EP0542753A4 - Epitopes of the pre-s region of hepatitis b virus surface antigen - Google Patents

Epitopes of the pre-s region of hepatitis b virus surface antigen

Info

Publication number
EP0542753A4
EP0542753A4 EP19910910584 EP91910584A EP0542753A4 EP 0542753 A4 EP0542753 A4 EP 0542753A4 EP 19910910584 EP19910910584 EP 19910910584 EP 91910584 A EP91910584 A EP 91910584A EP 0542753 A4 EP0542753 A4 EP 0542753A4
Authority
EP
European Patent Office
Prior art keywords
epitopes
hepatitis
region
surface antigen
virus surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910910584
Other languages
English (en)
Other versions
EP0542753A1 (en
Inventor
David R. Milich
George B. Thornton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of EP0542753A1 publication Critical patent/EP0542753A1/en
Publication of EP0542753A4 publication Critical patent/EP0542753A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP19910910584 1990-05-11 1991-05-10 Epitopes of the pre-s region of hepatitis b virus surface antigen Withdrawn EP0542753A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52266390A 1990-05-11 1990-05-11
US522663 1990-05-11

Publications (2)

Publication Number Publication Date
EP0542753A1 EP0542753A1 (en) 1993-05-26
EP0542753A4 true EP0542753A4 (en) 1993-09-08

Family

ID=24081802

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910910584 Withdrawn EP0542753A4 (en) 1990-05-11 1991-05-10 Epitopes of the pre-s region of hepatitis b virus surface antigen

Country Status (5)

Country Link
EP (1) EP0542753A4 (pt)
AU (1) AU7909391A (pt)
IE (1) IE911614A1 (pt)
PT (1) PT97632A (pt)
WO (1) WO1991017768A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759551A (en) * 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
JP2001500738A (ja) 1996-09-17 2001-01-23 カイロン コーポレイション 細胞内疾患を処置するための組成物および方法
DE10339927A1 (de) * 2003-08-29 2005-03-24 Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen
WO2021101813A1 (en) * 2019-11-18 2021-05-27 Vlp Biotech, Inc. Hybrid virus-like particles and uses thereof as a therapeutic hepatitis b vaccine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007896A1 (en) * 1986-06-20 1987-12-30 Scripps Clinic And Research Foundation T and b cell epitopes of the pre-s region of hepatitis b virus surface antigen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935235A (en) * 1979-05-24 1990-06-19 The Regents Of The University Of California Non-passageable viruses
US4861588A (en) * 1985-02-05 1989-08-29 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
US4847080A (en) * 1984-03-07 1989-07-11 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers
US4683136A (en) * 1985-03-06 1987-07-28 Scripps Clinic And Research Foundation Proteinaceous antigens with conformation-independent and conformation-dependent determinants
US4882145A (en) * 1986-12-09 1989-11-21 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007896A1 (en) * 1986-06-20 1987-12-30 Scripps Clinic And Research Foundation T and b cell epitopes of the pre-s region of hepatitis b virus surface antigen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANN. INST. PASTEUR VIROL. vol. 139, no. 1, 1988, pages 13 - 38 A. NEURATH ET AL. 'Delineation of contiguous determinants essential for biological functions of the pre-s sequence of hepatitis B virus envelope protein' *
PROC. NATL ACAD. SCI. USA vol. 85, 1988, pages 1610 - 1614 D. MILICH ET AL. 'Hepatitis B synthetic immunogen composed of nucleocapsid T-cell sites and an envelope B cell epitope' *
PROC. NATL. ACAD. SCI. USA vol. 86, 1989, pages 9084 - 9088 J. TAM 'Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines' *
See also references of WO9117768A1 *

Also Published As

Publication number Publication date
EP0542753A1 (en) 1993-05-26
PT97632A (pt) 1992-03-31
WO1991017768A1 (en) 1991-11-28
AU7909391A (en) 1991-12-10
IE911614A1 (en) 1992-09-23

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19921204

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: THORNTON, GEORGE B.

Inventor name: MILICH, DAVID R.

A4 Supplementary search report drawn up and despatched

Effective date: 19930726

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19931010