー Microchannel structure and microdroplet generation system
JP2007204382A (en) * 2006-01-31 2007-08-16 Kyoto Univ Method for producing liposome
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
US8293819B2 (en) 2006-11-24 2012-10-23 Canon Kabushiki Kaisha Method for producing particles and particles
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
JP5532921B2 (en) 2007-05-14 2014-06-25 コニカミノルタ株式会社 Liposome
JP5103191B2 (en) * 2008-01-09 2012-12-19 日本たばこ産業株式会社 Oil-in-water emulsion and production method thereof
JP5091784B2 (en) * 2008-07-10 2012-12-05 積水化学工業株式会社 Emulsion production apparatus, monodisperse fine particle production apparatus, emulsion production method, and monodisperse fine particle production method
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
WO2011062132A1 (en) * 2009-11-20 2011-05-26 コニカミノルタホールディングス株式会社 Process for production of w/o/w emulsion, process for production of liposome employing the process, and porous membrane for use in the methods
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (en) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド Digital specimen analysis
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
JP5415510B2 (en) * 2011-11-01 2014-02-12 日本たばこ産業株式会社 Method for producing oil-in-water emulsion
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
JP2020535224A (en) * 2017-09-26 2020-12-03 ナノミ・ベー・フェー Method of preparing microparticles by double emulsion technique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0452140A1 (en) * 1990-04-11 1991-10-16 Morinaga Milk Industry Co., Ltd. Method for producing emulsions, low-fat spread and oil-in-water-in-oil type spread
EP0481892A1 (en) * 1990-10-16 1992-04-22 Sugiura, Satoshi Process for producing inorganic particulate material in the form of fine balls approximately uniform in size

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH082416B2 (en) * 1988-09-29 1996-01-17 宮崎県 Method of producing emulsion
JP2847107B2 (en) * 1989-02-16 1999-01-13 富士シリシア化学株式会社 Preparation method of emulsion
JPH04219131A (en) * 1990-12-20 1992-08-10 Fuji Davison Chem Ltd Production of emulsion and spherical silica gel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0452140A1 (en) * 1990-04-11 1991-10-16 Morinaga Milk Industry Co., Ltd. Method for producing emulsions, low-fat spread and oil-in-water-in-oil type spread
EP0481892A1 (en) * 1990-10-16 1992-04-22 Sugiura, Satoshi Process for producing inorganic particulate material in the form of fine balls approximately uniform in size

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPIL Week 9020, Derwent Publications Ltd., London, GB; AN 90-151461 & JP-A-2 095 433 (MIYAZAKI KEN) 6 April 1990 *
DATABASE WPIL Week 9040, Derwent Publications Ltd., London, GB; AN 90-302269 & JP-A-2 214 537 (FUJI DEVISON KAGAKU) 27 August 1990 *
DATABASE WPIL Week 9238, Derwent Publications Ltd., London, GB; AN 92-312814 & JP-A-4 219 131 (FUJI DAVISON CHEM LTD) 10 August 1992 *
See also references of WO9300156A1 *

Also Published As

Publication number Publication date
EP0546174A1 (en) 1993-06-16
JPH05220382A (en) 1993-08-31
JP2733729B2 (en) 1998-03-30
EP0546174B1 (en) 1997-10-29

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